scholarly journals 20 years of expert review of anticancer therapy

Author(s):  
Gertjan J.L. Kaspers
Author(s):  
Sven Schneider ◽  
Katharina Diehl ◽  
Christina Bock ◽  
Raphael M. Herr ◽  
Manfred Mayer ◽  
...  

Zielsetzung: Die Hausarztpraxis gilt als ideales Setting für die Tabakentwöhnung. Die bundesweite „ÄSP-kardio-Studie“ liefert aktuelle Daten zum Status quo der Tabakentwöhnung nach der „5 A-Strategie“ in deutschen Hausarztpraxen. Methodik: Zwischen 10/2011 und 03/2012 wurden über 4.000 Hausärzte repräsentativ befragt. Der Fragebogen wurde vorab einem Expert Review unterzogen, durch kognitive Interviews validiert und in einer Pilotstudie getestet. Ergebnisse: Routinemäßig erfassten 89 % der Hausärzte etwaigen Tabakkonsum („Assess“), 82 % rieten Rauchern zu einem Rauchstopp („Advise“) und 12 % vereinbarten schriftliche Ziele einer Entwöhnung („Agree“). Hilfestellungen („Assist“) in Form einer Kurzintervention fanden mit 72 % deutlich häufiger statt als in Form von Informationsmaterial (33 %) oder einer Entwöhnungstherapie (27 %). Etwa die Hälfte (54 %) vereinbarte Folgetermine zur Überprüfung des Rauchstopps („Arrange“). Das Angebot war von arzt-, praxis- sowie patientenspezifischen Faktoren abhängig und in den nordöstlichen Bundesländern unterdurchschnittlich. Acht von 10 Hausärzten (77 %) bewerteten ihre Maßnahmen als nicht erfolgreich. Schlussfolgerungen: Deutlich wird die suboptimale und ungleich verteilte Versorgung von Rauchern mit angemessenen Entwöhnungsmaßnahmen in deutschen Hausarztpraxen.


Author(s):  
Antonius Prasetyo Hadi

: The use of learning media is one of the critical success factors in higher education, therefore an educator must have innovation to use of learning media. The purpose of this research is to develop learning media based on the Inspiring Suit 8 on arbitration material courses of theoretical and practice for Volleyball 1 academic year 2018/2019 at IKIP Budi Utomo Malang. The existence of media will be a big successful support in learning process, so that students do not feel boredom because of the weaknesses of the lecturers, in which they are unable to provided good learning variation or even have difficulty in conveying or transferring knowledge. The research was descriptive qualitative design. The research subjects were students of Physical Education, Health, and Recreation Study Program who took volleyball theory and practice courses in the even semester academic year 2018/2019. The instruments used were the media expert review questionnaire, the learning expert questionnaire, and the trial analysis questionnaire. The questionnaire will be analyzed to see the feasibility of the developed media. Based on the data results review by media expert volleyball, media learning expert and field trials, it can be concluded that media developed is useful in learning process. In addition, it is used to provide independent motivation, which can be used in lesson for students.


2020 ◽  
Author(s):  
Daniel Herp ◽  
Johannes Ridinger ◽  
Dina Robaa ◽  
Stephen A. Shinsky ◽  
Karin Schmidtkunz ◽  
...  

Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, esp. cancer. First HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc-dependent HDACs, HDAC10 has received relatively little attention by drug discovery campaigns, despite its involvement e.g. in the pathogenesis of neuroblastoma. This is due in part to a lack of robust enzymatic conversion assays. In contrast to the protein lysine deacetylase and deacylase activity of the other HDAC subtypes, it has recently been shown that HDAC10 has strong preferences for deacetylation of oligoamine substrates like spermine or spermidine. Hence, it also termed a polyamine deacetylase (PDAC). Here, we present the first fluorescent enzymatic conversion assay for HDAC10 using an aminocoumarin labelled acetyl spermidine derivative to measure its PDAC activity, which is suitable for high-throughput screening. Using this assay, we identified potent inhibitors of HDAC10 mediated spermidine deacetylation in-vitro. Among those are potent inhibitors of neuroblastoma colony growth in culture that show accumulation of lysosomes, implicating disturbance of autophagic flux.


2020 ◽  
Vol 27 (40) ◽  
pp. 6815-6824 ◽  
Author(s):  
Yuan Jiang ◽  
Chuanshan Xu ◽  
Wingnang Leung ◽  
Mei Lin ◽  
Xiaowen Cai ◽  
...  

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.


2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini

2013 ◽  
Vol 19 (22) ◽  
pp. 4131-4139 ◽  
Author(s):  
Tomoaki Tanaka ◽  
Tatsuya Nakatani ◽  
Tetsu Kamitani

Sign in / Sign up

Export Citation Format

Share Document