Antiproliferative function of glia maturation factor beta.
Keyword(s):
G1 Phase
◽
Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited. When tested simultaneously, GMF-beta suppresses the mitogenic effect of acidic fibroblasts growth factor (aFGF), but the two are synergistic in promoting the morphologic differentiation of cultured astrocytes. GMF-beta also counteracts the growth-stimulating effect of pituitary extract and cholera toxin on Schwann cells. The results underscore the regulatory role of GMF-beta and its intricate interaction with the mitogenic growth factors.
Keyword(s):
1987 ◽
Vol 80
(9)
◽
pp. 591-593
1994 ◽
Vol 345
(1313)
◽
pp. 257-263
◽
Keyword(s):
Keyword(s):
1996 ◽
Vol 270
(1)
◽
pp. H411-H415
◽
Keyword(s):
2008 ◽
Vol 2
(1)
◽
pp. 26-34
◽
1988 ◽
Vol 48
(sup190)
◽
pp. 24-25
2009 ◽
Vol 29
(1)
◽
pp. 50-58
◽
Keyword(s):