Subclinical vitamin D deficiency in neonates: definition and response to vitamin D supplements

Background: We postulated that the preoperative correction of vitamin D levels can significantly reduce the incidence of hunger bone syndrome among patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods: We performed a prospective, randomized, open-label study on 102 patients with primary hyperparathyroidism and coexisting vitamin D deficiency who were scheduled to undergo parathyroidectomy. Patients were divided into the following two groups: group I which included 52 patients who did not receive preoperative vitamin D supplementation; and group II which included 50 patients who received cholecalciferol 1000–2000 IU daily or 50000 IU weekly until they achieve vitamin D levels >20 ng/mL (group IIa = 25 patients) or vitamin D levels >30 ng/mL (group IIb = 25 patients). Results: The incidence of hunger bone syndrome in group IIb was lower than group I and group IIa (8% versus 16% versus 23%, respectively); however, this difference did not reach the level of statistical significance (p = 0.22). Patients with hunger bone syndrome were significantly younger and had higher serum phosphorus, alkaline phosphatase, magnesium, and bone mineral density at baseline than patients without hunger bone syndrome. On the other hand, patients with hunger bone syndrome had significantly lower 25-hydroxyvitamin D at baseline than patients without hunger bone syndrome (p = 0.001). The ROC curve showed that the baseline level of serum 25-hydroxyvitamin D was not an independent discriminator of hunger bone syndrome (area under curve = 0.21 (95% CI: 0.06–0.34); p = 0.011). Conclusion: Preoperative course of vitamin D supplements has no preventive role on the postoperative incidence of hunger bone syndrome among patients with primary hyperparathyroidism and coexisting vitamin D deficiency undergoing parathyroidectomy.

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Vitamin D Supplementation in Australia: Implications for the Development of Supplementation Guidelines

Journal of Nutrition and Metabolism ◽

10.1155/2014/374208 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

Kellie Bilinski ◽

Peter Talbot

Keyword(s):

Public Health ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D Supplementation ◽

Supplement Use ◽

The Past ◽

Threefold Increase ◽

Vitamin D Supplements ◽

Vitamin D Supplement ◽

Potential Public Health

High rates of vitamin D deficiency and testing have been reported in Australia, yet there are few reports regarding vitamin D supplement use. Australian wholesale sales data was obtained for vitamin D supplements for the period 2000–2011. There has been a threefold increase in supplement sales over the past decade, whereby over A$94 million supplements containing vitamin D in Australia were sold during the year 2010. There were eighty-nine manufacturers that produce a variety of 195 vitamin D products. The amount of vitamin D in these products varies considerably, from 40 to 1000 IU per unit, although supplements containing only vitamin D had the highest amount of vitamin D. There was a trend for sales to increase in winter months. Given the potential public health benefits of vitamin D, there is an urgent need for a better understanding of supplementation use and for the development of supplementation.

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Vitamin D status among immigrant mothers from Pakistan, Turkey and Somalia and their infants attending child health clinics in Norway

British Journal Of Nutrition ◽

10.1017/s0007114508055712 ◽

2008 ◽

Vol 101 (7) ◽

pp. 1052-1058 ◽

Cited By ~ 66

Author(s):

Ahmed A. Madar ◽

Lars C. Stene ◽

Haakon E. Meyer

Keyword(s):

Vitamin D ◽

Child Health ◽

Vitamin D Deficiency ◽

Positive Association ◽

Vitamin D Status ◽

Limited Information ◽

Immigrant Mothers ◽

Health Clinics ◽

Vitamin D Supplements ◽

Breast Fed

High prevalences of vitamin D deficiency have been reported in non-Western immigrants moving to Western countries, including Norway, but there is limited information on vitamin D status in infants born to immigrant mothers. We aimed to describe the vitamin D status and potentially correlated factors among infants aged 6 weeks and their mothers with Pakistani, Turkish or Somali background attending child health clinics in Norway. Eighty-six healthy infants and their mothers with immigrant background were recruited at the routine 6-week check-up at nine centres between 2004 and 2006. Venous or capillary blood was collected at the clinics from the mother and infant, and serum separated for analysis of 25-hydroxyvitamin D (s-25(OH)D) and intact parathyroid hormone (s-iPTH). The mean maternal s-25(OH)D was 25·8 nmol/l, with 57 % below 25 nmol/l and 15 % below 12·5 nmol/l. Of the mothers, 26 % had s-iPTH>5·7 pmol/l. For infants, mean s-25(OH)D was 41·7 nmol/l, with 47 % below 25 nmol/l and 34 % below 12·5 nmol/l. s-25(OH)D was considerably lower in the thirty-one exclusively breast-fed infants (mean 11·1 nmol/l; P < 0·0001). Use of vitamin D supplements and education showed a positive association with maternal s-25(OH)D. There was no significant association between mother's and child's s-25(OH)D, and no significant ethnic or seasonal variation in s-25(OH)D for mothers or infants. In conclusion, there is widespread vitamin D deficiency in immigrant mothers and their infants living in Norway. Exclusively breast-fed infants who did not receive vitamin D supplements had particularly severe vitamin D deficiency.

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Pancreatic secretion in man with subclinical vitamin D deficiency

Diabetologia ◽

10.1007/bf02427278 ◽

1986 ◽

Vol 29 (1) ◽

pp. 34-38 ◽

Cited By ~ 33

Author(s):

B. L. Nyomba ◽

J. Auwerx ◽

V. Bormans ◽

T. L. Peeters ◽

W. Pelemans ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Pancreatic Secretion ◽

Subclinical Vitamin

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Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

Journal of Nephropharmacology ◽

10.15171/npj.2018.13 ◽

2018 ◽

Vol 7 (2) ◽

pp. 55-60

Author(s):

Nozar Dorestan ◽

Sara Bahadoram ◽

Mohammad Bahadoram ◽

Mohammadreza Khosravi ◽

Mohammad Davoodi ◽

...

Keyword(s):

Vitamin D ◽

Kidney Disease ◽

Vitamin D Deficiency ◽

Heart Diseases ◽

Daily Intake ◽

Type I ◽

Bowel Diseases ◽

Progression Of Kidney Disease ◽

Vitamin D Supplements ◽

The Relationship

Vitamin D or cholecalciferol, as a steroidal hormone, regulates the calcium homeostasis, and bone formation with reabsorption through kidneys, parathyroid glands and bowel. There are at least 800 human genes connected with vitamin D. Previous research has confirmed the relationship between vitamin D and colorectal cancers, infections, heart diseases, multiple sclerosis (MS), bone disorders, inflammatory and autoimmune diseases, inflammatory bowel diseases, diabetes mellitus type-I and II and also progression of kidney disease. However, the relationship of vitamin D deficiency and developing of breast cancer, rheumatoid arthritis and osteoporosis is unknown. In fact, the effect of vitamin D deficiency on pathogenesis of different diseases is controversial. To cope with vitamin D deficiency, there are different recommendations such as daily intake of vitamin D supplements and more exposure to sunlight.

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The Effect of Vitamin D Replacement on Patient with Subclinical Hypothyroidism: A Pilot Randomized Clinical Trial

Galen Medical Journal ◽

10.31661/gmj.v9i0.1592 ◽

2020 ◽

Vol 9 ◽

pp. 1592

Author(s):

Babak Pezeshki ◽

Ali Ahmadi ◽

Aliasghar Karimi

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Subclinical Hypothyroidism ◽

Serum Levels ◽

Thyroid Stimulating Hormone ◽

T Test ◽

Overt Hypothyroidism ◽

Paired Samples ◽

The Difference ◽

Vitamin D Supplements

Background: Subclinical hypothyroidism (SCH) is characterized by an elevated Thyroid Stimulating Hormone (TSH) with a normal T4. The prevalence of Vitamin D deficiency in patients SCH is high. Some studies suggested that Vitamin D supplements could be reduced serum concentration of TSH so improve SCH and prevent overt hypothyroidism. This study aims to explore the effect of vitamin D replacement on subclinical hypothyroidism. Materials and Methods: Fifty-nine patients, diagnosed with both subclinical hypothyroidism and Vitamin D deficiency by the Endocrinology outpatient clinics between January 2018 and March 2019, were included in this trial. The patients with overt hypothyroidism, cardiovascular risk factors, or positive TPO antibody, abnormal T4, and pregnant women were excluded from this study. The 40 subjects were investigated who received vitamin D supplements for two months. Analyses were conducted through paired-samples t-test and independent-samples t-test using SPSS 24 (Armonk, NY: IBM Corp). Results: The mean serum levels of TSH was decreased from 6.89 mIU/l in the pre-test to 3.34 mIU/l in the post-test, and the difference was found to be statistically significant at P<0.001. Conclusion: We found that the TSH mean level significantly dropped through the use of vitamin D supplements. Thus, it is recommended that all the patients with subclinical hypothyroidism be screened and treated with vitamin D supplements. [GMJ.2020;9:e1592]

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