Is the fatty acid composition of immune cells the key to normal variations in human immune response?

Dietary fatty acids have been shown to affect the activity of the immune system in a variety of species through eicosanoid dependent or independent mechanisms (Miles 1998, Calder 2001). MLN and spleen are lymphoid tissues which play a key role in the immune function. Changing the fatty acid composition of these tissues could change the profile of eicosanoid produced by immune cells in these tissues and this could alter the immune response. This study was carried out to establish the extent to which different oil supplements could change the fatty acid composition of MLN and spleen in milk fed calves.

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1314 Abomasal infusions of linoleic and linolenic acid in lactating dairy cows differentially alter the fatty acid composition of plasma lipid fractions and immune cells

Journal of Animal Science ◽

10.2527/jam2016-1314 ◽

2016 ◽

Vol 94 (suppl_5) ◽

pp. 633-633

Author(s):

S. E. Schmidt ◽

V. E. Ryman ◽

C. L. Preseault ◽

L. M. Sordillo ◽

A. L. Lock

Keyword(s):

Fatty Acid Composition ◽

Fatty Acid ◽

Dairy Cows ◽

Linolenic Acid ◽

Acid Composition ◽

Immune Cells ◽

Plasma Lipid ◽

Lactating Dairy Cows ◽

Lipid Fractions

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Growth, Body Fatty Acid Composition, Immune Response, and Resistance toStreptococcus iniaeof Hybrid Tilapia,Oreochromis niloticus × Oreochromis aureus, Fed Diets Containing Various Levels of Linoleic and Linolenic Acids

Journal of the World Aquaculture Society ◽

10.1111/jwas.12014 ◽

2013 ◽

Vol 44 (1) ◽

pp. 42-55 ◽

Cited By ~ 25

Author(s):

Erchao Li ◽

Chhorn Lim ◽

Phillip H Klesius ◽

Thomas L Welker

Keyword(s):

Immune Response ◽

Fatty Acid Composition ◽

Fatty Acid ◽

Acid Composition ◽

Oreochromis Niloticus ◽

Oreochromis Aureus

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On the Coupling of Two Models of the Human Immune Response to an Antigen

BioMed Research International ◽

10.1155/2014/410457 ◽

2014 ◽

Vol 2014 ◽

pp. 1-19 ◽

Cited By ~ 4

Author(s):

Bárbara de M. Quintela ◽

Rodrigo Weber dos Santos ◽

Marcelo Lobosco

Keyword(s):

Immune Response ◽

Sensitivity Analysis ◽

Immune System ◽

Differential Equations ◽

Immune Cells ◽

Coupled Model ◽

Systemic Response ◽

Defense System ◽

Human Immune Response ◽

Human Immune

The development of mathematical models of the immune response allows a better understanding of the multifaceted mechanisms of the defense system. The main purpose of this work is to present a scheme for coupling distinct models of different scales and aspects of the immune system. As an example, we propose a new model where the local tissue inflammation processes are simulated with partial differential equations (PDEs) whereas a system of ordinary differential equations (ODEs) is used as a model for the systemic response. The simulation of distinct scenarios allows the analysis of the dynamics of various immune cells in the presence of an antigen. Preliminary results of this approach with a sensitivity analysis of the coupled model are shown but further validation is still required.

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