Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice

Silver nanoparticles pose a potential risk to ecosystems and living organisms due to their widespread use in various fields and subsequent gradual release into the environment. Only a few studies have investigated the effects of silver nanoparticles (AgNPs) toxicity on immunological functions. Furthermore, these toxic effects have not been fully explored. Recent studies have indicated that zebrafish are considered a good alternative model for testing toxicity and for evaluating immunological toxicity. Therefore, the purpose of this study was to investigate the toxicity effects of AgNPs on innate immunity using a zebrafish model and to investigate whether the natural compound pterostilbene (PTE) could provide protection against AgNPs-induced immunotoxicity. Wild type and neutrophil- and macrophage-transgenic zebrafish lines were used in the experiments. The results indicated that the exposure to AgNPs induced toxic effects including death, malformation and the innate immune toxicity of zebrafish. In addition, AgNPs affect the number and function of neutrophils and macrophages. The expression of immune-related cytokines and chemokines was also affected. Notably, the addition of PTE could activate immune cells and promote their accumulation in injured areas in zebrafish, thereby reducing the damage caused by AgNPs. In conclusion, AgNPs may induce innate immune toxicity and PTE could ameliorate this toxicity.

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Toxic effects of repeated oral exposure of silver nanoparticles on small intestine mucosa of mice

Toxicology Mechanisms and Methods ◽

10.3109/15376516.2013.764950 ◽

2013 ◽

Vol 23 (3) ◽

pp. 161-167 ◽

Cited By ~ 64

Author(s):

Brigesh Shahare ◽

Madhu Yashpal

Keyword(s):

Silver Nanoparticles ◽

Small Intestine ◽

Toxic Effects ◽

Oral Exposure ◽

Intestine Mucosa

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Acute toxic effects of sodium selenate on the epiphyseal plate of the rat

Calcified Tissue Research ◽

10.1007/bf02062621 ◽

1971 ◽

Vol 7 (1) ◽

pp. 318-330 ◽

Cited By ~ 3

Author(s):

Robert D. Campo ◽

Robert J. Bielen

Keyword(s):

Epiphyseal Plate ◽

Toxic Effects ◽

Sodium Selenate ◽

Acute Toxic

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Acute toxic effects of hydrogen peroxide, used for salmon lice treatment, on the survival of polychaetes Capitella sp. and Ophryotrocha spp.

Aquaculture Environment Interactions ◽

10.3354/aei00273 ◽

2018 ◽

Vol 10 ◽

pp. 363-368 ◽

Cited By ~ 4

Author(s):

J Fang ◽

OB Samuelsen ◽

Ø Strand ◽

H Jansen

Keyword(s):

Hydrogen Peroxide ◽

Toxic Effects ◽

Salmon Lice ◽

Acute Toxic

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FORECASTING THE DEVELOPMENT OF ACUTE TOXIC EFFECTS IN PROFESSIONAL CONTINGENTS AFTER COMBINED PESTICIDES APPLICATION FOR AGRICULTURAL CROPS PROTECTION

Technology transfer innovative solutions in medicine ◽

10.21303/2585-663.2017.00457 ◽

2017 ◽

pp. 26-28

Author(s):

Pavlo Stavnichenko ◽

Olesya Novohatska

Keyword(s):

Toxic Effects ◽

Agricultural Crops ◽

Acute Toxic

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UJI TOKSISITAS AKUT MINUMAN PROBIOTIK SIRSAK GUNUNG (Annona montana Macf.) DENGAN METODE BSLT (Brine Shrimp Lethality Test)

Jurnal Inovasi Penelitian ◽

10.47492/jip.v1i5.174 ◽

2020 ◽

Vol 1 (5) ◽

pp. 941-948

Author(s):

Ambar Fidyasari ◽

Sentot Joko Raharjo ◽

Melani Setyowati

Keyword(s):

Acute Toxicity ◽

Traditional Medicine ◽

Brine Shrimp ◽

Experimental Methods ◽

Test Method ◽

Toxic Effects ◽

Brine Shrimp Lethality ◽

Lc50 Value ◽

A Value ◽

Acute Toxic

Soursop fruit (Annona montana Macf.) is one of the plants can be used as as traditional medicine. This plant contains terpenoid and acetogenin which can cause toxicity. The fruit has a flavor that is tasteless so the innovation becomes probiotic drinks. This drink has been proven as an antioxidant, antibacterial, antihyperuricemia and antidiarrheal. The aim of this study was to know about acute toxicity of probiotic drink of soursop juice using brine shrimp lethality test method which will be indicated by LC50 value. This study used experimental methods conducted in the Laboratory of Farmakoknosi. There are several variations in concentration in this study, namely 10000 ppm, 20000 ppm, 30000 ppm, 40000 ppm, 50000 ppm, 60000 ppm, 70000 ppm, 80000 ppm and replication was done 3 times with total number of test animals used was 270. The results showed that probiotic drink of soursop juice can provide acute toxic effects on test animals with LC50 value of 29717,23 ppm. LC50 values indicate that the mountain soursop probiotic drink is not potentially toxic because it has a value of >1000 ppm.

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Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

Molecules ◽

10.3390/molecules26216610 ◽

2021 ◽

Vol 26 (21) ◽

pp. 6610

Author(s):

Ana T. Rufino ◽

Ana Ramalho ◽

Adelaide Sousa ◽

José Miguel P. Ferreira de Oliveira ◽

Paulo Freitas ◽

...

Keyword(s):

Silver Nanoparticles ◽

Protective Action ◽

Cell Types ◽

Protective Role ◽

Toxic Effects ◽

Oral Exposure ◽

Dietary Flavonoids ◽

Harmful Effects ◽

Human Intestinal Cells

Silver nanoparticles (AgNP) have been increasingly incorporated into food-related and hygiene products for their unique antimicrobial and preservative properties. The consequent oral exposure may then result in unpredicted harmful effects in the gastrointestinal tract (GIT), which should be considered in the risk assessment and risk management of these materials. In the present study, the toxic effects of polyethyleneimine (PEI)-coated AgNP (4 and 19 nm) were evaluated in GIT-relevant cells (Caco-2 cell line as a model of human intestinal cells, and neutrophils as a model of the intestinal inflammatory response). This study also evaluated the putative protective action of dietary flavonoids against such harmful effects. The obtained results showed that AgNP of 4 and 19 nm effectively induced Caco-2 cell death by apoptosis with concomitant production of nitric oxide, irrespective of the size. It was also observed that AgNP induced human neutrophil oxidative burst. Interestingly, some flavonoids, namely quercetin and quercetagetin, prevented the deleterious effects of AgNP in both cell types. Overall, the data of the present study provide a first insight into the promising protective role of flavonoids against the potentially toxic effects of AgNP at the intestinal level.

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