scholarly journals Inclination and azimuth evaluation point determinations in “YMN” Field “AMR-10” reservoir by using minimum of curvature method

2021 ◽  
Vol 1098 (6) ◽  
pp. 062040
Author(s):  
A Yamani ◽  
D A Chusniyah ◽  
A Hamid
Keyword(s):  
Evaluation Point

scholarly journals Extended single-dose toxicity study of [211At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer

2021 ◽  
Author(s):  
Tadashi Watabe ◽  
Kazuko Kaneda-Nakashima ◽  
Kazuhiro Ooe ◽  
Yuwei Liu ◽  
Kenta Kurimoto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Body Weight ◽  
Thyroid Cancer ◽  
Single Dose ◽  
General Condition ◽  
Blood Test ◽  
Differentiated Thyroid Cancer ◽  
Targeted Alpha Therapy ◽  
Evaluation Point ◽  
Alpha Therapy

Abstract Objective Astatine (211At) is a promising alpha emitter as an alternative to iodine (131I). We are preparing the first-in-human (FIH) clinical trial of targeted alpha therapy for differentiated thyroid cancer in consultation with Pharmaceuticals and Medical Devices Agency. Here, we performed an extended single-dose toxicity examination under a reliability standard, as a preclinical safety assessment of [211At]NaAt to determine the FIH dose. Methods [211At]NaAt solution was injected into normal 6-week-old mice (male (n = 50) and female (n = 50), body weight: male 33.2 ± 1.7 g, female 27.3 ± 1.5 g), which were then divided into four groups: 5 MBq/kg (n = 20), 20 MBq/kg (n = 20), 50 MBq/kg (n = 30), saline control (n = 30). The mice were followed up for 5 days (primary evaluation point for acute toxicity: n = 80) or 14 days (n = 20: evaluation point for recovery) to monitor general condition and body weight change. At the end of the observation period, necropsy, blood test, organ weight measurement, and histopathological examination were performed. For body weight, blood test, and organ weight, statistical analyses were performed to compare data between the control and injected groups. Results No abnormal findings were observed in the general condition of mice. In the 50 MBq/kg group, males (days 3 and 5) showed a significant decrease in body weight compared with the control. However, necropsy did not differ significantly beyond the range of spontaneous lesions. In the blood test, males (50 MBq/kg) and females (50 MBq/kg) showed a decrease in white blood cell and platelet counts on day 5, and recovery on day 14. In the testis, a considerable weight decrease was observed on day 14 (50 MBq/kg), and multinucleated giant cells were observed in all mice, indicating a significant change related to the administration of [211At]NaAt. Conclusions In the extended single-dose toxicity study of [211At]NaAt, administration of high doses resulted in weight loss, transient bone marrow suppression, and pathological changes in the testis, which require consideration in the FIH clinical trial.

An Evaluation Point Culling Algorithm for Radio Propagation Simulation based on the Imaging Method

1996 ◽  
pp. 111-121
Author(s):  
Satoshi Takahashi ◽  
Kazuhito Ishida ◽  
Hiroshi Yoshiura ◽  
Arata Nakagoshi
Keyword(s):  
Radio Propagation ◽  
Imaging Method ◽  
Evaluation Point ◽  
Simulation Based

scholarly journals EVALUATION OF MODEL RECOGNITION FOR GRAMMAR-BASED AUTOMATIC 3D BUILDING MODEL RECONSTRUCTION

2016 ◽  
Vol XLI-B4 ◽  
pp. 63-69
Author(s):  
Qian Yu ◽  
Petra Helmholz ◽  
David Belton
Keyword(s):  
Laser Scanning ◽  
Quality Evaluation ◽  
Evaluation Process ◽  
3D Models ◽  
Point Of View ◽  
Three Dimensions ◽  
Public And Private ◽  
Building Models ◽  
Evaluation Point ◽  
Increasing Demand

In recent years, 3D city models are in high demand by many public and private organisations, and the steadily growing capacity in both quality and quantity are increasing demand. The quality evaluation of these 3D models is a relevant issue both from the scientific and practical points of view. In this paper, we present a method for the quality evaluation of 3D building models which are reconstructed automatically from terrestrial laser scanning (TLS) data based on an attributed building grammar. The entire evaluation process has been performed in all the three dimensions in terms of completeness and correctness of the reconstruction. Six quality measures are introduced to apply on four datasets of reconstructed building models in order to describe the quality of the automatic reconstruction, and also are assessed on their validity from the evaluation point of view.

scholarly journals EVALUATION OF MODEL RECOGNITION FOR GRAMMAR-BASED AUTOMATIC 3D BUILDING MODEL RECONSTRUCTION

2016 ◽  
Vol XLI-B4 ◽  
pp. 63-69 ◽  
Author(s):  
Qian Yu ◽  
Petra Helmholz ◽  
David Belton
Keyword(s):  
Laser Scanning ◽  
Quality Evaluation ◽  
Evaluation Process ◽  
3D Models ◽  
Point Of View ◽  
Three Dimensions ◽  
Public And Private ◽  
Building Models ◽  
Evaluation Point ◽  
Increasing Demand

In recent years, 3D city models are in high demand by many public and private organisations, and the steadily growing capacity in both quality and quantity are increasing demand. The quality evaluation of these 3D models is a relevant issue both from the scientific and practical points of view. In this paper, we present a method for the quality evaluation of 3D building models which are reconstructed automatically from terrestrial laser scanning (TLS) data based on an attributed building grammar. The entire evaluation process has been performed in all the three dimensions in terms of completeness and correctness of the reconstruction. Six quality measures are introduced to apply on four datasets of reconstructed building models in order to describe the quality of the automatic reconstruction, and also are assessed on their validity from the evaluation point of view.

Successful Implementation of the Randomized Discontinuation Trial Design: An Application to the Study of the Putative Antiangiogenic Agent Carboxyaminoimidazole in Renal Cell Carcinoma—CALGB 69901

2005 ◽  
Vol 23 (16) ◽  
pp. 3726-3732 ◽  
Author(s):  
Walter M. Stadler ◽  
Gary Rosner ◽  
Eric Small ◽  
Donna Hollis ◽  
Brian Rini ◽  
...  
Keyword(s):  
Stable Disease ◽  
Renal Cell ◽  
Performance Status ◽  
Cell Cancer ◽  
Objective Response ◽  
Disease Rate ◽  
Successful Implementation ◽  
Evaluation Point ◽  
Randomized Discontinuation Trial ◽  
A Performance

Purpose To assess the disease-stabilizing activity of carboxyaminoimidazole (CAI) in patients with metastatic renal cell cancer (RCC) using a randomized discontinuation trial (RDT) design. Patients and Methods Recruited patients had a performance status of 0 to 2, minimal neuropathy or cerebellar dysfunction, measurable disease, and normal organ function. Treatment with 250 mg/d CAI was initiated in all patients and continued until disease progression in those with an objective response. Protocol treatment was discontinued for unacceptable toxicity or progressive disease; patients with stable disease at the 16-week evaluation point were randomly assigned in a double-blind manner to continued CAI or placebo. The primary end point was the stable disease rate in the randomized groups. Results A total of 368 patients were accrued and received therapy. Ninety percent had a performance status of 0 or 1, 80% underwent a prior nephrectomy, and 41% had received no prior systemic therapy. Serious or life-threatening toxicity was experienced by 34%, with asthenia (15%) and neuropsychiatric difficulties (7%) being most common. At the randomization point, 51% of patients had progressed, 30% withdrew, 1% experienced a partial response, and 17% had stable disease and were randomly assigned. A Bayesian futility analysis utilizing the first 49 randomly assigned patients suggested that the probability of demonstrating a higher stable disease rate in the experimental group was less than 9% even under the most optimistic a priori assumptions, and further trial accrual was halted. Conclusion CAI is inactive in RCC. The RDT design should be further explored for evaluating activity of putative disease stabilizing agents.

Abstract 406: Achievement of Treatment Target in Korean Patients With Familial Hypercholesterolemia

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Chan Joo Lee ◽  
Jaewon Oh ◽  
Jung Sun Kim ◽  
Sang-Hak Lee
Keyword(s):  
Total Cholesterol ◽  
Familial Hypercholesterolemia ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Treatment Target ◽  
Evaluation Point ◽  
The Mean ◽  
Artery Disease ◽  
Primary Evaluation

Background: In many cases of familial hypercholesterolemia (FH), there remains difficulty in achievement of treatment target. However, despite growing attention to FH, data on the treatment and its results in these patients are very limited. Methods: From nine sites in Korea, 122 consecutive unrelated men and women who were diagnosed with heterozygous FH by Simon Broome criteria were initially enrolled. Atorvastatin 20 mg or similar-potency drugs were prescribed and the dose was escalated every 2 months (for the first 6 months) or 6 months (thereafter) if needed. Forty one subjects were dropped and 81 subjects who underwent regular laboratory check-up were finally analyzed. The primary evaluation points were achievement rates of low-density lipoprotein cholesterol (LDL-C) <70 mg/dL, LDL-C<100 mg/dL, and LDL-C down to 50% of baseline levels at 12 month. The secondary evaluation point was % change of LDL-C at 12 month. Results: Patients’ mean age was 53 years and 59.3% were males. 21.0% were definite type FH and 28.4% had coronary artery disease (CAD). The mean total cholesterol and LDL-C were 319 mg/dL and 232 mg/dL, respectively. At 12 month, 7.4% received atorvastatin 10mg or similar, 21.0% received atorvastatin 20mg or similar, 16.0% received atorvastatin 40mg or similar, 4.9% received atorvastatin 80mg or similar, and 49.4% received atorvastatin (mean 57 mg) or similar plus ezetimibe 10mg. The mean follow-up total cholesterol and LDL-C were 201 mg/dL and 124 mg/dL, respectively. The mean % change of LDL-C was -45.6%. The achievement rates of LDL-C<70 mg/dL, <100 mg/dL, and LDL-C down to 50% of baseline were 1%, 21%, and 44%, respectively. The achievement rates were not significantly different between the patients without or with CAD (1.8%, 26.3%, 47.4% vs. 0%, 8.7%, 34.8%, respectively, all p values > 0.05). Conclusions: The achievement rate of treatment target in FH was low in Korea even after maximum tolerable dose of lipid lowering drugs. Improvement of awareness on this issue and more aggressive treatment are needed for this population.

Illustration of HLW Repository Performance: Using Alternative Yardsticks to Assess Modeled Radionuclide Fluxes

2008 ◽  
Vol 1107 ◽  
Author(s):  
Kaname Miyahara ◽  
Tomoko Kato
Keyword(s):  
Natural Radionuclides ◽  
Conventional Dose ◽  
Geological Processes ◽  
Groundwater Flux ◽  
Naturally Occurring ◽  
Evaluation Point ◽  
Naturally Occurring Radionuclides ◽  
Barrier Performance ◽  
Safety Case ◽  
Hlw Repository

AbstractComplementary indicators have been used in developing a safety case in order to avoid uncertainties in the biosphere modeling used to estimate conventional dose or risk. For example, radionuclide fluxes can be used to evaluate the effectiveness of barrier performance. However, it is difficult to define relevant yardsticks for comparison, because the fluxes of naturally occurring radionuclides due to geological processes vary considerably depending on time and location. This paper discusses the relevance of alternative yardsticks for assessing modeled radionuclide fluxes by selecting yardsticks calculated from fluxes of natural radionuclides at the groundwater discharge point from the geosphere to an aquifer; these are then compared with fluxes of repository-derived radionuclides at the same point. Such yardsticks avoid surface geological processes that may also contribute to natural fluxes, allowing comparison at a suitable, common evaluation point that avoids dependence on site-specific conditions. The effectiveness and robustness of barrier performance is demonstrated using the developed yardsticks and the sensitivity of the analysis to groundwater flux is illustrated.

Sensitivity Analysis of External Exposure Dose for Future Burial Measures of Decontamination Soil Generated Outside Fukushima Prefecture

2020 ◽  
Author(s):  
Asako Shimada ◽  
Takuma Sawaguchi ◽  
Seiji Takeda
Keyword(s):  
Sensitivity Analysis ◽  
Nuclear Power ◽  
Soil Depth ◽  
Exposure Dose ◽  
External Exposure ◽  
Large Area ◽  
Power Station ◽  
Cover Soil ◽  
Evaluation Point ◽  
Fukushima Daiichi

Abstract A large area of east Japan was contaminated by radiocesium following a nuclear accident at the Fukushima Daiichi Nuclear Power Station. Following decontamination of the soil, external effective dose conversion factors were calculated by changing the volume of decontamination soil, depth of cover soil, and distance of the evaluation point from the decontamination soil. The decrement of the factors with an increase of the distance was larger for the smaller volume of decontamination soil. The factors decrease exponentially with an increase of the depth of cover soil in all cases. When there was no cover soil, annual external exposure doses for residents at 1 m from the repository site and public entry were over 10 μSv/y, even for the smallest size (2m × 2m × 1m) and 50 percentile value of radiation concentration (700 Bq/kg). When the surface was covered by 30 cm of non-contaminated soil, the annual external exposure doses were less than 10 μSv/y for the largest size (200m × 200m × 10m) and 95 percentile concentration (2500 Bq/kg).

Lifetime visual outcomes of patients undergoing trabeculectomy

2020 ◽  
pp. bjophthalmol-2020-317004
Author(s):  
Ruth Chen ◽  
Anthony J King
Keyword(s):  
Visual Field ◽  
End Of Life ◽  
Vision Loss ◽  
Demographic Data ◽  
Service Evaluation ◽  
Mean Deviation ◽  
Female Ratio ◽  
Age At Surgery ◽  
Evaluation Point ◽  
Severe Vision Loss

BackgroundThe most important outcome for patients undergoing trabeculectomy is to maintain the quality of life in their remaining years. This study quantifies end of life vision in terms of visual acuity (VA) and visual field status.MethodsA prospective service evaluation of patients undergoing trabeculectomy (from 2000 to 2012) who died prior to the study evaluation point (November 2018). Demographic data including socioeconomic status were collected and change in clinical measurement for the cohort between time of surgery and death was measured.Results160 of 659 patients had died (24.3%), 4 were excluded due to insufficient data, leaving 156 patients (196 eyes) for evaluation. Male-to-female ratio was 3:2, 86% of patients were Caucasian. Mean age at surgery on first eye was 76.5 years (SD 9.0). Life expectancy post-trabeculectomy was 7.5 years (0.1–17.2). Mean change in VA was logarithm of the mean angle of resolution (LogMAR) 0.32 (SD 0.59) and visual field mean deviation progressed at a median of −0.44 dB/year (from −5.98 to 3.9) for eyes with at least a year of follow-up. Severe vision loss (loss of ≥10 letters on LogMAR) occurred in 78 eyes (40%) of which 18 (9%) were due to glaucoma, 69 patients (44%) required glaucoma drops at end of life.ConclusionTrabeculectomy is successful in slowing or preventing further glaucoma progression and thus maintaining visual function in the majority of eyes for the remainder of life. For those with severe vision loss at the end of life, only one in four was due to further progression of their glaucoma.

Aspects of the Structure and Corrosion Resistance of Materials Used in Tongue Piercings

2017 ◽  
Vol 750 ◽  
pp. 80-84
Author(s):  
Corina Mona Buzea ◽  
Ioana Csáki ◽  
Mihai Cosmin Cotruț
Keyword(s):  
Corrosion Resistance ◽  
Artificial Saliva ◽  
Steel Sample ◽  
Point Of View ◽  
Alloy Sample ◽  
Stainless Steel Sample ◽  
Metallic Biomaterials ◽  
Evaluation Point ◽  
Materials Used ◽  
Tongue Piercing

For centuries, piercing was an expression of art around the world and constituted a significant part of the culture and rituals of many different civilizations. This study evaluated the microstructure and the corrosion resistance in artificial saliva of two newly implantable devices used in tongue piercing. We investigated materials microstructure by optical microscopy and scanning electron microscopy (SEM), followed by an energy-dispersive X-ray spectroscopy (EDX) analysis in order to determine elemental composition. The corrosion resistance was determined by linear polarization technique. The corrosion tests were performed in artificial saliva Fusayama Meyer (composition: 0.4 gl-1NaCl, 0.9 gl-1 KCl, 1 gl-1 urea, 0.69 gl-1 NaH2PO4, 0.795 gl-1 CaCl * 2H2O) with a pH = 5.2 at temperature of 37 ± 0.5°C. The materials used for these types of implants were identified as Ti-6Al-4V alloy (sample 1) and austenitic stainless steel (sample 2). From corrosion resistance evaluation point of view, sample 1 showed the most electropositive value and hence better corrosion behavior compared to sample 2, having the Ecor potential -398.24 mV but this is clearly according the chemical composition of these two metallic biomaterials.

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