scholarly journals Correction of homeostatic mechanisms of humoral regulation of bone remodeling processes in piglets with pathology of vitamin-mineral metabolism

2019 ◽  
Vol 403 ◽  
pp. 012048
Author(s):  
T Derezina ◽  
T Ushakova ◽  
I Kapelist ◽  
G Zelenkova ◽  
T Tambiev ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Mineral Metabolism ◽  
Homeostatic Mechanisms ◽  
Humoral Regulation

scholarly journals Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling

2021 ◽  
Vol 22 (18) ◽  
pp. 10010
Author(s):  
Francesca Salamanna ◽  
Melania Maglio ◽  
Maria Sartori ◽  
Maria Paola Landini ◽  
Milena Fini
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Remodeling ◽  
Bone Health ◽  
Feedback Loop ◽  
Mineral Metabolism ◽  
Bone Fragility ◽  
Preliminary Information ◽  
Pathological Conditions ◽  
Global Data

Global data correlate severe vitamin D deficiency with COVID-19-associated coagulopathy, further suggesting the presence of a hypercoagulable state in severe COVID-19 patients, which could promote thrombosis in the lungs and in other organs. The feedback loop between COVID-19-associated coagulopathy and vitamin D also involves platelets (PLTs), since vitamin D deficiency stimulates PLT activation and aggregation and increases fibrinolysis and thrombosis. Vitamin D and PLTs share and play specific roles not only in coagulation and thrombosis but also during inflammation, endothelial dysfunction, and immune response. Additionally, another ‘fil rouge’ between vitamin D and PLTs is represented by their role in mineral metabolism and bone health, since vitamin D deficiency, low PLT count, and altered PLT-related parameters are linked to abnormal bone remodeling in certain pathological conditions, such as osteoporosis (OP). Hence, it is possible to speculate that severe COVID-19 patients are characterized by the presence of several predisposing factors to bone fragility and OP that may be monitored to avoid potential complications. Here, we hypothesize different pervasive actions of vitamin D and PLT association in COVID-19, also allowing for potential preliminary information on bone health status during COVID-19 infection.

scholarly journals Impact of Tenofovir-Based Pre-exposure Prophylaxis on Biomarkers of Bone Formation, Bone Resorption, and Bone Mineral Metabolism in HIV-Negative Adults

2019 ◽  
Vol 6 (10) ◽  
Author(s):  
Thomas L Nickolas ◽  
Michael T Yin ◽  
Ting Hong ◽  
Kenneth K Mugwanya ◽  
Andrea D Branch ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Fibroblast Growth Factor 23 ◽  
Separate Analysis ◽  
Mineral Density ◽  
Bone Mineral Metabolism ◽  
Exposure Prophylaxis ◽  
The Impact ◽  
Hiv Negative

Abstract Background Pre-exposure prophylaxis (PrEP) with emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) reduces the risk of HIV seroconversion but may promote bone mineral density (BMD) decline. The mechanisms of BMD decline with FTC/TDF remain unclear, and studies in HIV-positive individuals have been confounded by the effects of HIV and concomitant antiretroviral medications. We evaluated the impact of FTC/TDF on biomarkers of bone remodeling and bone mineral metabolism in HIV-negative men and women enrolled in the Partners PrEP Study. Methods In a random sample of HIV-negative participants randomized to FTC/TDF PrEP (n = 50) or placebo (n = 50), serum parathyroid hormone (PTH), bone biomarkers (C-telopeptide, procollagen 1 intact N-terminal propeptide, and sclerostin), and plasma fibroblast growth factor 23 were measured at baseline and month 24, and the percentage change was compared between groups. In a complementary analysis, we compared the change in biomarkers between participants with and without a 25% decline in glomerular filtration rate (GFR) on FTC/TDF. Results Baseline characteristics were similar between the groups (median age, 38 years; 40% women). Vitamin D insufficiency was common, but baseline GFR and PTH were in the normal range. We observed a significantly greater percent increase in serum C-telopeptide in participants randomized to FTC/TDF vs placebo (P = .03), suggesting an increase in bone remodeling. We observed no differences in the other biomarkers, or in a separate analysis comparing participants with and without a decline in GFR. Conclusions Increased bone remodeling may mediate the BMD decline observed with tenofovir-containing PrEP and antiretroviral therapy, independent of a TDF-mediated decrease in kidney function.

scholarly journals Regulation of Bone’s Metabolic Process under Dental Implantation Procedure

2020 ◽  
pp. 1-4
Author(s):  
A.S. Belyakova ◽  
A.M. Mkrtumyan ◽  
A.S. Belyakova ◽  
L.S. Dzikovitskaya ◽  
M.V. Kozlova
Keyword(s):  
Computed Tomography ◽  
Vitamin D ◽  
Bone Remodeling ◽  
Mineral Metabolism ◽  
Metabolic Process ◽  
The State ◽  
Cone Beam ◽  
Dental Implantation ◽  
Lower Jaw ◽  
Implantation Procedure

Aim: increase of efficiency of dental implantation in patients with imbalance of bone remodeling processes. Material and Methods: under observation were men with osteoporosis, who applied for restoration of defects of the dentition with dental implants. Correction of bone remodeling imbalance was performed with bisphosphonates, calcium and vitamin D preparations. Before dental implantation, the state of microarchitectonics of the lower jaw was studied using cone-beam computed tomography, histomorphometry, and the state of mineral metabolism in the blood. Results and Conclusions: the success of osseointegration dental implantation in patients with bone remodeling imbalance is determined by the qualitative parameters of the bone tissue, of the receiving bed, reflecting metabolic and reparative processes. Complex antiosteoporetic therapy with bisphosphonates and calcium preparations with vitamin D helps to restore the qualitative parameters of the alveolar part and helps to optimize the processes of osteointegration.

scholarly journals TGF-Beta Signaling in Bone with Chronic Kidney Disease

2018 ◽  
Vol 19 (8) ◽  
pp. 2352 ◽  
Author(s):  
Yoshiko Iwasaki ◽  
Hideyuki Yamato ◽  
Masafumi Fukagawa
Keyword(s):  
Chronic Kidney Disease ◽  
Growth Factor ◽  
Kidney Disease ◽  
Bone Remodeling ◽  
Transforming Growth Factor ◽  
Mineral Metabolism ◽  
Fibroblast Growth Factor 23 ◽  
Ectopic Calcification ◽  
Bone Homeostasis ◽  
Humoral Factors

Transforming growth factor (TGF)-β signaling is not only important in skeletal development, but also essential in bone remodeling in adult bone. The bone remodeling process involves integrated cell activities induced by multiple stimuli to balance bone resorption and bone formation. TGF-β plays a role in bone remodeling by coordinating cell activities to maintain bone homeostasis. However, mineral metabolism disturbance in chronic kidney disease (CKD) results in abnormal bone remodeling, which leads to ectopic calcification in CKD. High circulating levels of humoral factors such as parathyroid hormone, fibroblast growth factor 23, and Wnt inhibitors modulate bone remodeling in CKD. Several reports have revealed that TGF-β is involved in the production and functions of these factors in bone. TGF-β may act as a factor that mediates abnormal bone remodeling in CKD.

Bone Mineral Metabolism in Experimental Diabetes Mellitus: Osteocalcin as a Measure of Bone Remodeling

Endocrinology ◽  
1988 ◽  
Vol 123 (1) ◽  
pp. 290-295 ◽  
Author(s):  
N. GLAJCHEN ◽  
S. EPSTEIN ◽  
F. ISMAIL ◽  
S. THOMAS ◽  
M. FALLON ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Experimental Diabetes ◽  
Mineral Metabolism ◽  
Experimental Diabetes Mellitus ◽  
Bone Mineral Metabolism

Does short-term administration of glucagon-like peptide type 2 affect bone mass and markers of bone remodeling in short bowel patients?

2001 ◽  
Vol 120 (5) ◽  
pp. A314-A314
Author(s):  
K HADERSLEV ◽  
P JEPPESEN ◽  
B HARTMANN ◽  
J THULESEN ◽  
J GRAFF ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Remodeling ◽  
Short Term ◽  
Short Bowel ◽  
Term Administration ◽  
Glucagon Like Peptide

Abstract #510 Mineral Metabolism and Bone Mineral Density in Patients with Neuroendocrine Tumors

2018 ◽  
Vol 24 ◽  
pp. 110-111
Author(s):  
Franco Grimaldi ◽  
Elda Kara ◽  
Fabio Vanin ◽  
Maria Carpentieri ◽  
Claudia Cipri ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Neuroendocrine Tumors ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Mineral Density

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

Bioactive Sclerostin: better analyte definition in the measurement of bone remodeling

2019 ◽  
Author(s):  
A Bitzer ◽  
J Wallwitz ◽  
E Gadermaier ◽  
G Berg ◽  
G Himmler
Keyword(s):  
Bone Remodeling
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