scholarly journals Invited Commentary: Relationship Between Ovulation and Markers of Systemic Inflammation Versus Markers of Localized Inflammation

2019 ◽  
Vol 189 (7) ◽  
pp. 671-673 ◽  
Author(s):  
Joellen M Schildkraut
Keyword(s):  
Ovarian Cancer ◽  
Systemic Inflammation ◽  
Ovarian Cancer Risk ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Mechanisms Of Carcinogenesis ◽  
New Research ◽  
Research Initiatives ◽  
The Relationship ◽  
Circulating Levels

Abstract In this issue of the American Journal of Epidemiology, Huang et al. (Am J Epidemiol. 2020;189(7):660–670) report an inverse relationship between lifetime ovulatory years (LOY) and circulating levels of C-reactive protein (CRP), counter to their hypothesis. CRP is a nonspecific systemic marker of chronic inflammation, and there is evidence that there are other drivers of systemic inflammation as measured by CRP. There also is a body of evidence supporting the possibility that ovulation may be responsible for a localized inflammatory response. Because ovarian cancer is the fifth most common cause of cancer death in women, preventive strategies are urgently needed. The findings of this report underscore the need for new research initiatives to determine the relationship between incessant ovulation and ovarian cancer risk in order to identify mechanisms of carcinogenesis.

C-Reactive Protein Concentrations and Subsequent Ovarian Cancer Risk

2007 ◽  
Vol 109 (4) ◽  
pp. 933-941 ◽  
Author(s):  
Meghan A. McSorley ◽  
Anthony J. Alberg ◽  
Diane S. Allen ◽  
Naomi E. Allen ◽  
Louise A. Brinton ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Ovarian Cancer Risk ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Changes in pre-diagnostic serum C-reactive protein concentrations and ovarian cancer risk: a longitudinal study

2011 ◽  
Vol 22 (8) ◽  
pp. 1916-1921 ◽  
Author(s):  
A.T. Toriola ◽  
K. Grankvist ◽  
C.B. Agborsangaya ◽  
A. Lukanova ◽  
M. Lehtinen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Longitudinal Study ◽  
Cancer Risk ◽  
Ovarian Cancer Risk ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1195
Author(s):  
Jiong Yu ◽  
Xiaowei Shi ◽  
Jing Ma ◽  
Ronggao Chen ◽  
Siyi Dong ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bacterial Infection ◽  
Systemic Inflammation ◽  
Bacterial Infections ◽  
Cox Regression ◽  
Prognostic Models ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Clinically Significant ◽  
The Relationship

The relationship between aseptic systemic inflammation and postoperative bacterial infection is unclear. We investigated the correlation of systemic inflammation biomarkers with 30-day clinically significant bacterial infections (CSI) after liver transplantation (LT). This retrospective study enrolled 940 patients who received LT and were followed for 30 days. The primary end point was 30-day CSI events. The cohort was divided into exploratory (n = 508) and validation (n = 432) sets according to different centers. Area under the receiver operated characteristic (AUROC) and Cox regression models were fitted to study the association between baseline systemic inflammation levels and CSI after LT. A total of 255 bacterial infectious events in 209 recipients occurred. Among systemic inflammation parameters, baseline C-reactive protein (CRP) was independently associated with 30-day CSI in the exploratory group. The combination of CRP and organ failure number showed a good discrimination for 30-day CSI (AUROC = 0.80, 95% CI, 0.76–0.84) and the results were confirmed in an external verification group. Additionally, CRP levels were correlated with bacterial product lipopolysaccharide. In conclusion, our study suggests that pre-transplantation CRP is independent of other prognostic factors for 30-day CSI post-LT, and can be integrated into tools for assessing the risk of bacterial infection post-LT or as a component of prognostic models.

scholarly journals PROGNOSTIC INDICES AND MARKERS OF SYSTEMIC INFLAMMATION IN PATIENTS WITH COPD AND CAD

2017 ◽  
pp. 81-85
Author(s):  
G. L. IGNATOVA ◽  
V. N. ANTONOV
Keyword(s):  
Systemic Inflammation ◽  
Prognostic Markers ◽  
Functional Disorders ◽  
Inflammation Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Male Patients ◽  
The Impact ◽  
The Relationship

The article discusses the problem of COPD combined with CAD, determination of inflammatory markers and the prognostic BODE, DOSE and ADO indices. The aim of the study was to evaluate the effect of PCV13 immunization on clinical and functional manifestations of systemic inflammation in patients with COPD and CAD, as well as the relationship with the prognostic markers. Material and methods: The study included 36 male patients with COPD and 36 patients with COPD and CAD, FC II-III stable angina who were treated at Regional Clinical Hospital _4 in Chelyabinsk during the period 2015--2016. Conclusions: 1. Patients with COPD combined with CAD had statistically significant clinical and functional disorders manifested by an increase in the degree of dyspnea and reduction in FEV1. 2. In patients with COPD concomitant with CAD, against the background of the comorbidities, the levels of systemic inflammation markers — C-reactive protein, fibrinogen and procalcitonin — were more overt than in patients only with COPD. 3. Monitoring changes in procalcitonin levels could be used as an additional highly informative method for estimating the probability of the presence of bacterial inflammation and effectiveness of therapy. 4. The prognostic BODE, DOSE and ADO indices tend to decrease unidirectionally under the impact of vaccination with pneumococcal conjugate vaccine. 5. PCV13 can reduce the level of systemic inflammation within 1 year after its application.

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

Abstract 2270: C-reactive protein and ovarian cancer risk: preliminary results from the Ovarian Cancer Cohort Consortium (OC3)

2017 ◽  
Author(s):  
Elizabeth M. Poole ◽  
Britton Trabert ◽  
Renée T. Fortner ◽  
Nicolas Wentzensen ◽  
Shelley S. Tworoger
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Ovarian Cancer Risk ◽  
C Reactive Protein ◽  
Preliminary Results ◽  
Reactive Protein

scholarly journals Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach

2010 ◽  
Vol 95 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Paul Welsh ◽  
Eliana Polisecki ◽  
Michele Robertson ◽  
Sabine Jahn ◽  
Brendan M. Buckley ◽  
...  
Keyword(s):  
Mendelian Randomization ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Score Distribution ◽  
Single Nucleotide ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Causal Direction ◽  
The Relationship ◽  
Circulating Levels

Abstract Context: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. Objective: The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach. Methods: In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205) and adiposity SNPs (FTO and MC4R) to body mass index (BMI) as well as circulating levels of CRP and leptin. We gave each individual two allele scores ranging from zero to 4, counting each pair of alleles related to CRP levels or BMI. Results: With increasing CRP allele score, there was a stepwise decrease in CRP levels (P for trend &lt; 0.0001) and a 1.98 mg/liter difference between extremes of the allele score distribution, but there was no associated change in BMI or leptin levels (P ≥ 0.89). By contrast, adiposity allele score was associated with 1) an increase in BMI (1.2 kg/m2 difference between extremes; P for trend 0.002); 2) an increase in circulating leptin (5.77 ng/ml difference between extremes; P for trend 0.0027); and 3) increased CRP levels (1.24 mg/liter difference between extremes; P for trend 0.002). Conclusions: Greater adiposity conferred by FTO and MC4R SNPs led to higher CRP levels, with no evidence for any reverse pathway. Future studies should extend our findings to other circulating inflammatory parameters. This study illustrates the potential power of Mendelian randomization to dissect directions of causality between intercorrelated metabolic factors.

Abstract B21: C-reactive protein and ovarian cancer risk in the Ovarian Cancer Cohort Consortium

2018 ◽  
Author(s):  
Britton Trabert ◽  
Renee Fortner ◽  
Elizabeth Poole ◽  
Nicolas Wentzensen ◽  
Shelley Tworoger
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Ovarian Cancer Risk ◽  
C Reactive Protein ◽  
Reactive Protein
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