scholarly journals Metabolic response to fasting predicts weight gain during low-protein overfeeding in lean men: further evidence for spendthrift and thrifty metabolic phenotypes

2019 ◽  
Vol 110 (3) ◽  
pp. 593-604 ◽  
Author(s):  
Tim Hollstein ◽  
Takafumi Ando ◽  
Alessio Basolo ◽  
Jonathan Krakoff ◽  
Susanne B Votruba ◽  
...  
Keyword(s):  
Weight Gain ◽  
Fat Mass ◽  
Metabolic Response ◽  
Metabolic Phenotype ◽  
Fibroblast Growth Factor 21 ◽  
Average Weight ◽  
Cumulative Energy ◽  
Bomb Calorimetry ◽  
Metabolic Phenotypes ◽  
Low Protein

ABSTRACT Background Greater increase in 24-h energy expenditure (24EE) during overfeeding and smaller decrease in 24EE during fasting (“spendthrift” metabolic phenotype) are associated with more weight loss during sustained caloric restriction in overweight subjects. Objectives The aim of this study was to investigate whether these acute metabolic responses can also predict weight gain during sustained overfeeding in lean individuals. Methods Seven lean men participated in this study. Prior to overfeeding, 24EE responses to fasting and 200% normal-protein overfeeding were measured in a whole-room indirect calorimeter. Volunteers underwent 6 wk of 150% low-protein (2%) overfeeding followed by another wk of weight-maintaining diet, during which 24EE was revaluated. Body composition, 24EE, and various hormone concentrations, including fibroblast growth factor 21 (FGF21), were assessed at baseline, at wk 1, 3, and 6 of the overfeeding period, and 1 wk following overfeeding through the use of dual-energy X-ray absorptiometry, indirect calorimetry, and ELISA. Cumulative energy surplus was calculated from 24EE, daily physical activity, and direct measurements of calories of nutrient intake, feces, and urine by bomb calorimetry. Results The average weight gain during 6 wk of low-protein overfeeding was 3.8 kg (6.1%, min: +2.5%, max: +8.0%). During 24-h fasting at baseline, 24EE decreased on average (mean ± SD) by 158 ± 81 kcal/d (P = 0.007). Subjects with less 24EE decrease during fasting (more metabolically spendthrift individuals) gained less weight (r = −0.84, P = 0.03), less fat mass (r = −0.81, P = 0.049), and stored less calories (r = −0.91, P = 0.03) during overfeeding. Following overfeeding, increased 24EE above requirements for achieved body size was associated with less weight and fat mass gain (r = −0.78, P = 0.04) and with the increase in 24EE during 200% normal-protein overfeeding measured at baseline (r = 0.91, P = 0.005). Serum FGF21 concentrations increased up to 44-fold during overfeeding (P <  0.0001). Conclusions Low-protein overfeeding may be an important tool to identify metabolic phenotypes (spendthrift compared with thrifty) that characterize susceptibility to weight gain. This trial was registered at clinicaltrials.gov as NCT00687115.

Metabolic Response to Fasting Predicts Weight Gain During Low-Protein Overfeeding: Further Evidence for Spendthrift and Thrifty Metabolic Phenotypes

2018 ◽  
Author(s):  
Tim Hollstein ◽  
Takafumi Ando ◽  
Alessio Basolo ◽  
Jonathan Krakoff ◽  
Susanne Votruba ◽  
...  
Keyword(s):  
Weight Gain ◽  
Metabolic Response ◽  
Metabolic Phenotypes ◽  
Low Protein

1950-P: Fat Mass Affects Metabolic Response to Erythropoietin in Mice

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1950-P
Author(s):  
HEATHER ROGERS ◽  
CONSTANCE T. NOGUCHI
Keyword(s):  
Fat Mass ◽  
Metabolic Response

Pengaruh Penambahan Bungkil Kedelai terhadap Konsumsi Pakan, Pertambahan Bobot Badan Harian, dan Konversi Pakan pada Sapi Peranakan Simmental

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Rico Rico ◽  
Novi Eka Wati ◽  
Adisti Rastosari
Keyword(s):  
Weight Gain ◽  
Soybean Meal ◽  
Crude Protein ◽  
Dry Matter ◽  
T Test ◽  
Daily Weight Gain ◽  
Feed Consumption ◽  
Average Weight ◽  
Protein Consumption ◽  
Simmental Cattle

The objective of the researh was to study the effect of additions soybean meal in ration on the feed consumption, daily weight gain and feed convertion in Simmental cattle. The experiment used eight male Simmental cattle around 2 years old with an average weight of 198,65 ± 14,57 kilograms. The cattle kept for 35 days and given rations P0 (rations ranchers) and P1 (rations plus soybean meal). Data was obtained, then analyzed using independent sample t-test assisted with SPSS version 17.00 software. The result showed that the addition of soybean meal did not affect on dry matter consumption, daily weight gain, and feed convertion but, the crude protein consumption was increased. Keywords: dry matter consumption, daily weight gain, feed convertion

scholarly journals The Positive Effects of GH-Releasing Peptide-6 on Weight Gain and Fat Mass Accrual Depend on the Insulin/Glucose Status

2010 ◽  
Vol 95 (3) ◽  
pp. 1477-1477
Author(s):  
Miriam Granado ◽  
Cristina García-Cáceres ◽  
Laura M. Frago ◽  
Jesús Argente ◽  
Julie A. Chowen
Keyword(s):  
Weight Gain ◽  
Fat Mass ◽  
Positive Effects ◽  
Glucose Status

scholarly journals Minimal impact of age and housing temperature on the metabolic phenotype of Acc2−/− mice

2015 ◽  
Vol 228 (3) ◽  
pp. 127-134 ◽  
Author(s):  
Amanda E Brandon ◽  
Ella Stuart ◽  
Simon J Leslie ◽  
Kyle L Hoehn ◽  
David E James ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Energy Expenditure ◽  
Glucose Tolerance ◽  
Fat Mass ◽  
Knockout Mice ◽  
Muscle Glycogen ◽  
Insulin Action ◽  
Metabolic Phenotype ◽  
Whole Body

An important regulator of fatty acid oxidation (FAO) is the allosteric inhibition of CPT-1 by malonyl-CoA produced by the enzyme acetyl-CoA carboxylase 2 (ACC2). Initial studies suggested that deletion of Acc2 (Acacb) increased fat oxidation and reduced adipose tissue mass but in an independently generated strain of Acc2 knockout mice we observed increased whole-body and skeletal muscle FAO and a compensatory increase in muscle glycogen stores without changes in glucose tolerance, energy expenditure or fat mass in young mice (12–16 weeks). The aim of the present study was to determine whether there was any effect of age or housing at thermoneutrality (29 °C; which reduces total energy expenditure) on the phenotype of Acc2 knockout mice. At 42–54 weeks of age, male WT and Acc2−/− mice had similar body weight, fat mass, muscle triglyceride content and glucose tolerance. Consistent with younger Acc2−/− mice, aged Acc2−/− mice showed increased whole-body FAO (24 h average respiratory exchange ratio=0.95±0.02 and 0.92±0.02 for WT and Acc2−/− mice respectively, P<0.05) and skeletal muscle glycogen content (+60%, P<0.05) without any detectable change in whole-body energy expenditure. Hyperinsulinaemic–euglycaemic clamp studies revealed no difference in insulin action between groups with similar glucose infusion rates and tissue glucose uptake. Housing Acc2−/− mice at 29 °C did not alter body composition, glucose tolerance or the effects of fat feeding compared with WT mice. These results confirm that manipulation of Acc2 may alter FAO in mice, but this has little impact on body composition or insulin action.

scholarly journals Considerations to maximize fat mass gain in a mouse model of diet-induced weight gain

2013 ◽  
Vol 47 (4) ◽  
pp. 266-273 ◽  
Author(s):  
KC Carpenter ◽  
K Strohacker ◽  
BK McFarlin
Keyword(s):  
Weight Gain ◽  
Mouse Model ◽  
Fat Mass ◽  
Mass Gain

Abstract 003: Change in Cardiovascular Risk Factors Associated with Weight Gain in the Dallas Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Tiffany M Powell ◽  
Colby R Ayers ◽  
James A de Lemos ◽  
Amit Khera ◽  
Susan G Lakoski ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Weight Gain ◽  
Cardiovascular Risk Factors ◽  
Average Weight ◽  
Men And Women ◽  
Significant Weight Gain ◽  
Heart Study ◽  
Dallas Heart Study ◽  
The Impact

Background: Concerning trends in weight gain from 2000-2009 exist in the Dallas Heart Study (DHS), a probability-based sample of Dallas County residents aged 30-65. However, the impact of significant weight gain (≥ 5% increase in body weight) on cardiovascular risk factors (CVRF) in this contemporary, multi-ethnic population is not known. Methods: We measured weight, LDL-c, blood pressure (SBP and DBP), and fasting glucose (FG) in 2,022 DHS participants (58% female) at study entry in 2000 and in 2009. Using logistic regression stratified by sex and race/ethnicity, we determined the age-adjusted odds of worsening CVRF (any increase in LDL-c, SBP, DBP or FG) for people who gained significant weight compared to those who did not. Results: Among women, 43% (N=500) gained significant weight, compared to 42% of men (N=355). Despite similar average weight gain (9.7±5.8 kg for women vs. 10±5.6 kg for men, p=0.4), women who gained significant weight had almost twice as large an increase in LDL-c (14±34 vs. 8±39 mg/dl, p=0.01) and SBP (12±18 vs. 6±19 mmHg, p<0.001) compared with men who gained significant weight. Increases in DBP (5±10 vs. 4±11 mmHg, p=0.05) and FG (4±29 vs. 2±32 mg/dl, p=0.30) were not significantly different between men and women. Among those with significant weight gain who were not on medications, SBP and LDL-c increases were higher in women compared with men (p<0.05). Differences in the amount of weight gained stratified by race and sex were modest (Table). Black women who gained significant weight were likely to have a worsening of all CVRF, while Hispanic women had the highest likelihood of having an increase in SBP associated with weight gain. In contrast, significant weight gain among men was not associated with worsening CVRF. Conclusions: Significant weight gain was associated with a deleterious impact on CVRF among women but not men. Disparate effects of weight gain between men and women highlight the importance of targeting aggressive weight control interventions toward women to help prevent adverse cardiac outcomes.

scholarly journals Effect of mineral protein suplements on live weight gain of grazing cattle

2009 ◽  
Vol 33 (6) ◽  
pp. 1643-1648
Author(s):  
Lucas Alberto Teixeira de Rezende ◽  
Júlio César Teixeira ◽  
Antônio Ricardo Evangelista ◽  
Juan Ramón Olalquiaga Pérez ◽  
Joel Augusto Muniz ◽  
...  
Keyword(s):  
Weight Gain ◽  
Live Weight ◽  
Mineral Salt ◽  
Daily Weight Gain ◽  
Average Weight ◽  
Protein Supplement ◽  
Protein Nitrogen ◽  
Live Weight Gain ◽  
Grazing Cattle ◽  
Control Protein

This work was carried out to evaluate the effect of supplements based on non-protein nitrogen (NPN) as: urea, amirea and multinutritional block, on live weight gain and cost analysis for cattle kept in pastures. During a period of 104 days(April to July 2004), 40 crossbreed bulls, uncastrated and initial average weight of 379kg, were allocated into 4 paddocks with Brachiaria brizantha cv. Marandu, in continuous pasture system receiving, in troughs, the following treatments: mineral salt (control), protein supplement containing amirea, protein supplement containing urea and multinutritional block. The experimental design used was randomized blocks with repetition within the block. Results of availability bromatological composition of pasture, supplement consumption and daily weight gain of animals were evaluated in two experimental sub-periods: 0 to 45 and 45 to 90 days. In the first sub-period, there was no effect of treatments (P>0.05) on daily weight gain but in the second sub-period, the multinutritional block showed smaller (P<0.05) weight gain than the ones which were similar among themselves, being: 0.60; 0.59; 0.61 and 0.22kg/animal/day, respectively, for the treatments with mineral salt, amirea, urea and multinutritional block. Before these edafoclimatic conditions, the period and duration of the experiment, the supplementation with mineral salt provided the higher profit.

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