scholarly journals Lactic acid level in soccer who consume red dragon fruit juice and regular exercise

2021 ◽  
Vol 1811 (1) ◽  
pp. 012059
Author(s):  
N S Harahap ◽  
S Suprayitno ◽  
N Simatupang ◽  
R M Sari
Keyword(s):  
Lactic Acid ◽  
Acid Level ◽  
Fruit Juice ◽  
Regular Exercise ◽  
Lactic Acid Level ◽  
Dragon Fruit

scholarly journals Red Dragon Fruit (Hylocereus Polyrhizus) Extract Decreases Lactic Acid Level and Creatine Kinase Activity in Rats Receiving Heavy Physical Exercise

2019 ◽  
Vol 7 (14) ◽  
pp. 2232-2235 ◽  
Author(s):  
Novita Sari Harahap ◽  
Rina Amelia
Keyword(s):  
Creatine Kinase ◽  
Lactic Acid ◽  
Free Radical ◽  
Physical Exercise ◽  
Acid Level ◽  
Radical Formation ◽  
Male Rats ◽  
Lactic Acid Level ◽  
Dragon Fruit ◽  
Free Radical Formation

BACKGROUND: Heavy physical exercise causes relative hypoxia. In hypoxic condition, the cell’s energy comes from anaerobic metabolism that produces lactic acid. An increment of oxygen need leads to ischemia-reperfusion, triggers free radical formation and damages muscles. Creatine kinase (CK) is a marker of muscle tissue damage. Red dragon fruit (RDF) has potential as antioxidant to reduce free radical formation. AIM: This study aims to determine RDF extract potential to reduce the lactic acid level and CK activity after heavy physical exercise. METHODS: A total of 32 male rats (Rattus Norvegicus) were randomly divided into 4 groups: group NORDF, treated heavy physical exercise and distilled water; group RDF100, treated heavy physical exercise and at 100 mg/kg BW RDF extract; group RDF200, treated heavy physical exercise and at 200 mg/kg BW RDF extract and group RDF300, treated heavy physical exercise and at 300 mg/kg BW RDF extract. The rats swam for 20 minutes, 3 times a week for 3 weeks. RESULTS: RDF300 group showed lower lactic acid level and CK activity as compared to that of NORDF (p = 0.00) and RDF100 (p = 0.00) groups, but RDF300 are not significantly different for lactic acid (p = 0.45) and for CK (p = 0.68). CONCLUSION: Red dragon fruit extract has potential in lowering lactic acid level and CK activity in male rats receiving heavy physical exercise.

Construction and Evaluation of a Rat Model of Postpartum Fatigue

2021 ◽  
pp. 1-9
Author(s):  
Ting Bai ◽  
Fan Wu ◽  
Shuhan Yan ◽  
Feng Zhang ◽  
Xujuan Xu
Keyword(s):  
Lactic Acid ◽  
Rat Model ◽  
Water Maze ◽  
Acid Level ◽  
Model Building ◽  
Small Sample ◽  
Control Group ◽  
Lactic Acid Level ◽  
Physical Fatigue ◽  
Postpartum Fatigue

<b><i>Objectives:</i></b> The aim of the study was to construct and evaluate a rat model of postpartum fatigue. <b><i>Design:</i></b> This is an article about animal model building. <b><i>Methods:</i></b> Sprague-Dawley rats on the 1st day after delivery were randomized into control group and fatigue group. The deep sleep of rats was interfered with by forcing them to stand in water, to make the rats experience mental and physical fatigue. To maintain galactosis and lactation, rats and pups were caged for 90 min after every 3 h of separation. The control group was separated routinely without any stimulus. The model was evaluated from mental and physical fatigue on the 8th day and 15th day. The mental fatigue was evaluated by a water maze test and the rat’s 5-hydroxytryptamine (5-HT) level in hippocampus, while the physical fatigue was evaluated using lactic acid level in serum and duration of weight-loaded forced swimming. <b><i>Results:</i></b> Among the 7-day and 14-day modeling groups, compared with the control group, the success rate of water maze landing was significantly decreased, the time for water maze landing was significantly prolonged and 5-HT level in hippocampus significantly decreased in the fatigue group. With respect to physical fatigue, among the 7-day and 14-day modeling groups, the lactic acid level in serum in the fatigue group was significantly increased, and the duration of exhaustive swimming of rats was significantly shortened. <b><i>Limitations:</i></b> A small sample size was the main limitation of this study. <b><i>Conclusions:</i></b> We have successfully constructed a rat model of postpartum fatigue by forcing postpartum rats to stand in water, which was similar to a level of stress that contributes to the development of postpartum fatigue. Our model opens the door for future studies evaluating the effectiveness of pharmacological and behavioral therapies.

scholarly journals Lactic acid level as an outcome predictor in pediatric patients with intussusception in the emergency department

2020 ◽  
Author(s):  
Jeong-Yong Lee ◽  
Young-Hoon Byun ◽  
Jun-Sung Park ◽  
Jong Seung Lee ◽  
Jeong-Min Ryu ◽  
...  
Keyword(s):  
Emergency Department ◽  
Lactic Acid ◽  
Acid Level ◽  
Pediatric Patients ◽  
Lactic Acid Level ◽  
Predictive Values ◽  
The Poor ◽  
Two Factors ◽  
Blood Gas Analyses ◽  
Poor Outcomes

Abstract Background: Intussusception decreases blood flow to the bowel, and tissue hypoperfusion results in increased lactic acid levels. We aimed to determine whether lactic acid levels are associated with pediatric intussusception outcomes. Methods: The electronic medical records of our emergency department pediatric patients diagnosed with intussusception, between January 2015 and October 2018, were reviewed. An outcome was considered poor when intussusception recurred within 48 hours of reduction or when surgical reduction was required due to air enema failure. Results: A total of 249 patients were included in the study, including 39 who experienced intussusception recurrence and 11 who required surgical reductions; hence, 50 patients were included in the poor outcome group. The poor and good outcome groups showed significant differences in their respective blood gas analyses for pH (7.39 vs. 7.41, P = .001), lactic acid (1.70 vs. 1.30 mmol/L, P < .001), and bicarbonate (20.70 vs. 21.80 mmol/L, P = .036). Multivariable logistic regression analyses showed that pH and lactic acid levels were the two factors significantly associated with poor outcomes. When the lactic acid level cutoff values were ≥1.5, ≥2.0, ≥2.5, and ≥3.0 mmol/L, the positive predictive values for poor outcomes were 30.0%, 34.6%, 50.0%, and 88.9%, respectively. Conclusion: Lactic acid levels affect outcomes in pediatric patients with intussusception; higher lactic acid levels are associated with higher positive predictive values for poor outcomes.

scholarly journals Erroneously High Lactate: A Guide to Diagnosing Ethylene Glycol Poisoning

2019 ◽  
Vol 4 (2) ◽  
pp. 1-3
Author(s):  
Mayanka Kamboj ◽  
Harini Bejjanki ◽  
Saraswathi Gopal ◽  
Rupam Ruchi
Keyword(s):  
Lactic Acid ◽  
Lactic Acidosis ◽  
Ethylene Glycol ◽  
Critically Ill Patients ◽  
Poor Prognosis ◽  
Acid Level ◽  
Lactic Acid Level ◽  
Analytical Interference ◽  
Ethylene Glycol Poisoning ◽  
High Lactate

A high lactic acid level in critically ill patients is a marker of poor prognosis. However, lactic acidosis in ethylene glycol (EG) poisoning should be interpreted cautiously as analytical interference is observed with EG metabolites.

scholarly journals Serum lactic acid level predicts poor myocardial perfusion and in-hospital outcomes in patients undergoing primary percutaneous coronary intervention

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M Y Liu ◽  
C F Dai ◽  
Z W Chen ◽  
J Y Qian ◽  
J B Ge
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Lactic Acid ◽  
Risk Score ◽  
Acid Level ◽  
Coronary Intervention ◽  
Hospital Death ◽  
Lactic Acid Level ◽  
Hospital Outcomes ◽  
Grace Risk Score

Abstract Background Elevated serum lactic acid level is associated with poor outcomes in patients with critical diseases like shock. However, the clinical implication of this biomarker in patients with acute myocardial infarction remains unclear. Purpose We aimed to explore the predictive power of serum lactic acid level on admission for in-hospital outcomes in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention (pPCI). Methods Consecutive patients undergoing pPCI with available data on serum lactid acid level were evaluated for eligbility in this retrospective cohort study. The primary outcome was all-cause death during hospitalization. Enzymatic infarct size and major adverse cardiovascular events (MACE, defined as a combination of all-cause death, recurrent myocardial infarction, and unplanned repeated revascularization) were considered secondary outcomes. Independent preditors of in-hospital death were determined by multiple logisic regression analysis. Odds ratio (OR) with 95% confidence interval (CI) was used to demonstrate the association. The predictive power of serum latictic acid level for in-hospital death was evaluated through receiver operator characteristic curve, which generated C-statictic. A combination model was further constructed by adding serum latictic acid level to the Global Registry of Acute Coronary Events (GRACE) risk score (LA-GRACE risk score). The linear dependence between serum lactic acids level and othe clinical variables was analysed using Spearman rank correlation. Results Of the 302 patients enrolled in the current analysis, 15 (5.0%) died during hospitalization. Serum lactic acid level (OR=1.657, 95% CI: 1.115 to 2.463, p=0.012)and left ventricular ejection fraction (OR=0.858, 95% CI: 0.767 to 0.959, p=0.007) were the only two independent predictors of in-hospital death. The C-statistic of serum lactic acid level for predicting in-hospital death was 0.886 (95% CI: 0.793 to 0.979). The LA-GRACE risk score improved the C-statistic of the GRACE score from 0.898 to 0.911 (p=0.294), with continuous net reclassification improvement of 0.567 (p=0.023) and integrated discrimination improvement of 0.206 (p=0.003). High serum lactic acid level was also asscoiated with larger enzymatic infarct size (p=0.002) and MACE (p=0.004). Further, it significantly correlated with white blood cell counts (r=0.264, p&lt;0.001), serum creatinine level (r=0.189, p=0.001), and systolic blood pressure (r=−0.122, p=0.034). Conclusion Serum lactic acid level on admission is asscoiated with poor myocardial perfusion and in-hospital outcomes in patients with acute myocardial infarction undergoing pPCI. It may contribute to better risk stratification in these populations. FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This study was supported by the National Program on Key Basic Research Project of China (Grant No: 2019YFC0840601 and 2014CBA02003), National Natural Science Foundation of China (Grant No: 81870267, 81970295, 81521001, 81670318 and 81570314), Grant of Shanghai Shenkang on Key Clinical Research Project (Grant No: SHDC2020CR2015A and SHDC12019104), Grant of Shanghai Science and Technology Committee (Grant No: 19MC1910300, 18411950200 and 20JC1410800), Key Medical and Health Projects of Xiamen Province (No: 3502Z20204004), Grant of Shanghai Municipal Commission of Health and Family Planning (Grant No: 2017YQ057), Grant of Zhongshan Hospital Affiliated to Fudan University (Grant No: 2018ZSLC01), VG Funding of Clinical Trials (2017-CCA-VG-036) and Merck Funding (Xinxin-merck-fund-051). ROC of lactic acid and GRACE score

Body Temperature and Lactic Acid Level as Prognostic Factors in Hypoglycemic Coma (P07.153)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P07.153-P07.153
Author(s):  
T. Ikeda ◽  
T. Takahashi ◽  
A. Sato ◽  
H. Tanaka ◽  
S. Igarashi ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Prognostic Factors ◽  
Body Temperature ◽  
Acid Level ◽  
Lactic Acid Level ◽  
Hypoglycemic Coma

Mechanism of Circular RNA RAD23B for Regulating Glycolysis and Proliferation of Ovarian Cancer Cells by Targeting MicroRNA-519b-3p

2021 ◽  
Vol 11 (6) ◽  
pp. 1078-1083
Author(s):  
Jinmei Yu ◽  
Yunting An ◽  
Meiyan Zou ◽  
Xia Li ◽  
Xiaoyuan Dong
Keyword(s):  
Ovarian Cancer ◽  
Lactic Acid ◽  
Cell Viability ◽  
Cancer Cells ◽  
Protein Level ◽  
Acid Level ◽  
Glucose Consumption ◽  
Ovarian Cancer Cells ◽  
Lactic Acid Level ◽  
P21 Protein

We investigated whether circRAD23B regulates glycolysis and proliferation of ovarian cancer cells by targeting miRNA-519b-3p. circRAD23B expression in ovarian cancer tissues was significantly higher than that in paracancerous tissues, and miRNA-519b-3p expression in ovarian cance tissues was significantly lower than that in paracancerous tissues (P < 0.05). Transfection sicircRAD23B or miRNA-519b-3p mimics can greatly attenuate cell viability, glucose consumption, lactic acid level, and CyclinD1 protein level (P < 0.05), and increase p21 protein level (P < 0.05). Double luciferase reporter experiment confirmed that circRAD23B could function as a miRNA-519b-3p sponge molecule. Co-transfection of si-circRAD23B and anti-miRNA-519b-3p could greatly decrease cell viability, glucose consumption, lactic acid level, and CyclinD1 protein level (P < 0.05), and increase p21 protein level by comparison with si-circRAD23B+anti-miRNA-NC group (P < 0.05). Inhibiting circRAD23B expression can, in turn, inhibit glycolysis and the proliferation of ovarian cancer cells by up-regulating miRNA-519b-3p expression.

Studi Potensi Buah Kurma (Phoenix dactylifera L), Suhu dan Lama Penyimpanan terhadap Perubahan karakterisitk Susu Acidophillus

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Sarlini Martha ◽  
Yurliasni Yurliasni ◽  
Yusdar Zakaria
Keyword(s):  
Lactic Acid ◽  
Acid Level ◽  
Storage Time ◽  
Ph Value ◽  
Phoenix Dactylifera ◽  
Lactic Acid Level ◽  
Storage Duration ◽  
Phoenix Dactylifera L ◽  
And Storage

Abstrak.  Kualitas susu fermentasi sangat dipengaruhi oleh pertumbuhan mikroba, kadar air, proses pengolahan, suhu dan lama penyimpanan. Variasi dan fluktuasi suhu pada saat penyimpanan dapat mempengaruhi mutu baik secara fisik, kimia dan mikrobiologi. Penelitian bertujuan untuk mempelajari pengaruh suhu dan lama penyimpanan yang berbeda pada susu Acidophillus yang ditambah buah kurma. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) pola faktorial yang terdiri dari 2 faktor yaitu faktor A (suhu) terdiri dari A1=5 °C, A2=10 °C. Faktor B (lama penyimpanan) terdiri B1=0 hari, B2=14 hari, B3=28 hari, B4=42 hari dan dianalisis meliputi viabilitas L. acidophillus, nilai pH, kadar asam laktat, sineresis, dan kadar protein. Hasil analisis menunjukkan bahwa lama penyimpanan berpengaruh sangat nyata (P0.01) terhadap viabilitas L. acidophillus, nilai pH, kadar asam laktat dan kadar protein, akan tetapi pada sineresis tidak terdapat pengaruh yang nyata.  Disimpulkan bahwa lama penyimpanan dapat mengakibatkan pertumbuhan L. acidophillus tidak stabil dan terjadinya perubahan karakteristik fisik susu Acidophillus.Study of dates Potensil (Phoenix dactylifera L), Temperature and Storage Length on Change of Acidophillus milk CharacteristicsAbstract. The quality of fermented milk is strongly influenced by the growth of microbes, moisture content, processing, temperature and storage time. Variations and fluctuations in temperature during storage may affect the quality of both physical, chemical and microbiological. The study aimed to study the effect of temperature and different storage time on Acidophillus milk plus dates.This research uses Completely Randomized Design (RAL) of factorial pattern consisting of 2 factors ie factor A (temperature) consisting of A1 = 5 °C, A2 = 10 °C. Factor B (storage duration) consisted of B1 = 0 days, B2 = 14 days, B3 = 28 days, B4 = 42 days and analyzed including viability of L. acidophillus, pH value, lactic acid level, syneresis, and protein content.The results showed that storage duration had significant effect (P 0.01) on the viability of L. acidophillus, pH value, lactic acid level and protein content, but there was no significant effect on sineresis. It was concluded that long storage may lead to unstable growth of L. acidophillus and the change in physical characteristics of Acidophilus milk.

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