scholarly journals PROGNOSTIC INDICES AND MARKERS OF SYSTEMIC INFLAMMATION IN PATIENTS WITH COPD AND CAD

2017 ◽  
pp. 81-85
Author(s):  
G. L. IGNATOVA ◽  
V. N. ANTONOV
Keyword(s):  
Systemic Inflammation ◽  
Prognostic Markers ◽  
Functional Disorders ◽  
Inflammation Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Male Patients ◽  
The Impact ◽  
The Relationship

The article discusses the problem of COPD combined with CAD, determination of inflammatory markers and the prognostic BODE, DOSE and ADO indices. The aim of the study was to evaluate the effect of PCV13 immunization on clinical and functional manifestations of systemic inflammation in patients with COPD and CAD, as well as the relationship with the prognostic markers. Material and methods: The study included 36 male patients with COPD and 36 patients with COPD and CAD, FC II-III stable angina who were treated at Regional Clinical Hospital _4 in Chelyabinsk during the period 2015--2016. Conclusions: 1. Patients with COPD combined with CAD had statistically significant clinical and functional disorders manifested by an increase in the degree of dyspnea and reduction in FEV1. 2. In patients with COPD concomitant with CAD, against the background of the comorbidities, the levels of systemic inflammation markers — C-reactive protein, fibrinogen and procalcitonin — were more overt than in patients only with COPD. 3. Monitoring changes in procalcitonin levels could be used as an additional highly informative method for estimating the probability of the presence of bacterial inflammation and effectiveness of therapy. 4. The prognostic BODE, DOSE and ADO indices tend to decrease unidirectionally under the impact of vaccination with pneumococcal conjugate vaccine. 5. PCV13 can reduce the level of systemic inflammation within 1 year after its application.

scholarly journals THE ROLE OF INFLAMMATION AND COAGULATION CASCADE IN THE PATHOGENESIS OF ATRIAL FIBRILLATION

ASJ. ◽  
2020 ◽  
Vol 3 (41) ◽  
pp. 8-10
Author(s):  
L. Hazarapetyan ◽  
S. Grigoryan ◽  
A. Sarksyan
Keyword(s):  
Atrial Fibrillation ◽  
Coagulation Cascade ◽  
Control Group ◽  
Atrial Remodeling ◽  
Inflammation Markers ◽  
Reactive Protein ◽  
Gender And Age ◽  
The Impact ◽  
The Relationship

Introduction: Atrial fibrillation (AF) is associated with prothrombotic or hypercoagulable states, various inflammation markers such as interleukin-6 (IL-6) and hsC-reactive protein (hsCRP) have also been associated with AF. The aim of this study is to investigate the relationship between inflammation markers and the prothrombotic state in the setting of AF and the impact on outcome in patients with AF. Methods: We observed 141 patients with non-valvular AF. As a control group patients similar in gender and age without AF were examined. Clinical, instrumental and laboratory tests were performed on the observed patients. The markers of the coagulation cascade (TF and F) and of inflammatory markers (hsCRP and IL-6) were studied additionally by ELISA on the analyzer "Stat Fax 303 Plus". Studies were conducted using SPSS 13.0 and EXCEL-2013. Results: The obtained results showed that compared to the control group, AF patients had significantly higher levels of IL-6 (p = 0.043), hsCRP (p = 0.002), TF (p = 0.026), and F (p = 0.025). Moreover, levels of hsCRP were higher among AF patients at "high" risk of stroke by CHA2DS2-VASc Score (p = 0.003). Besides, the levels of hsCRP and IL-6 were markedly elevated in patients with dilated left atrium (p = 0.001), poorly functioning left atrial appendage (p = 0.023) and longer duration of AF (p = 0.002). Conclusion: We have demonstrated that the increased plasma levels of IL-6 and hsCRP are related to indices of the coagulation cascade and contribute to structural atrial remodeling in patients with AF.

scholarly journals C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1195
Author(s):  
Jiong Yu ◽  
Xiaowei Shi ◽  
Jing Ma ◽  
Ronggao Chen ◽  
Siyi Dong ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bacterial Infection ◽  
Systemic Inflammation ◽  
Bacterial Infections ◽  
Cox Regression ◽  
Prognostic Models ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Clinically Significant ◽  
The Relationship

The relationship between aseptic systemic inflammation and postoperative bacterial infection is unclear. We investigated the correlation of systemic inflammation biomarkers with 30-day clinically significant bacterial infections (CSI) after liver transplantation (LT). This retrospective study enrolled 940 patients who received LT and were followed for 30 days. The primary end point was 30-day CSI events. The cohort was divided into exploratory (n = 508) and validation (n = 432) sets according to different centers. Area under the receiver operated characteristic (AUROC) and Cox regression models were fitted to study the association between baseline systemic inflammation levels and CSI after LT. A total of 255 bacterial infectious events in 209 recipients occurred. Among systemic inflammation parameters, baseline C-reactive protein (CRP) was independently associated with 30-day CSI in the exploratory group. The combination of CRP and organ failure number showed a good discrimination for 30-day CSI (AUROC = 0.80, 95% CI, 0.76–0.84) and the results were confirmed in an external verification group. Additionally, CRP levels were correlated with bacterial product lipopolysaccharide. In conclusion, our study suggests that pre-transplantation CRP is independent of other prognostic factors for 30-day CSI post-LT, and can be integrated into tools for assessing the risk of bacterial infection post-LT or as a component of prognostic models.

scholarly journals The Interaction of C - Reactive Protein, Bisphenol A, & Cardiovascular Disease: A Demographical Analysis

2016 ◽  
Vol 9 (3) ◽  
pp. 63 ◽  
Author(s):  
Hassan Naji
Keyword(s):  
Cardiovascular Disease ◽  
Bisphenol A ◽  
Quantitative Research ◽  
The Body ◽  
Spearman Correlation ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Impact ◽  
The Relationship

<p><strong>OBJECTIVE: </strong>The main objective of the study was to investigate the role of C-reactive protein on the relationship between Bisphenol A &amp; Cardiovascular Disease, where the C-reactive protein has been taken as a moderating variable.</p><p><strong>METHODS: </strong>Quantitative research design has been incorporated for evaluating the role of C-reactive protein. Similarly, non-parametric Spearman correlation test has been conducted to assess the relationship between BPA and CVD. The data was taken out from the National Health and Nutrition Examination Survey (NHANES), which was collected in the year 2009-2010.</p><p><strong>RESULTS: </strong>The impact of urinary Bisphenol A on serum C-reactive protein was found statistically significant according to the Spearman correlation coefficient, <em>r</em>s<em>= </em>.06, <em>p </em>= .015. The scatter plots found that there is no relationship between the two variables; this observation held true after filtering the outliers from the plot.</p><p><strong>CONCLUSION:</strong> The results might have positive change by contributing to the body of knowledge on bisphenol A and by rising scientific examination of substances used by the people in the daily life. Further research to identify other possible causes of CVD and elevation of CRP is recommended.</p>

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

Impact of Inflammation on Atrial Fibrillation in patients with Metabolic Syndrome

2021 ◽  
Author(s):  
Ylber Jani ◽  
Kastriot Haxhirexha ◽  
Nehat Baftiu ◽  
Bekim Pocesta ◽  
Atila Rexhepi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Metabolic Syndrome ◽  
Systemic Inflammation ◽  
Left Atrial ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Structural Remodeling ◽  
Reactive Protein ◽  
The Impact

Abstract BACKGROUND: Inflammation have been involved in the pathogenesis of both metabolic syndrome(MS) and atrial fibrillation(AF). The magnitude of elevations in plasma C-reactive protein(CRP) a marker of inflammation, is probably related to atrial structural remodeling and impaired atrial function.In patient with MS,limited data exist regarding impact of plasma levels of inflammatory markers,such as C-reactive protein on the: type of AF and atrial structural and functional remodeling. OBJECTIVE: We set to analyze the impact of degree of systemic inflammation (assessed acrording to CRP levels),on the type of AF,atrial functional and structural remodeling in patients with MS.METHODS: We conducted an multicenter observational cross-sectional study. Recruited were 425 consecutive participants,with MS and AF(paroxysmal, persistent and permanent AF),who attended outpatient visits at 7 general cardiology Health Care Clinics, during 1 calendar year,stratified according CRP-levels:(211 participans with level of CRP ≥3mg/l, and 214, with level of CRP <3mg/l). RESULTS: Permanent type of AF, was more common in participans with CRP-levels ≥3mg/l(54.6% vs.20.5%,p= 0.000),whereas parhoxysmal AF, was more common in participans with CRP-levels of <3 mg/l (9.9% vs.52.3%,p=0.000).Patients who had CRP levels above the cut-off of 3 mg/l,had increased dimension of left atrium{(LA),(4.2±0.3 vs. 3.7±0.2,p=0.000)},higher prevalence of enlargement of LA {defined as left atrial volum index(LAVI) ≥29ml/m2(84.1% vs.48.5%,p=0.002)} and inverse relationship of LA function(defined as left atrial emptying fraction(LAEF <45%, (30.8±3.4 vs.41.9±2.6, p=0.00). There was observed significant association of CRP levels above the cut-off of 3 mg/l and: frequence of persistent AF(OR=8.824,95% CI 1.689-46.100), permanent AF(OR=13.955, 95%CI 2.676 -72.780),increased LA dimension (OR=3.817,95% CI 0.989 -1.544), and decreased LA function.{(expressed by: LAVI >29ml/m2OR=4.014, 95% CI 2.620-6.152),LAEF <45%(OR=3.323,95%CI 2.062 -5.351) and LAVI>29 + LAEF-reduced (OR=3.354,95% CI 1.693 - 6.646)}.CONCLUSIONS: In patients with Metabolic Syndrome,degree of systemic inflammation have significant impact on clinical presentation of Atrial Fibrillation,atrial functional and structural remodeling .

scholarly journals Anaemia is Associated with Severe Illness in COVID-19: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Zheying Tao ◽  
Mingyu Liu ◽  
Jingyi Wu ◽  
Jing Xu ◽  
Wei Chen ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Virus Disease ◽  
Severe Illness ◽  
C Reactive Protein ◽  
Severe Condition ◽  
Laboratory Findings ◽  
Logistic Regression Models ◽  
Reactive Protein ◽  
The Impact ◽  
The Relationship

Abstract Background and objective:Anaemia commonly aggravates the severity of respiratory diseases, whereas thus far, no study has elucidated the impact of anaemiaonCorona Virus Disease 2019(COVID-19). The aim of this study was to evaluate the clinical characteristics of patients with anaemia, and to further explore the relationship between anaemiaand the severity of COVID-19.METHODS:In this single-center, retrospective, observational study, a total of 222 patients were recruited, including 79 patients with anaemia and 143 patients without anaemia. Clinical characteristics, laboratory findings, disease progression and prognosis were collected and analyzed. Risk factors associated with the severe illness in COVID-19were established by univariable and multivariable logistic regression models.Result：In our cohort, compared to patients without anaemia, patients with anaemia were more likely to experience one or more comorbidities and severe COVID-19 illness, as well as higher mortality. More patients demonstrated elevated levels of C-reactive protein (CRP), procalcitonin(PCT) and creatinine in anaemia group. Levels of erythrocyte sedimentation rate(ESR), D-dimer, myoglobin, T-pro brain natriuretic peptide(T-pro-BNP) and urea nitrogen(BUN)in patients with anaemia were significantly higher than those without. In addition,the proportion of patients with dyspnoea，elevated CRP and PCT was positively associated with the severity of anaemia. The Odd Ratio (OR) of anaemia related to the severe condition of COVID-19 was 5.07 (95% CI:1.82-14.18, P=0.002) and 3.47 (95% CI:1.02-11.75, P=0.046) after adjustment for baseline date and laboratory indices, respectively.Conclusion:Anaemia is an independent risk factor associated with the severe illness of COVID-19, and healthcare professionals should be more sensitive to the haemoglobin levels of COVID-19 patients on admission. To avoid rapid deterioration, more intensive care should be given to patients with anaemia.Trial registration: Ethics committee of Wuhan University People's Hospital (wdry2020-k064)

scholarly journals Invited Commentary: Relationship Between Ovulation and Markers of Systemic Inflammation Versus Markers of Localized Inflammation

2019 ◽  
Vol 189 (7) ◽  
pp. 671-673 ◽  
Author(s):  
Joellen M Schildkraut
Keyword(s):  
Ovarian Cancer ◽  
Systemic Inflammation ◽  
Ovarian Cancer Risk ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Mechanisms Of Carcinogenesis ◽  
New Research ◽  
Research Initiatives ◽  
The Relationship ◽  
Circulating Levels

Abstract In this issue of the American Journal of Epidemiology, Huang et al. (Am J Epidemiol. 2020;189(7):660–670) report an inverse relationship between lifetime ovulatory years (LOY) and circulating levels of C-reactive protein (CRP), counter to their hypothesis. CRP is a nonspecific systemic marker of chronic inflammation, and there is evidence that there are other drivers of systemic inflammation as measured by CRP. There also is a body of evidence supporting the possibility that ovulation may be responsible for a localized inflammatory response. Because ovarian cancer is the fifth most common cause of cancer death in women, preventive strategies are urgently needed. The findings of this report underscore the need for new research initiatives to determine the relationship between incessant ovulation and ovarian cancer risk in order to identify mechanisms of carcinogenesis.

scholarly journals Determination of the reference interval of the C-reactive protein/albumin ratio and its efficiency, CRP and albumin as prognostic markers in dogs

2020 ◽  
Vol 40 (3) ◽  
pp. 202-209
Author(s):  
Andrei K. Fabretti ◽  
Raquel C.S. Siqueira ◽  
Higo F. Amaral ◽  
Daniella A.G. Kemper ◽  
Rafael O. Chaves ◽  
...  
Keyword(s):  
Disease Severity ◽  
Systemic Disease ◽  
Length Of Hospital Stay ◽  
Reference Interval ◽  
Underlying Disease ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
The Relationship

ABSTRACT: The objective of this research was to creates a reference interval for C-reactive protein (CRP)/albumin ratio (CAR) in the canine species and to analyze the potential of CRP, albumin and the relationship between both, to serve as indicators of disease severity, length of hospital stay (LoS) and mortality in this species. For this, an outcome study was conducted in a Veterinary Teaching Hospital in southern Brazil. One hundred ninety dogs were included randomly, without distinction of gender, age, or breed, from June 2013 to November 2016. Plasma was collected from them and analyzed for assessment of CRP and albumin. The reference range stipulated for CAR in dogs was 0.36-0.60, as determined by the confidence interval of mean resamplings (in percentiles). The frequencies mean, and standard deviations of the variables, correlation analysis, and comparative analysis (Kruskal-Wallis in α = 5%) were calculated. Elevation (above reference) of CAR was determined to be proportional to the severity of the underlying disease, and CRP means were reasonable. Besides, hypoalbuminemia was indicative of systemic disease, but not of severity. Thus, CAR was a better marker of disease severity than were CRP and albumin, analyzed separately. Concerning LoS, there was a positive correlation with CAR (p<0.01) in patients, and the same was not observed with CRP and albumin. Concerning mortality, hypoalbuminemia was the only marker valid in animals with a critical illness (p=0.04). In conclusion, CAR is a better marker of disease severity and LoS in dogs than are CRP and albumin analyzed separately.

scholarly journals Harsh Parenting and Youth Systemic Inflammation_In Press

2019 ◽  
Author(s):  
Assaf Oshri ◽  
Erinn Duprey ◽  
Sihong Liu ◽  
Katherine Ehrlich
Keyword(s):  
Nervous System ◽  
Systemic Inflammation ◽  
Interleukin 6 ◽  
Family Stress ◽  
Harsh Parenting ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Impact

Objective: The present study aimed to test the role of the autonomic nervous system (ANS) in modulating the impact of family stress, induced by harsh parenting, on youths’ inflammation. First, we examined the direct effect of severity of adverse parenting behaviors on two serum biomarkers of systemic inflammation (C-reactive protein and interleukin-6) among youth. Second, we tested the moderating role of ANS reactivity in response to laboratory-induced stress in the association between harsh parenting and inflammation among these youth. Methods: The sample included 101 low-income children (75.2% African-American) between 9 and 12 years of age (Mage =10.9; SDage = 1.2) who participated in a conflict task with their primary caregiver in a laboratory setting. Heart rate variability reactivity (HRV-R), skin conductance level reactivity (SCL-R), and pre-ejection period reactivity (PEPr-R) were used to index parasympathetic and sympathetic nervous system reactivity. Markers of low-grade inflammation (C-reactive protein and interleukin-6) were obtained from serum. Results: After adjusting for confounding variables, ANS activity moderated the associations between family stress and systemic inflammation. Specifically, elevated HRV-R buffered the effect of family stress on youths’ inflammation, whereas elevated PEPr-R and SCL-R exacerbated the effect. Conclusion: These findings show that self-regulatory capacity and threat sensitivity, as indicated by ANS function, may have an impact on the associations between family stress and systemic inflammation.

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