scholarly journals Changing from a Western to a Mediterranean-style diet does not affect iron or selenium status: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) 1-year randomized clinical trial in elderly Europeans

2019 ◽  
Vol 111 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Amy Jennings ◽  
Jonathan Tang ◽  
Rachel Gillings ◽  
Antonio Perfecto ◽  
John Dutton ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Elderly Population ◽  
Iron Status ◽  
Intervention Group ◽  
The Elderly ◽  
Serum Selenium ◽  
Selenium Status ◽  
Positive Effects ◽  
Dietary Strategies ◽  
Study Center

ABSTRACT Background Mediterranean diets limit red meat consumption and increase intakes of high-phytate foods, a combination that could reduce iron status. Conversely, higher intakes of fish, a good source of selenium, could increase selenium status. Objectives A 1-y randomized controlled trial [New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE)] was carried out in older Europeans to investigate the effects of consuming a Mediterranean-style diet on indices of inflammation and changes in nutritional status. Methods Selenium and iron intakes and status biomarkers were measured at baseline and after 1 y in 1294 people aged 65–79 y from 5 European countries (France, Italy, the Netherlands, Poland, and the United Kingdom) who had been randomly allocated either to a Mediterranean-style diet or to remain on their habitual, Western diet. Results Estimated selenium intakes increased significantly with the intervention group (P < 0.01), but were not accompanied by changes in serum selenium concentrations. Iron intakes also increased (P < 0.001), but there was no change in iron status. However, when stratified by study center, there were positive effects of the intervention on iron status for serum ferritin for participants in Italy (P = 0.04) and France (P = 0.04) and on soluble transferrin receptor (sTfR) for participants in Poland (P < 0.01). Meat intake decreased and fish intake increased to a greater degree in the intervention group, relative to the controls (P < 0.01 for both), but the overall effects of the intervention on meat and fish intakes were mainly driven by data from Poland and France. Changes in serum selenium in the intervention group were associated with greater changes in serum ferritin (P = 0.01) and body iron (P = 0.01), but not sTfR (P = 0.73); there were no study center × selenium status interactions for the iron biomarkers. Conclusions Consuming a Mediterranean-style diet for 1 y had no overall effect on iron or selenium status, although there were positive effects on biomarkers of iron status in some countries. The NU-AGE trial was registered at clinicaltrials.gov as NCT01754012.

Low Selenium Status in the Elderly Influences Thyroid Hormones

1995 ◽  
Vol 89 (6) ◽  
pp. 637-642 ◽  
Author(s):  
Oliviero Olivieri ◽  
Domenico Girelli ◽  
Margherita Azzini ◽  
Anna Maria Stanzial ◽  
Carla Russo ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Thyroid Hormones ◽  
Peroxidase Activity ◽  
Controlled Trial ◽  
The Elderly ◽  
Serum Selenium ◽  
Selenium Status ◽  
Glutathione Peroxidase Activity ◽  
Double Blind ◽  
Double Blind Placebo

1. Iodothyronine 5′-deiodinase, which is mainly responsible for peripheral triiodothyronine (T3) production, has recently been demonstrated to be a selenium-containing enzyme. In the elderly, reduced peripheral conversion of thyroxine (T4) to T3 and overt hypothyroidism are frequently observed. 2. We measured serum selenium and erythrocyte glutathione peroxidase (as indices of selenium status), thyroid hormones and thyroid-stimulating hormone in 109 healthy euthyroid subjects (52 women, 57 men), carefully selected to exclude abnormally low thyroid hormone levels induced by acute or chronic diseases or calorie restriction. The subjects were subdivided into three age groups. To avoid conditions of undernutrition or malnutrition, dietary records were obtained for a sample of 24 subjects, randomly selected and representative of the whole population for age and sex. 3. In order to properly assess the influence of selenium status on iodothyronine 5′-deiodinase type I activity, a double-blind placebo-controlled trial was also carried out on 36 elderly subjects, resident at a privately owned nursing home. 4. In the free-living population, a progressive reduction of the T3/T4 ratio (due to increased T4 levels) and of selenium and erythrocyte glutathione peroxidase activity was observed with advancing age. A highly significant linear correlation between T4, T3/T4 and selenium was observed in the population as a whole (for T4, R = −0.312, P < 0.002; for T3/T4 ratio, R = 0.32, P < 0.01) and in older subjects (for T4, R = −0.40, P < 0.05; for T3/T4 ratio, R = 0.54, P < 0.002). 5. The main result of the double-blind placebo-controlled trial was a significant improvement of selenium indices and a decrease in the T4 level in selenium-treated subjects; serum selenium, erythrocyte glutathione peroxidase activity and thyroid hormones did not change in placebo-treated subjects. 6. We concluded that selenium status influences thyroid hormones in the elderly, mainly modulating T4 levels.

scholarly journals The effect of exercise on anxiety in the elderly worldwide: a systematic review and meta-analysis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Mohsen Kazeminia ◽  
Nader Salari ◽  
Aliakbar Vaisi-Raygani ◽  
Rostam Jalali ◽  
Alireza Abdi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Elderly Care ◽  
Intervention Group ◽  
Exercise Program ◽  
The Elderly ◽  
Anxiety Score ◽  
Anxiety Reduction ◽  
Positive Effects ◽  
Before And After

Abstract Background Physical activity and exercise are among the most important, simplest, and cheapest approaches to anxiety treatment, especially for the elderly. Their positive effects on improvement of mental disorders in the elderly have attracted a considerable level of attention. Therefore, the present study was conducted to determine the effect of sport on reducing anxiety in the elderly using meta-analysis. Methods In this study, national and international databases of SID, MagIran, IranMedex, IranDoc, Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science were searched to find studies published electronically from 1999 to 2019. Heterogeneity between the collected studies was determined using the Cochran's test (Q) and I2. Due to presence of heterogeneity, the random effects model was used to estimate the standardized mean difference of sport test scores obtained from the measurement of anxiety reduction among the elderly, between the intervention group before and after the test. Results In this meta-analysis and systematic review, 19 papers finally met the inclusion criteria. The overall sample size of all collected studies for the meta-analysis was 841 s. Mean anxiety score before and after intervention were 38.7 ± 5.6 33.7 ± 3.4 respectively, denoting a decrease in anxiety score after intervention. Conclusion Results of this study indicates that Sport significantly reduces Anxiety in the Elderly. Therefore, a regular exercise program can be considered as a part of the elderly care program.

scholarly journals Low Back Pain in Elderly from Belém-Pa, Brazil: Prevalence and Association with Functional Disability

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1658
Author(s):  
Elaine Miyuka Sato ◽  
Mauricio Oliveira Magalhães ◽  
Beatriz Coelho Jenkins ◽  
Lays da Silva Ferreira ◽  
Hallyson Andrey Raposo da Silva ◽  
...  
Keyword(s):  
Physical Activity ◽  
Low Back Pain ◽  
Back Pain ◽  
Healthy Aging ◽  
Elderly Population ◽  
Functional Disability ◽  
The Elderly ◽  
Low Back ◽  
Physical And Mental Health ◽  
Modifiable Factors

Background: This cross-sectional study aimed to determine the prevalence of low back pain (LBP) in the elderly population living in Belém-Pará and to assess the spectrum of problems related to these diseases including the demographic, socioeconomic, occupational characteristics and disability in this population. Methods: Three structured questionnaires were applied in a randomly selected representative sample of 512 elderly people aged ≥60 years. Results: LBP prevalence in the elderly population was 55.7%. Among then, 56.1% had pain at the time of the interview (punctual prevalence), 91.7% had LBP in the last 365 days (prevalence in the last year), and 85.3% at some point in life (prevalence at some point in life). Overall, most studies are above average. LBP was positively associated with hypertension and the influence of the physical and mental health on their social activities ranged from slightly to extreme. LBP was negatively associated with characteristics, such as education (over 11 years), class A or B income, physical activity, high satisfaction with previous work, and excellent self-perceived health, corroborating to the literature. Conclusions: Greater intensity of pain and functional disability were associated with the presence of comorbidities, smoking habits, and low physical activity. LBP prevalence was high, above the national average, mainly affecting the underprivileged classes related to several modifiable factors, highlighting the importance of preventive and interventionist actions for healthy aging.

scholarly journals Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1129
Author(s):  
Jakub Kortas ◽  
Ewa Ziemann ◽  
Dariusz Juszczak ◽  
Katarzyna Micielska ◽  
Marta Kozłowska ◽  
...  
Keyword(s):  
Body Mass ◽  
Fat Mass ◽  
Iron Metabolism ◽  
Elderly Women ◽  
Iron Status ◽  
Intervention Group ◽  
Control Group ◽  
Nordic Walking ◽  
Positive Effects ◽  
Increased Risk

Impaired iron metabolism is associated with increased risk of many morbidities. Exercise was shown to have a beneficial role; however, the mechanism is not well understood. The purpose of this study was to assess the relationship between exerkines and iron metabolism in elderly women before and after 12 weeks of Nordic Walking (NW) training. Exerkines like myostatin, adiponectin, and osteocalcin have been shown to have several positive effects on metabolism. Thirty-six post-menopausal women (66 ± 5 years old, mean ± SD) were randomly assigned to a NW intervention group (n = 18; body mass, 68.8 ± 11.37 kg; fat, 23.43 ± 7.5 kg; free fat mass, 45.37 ± 5.92 kg) or a control group (n = 18; body mass, 68.34 ± 11.81 kg; fat, 23.61 ± 10.03 kg; free fat mass, 44.73 ± 3.9 kg). The training was performed three times a week for 12 weeks, with the intensity adjusted to 70% of the individual maximum ability. Before and one day after the 12-weeks intervention, performance indices were assessed using a senior fitness test. Blood samples (5 mL) were obtained from the participants between 7 and 8 AM, following an overnight fast, at baseline and one day immediately after the 12-week training program. A significant and large time × group interaction was observed for iron (NW: 98.6 ± 26.68 to 76.1 ± 15.31; CON: 100.6 ± 25.37 to 99.1 ± 27.2; p = 0.01; η p 2 = 0.21), myostatin (NW: 4.42 ± 1.97 to 3.83 ± 1.52; CON: 4.11 ± 0.95 to 4.84 ± 1.19; p = 0.00; η p 2 = 0.62), adiponectin (NW: 12.0 ± 9.46 to 14.6 ± 10.64; CON: 12.8 ± 8.99 to 11.9 ± 8.53; p = 0.00; η p 2 = 0.58), and osteocalcin (NW: 38.9 ± 26.04 to 41.6 ± 25.09; CON: 37.1 ± 33.2 to 37.2 ± 32.29; p = 0.03; η p 2 = 0.13). Furthermore, we have observed the correlations: basal ferritin levels were inversely correlated with changes in myostatin (r = −0.51, p = 0.05), change in adiponectin, and change in serum iron (r = −0.45, p = 0.05), basal iron, and osteocalcin after training (r = -0.55, p = 0.04). These findings indicate that iron modulates NW training-induced changes in exerkine levels.

Selenium Status in Elderly People: Longevity and Age-Related Diseases

2019 ◽  
Vol 25 (15) ◽  
pp. 1694-1706 ◽  
Author(s):  
Harry Robberecht ◽  
Tess De Bruyne ◽  
Elisabeth Davioud-Charvet ◽  
John Mackrill ◽  
Nina Hermans
Keyword(s):  
Oxidative Stress ◽  
Trace Element ◽  
Elderly People ◽  
Biological Samples ◽  
Elderly Population ◽  
Selenium Concentration ◽  
The Elderly ◽  
Healthy Adults ◽  
Selenium Status ◽  
Age Related

Background:Selenium (Se) is a trace element active in selenoproteins, which can regulate oxidative stress. It is generally perceived as an import factor for maintaining health in the elderly.Methods:The goal of this review is to discuss selenium concentration in biological samples, primarily serum or plasma, as a function of age and its relation with longevity. The elemental level in various age-related diseases is reviewed.Conclusion:Highest selenium values were observed in healthy adults, while in an elderly population significantly lower concentrations were reported. Variables responsible for contradictory findings are mentioned. Risk and benefits of Se-supplementation still remain under debate.

Plasma fibroblast growth factor 23 concentration and iron status. Does the relationship exist in the elderly population?

2015 ◽  
Vol 48 (6) ◽  
pp. 431-436 ◽  
Author(s):  
Maria Bożentowicz-Wikarek ◽  
Piotr Kocełak ◽  
Aleksander Owczarek ◽  
Magdalena Olszanecka-Glinianowicz ◽  
Małgorzata Mossakowska ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Elderly Population ◽  
Iron Status ◽  
Fibroblast Growth Factor 23 ◽  
The Elderly ◽  
Fibroblast Growth ◽  
The Relationship

scholarly journals Cognitive Training in the Elderly: Bottlenecks and New Avenues

2017 ◽  
Vol 29 (9) ◽  
pp. 1473-1482 ◽  
Author(s):  
Nahid Zokaei ◽  
Christopher MacKellar ◽  
Giedrė Čepukaitytė ◽  
Eva Zita Patai ◽  
Anna Christina Nobre
Keyword(s):  
Cognitive Function ◽  
Cognitive Training ◽  
Cognitive Functions ◽  
Cognitive Rehabilitation ◽  
Healthy Aging ◽  
Elderly Population ◽  
The Elderly ◽  
Assessment Protocol ◽  
Training Interventions ◽  
Computer Based

Development of measures to preserve cognitive function or even reverse cognitive decline in the ever-growing elderly population is the focus of many research and commercial efforts. One such measure gaining in popularity is the development of computer-based interventions that “exercise” cognitive functions. Computer-based cognitive training has the potential to be specific and flexible, accommodates feedback, and is highly accessible. As in most budding fields, there are still considerable inconsistencies across methodologies and results, as well as a lack of consensus on a comprehensive assessment protocol. We propose that the success of training-based therapeutics will rely on targeting specific cognitive functions, informed by comprehensive and sensitive batteries that can provide a “fingerprint” of an individual's abilities. Instead of expecting a panacea from training regimens, focused and personalized training interventions that accommodate individual differences should be developed to redress specific patterns of deficits in cognitive rehabilitation, both in healthy aging and in disease.

scholarly journals Perubahan Fungsi Paru Pada Usia Tua

2019 ◽  
Vol 3 (2) ◽  
pp. 52
Author(s):  
Helmia Hasan ◽  
Rena Arusita Maranatha
Keyword(s):  
Respiratory System ◽  
Healthy Aging ◽  
Elderly Population ◽  
Functional Decline ◽  
The Elderly ◽  
Maximum Function ◽  
Progressive Decline ◽  
Functional Changes ◽  
Clinical Complexity ◽  
And Function

Aging causes many changes in biological processes characterized by progressive and widespread changes associated with increased susceptibility to various diseases. Aging is not a homogeneous process. In contrast, human organs aging at different rates are affected by several factors, including genetic factors, lifestyle, and environmental exposure. Healthy aging remains accompanied by some morphological and functional changes in the respiratory system. During the first two decades of life, the lungs undergo a phase of growth and maturation. Respiratory system achieves maximum function at the age of 20 years for women and 25 years for men. Throughout the rest of life, aging is associated with a progressive decline in pulmonary performance and function. The normal aging of the respiratory system is associated with structural and functional decline in the respiratory system, resulting in increased respiratory work compared to younger subjects and is associated with reduced reserves in cases of acute illness, such as heart failure, infection, or airway obstruction. Pulmonary function decreases slowly throughout life even in healthy people. Disabilities and diseases related to aging are a global problem due to the longevity of life expectancy. An increased proportion of the elderly population is a challenge for doctors because of the clinical complexity of the elderly. A better understanding of change can help diagnose and treat lung disease in the elderly population.

scholarly journals Quality of life among elderly population in an urban slum of Tirupati city

2019 ◽  
Vol 6 (6) ◽  
pp. 2430
Author(s):  
Visweswara Rao Guthi ◽  
Tirupati Venkata Devi Prathyusha ◽  
Nagaraj Kondagunta ◽  
Nakkala Kavyasree ◽  
Chimmata Kavitha ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Healthy Aging ◽  
Elderly Population ◽  
Well Being ◽  
The Elderly ◽  
Urban Slum ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Study Population

Background: Healthy aging is a process of developing and maintaining the functional ability that enables well- being in older age. Objective of the present study is to assess the quality of life among elderly population using WHOQOL-BREF scale and to determine the association between socio demographic factors and quality of life.Methods: Community based cross- sectional study was conducted in the urban field practice areas of SVIMS-Sri Padmavathi Medical College for women, Tirupati for a period of one month (February 2019 to March 2019). Study population were Elderly of age 60 years and above. Total 60 elderly were included in the study. Quality of life was assessed using WHOQOL-BREF questionnaire.Results: Most of the study population was in the age group of 60-64 years, Most of them were females (71.7%). More than one third were illiterates (36.7%), 30% were studied up to primary school. 93.3% of study population were suffered from some form of illness. Mean total transformed score was high among ≥70 years compared to <70 years, Males were showing high mean total transformed score compared to females, literates were showing high score and persons with illness were showing high scores and persons without illness.Conclusions: It is concluded from this study that most of the elderly population are suffered from some form of illness. Overall quality of life is good among elderly within 70 years of age, males, literates and who are in living as married compared to their counter parts.

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