scholarly journals Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study

2019 ◽  
Vol 110 (4) ◽  
pp. 1015-1025 ◽  
Author(s):  
Benjamin J J McCormick ◽  
Laura E Murray-Kolb ◽  
Gwenyth O Lee ◽  
Kerry J Schulze ◽  
A Catharine Ross ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Transferrin Receptor ◽  
Lower Risk ◽  
Micronutrient Deficiency ◽  
Dietary Intakes ◽  
Micronutrient Deficiencies ◽  
Complementary Foods ◽  
Nutrient Density ◽  
Micronutrient Status ◽  
Increased Risk

ABSTRACTBackgroundEnvironmental enteric dysfunction (EED) is thought to increase the risk of micronutrient deficiencies, but few studies adjust for dietary intakes and systemic inflammation.ObjectiveWe tested whether EED is associated with micronutrient deficiency risk independent of diet and systemic inflammation, and whether it mediates the relation between intake and micronutrient status.MethodsUsing data from 1283 children in the MAL-ED (Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health) birth cohort we evaluated the risk of anemia, low retinol, zinc, and ferritin, and high transferrin receptor (TfR) at 15 mo. We characterized gut inflammation and permeability by myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT) concentrations from asymptomatic fecal samples averaged from 9 to 15 mo, and averaged the lactulose:mannitol ratio z-score (LMZ) at 9 and 15 mo. Nutrient intakes from complementary foods were quantified monthly from 9 to 15 mo and densities were averaged for analyses. α-1-Acid glycoprotein at 15 mo characterized systemic inflammation. Relations between variables were modeled using a Bayesian network.ResultsA greater risk of anemia was associated with LMZ [1.15 (95% CI: 1.01, 1.31)] and MPO [1.16 (1.01, 1.34)]. A greater risk of low ferritin was associated with AAT [1.19 (1.03, 1.37)] and NEO [1.22 (1.04, 1.44)]. A greater risk of low retinol was associated with LMZ [1.24 (1.08, 1.45)]. However, MPO was associated with a lower risk of high transferrin receptor [0.86 (0.74, 0.98)], NEO with a lower risk of low retinol [0.75 (0.62, 0.89)], and AAT with a lower risk of low plasma zinc [0.83 (0.70, 0.99)]. Greater nutrient intake densities (vitamins A and B6, calcium, protein, and zinc) were negatively associated with EED. Inverse associations between nutrient densities and micronutrient deficiency largely disappeared after adjustment for EED, suggesting that EED mediates these associations.ConclusionsEED is independently associated with an increased risk of low ferritin, low retinol, and anemia. Greater nutrient density from complementary foods may reduce EED, and the control of micronutrient deficiencies may require control of EED.

scholarly journals Intestinal Permeability and Inflammation Mediate Dietary Intake Associated Risks of Micronutrient Deficiencies at 15 Months: Results from the MAL-ED Study (OR07-04-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Laura Caulfield ◽  
Benjamin McCormick ◽  
Laura Murray-Kolb ◽  
Gwenyth Lee ◽  
Kerry Schulze ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Lower Risk ◽  
High Plasma ◽  
Micronutrient Deficiency ◽  
Micronutrient Deficiencies ◽  
Complementary Foods ◽  
Nutrient Density ◽  
Lm Tests ◽  
Increased Risk ◽  
Alpha 1 Antitrypsin

Abstract Objectives We tested whether environmental enteric dysfunction (EED) is associated with risk of micronutrient deficiencies adjusting for diet and systemic inflammation, and whether it mediates the relation between intake and micronutrient status. Methods Data from 1283 children in the MAL-ED birth cohort were examined to evaluate risk of anemia, low plasma retinol, zinc, and ferritin, and high plasma transferrin receptor (TfR) at 15 months. We characterized gut inflammation and permeability by myeloperoxidase, neopterin, and alpha-1-antitrypsin concentrations from monthly asymptomatic fecal samples averaged from 9–15 months, and urinary recovery of lactulose (L) and mannitol (M) from LM tests at 9 and 15 months, converted to a ratio z score (LMZ) and averaged. Nutrient intakes from complementary foods were quantified monthly from 9–15 months and densities were averaged. Plasma alpha-1 acid glycoprotein at 15 months characterized systemic inflammation. Relationships among variables were modelled using a direct acyclic graph. Results Greater risk of anemia was associated with permeability [LMZ: 1.15 (95% confidence interval: 1.01–1.31)] and inflammation [myeloperoxidase: 1.16 (1.01–1.34)]. Greater risk of low ferritin was associated with alpha-1-antitrypsin [1.19 (1.03–1.37)] and neopterin [1.22 (1.04–1.43)]. Greater risk of low retinol was associated with LMZ [1.25 (1.07–1.45)]. However, myeloperoxidase was associated with lower risk of high TfR [0.86 (0.74–0.98)], neopterin with lower risk of low retinol [0.75 (0.62–0.89)], and alpha-1-antripysin with lower risk of low plasma zinc [0.83 (0.70–0.99)]. Greater nutrient densities of vitamin A, B6, calcium, protein and zinc were negatively associated with EED. Inverse associations between nutrient densities and micronutrient deficiency largely disappeared after adjustment for EED, suggesting that EED mediates associations between intake and status. Conclusions EED is independently associated with increased risk of low ferritin, low retinol and anemia. Greater nutrient density from complementary foods may reduce EED, and control of micronutrient deficiency may require control of EED. Funding Sources The MAL-ED study was supported by the Bill & Melinda Gates Foundation, through awards to the Foundation for the NIH and NIH/FIC.

scholarly journals Complementary Foods and Milk-Based Formulas Provide Excess Protein but Suboptimal Key Micronutrients and Essential Fatty Acids in the Intakes of Infants and Toddlers from Urban Settings in Malaysia

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2354
Author(s):  
Geok Lin Khor ◽  
Siew Siew Lee
Keyword(s):  
Fatty Acids ◽  
Fast Food ◽  
Protein Intake ◽  
Essential Fatty Acids ◽  
Dietary Intakes ◽  
Micronutrient Deficiencies ◽  
Care Providers ◽  
Complementary Foods ◽  
Rapid Weight Gain ◽  
Increased Risk

This study determined the intakes of complementary foods (CFs) and milk-based formulas (MFs) by a total of 119 subjects aged 6–23.9 months from urban day care centers. Dietary intakes were assessed using two-day weighed food records. Intake adequacy of energy and nutrients was compared to the Recommended Nutrient Intakes (RNI) for Malaysia. The most commonly consumed CFs were cereals (rice, noodles, bread). The subjects derived approximately half of their energy requirements (kcals) from CFs (57 ± 35%) and MFs (56 ± 31%). Protein intake was in excess of their RNI requirements, from both CFs (145 ± 72%) and MFs (133 ± 88%). Main sources of protein included meat, dairy products, and western fast food. Intake of CFs provided less than the RNI requirements for vitamin A, thiamine, riboflavin, folate, vitamin C, calcium, iron, and zinc. Neither CF nor MF intake met the Adequate Intake (AI) requirements for essential fatty acids. These findings indicate imbalances in the dietary intake of the subjects that may have adverse health implications, including increased risk of rapid weight gain from excess protein intake, and linear growth faltering and intellectual impairment from multiple micronutrient deficiencies. Interventions are needed to improve child feeding knowledge and practices among parents and child care providers.

scholarly journals Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet—A Randomized Controlled Trial in Healthy Participants

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2815 ◽  
Author(s):  
Ann-Kathrin Lederer ◽  
Luciana Hannibal ◽  
Manuel Hettich ◽  
Sidney Behringer ◽  
Ute Spiekerkoetter ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Controlled Trial ◽  
Serum Vitamin ◽  
Vegan Diet ◽  
Micronutrient Deficiencies ◽  
Short Term ◽  
Micronutrient Status ◽  
Increased Risk ◽  
Cholesterol Intake ◽  
Healthy Participants

Vegans are at an increased risk for certain micronutrient deficiencies, foremost of vitamin B12. Little is known about the short-term effects of dietary change to plant-based nutrition on vitamin B12 metabolism. Systemic biomarkers of vitamin B12 status, namely, serum vitamin B12 and holotranscobalamin, may respond quickly to a reduced intake of vitamin B12. To test this hypothesis, 53 healthy omnivore subjects were randomized to a controlled unsupplemented vegan diet (VD, n = 26) or meat-rich diet (MD, n = 27) for 4 weeks. Vitamin B12 status was examined by measurement of serum vitamin B12, holotranscobalamin (holo-TC), methylmalonic acid (MMA) and total plasma homocysteine (tHcy). Holo-TC decreased significantly in the VD compared to the MD group after four weeks of intervention, whereas metabolites MMA and tHcy were unaffected. Body weight remained stable in both groups. VD intervention led to a significant reduction of cholesterol intake, and adequate profiles of nutrient and micronutrient status. Lower intake of vitamin B12 was observed in VD, which was mirrored by a lower concentration of serum vitamin B12 and reduced holo-TC after 4 weeks. Plasma holo-TC may be a fast-responding biomarker to monitor adequate supply of vitamin B12 in plant-based individuals.

scholarly journals The contribution of environmental enteropathy to the global problem of micronutrient deficiency

2021 ◽  
pp. 1-8
Author(s):  
Paul Kelly
Keyword(s):  
Global Scale ◽  
Micronutrient Deficiency ◽  
Micronutrient Deficiencies ◽  
Disadvantaged Populations ◽  
Environmental Enteropathy ◽  
Micronutrient Status ◽  
Hidden Hunger ◽  
High Prevalence ◽  
And Function ◽  
Very High

Sometimes referred to as hidden hunger, micronutrient deficiencies persist on a global scale. For some micronutrients this appears to be due to inadequate intake, for others intake may not match increased requirements. However, for most micronutrient deficiencies there is uncertainty as to the dominant driver, and the question about the contribution of malabsorption is open. Environmental enteropathy (EE), formerly referred to as tropical enteropathy and also referred to as environmental enteric dysfunction, is an asymptomatic disorder of small intestinal structure and function which is very highly prevalent in many disadvantaged populations. Recent studies of the pathology and microbiology of this disorder suggest that it is driven by very high pathogen burdens in children and adults living in insanitary environments and is characterised by major derangements of the epithelial cells of the intestinal mucosa. Transcriptomic data suggest that it may lead to impaired digestion and absorption of macronutrients. Given the very high prevalence of EE, marginal malabsorption could have large impacts at population scales. However, the relative contributions of inadequate soil and crop micronutrient contents, inadequate intake, malabsorption and increased requirements are unknown. Malabsorption may compromise attempts to improve micronutrient status, but with the exception of zinc there is currently little evidence to confirm that malabsorption contributes to micronutrient deficiency. Much further research is required to understand the role of malabsorption in hidden hunger, especially in very disadvantaged populations where these deficiencies are most prevalent.

scholarly journals Disadvantaged pre-schoolers attending day care in Salvador, Northeast Brazil have a low prevalence of anaemia and micronutrient deficiencies

2013 ◽  
Vol 17 (9) ◽  
pp. 1984-1992 ◽  
Author(s):  
Rebecca L Lander ◽  
Karl B Bailey ◽  
Alastair G Lander ◽  
Abdulmonem A Alsaleh ◽  
Hugo C Costa-Ribeiro ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Day Care ◽  
Serum Folate ◽  
Parasitic Infections ◽  
Vitamin B ◽  
Northeast Brazil ◽  
Micronutrient Deficiencies ◽  
Cross Sectional ◽  
Micronutrient Status ◽  
Day Care Centres

AbstractObjectiveTo examine the micronutrient status of disadvantaged pre-schoolers from Northeast Brazil, following the introduction of pro-poor policies, by assessing the prevalence of anaemia and micronutrient deficiencies and the role of sociodemographic factors, genetic Hb disorders and parasitic infections.DesignIn a cross-sectional study, data on sociodemographic status, health, growth, genetic Hb disorders, parasites and nutrient supply from day-care meals were obtained. Fasting blood samples were collected and analysed for Hb, serum ferritin, transferrin receptor, folate, vitamin B12, retinol, Zn and Se.SettingSeven philanthropic day-care centres serving urban slums in Salvador, Northeast Brazil.SubjectsPre-schoolers aged 3–6 years from disadvantaged households.ResultsOf the 376 sampled children, 94 % were of black or mixed race; 33 % and 29 % had at least one genetic Hb disorder and intestinal parasite, respectively. Stunting and underweight were ≤5 %; 14 % were overweight. Day-care centres supplied micronutrient-dense meals and snacks each weekday. Less than 10 % of pre-schoolers had anaemia and micronutrient deficiencies. Predictors (P< 0·05) of Hb were α3·7thalassaemia, Se and retinol (but not ferritin). Micronutrient predictors (P< 0·05) were: elevated α1-glycoprotein for ferritin, Hb AS and BMIZ-score >1 for transferrin receptor, Zn and elevated α1-glycoprotein for retinol, sex and helminths for Se, helminths for vitamin B12, andGiardia intestinalisinfection for serum folate.ConclusionsImpaired growth, anaemia and micronutrient deficiencies were uncommon among these disadvantaged pre-schoolers attending day care. A range of interventions including provision of micronutrient-dense, fortified day-care meals, deworming and vitamin A supplementation likely contributed to improved micronutrient status, suggesting expanded coverage of these programmes.

scholarly journals Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis

2020 ◽  
Vol 7 (1) ◽  
pp. e000490
Author(s):  
Md. Nure Alam Afsar ◽  
Zannatun Nahar Jhinu ◽  
Md. Aminul Islam Bhuiyan ◽  
Zhahirul Islam ◽  
Towfida Jahan Siddiqua
Keyword(s):  
Systematic Review ◽  
Helicobacter Pylori ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Micronutrient Deficiency ◽  
Micronutrient Deficiencies ◽  
Increased Risk ◽  
Adverse Pregnancy ◽  
H Pylori

BackgroundOver the last few years, epidemiological studies have shown that infection with Helicobacter pylori has a major effect on micronutrient deficiency as well as on adverse pregnancy outcomes. Importantly, there are gaps in understanding the linkage of H. pylori infection with micronutrients deficiency in pregnant women.ObjectiveWe conducted a systematic review and meta-analysis to estimate the association between H. pylori infection and micronutrient deficiencies in pregnant women.MethodsA systematic literature search was conducted for relevant articles using PubMed, Web of Science, and Scopus database from inception to March 2020. The OR with 95% CIs was determined by meta-analysis of data extracted from the selected studies.ResultsFrom 2384 primary articles, 6 studies were selected for systematic reviews and 4 studies distinctively (with 1274 participants: 553 cases and 721 controls) were selected for meta-analysis. The meta-analysed fixed effect model estimated the odds of having H. pylori infection was not significantly higher among pregnant women with micronutrient deficiencies than those without deficiencies (OR=1.12, 95% CI 0.88 to 1.42, p=0.37). In the subgroup analysis, no correlation was found between H. pylori infection and vitamin B12 (OR=0.74, 95% CI 0.45 to 1.21, p=0.22), folate (OR=1.07, 95% CI 0.73 to 1.58, p=0.73), and ferritin (OR=0.81, 95% CI 0.51 to 1.31, p=0.4). However, a positive correlation was found between iron-deficiency anaemia (IDA) and H. pylori infection (OR=16.23, 95% CI 4.19 to 62.93, p<0.0001) during pregnancy.ConclusionH. pylori infection is associated with increased risk of IDA but not with deficiency of other micronutrients in pregnancy.PROSPERO registration numberCRD42019135683.

scholarly journals Can human micronutrient status be improved by supplementing domestic animals?

2003 ◽  
Vol 62 (2) ◽  
pp. 399-402 ◽  
Author(s):  
Susanne Biigel
Keyword(s):  
Domestic Animals ◽  
Micronutrient Deficiency ◽  
Micronutrient Deficiencies ◽  
Human Welfare ◽  
Animal Products ◽  
Micronutrient Status ◽  
High Doses ◽  
The Third World ◽  
Lifestyle Diseases ◽  
The Given

Micronutrient deficiencies are a major problem throughout the world and hundreds of millions of the world's population are affected by micronutrient deficiency disorders. In Europe the prevalence of clinical micronutrient deficiency disorders is less than that in the Third World. However, marginal deficiency of some of the micronutrients might be involved in the aetiology of many of the so-called lifestyle diseases, e.g. cancer, cardiovascular diseases, diabetes, osteoporosis. Supplementing domestic animals with micronutrients in excess of their needs could be one strategy to increase the intake and, thereby, status of micronutrients in the human population. This approach should, however, be considered carefully, in relation to both animal and human welfare. Many micronutrients that may accumulate in animal foods are toxic in high doses. It would also be unethical to expose animals to doses that might have deleterious effects on their health, and concentrations in animal products that might have adverse effects when consumed by man should be avoided. Furthermore, food quality should not be impaired by the supplement. On the other hand, to be relevant in relation to human nutrition, the given micronutrient should accumulate in animal tissue in concentrations that make an important contribution to total intake. Finally, the micronutrient should be incorporated in a way and in a form that is bioavailable to man, i.e. is well absorbed and utilized.

scholarly journals Self-Rated Health and Psychological Distress among Emerging Adults in Italy: A Comparison between Data on University Students, Young Workers and Working Students Collected through the 2005 and 2013 National Health Surveys

2021 ◽  
Vol 18 (12) ◽  
pp. 6403
Author(s):  
Isabella Giulia Franzoi ◽  
Fabrizio D’Ovidio ◽  
Giuseppe Costa ◽  
Angelo d’Errico ◽  
Antonella Granieri
Keyword(s):  
Mental Health ◽  
University Students ◽  
Physical Health ◽  
Emerging Adults ◽  
Lower Risk ◽  
Health Surveys ◽  
Poor General Health ◽  
Working Students ◽  
Increased Risk ◽  
National Health Surveys

Background. The present study aimed at comparing self-reported physical health and mental health among university students, workers, and working students aged between 19 years and 29 years. Method. Using data from National Health Surveys held in 2005 and 2013, a cross-sectional study was conducted on 18,612 Italian emerging adults grouped into three groups: university students, workers, and working students. The odds ratios of self-reported anxiety or depression, poor general health, and poor mental health and physical health (as assessed through SF-12) were estimated through logistic regression models adjusted for potential confounders. Results. Compared with workers, students showed an increased risk of anxiety or depression and a lower risk of poor general health. Students and working students showed an increased risk of reporting weak mental health compared with that in workers, while students displayed a lower risk of poor physical health. Significant differences were not found between the 2005 and 2013 surveys. Conclusions. These results are of considerable importance for psychologists as well as educational and occupation-based institutions for planning prevention programs and clinical interventions.

scholarly journals Perceived Social Status and Suicidal Ideation in Maltreated Children and Adolescents

2021 ◽  
Author(s):  
Kelli L. Dickerson ◽  
Helen M. Milojevich ◽  
Jodi A. Quas
Keyword(s):  
Risk Factor ◽  
Suicidal Ideation ◽  
Children And Adolescents ◽  
Social Status ◽  
Lower Risk ◽  
Developmental Patterns ◽  
Factors Associated ◽  
Established Risk Factor ◽  
Increased Risk ◽  
Perceived Social Status

AbstractRecent decades have seen an alarming increase in rates of suicide among young people, including children and adolescents (“youth”). Although child maltreatment constitutes a well-established risk factor for suicidal ideation in youth, few efforts have focused on identifying factors associated with maltreated youths’ increased risk for suicidal ideation, especially across development. The present study examined the relations between maltreated youths' (N = 279, M = 12.06 years, 52% female, 53% Latinx) perceptions of their social status and suicidal ideation and compared those relations between pre-adolescents and adolescents. Findings revealed unique developmental patterns: Perceived social status was associated with suicidal ideation, but only in adolescents, who showed greater risk for suicidal ideation if they viewed themselves as lower ranked in society and lower risk for suicidal ideation if they viewed themselves as higher ranked in society. Findings have implications for scientific and practical efforts aimed at better understanding and preventing suicide in a high-risk developmental population.

scholarly journals Dietary Micronutrients and Risk of Chronic Kidney Disease: A Cohort Study with 12 Year Follow-Up

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1517
Author(s):  
Juyeon Lee ◽  
Kook-Hwan Oh ◽  
Sue-Kyung Park
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Epidemiologic Study ◽  
Population Based ◽  
Dietary Guidelines ◽  
Dietary Intakes ◽  
Increased Risk ◽  
Ckd Stage

We investigated the association between dietary micronutrient intakes and the risk of chronic kidney disease (CKD) in the Ansan-Ansung study of the Korean Genome and Epidemiologic Study (KoGES), a population-based prospective cohort study. Of 9079 cohort participants with a baseline estimate glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and a urine albumin to creatinine ratio (UACR) <300 mg/g and who were not diagnosed with CKD, we ascertained 1392 new CKD cases over 12 year follow-up periods. The risk of CKD according to dietary micronutrient intakes was presented using hazard ratios (HRs) and 95% confidence intervals (95% CIs) in a full multivariable Cox proportional hazard models, adjusted for multiple micronutrients and important clinico-epidemiological risk factors. Low dietary intakes of phosphorus (<400 mg/day), vitamin B2 (<0.7 mg/day) and high dietary intake of vitamin B6 (≥1.6 mg/day) and C (≥100 mg/day) were associated with an increased risk of CKD stage 3B and over, compared with the intake at recommended levels (HR = 6.78 [95%CI = 2.18–21.11]; HR = 2.90 [95%CI = 1.01–8.33]; HR = 2.71 [95%CI = 1.26–5.81]; HR = 1.83 [95%CI = 1.00–3.33], respectively). In the restricted population, excluding new CKD cases defined within 2 years, an additional association with low folate levels (<100 µg/day) in higher risk of CKD stage 3B and over was observed (HR = 6.72 [95%CI = 1.40–32.16]). None of the micronutrients showed a significant association with the risk of developing CKD stage 3A. Adequate intake of micronutrients may lower the risk of CKD stage 3B and over, suggesting that dietary guidelines are needed in the general population to prevent CKD.

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