The acute toxic effects of silver nanoparticles on myocardial transmembrane potential, INa and IK1 channels and heart rhythm in mice

2017 ◽  
pp. 1-11 ◽  
Author(s):  
Cai-Xia Lin ◽  
Su-Yu Yang ◽  
Jing-Li Gu ◽  
Jie Meng ◽  
Hai-Yan Xu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Transmembrane Potential ◽  
Heart Rhythm ◽  
Toxic Effects ◽  
Acute Toxic

Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice

2012 ◽  
Vol 32 (11) ◽  
pp. 890-899 ◽  
Author(s):  
Yuying Xue ◽  
Shanshan Zhang ◽  
Yanmei Huang ◽  
Ting Zhang ◽  
Xiaorun Liu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Intravenous Injection ◽  
Toxic Effects ◽  
And Gender ◽  
Acute Toxic

scholarly journals Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene

2021 ◽  
Vol 22 (5) ◽  
pp. 2536
Author(s):  
Rong-Jane Chen ◽  
Chiao-Ching Huang ◽  
Rosita Pranata ◽  
Yu-Hsuan Lee ◽  
Yu-Ying Chen ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Good Alternative ◽  
Innate Immune ◽  
Toxic Effects ◽  
Transgenic Zebrafish ◽  
Zebrafish Model ◽  
Cytokines And Chemokines ◽  
Living Organisms ◽  
And Function ◽  
Immune Toxicity

Silver nanoparticles pose a potential risk to ecosystems and living organisms due to their widespread use in various fields and subsequent gradual release into the environment. Only a few studies have investigated the effects of silver nanoparticles (AgNPs) toxicity on immunological functions. Furthermore, these toxic effects have not been fully explored. Recent studies have indicated that zebrafish are considered a good alternative model for testing toxicity and for evaluating immunological toxicity. Therefore, the purpose of this study was to investigate the toxicity effects of AgNPs on innate immunity using a zebrafish model and to investigate whether the natural compound pterostilbene (PTE) could provide protection against AgNPs-induced immunotoxicity. Wild type and neutrophil- and macrophage-transgenic zebrafish lines were used in the experiments. The results indicated that the exposure to AgNPs induced toxic effects including death, malformation and the innate immune toxicity of zebrafish. In addition, AgNPs affect the number and function of neutrophils and macrophages. The expression of immune-related cytokines and chemokines was also affected. Notably, the addition of PTE could activate immune cells and promote their accumulation in injured areas in zebrafish, thereby reducing the damage caused by AgNPs. In conclusion, AgNPs may induce innate immune toxicity and PTE could ameliorate this toxicity.

Acute toxic effects of sodium selenate on the epiphyseal plate of the rat

1971 ◽  
Vol 7 (1) ◽  
pp. 318-330 ◽  
Author(s):  
Robert D. Campo ◽  
Robert J. Bielen
Keyword(s):  
Epiphyseal Plate ◽  
Toxic Effects ◽  
Sodium Selenate ◽  
Acute Toxic

scholarly journals Relationship between Chemotherapy and Atrial Fibrillation: Clinical Case

2021 ◽  
Vol 17 (5) ◽  
pp. 785-791
Author(s):  
A. A. Avagimyan ◽  
L. H. Mkrtchyan ◽  
A. A. Gevorkyan ◽  
N. B. Kononchuk ◽  
L. V. Kakturskiy ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiovascular System ◽  
Young Woman ◽  
Clinical Case ◽  
Detrimental Effect ◽  
Heart Rhythm ◽  
Toxic Effects ◽  
Highly Effective

The aim of this article is to represent the characterization of the clinical case of chemotherapy-related atrial fibrillation (AF) development in the young woman, elaborated as a result of multiple neoadjuvant and adjuvant modes of the intake of chemotherapy (both anthracycline based and non-anthracycline ones). In this case, the noted disturbances of heart rhythm should be recognized as a manifestation of cardiotoxicity. The latter implies the degree of detrimental effect of chemotherapeutical medication on the morphophynctional parameters of the cardiovascular system. Anthracycline drugs, being highly effective chemotherapytical agents, provide well-known toxic effects on the heart and vessels. Anthracycline mediated cardiotoxicity is a well- known veracity that dates back to the 60s of the last century, but up to now this medication sustains irreplaceable components of big volume of chemotherapy modes. Moreover, it should be noted that relatively newer drugs also posses certain cardiotoxicogenic potential.

scholarly journals UJI TOKSISITAS AKUT MINUMAN PROBIOTIK SIRSAK GUNUNG (Annona montana Macf.) DENGAN METODE BSLT (Brine Shrimp Lethality Test)

2020 ◽  
Vol 1 (5) ◽  
pp. 941-948
Author(s):  
Ambar Fidyasari ◽  
Sentot Joko Raharjo ◽  
Melani Setyowati
Keyword(s):  
Acute Toxicity ◽  
Traditional Medicine ◽  
Brine Shrimp ◽  
Experimental Methods ◽  
Test Method ◽  
Toxic Effects ◽  
Brine Shrimp Lethality ◽  
Lc50 Value ◽  
A Value ◽  
Acute Toxic

Soursop fruit (Annona montana Macf.) is one of the plants can be used as as traditional medicine. This plant contains terpenoid and acetogenin which can cause toxicity. The fruit has a flavor that is tasteless so the innovation becomes probiotic drinks. This drink has been proven as an antioxidant, antibacterial, antihyperuricemia and antidiarrheal. The aim of this study was to know about acute toxicity of probiotic drink of soursop juice using brine shrimp lethality test method which will be indicated by LC50 value. This study used experimental methods conducted in the Laboratory of Farmakoknosi. There are several variations in concentration in this study, namely 10000 ppm, 20000 ppm, 30000 ppm, 40000 ppm, 50000 ppm, 60000 ppm, 70000 ppm, 80000 ppm and replication was done 3 times with total number of test animals used was 270. The results showed that probiotic drink of soursop juice can provide acute toxic effects on test animals with LC50 value of 29717,23 ppm. LC50 values ​​indicate that the mountain soursop probiotic drink is not potentially toxic because it has a value of >1000 ppm.

scholarly journals Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6610
Author(s):  
Ana T. Rufino ◽  
Ana Ramalho ◽  
Adelaide Sousa ◽  
José Miguel P. Ferreira de Oliveira ◽  
Paulo Freitas ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Protective Action ◽  
Cell Types ◽  
Protective Role ◽  
Toxic Effects ◽  
Oral Exposure ◽  
Dietary Flavonoids ◽  
Harmful Effects ◽  
Human Intestinal Cells

Silver nanoparticles (AgNP) have been increasingly incorporated into food-related and hygiene products for their unique antimicrobial and preservative properties. The consequent oral exposure may then result in unpredicted harmful effects in the gastrointestinal tract (GIT), which should be considered in the risk assessment and risk management of these materials. In the present study, the toxic effects of polyethyleneimine (PEI)-coated AgNP (4 and 19 nm) were evaluated in GIT-relevant cells (Caco-2 cell line as a model of human intestinal cells, and neutrophils as a model of the intestinal inflammatory response). This study also evaluated the putative protective action of dietary flavonoids against such harmful effects. The obtained results showed that AgNP of 4 and 19 nm effectively induced Caco-2 cell death by apoptosis with concomitant production of nitric oxide, irrespective of the size. It was also observed that AgNP induced human neutrophil oxidative burst. Interestingly, some flavonoids, namely quercetin and quercetagetin, prevented the deleterious effects of AgNP in both cell types. Overall, the data of the present study provide a first insight into the promising protective role of flavonoids against the potentially toxic effects of AgNP at the intestinal level.

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