CTIP2 AND LIPID METABOLISM: REGULATION IN SKIN DEVELOPMENT AND ASSOCIATED DISEASES

Background: Animal and clinical studies have shown that remote ischemic conditioning (RIC) has protective effects for cerebral vascular diseases, with induced humoral factor changes in the peripheral blood. However, many findings are heterogeneous, perhaps due to differences in the RIC intervention schemes, enrolled populations, and sample times. This study aimed to examine the RIC-induced changes in the plasma proteome using rhesus monkey models of strokes. Methods: Two adult rhesus monkeys with autologous blood clot-induced middle cerebral artery (MCA) occlusion underwent RIC interventions twice a week for five consecutive weeks. Each RIC treatment included five cycles of five minutes of ischemia alternating with five minutes of reperfusion of the forearm. The blood samples were taken from the median cubital vein of the monkeys at baseline and immediately after each week’s RIC stimulus. The plasma samples were isolated for a proteomic analysis using mass spectrometry (MS). Results: Several proteins related to lipid metabolism (Apolipoprotein A-II and Apolipoprotein C-II), coagulation (Fibrinogen alpha chain and serpin), immunoinflammatory responses (complement C3 and C1), and endovascular hemostasis (basement membrane-specific heparan sulfate proteoglycan) were significantly modulated after the RIC intervention. Many of these induced changes, such as in the lipid metabolism regulation and anticoagulation responses, starting as early as two weeks following the RIC intervention. The complementary activation and protection of the endovascular cells occurred more than three weeks postintervention. Conclusions: Multiple protective effects were induced by RIC and involved lipid metabolism regulation (anti-atherogenesis), anticoagulation (antithrombosis), complement activation, and endovascular homeostasis (anti-inflammation). In conclusion, this study indicates that RIC results in significant modulations of the plasma proteome. It also provides ideas for future research and screening targets.

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Serum Lipoproteins and their Role in Mechanisms of Lipid Metabolism Regulation in the Carp Organism over Cultivation in the Heated Water

Hydrobiological Journal ◽

10.1615/hydrobj.v57.i2.70 ◽

2021 ◽

Vol 57 (2) ◽

pp. 79-86

Author(s):

N. Yu. Yevtushenko

Keyword(s):

Lipid Metabolism ◽

Serum Lipoproteins ◽

Metabolism Regulation ◽

Heated Water

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Pretreatment of buckwheat globulin by ultra-high pressure: Effects on enzymatic hydrolysis and final hydrolysate lipid metabolism regulation capacities

Food Chemistry ◽

10.1016/j.foodchem.2022.132102 ◽

2022 ◽

pp. 132102

Author(s):

Yiming Zhou ◽

Tian Wang ◽

Xuanming She ◽

Yun Wei ◽

Xiaoli Zhou ◽

...

Keyword(s):

High Pressure ◽

Lipid Metabolism ◽

Enzymatic Hydrolysis ◽

Pressure Effects ◽

Metabolism Regulation ◽

Ultra High Pressure ◽

High Pressure Effects

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Intestinal miRNAs regulated in response to dietary lipids

Scientific Reports ◽

10.1038/s41598-020-75751-w ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Judit Gil-Zamorano ◽

João Tomé-Carneiro ◽

María-Carmen Lopez de las Hazas ◽

Lorena del Pozo-Acebo ◽

M. Carmen Crespo ◽

...

Keyword(s):

Small Intestine ◽

Lipid Metabolism ◽

Chronic Exposure ◽

Potential Role ◽

In Vitro Models ◽

Dietary Lipids ◽

Metabolism Regulation

Abstract The role of miRNAs in intestinal lipid metabolism is poorly described. The small intestine is constantly exposed to high amounts of dietary lipids, and it is under conditions of stress that the functions of miRNAs become especially pronounced. Approaches consisting in either a chronic exposure to cholesterol and triglyceride rich diets (for several days or weeks) or an acute lipid challenge were employed in the search for intestinal miRNAs with a potential role in lipid metabolism regulation. According to our results, changes in miRNA expression in response to fat ingestion are dependent on factors such as time upon exposure, gender and small intestine section. Classic and recent intestinal in vitro models (i.e. differentiated Caco-2 cells and murine organoids) partially mirror miRNA modulation in response to lipid challenges in vivo. Moreover, intestinal miRNAs might play a role in triglyceride absorption and produce changes in lipid accumulation in intestinal tissues as seen in a generated intestinal Dicer1-deletion murine model. Overall, despite some variability between the different experimental cohorts and in vitro models, results show that some miRNAs analysed here are modulated in response to dietary lipids, hence likely to participate in the regulation of lipid metabolism, and call for further research.

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Phytosterols and their derivatives: Potential health‐promoting uses against lipid metabolism and associated diseases, mechanism, and safety issues

Comprehensive Reviews in Food Science and Food Safety ◽

10.1111/1541-4337.12560 ◽

2020 ◽

Vol 19 (4) ◽

pp. 1243-1267 ◽

Cited By ~ 2

Author(s):

Simin Feng ◽

Tarun Belwal ◽

Li Li ◽

Jarukitt Limwachiranon ◽

Xingquan Liu ◽

...

Keyword(s):

Lipid Metabolism ◽

Potential Health ◽

Safety Issues ◽

Associated Diseases ◽

Health Promoting

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A systemic study of lipid metabolism regulation in salmon fingerlings and early juveniles fed plant oil

British Journal Of Nutrition ◽

10.1017/s0007114518001885 ◽

2018 ◽

Vol 120 (6) ◽

pp. 653-664 ◽

Cited By ~ 5

Author(s):

Yang Jin ◽

Rolf E. Olsen ◽

Gareth B. Gillard ◽

Mari-Ann Østensen ◽

Sven A. Korsvoll ◽

...

Keyword(s):

Lipid Metabolism ◽

Fish Oil ◽

Cholesterol Metabolism ◽

Treatment Plant ◽

Regulatory Control ◽

Liver Cholesterol ◽

Fish Feed ◽

Plant Oil ◽

Pyloric Caeca ◽

Metabolism Regulation

AbstractIn salmon farming, the scarcity of fish oil has driven a shift towards the use of plant-based oil from vegetable or seed, leading to fish feed low in long-chain PUFA (LC-PUFA) and cholesterol. Atlantic salmon has the capacity to synthesise both LC-PUFA and cholesterol, but little is known about the regulation of synthesis and how it varies throughout salmon life span. Here, we present a systemic view of lipid metabolism pathways based on lipid analyses and transcriptomic data from salmon fed contrasting diets of plant or fish oil from first feeding. We analysed four tissues (stomach, pyloric caeca, hindgut and liver) at three life stages (initial feeding 0·16 g, 2·5 g fingerlings and 10 g juveniles). The strongest response to diets higher in plant oil was seen in pyloric caeca of fingerlings, with up-regulation of thirty genes in pathways for cholesterol uptake, transport and biosynthesis. In juveniles, only eleven genes showed differential expression in pyloric caeca. This indicates a higher requirement of dietary cholesterol in fingerlings, which could result in a more sensitive response to plant oil. The LC-PUFA elongation and desaturation pathway was down-regulated in pyloric caeca, probably regulated bysrebp1genes. In liver, cholesterol metabolism and elongation and desaturation genes were both higher on plant oil. Stomach and hindgut were not notably affected by dietary treatment. Plant oil also had a higher impact on fatty acid composition of fingerlings compared with juveniles, suggesting that fingerlings have less metabolic regulatory control when primed with plant oil diet compared with juveniles.

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Insulin, IGF-I, and muscle MAPK pathway responses after sustained exercise and their contribution to growth and lipid metabolism regulation in gilthead sea bream

Domestic Animal Endocrinology ◽

10.1016/j.domaniend.2013.08.001 ◽

2013 ◽

Vol 45 (3) ◽

pp. 145-153 ◽

Cited By ~ 12

Author(s):

J. Sánchez-Gurmaches ◽

L. Cruz-Garcia ◽

A. Ibarz ◽

J. Fernández-Borrás ◽

J. Blasco ◽

...

Keyword(s):

Lipid Metabolism ◽

Mapk Pathway ◽

Gilthead Sea Bream ◽

Sea Bream ◽

Metabolism Regulation ◽

Igf I

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SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer

Cell Death and Disease ◽

10.1038/s41419-021-04411-2 ◽

2021 ◽

Vol 12 (12) ◽

Author(s):

Ying Yang ◽

Jiaxing He ◽

Bo Zhang ◽

Zhansheng Zhang ◽

Guozhan Jia ◽

...

Keyword(s):

Colorectal Cancer ◽

Lipid Metabolism ◽

Energy Metabolism ◽

Cell Apoptosis ◽

De Novo ◽

Lipid Synthesis ◽

Growth And Survival ◽

Metabolism Regulation

AbstractAbnormal lipid metabolism has been commonly observed in various human cancers, including colorectal cancer (CRC). The mitochondrial citrate carrier SLC25A1 (also known as mitochondrial citrate/isocitrate carrier, CIC), has been shown to play an important role in lipid metabolism regulation. Our bioinformatics analysis indicated that SLC25A1 was markedly upregulated in CRC. However, the role of SLC25A1 in the pathogenesis and aberrant lipid metabolism in CRC remain unexplored. Here, we found that SLC25A1 expression was significantly increased in tumor samples of CRC as compared with paired normal samples, which is associated with poor survival in patients with CRC. Knockdown of SLC25A1 significantly inhibited the growth of CRC cells by suppressing the progression of the G1/S cell cycle and inducing cell apoptosis both in vitro and in vivo, whereas SLC25A1 overexpression suppressed the malignant phenotype. Additionally, we demonstrated that SLC25A1 reprogrammed energy metabolism to promote CRC progression through two mechanisms. Under normal conditions, SLC25A1 increased de novo lipid synthesis to promote CRC growth. During metabolic stress, SLC25A1 increased oxidative phosphorylation (OXPHOS) to protect protects CRC cells from energy stress-induced cell apoptosis. Collectively, SLC25A1 plays a pivotal role in the promotion of CRC growth and survival by reprogramming energy metabolism. It could be exploited as a novel diagnostic marker and therapeutic target in CRC.

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