scholarly journals Composite thin films based on multilayer carbon nanotubes and calcium phosphate with electrical conductive properties for bone tissue engineering

2021 ◽  
Vol 2091 (1) ◽  
pp. 012018
Author(s):  
S Z Zhovnir ◽  
M S Savelyev ◽  
A V Kuksin ◽  
U E Kurilova ◽  
A Yu Gerasimenko ◽  
...  
Keyword(s):  
Thin Films ◽  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphates ◽  
Composite Thin Films ◽  
Multilayer Carbon Nanotubes ◽  
Subsequent Exposure ◽  
Multi Walled Carbon Nanotubes

Abstract This work is aimed at developing of electrically conductive composite thin films based on calcium phosphates (CP) and multi-walled carbon nanotubes (MWCNT) for bone tissue engineering. A method based on the sputtering of an dispersion of CPs and MWCNTs on a substrate with subsequent exposure to a laser with different power values to form connected networks of nanotubes has been proposed. It is shown that the electrical conductivity of CP/MWCNT films reaches high values for dispersions with a MWCNT concentration of 1 mg/ml when exposed to laser radiation with a power of 2.1–3.0 W. It was found that ablation areas of CPs and MWCNTs as a result of exposure to a high-power laser are found in areas of the film with increased resistance.

pH-Switchable electroactive composite films of carboxylated multi-walled carbon nanotubes and Prussian blue

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103184-103188
Author(s):  
Ying Tong ◽  
Yuanyuan Wang ◽  
Bowen Gao ◽  
Lei Su ◽  
Xueji Zhang
Keyword(s):  
Thin Films ◽  
Carbon Nanotubes ◽  
Prussian Blue ◽  
Composite Films ◽  
Ph Responsive ◽  
Composite Thin Films ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Here the combination of carboxylated multi-walled carbon nanotubes (CMWCNTs) and Prussian blue (PB) for fabricating pH-responsive electroactive composite thin films is reported.

scholarly journals Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass

Materials ◽  
2019 ◽  
Vol 12 (17) ◽  
pp. 2711
Author(s):  
Ana S. Neto ◽  
Daniela Brazete ◽  
José M.F. Ferreira
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphates ◽  
Sol Gel ◽  
Biological Properties ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Hydrothermal Transformation

The combination of calcium phosphates with bioactive glasses (BG) has received an increased interest in the field of bone tissue engineering. In the present work, biphasic calcium phosphates (BCP) obtained by hydrothermal transformation of cuttlefish bone (CB) were coated with a Sr-, Mg- and Zn-doped sol-gel derived BG. The scaffolds were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The initial CB structure was maintained after hydrothermal transformation (HT) and the scaffold functionalization did not jeopardize the internal structure. The results of the in-vitro bioactivity after immersing the BG coated scaffolds in simulated body fluid (SBF) for 15 days showed the formation of apatite on the surface of the scaffolds. Overall, the functionalized CB derived BCP scaffolds revealed promising properties, but further assessment of the in-vitro biological properties is needed before being considered for their use in bone tissue engineering applications.

scholarly journals Properties of chitosan matrix composites with hydroxyapatite and carbon nanotubes, and their use in bone tissue engineering

2019 ◽  
Vol 1 (1) ◽  
pp. 139-148 ◽  
Author(s):  
João Victor Freitas Barros Correia ◽  
Matheus Freitas Barros Correia
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Homogeneous Distribution ◽  
Matrix Composites ◽  
Chitosan Matrix ◽  
Current State ◽  
Synthetic Materials ◽  
Innovative Material

There is a growing demand for bone grafts by various clinical sectors, such as aesthetic procedures, treatment of injuries and dentistry, the use of synthetic materials is shown to be good due to the availability and the reduction of risks that their use brings, among the materials that are used in the clinic can be cited the chitosan matrix composites (CHI) with hydroxyapatite (HA) and carbon nanotubes (CNTs), which uses materials that are already used in the clinic HA and CHI with an innovative material in the sector the CNTs. The aim was to analyze and compare data from the current state of the art of CHI matrix composites with HA and CNTs applied in bone tissue engineering. This study is based on a review of the specialized literature on articles in online scientific journals, with thematic issues related to the properties of the biocomposite on board. The influence of the use on the composite properties generated by the use of CNTs together with the HA in the CHI matrix, for biomedical applications, more specifically in bone tissue engineering, was observed. It was observed that with subtle increases of CNTs in the CH composite Ha composites, the bioactivity, osteoconduction, antibacterial activity, mechanical properties of the composites, changes in the nanotexturas, and a homogeneous distribution of the materials occur, potentiality of its use in more than one application within bone tissue engineering. In the present study it was possible to observe that CHI matrix composites with HA and CNTs present a combination of properties highlighting the potential for application in bone tissue engineering.  

scholarly journals Calcium phosphate materials in bone tissue engineering

2014 ◽  
Vol 61 (2) ◽  
pp. 93-101 ◽  
Author(s):  
Vukoman Jokanovic ◽  
Bozana Colovic ◽  
Marija Zivkovic-Sandic ◽  
Violeta Petrovic ◽  
Slavoljub Zivkovic
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
21St Century ◽  
Bone Disease ◽  
Calcium Phosphates ◽  
Current Paper ◽  
National Book ◽  
Young Researchers

Calcium phosphates, together with polymers, are most commonly used materials in bone engineering since their composition is similar to bone. They are used to fulfill various defects caused by injury or bone disease, as well as for the preparation of endodontic mixtures. Because of their great importance in dentistry, these materials are given special attention in the current paper. This paper is a part of the monograph entitled ?Nanomedicine, the Greatest Challenge of the 21st Century?, which attracted great interest of technical and professional communities in different areas of medicine. Also for the last two years this book is promoted by the Student Cultural Centre as the only national book chosen in the narrowest election. That fact is very important for young researchers who study tissue engineering, endodontics and implantology.

scholarly journals Material-Dependent Formation and Degradation of Bone Matrix—Comparison of Two Cryogels

2020 ◽  
Vol 7 (2) ◽  
pp. 52 ◽  
Author(s):  
Weidong Weng ◽  
Victor Häussling ◽  
Romina H. Aspera-Werz ◽  
Fabian Springer ◽  
Helen Rinderknecht ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mineral Content ◽  
Platelet Rich Plasma ◽  
Calcium Phosphates ◽  
Bone Matrix ◽  
Osteogenic Potential ◽  
Toxic Substances ◽  
The Matrix

Cryogels represent ideal carriers for bone tissue engineering. We recently described the osteogenic potential of cryogels with different protein additives, e.g., platelet-rich plasma (PRP). However, these scaffolds raised concerns as different toxic substances are required for their preparation. Therefore, we developed another gelatin (GEL)-based cryogel. This study aimed to compare the two scaffolds regarding their physical characteristics and their influence on osteogenic and osteoclastic cells. Compared to the PRP scaffolds, GEL scaffolds had both larger pores and thicker walls, resulting in a lower connective density. PRP scaffolds, with crystalized calcium phosphates on the surface, were significantly stiffer but less mineralized than GEL scaffolds with hydroxyapatite incorporated within the matrix. The GEL scaffolds favored adherence and proliferation of the osteogenic SCP-1 and SaOS-2 cells. Macrophage colony-stimulating factor (M-CSF) and osteoprotegerin (OPG) levels seemed to be induced by GEL scaffolds. Levels of other osteoblast and osteoclast markers were comparable between the two scaffolds. After 14 days, mineral content and stiffness of the cryogels were increased by SCP-1 and SaOS-2 cells, especially of PRP scaffolds. THP-1 cell-derived osteoclastic cells only reduced mineral content and stiffness of PRP cryogels. In summary, both scaffolds present powerful advantages; however, the possibility to altered mineral content and stiffness may be decisive when it comes to using PRP or GEL scaffolds for bone tissue engineering.

scholarly journals Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1570 ◽  
Author(s):  
Tanya J. Levingstone ◽  
Simona Herbaj ◽  
Nicholas J. Dunne
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Viral Vectors ◽  
Bone Repair ◽  
Calcium Phosphates ◽  
The Body ◽  
Therapeutic Factors ◽  
Calcium Phosphate Nanoparticles

Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led the research community’s efforts to establish efficacious bone tissue engineering solutions. There has been a recent focus on the use of biomaterial-based nanoparticles for the delivery of therapeutic factors. Among the biomaterials being considered to date, calcium phosphates have emerged as one of the most promising materials for bone repair applications due to their osteoconductivity, osteoinductivity and their ability to be resorbed in the body. Calcium phosphate nanoparticles have received particular attention as non-viral vectors for gene therapy, as factors such as plasmid DNAs, microRNAs (miRNA) and silencing RNA (siRNAs) can be easily incorporated on their surface. Calcium phosphate nanoparticles loaded with therapeutic factors have also been delivered to the site of bone injury using scaffolds and hydrogels. This review provides an extensive overview of the current state-of-the-art relating to the design and synthesis of calcium phosphate nanoparticles as carriers for therapeutic factors, the mechanisms of therapeutic factors’ loading and release, and their application in bone tissue engineering.

Bio-inspired hybrid scaffold of zinc oxide-functionalized multi-wall carbon nanotubes reinforced polyurethane nanofibers for bone tissue engineering

2017 ◽  
Vol 133 ◽  
pp. 69-81 ◽  
Author(s):  
Bishnu Kumar Shrestha ◽  
Sita Shrestha ◽  
Arjun Prasad Tiwari ◽  
Jeong-In Kim ◽  
Sung Won Ko ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Zinc Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hybrid Scaffold ◽  
Multi Wall Carbon Nanotubes
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