Gene Therapy “Made in Germany”: A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy

2021 ◽  
Vol 32 (19-20) ◽  
pp. 987-996
Author(s):  
Hildegard Büning ◽  
Boris Fehse ◽  
Zoltán Ivics ◽  
Stefan Kochanek ◽  
Ulrike Koehl ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Historical Perspective ◽  
German Society ◽  
Status Quo ◽  
Recommendations For Action ◽  
The Status ◽  
Perspective Analysis ◽  
Made In

Against Permanent Sovereignty

2017 ◽  
Author(s):  
Chris Armstrong
Keyword(s):  
Natural Resources ◽  
International Politics ◽  
Local Communities ◽  
Status Quo ◽  
Nation States ◽  
The Status ◽  
Made In

The status quo within international politics is that individual nation-states enjoy extensive and for the most part exclusive rights over the resources falling within their borders. Egalitarians have often assumed that such a situation cannot be defended, but perhaps some sophisticated defences of state or national rights over natural resources which have been made in recent years prove otherwise. This chapter critically assesses these various arguments, and shows that they are not sufficient to justify the institution of ‘permanent sovereignty’ over resources. Even insofar as those arguments have some weight, they are compatible with a significant dispersal of resource rights away from individual nation-states, both downwards towards local communities, and upwards towards transnational and global agencies.

GDNF Therapy: Can We Make It Work?

2021 ◽  
pp. 1-4
Author(s):  
Anders Björklund
Keyword(s):  
Gene Therapy ◽  
Transcription Factor ◽  
Signaling Pathway ◽  
Therapeutic Potential ◽  
Threshold Level ◽  
New Findings ◽  
The Status ◽  
Interesting Discussion ◽  
Postmortem Studies ◽  
Made In

In two recent postmortem studies, Jeffrey Kordower and colleagues report new findings that open up for an interesting discussion on the status of GDNF/NRTN signaling in patients with Parkinson’s disease (PD), adding an interesting perspective on the, admittedly very limited, signs of restorative effects previously seen in GDNF/NRTN-treated patients. Their new findings show that the level of the GDNF signaling receptor Ret is overall reduced by about 65% relative to non-PD controls, and most severely, up to 80%, in nigral neurons containing α-synuclein inclusions, accompanied by impaired signaling downstream of the Ret receptor. Notably, however, the vast majority of the remaining nigral neurons retained a low level of Ret expression, and hence a threshold level of signaling. Further observations made in two patients who had received AAV-NRTN gene therapy 8–10 years earlier suggest the intriguing possibility that NRTN is able to restore Ret expression and upregulate its own signaling pathway. This “wind-up” mechanism, which is likely to depend on an interaction with dopaminergic transcription factor Nurr1, has therapeutic potential and should encourage renewed efforts to turn GDNF/NRTN therapy into success, once the recurring problem of under-dosing is resolved.

Marketing and delivering information literacy on the web, yesterday and today, from 2009 to 2012

2014 ◽  
Vol 31 (4) ◽  
pp. 10-13 ◽  
Author(s):  
Sharon Q. Yang
Keyword(s):  
Information Literacy ◽  
Web Sites ◽  
Academic Libraries ◽  
Design Methodology ◽  
Status Quo ◽  
Content Type ◽  
The Status ◽  
Practical Implications ◽  
The Web ◽  
Made In

Purpose – This study aims to ascertain the trends and changes of how academic libraries market and deliver information literacy (IL) on the web. Design/methodology/approach – The author compares the findings from two separate studies that scanned the Web sites for IL-related activities in 2009 and 2012, respectively. Findings – Academic libraries intensified their efforts to promote and deliver IL on the web between 2009 and 2012. There was a significant increase in IL-related activities on the web in the three-year period. Practical implications – The findings describe the status quo and changes in IL-related activities on the libraries’ Web sites. This information may help librarians to know what they have been doing and if there is space for improvement. Originality/value – This is the only study that spans three years in measuring the progress librarians made in marketing and delivering IL on the Web.

scholarly journals The Peripheral Housing Estate as a Form of Urban Spatial Development. The Status Quo and Perspectives

2010 ◽  
Vol 14 (1) ◽  
pp. 273-281 ◽  
Author(s):  
Marek Pieniążek
Keyword(s):  
Field Research ◽  
Status Quo ◽  
Housing Estate ◽  
The Third ◽  
City Hall ◽  
Residential Units ◽  
The Status ◽  
The City ◽  
Housing Estates ◽  
Made In

Abstract Presentation of contemporary trends in development of such residential units as peripheral housing estates in large Polish cities, as exemplified by Warsaw, is the objective of the paper. Such units are compared with their counterparts being built in Berlin. Research was carried out in three housing estates in the western part of the Bemowo District of Warsaw, i.e. Lazurowa (developer J.W. Construction), Nad Jeziorem (developer DoR Group) and Villa L’Azur (developer Bouygues Immobilier Polska). The first two were completed at the turn of 2008/2009. The third is in the final stage of construction. All three are located inside immediate city borders. Within framework of research were carried out analysis of developers’ materials, cartographic materials from the City Hall as well as field research. The results were juxtaposed with research made in 2008 in Berlin.

Communology:

2019 ◽  
Vol 118 (4) ◽  
pp. 725-746
Author(s):  
Ugo Mattei ◽  
Mark Mancall
Keyword(s):  
Social Sciences ◽  
Historical Perspective ◽  
Status Quo ◽  
End Of History ◽  
The Status ◽  
Private And Public ◽  
The Commons ◽  
Late Nineteenth ◽  
The End Of History ◽  
Positivist Approach

Against the spectacle of environmental, economic, social, and institutional crises spawned by capitalism, the authors advocate the urgency of a radically new social science: the nascent field of communology. As Marxism did in the late nineteenth and early twentieth centuries, communology challenges orthodoxy. This article presents communology’s evolving terminology, historical perspective, and intersections with law, politics, technology, and social sciences. The commons are subversive to the status quo; they do not assume—as given—sovereignty, statehood, boundaries, or territorial or property structures. That is precisely why their study within the positivist approach dominant today is inadequate, often misleading, and even dangerous to projects of emancipation. Commoners constantly struggle for a different world, for a radically inclusive alternative to all patterns of capitalist exclusion, both private and public. Neither capitalism nor socialism, in any of their forms, constitutes “the end of history.”

scholarly journals The status quo of digital transformation in insurance sales: an empirical analysis of the german insurance industry

2021 ◽  
Author(s):  
Christian Eckert ◽  
Johanna Eckert ◽  
Armin Zitzmann
Keyword(s):  
Empirical Analysis ◽  
Insurance Industry ◽  
Digital Technologies ◽  
Status Quo ◽  
Digital Transformation ◽  
Social Classes ◽  
Insurance Companies ◽  
Recommendations For Action ◽  
The Status ◽  
The Impact

AbstractIn this paper, we focus on the impact of digital transformation on traditional ways to sell insurance products. Our goal is to investigate how widespread the use of digital technologies in insurance sales is and which values of these digital technologies are perceived by insurance intermediaries. Moreover, we aim to analyze underlying influencing factors in this regard. We conducted a survey in July 2020, i.e., after the first wave of COVID-19, in which 671 exclusive agents from various insurance companies, independent agents and independent brokers from Germany participated. Our results show that even at this point of time, in a high proportion of sales workforces, digital transformation is not yet very advanced. Further analyses show that exclusive agents and younger people are further ahead in digital transformation even though COVID-19 pushes digital life across all ages and social classes. Based on our results, we derive initial recommendations for action for the insurer.

Bosnia’s Perpetual Purgatory: The Inability to Fulfill EU Accession Requirements

2021 ◽  
Vol 1 (2) ◽  
pp. 1-18
Author(s):  
Gabrielle Regimbal
Keyword(s):  
European Commission ◽  
Ethnic Groups ◽  
Historical Context ◽  
Status Quo ◽  
Eu Accession ◽  
State Institutions ◽  
The Status ◽  
Accession Process ◽  
The Eu ◽  
Made In

This paper argues that Bosnia and Herzegovina (BiH) should not begin the European Union’s accession process, and should instead remain on the ‘potential candidates’ list due to their continuous inability to meet the EU acquis. While some progress was made in 2020 towards meeting this goal, such as moderate candidate victories in the November election (over the reigning populist politicians) and the first elections being held in Mostar in December, BiH has failed to address the root of the issues. By examining the European Commission reports for BiH and researching the historical context surrounding the flawed state institutions, the following conclusion was determined. Due to BiH’s failure to comply with EU accession’s political, legal, and economic requirements, they are unable to be considered for induction, and the status quo should remain. Instead, the EU should foster methods of reconciliation for the three ethnic groups that dominate Bosnian society to help build consensus and foster compromise to fulfill accession requirements.

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