Systematic Review and Dose–Response Meta-Analysis on the Relationship Between Alcohol Consumption and Sickness Absence

2021 ◽  
Author(s):  
Melvin Marzan ◽  
Sarah Callinan ◽  
Michael Livingston ◽  
Geoffrey Leggat ◽  
Heng Jiang
Keyword(s):  
High Risk ◽  
Alcohol Consumption ◽  
Sickness Absence ◽  
Dose Response ◽  
Meta Analysis ◽  
Population Based ◽  
Heavy Episodic Drinking ◽  
Economic Evaluations ◽  
Cross Sectional ◽  
The Relationship

ABSTRACT Aims Alcohol consumption (AC) may cause workplace absence, but the findings of individual studies vary markedly. To date, no dose–response meta-analysis (DRMA) of the relationship between AC and sickness absence (SA) has been completed. This paper aims to estimate the dose–response relationship between AC and the risk of SA based on published observational studies. Methods We used DRMA and modelling to investigate the effects of varying doses of AC (including heavy episodic drinking (HED)) onSA. Results The meta-analysis included 21 studies (12 cohort studies and 9 cross-sectional). It showed that HED, risky (20–40 g of alcohol/day) and high-risk (>40 g of alcohol/day) drinkers had an elevated risk of SA when compared with light-to-moderate drinkers for both sexes. Those who abstained from alcohol had a higher risk of SA than those who drink moderately. Conclusions Our results indicate that risky, high-risk drinking and HED may increase the risk of absenteeism. The implementation of population-based strategies may be appropriate to address the burdens of alcohol-related SA. Additionally, economic evaluations of alcohol policies should incorporate their impacts on SA. However, the current literature has substantial limitations, relying on modestly designed studies from just a few settings and more studies are needed—especially those that measure abstention in more nuancedways.

scholarly journals A systematic review and meta-analysis uncovering the relationship between alcohol consumption and sickness absence. When type of design, data, and sickness absence make a difference

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262458
Author(s):  
Neda S. Hashemi ◽  
Jens Christoffer Skogen ◽  
Aleksandra Sevic ◽  
Mikkel Magnus Thørrisen ◽  
Silje Lill Rimstad ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Sickness Absence ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Strong Relationship ◽  
Short Term ◽  
Design Data ◽  
Cross Sectional ◽  
Increased Risk

Aim Earlier research has revealed a strong relationship between alcohol use and sickness absence. The aim of this review was to explore and uncover this relationship by looking at differences in type of design (cross-sectional vs. longitudinal), type of data (self-reported vs. registered data), and type of sickness absence (long-term vs. short term). Method Six databases were searched through June 2020. Observational and experimental studies from 1980 to 2020, in English or Scandinavian languages reporting the results of the association between alcohol consumption and sickness absence among working population were included. Quality assessment, and statistical analysis focusing on differences in the likelihood of sickness absence on subgroup levels were performed on each association, not on each study. Differences in the likelihood of sickness absence were analyzed by means of meta-analysis. PROSPERO registration number: CRD42018112078. Results Fifty-nine studies (58% longitudinal) including 439,209 employees (min. 43, max. 77,746) from 15 countries were included. Most associations indicating positive and statistically significant results were based on longitudinal data (70%) and confirmed the strong/causal relationship between alcohol use and sickness absence. The meta-analysis included eight studies (ten samples). The increased risk for sickness absence was likely to be found in cross-sectional studies (OR: 8.28, 95% CI: 6.33–10.81), studies using self-reported absence data (OR: 5.16, 95% CI: 3.16–8.45), and those reporting short-term sickness absence (OR: 4.84, 95% CI: 2.73–8.60). Conclusion This review supports, but also challenges earlier evidence on the association between alcohol use and sickness absence. Certain types of design, data, and types of sickness absence may produce large effects. Hence, to investigate the actual association between alcohol and sickness absence, research should produce and review longitudinal designed studies using registry data and do subgroup analyses that cover and explain variability of this association.

scholarly journals ALCOHOL CONSUMPTION AND COGNITIVE AND FUNCTIONAL PERFORMANCE IN OLDER ADULTS AGED 75+ YEARS: THE PIETÀ STUDY

2021 ◽  
Author(s):  
Mariana Almeida ◽  
Paulo Caramelli ◽  
Maira Barbosa ◽  
Ana Paula Santos ◽  
Karolina Carmona
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Alcohol Consumption ◽  
Functional Performance ◽  
Population Based ◽  
Cognitive Profile ◽  
Cross Sectional ◽  
Dichotomous Variable ◽  
Diagnosis Of Dementia ◽  
The Relationship

Introduction: The relationship between alcohol and cognition is complex. Objective: To investigate the association of alcohol consumption with cognitive impairment, functionality, psychiatric and neurological diagnoses. Methods: Cross-sectional population-based study. 602 subjects 75+ years were categorized according to the number of drinks consumed per week: 0 (abstainers); 0.1 to 7 (light); 7.1 to 14 (moderate); > 14 (heavy). Cognitive diagnoses were established: dementia, cognitive impairment no dementia (CIND) and without cognitive impairment. Results: On multivariate analysis there was no association between cognitive profile and current or previous alcohol consumption. When previous alcohol consumption was treated as dichotomous variable, no association emerged with cognitive profile (p=0.109). As for current habit of alcohol intake treated as dichotomous variable, the absence of alcohol consumption was associated with dementia (OR=2.34; 95%CI: 1.39- 3.90), stroke (p=0.014), current major depression (p=0.013), parkinsonism (p=0.041) and worse functionality (p=0.001). Cachaça consumption was associated with dementia (OR=2.52; 95%CI: 1.25-5.04). Conclusion: Absence of current alcohol consumption was associated with diagnosis of dementia, stroke, major depression, parkinsonism and worse functionality. On the other hand, intake of cachaça was associated with dementia.

scholarly journals Addressing alcohol in routine healthcare in Sweden—population-based surveys in 2010 and 2017

2019 ◽  
Vol 29 (4) ◽  
pp. 748-753 ◽  
Author(s):  
Nadine E. Karlsson ◽  
Amy J O’Donnell ◽  
Latifa Abidi ◽  
Janna M E Skagerström ◽  
Per M Nilsen
Keyword(s):  
Alcohol Consumption ◽  
Study Design ◽  
Response Rate ◽  
Population Based ◽  
National Guidelines ◽  
Cross Sectional ◽  
The Past ◽  
Healthcare Practice ◽  
The Relationship

Abstract Background The aim of the study was to compare how alcohol was addressed in routine healthcare practice in Sweden in 2010 and 2017, following the 2011 implementation of national drinking guidelines. Methods Population-based cross-sectional surveys were conducted in 2010 and in 2017. Subjects were 3200 respondents in 2010 (response rate 54%) and 3000 respondents in 2017 (response rate 51%) in Sweden. Both the 2010 and 2017 surveys collected data on: socio-demographics; alcohol consumption; healthcare visits in the past 12 months and characteristics of alcohol conversations in healthcare (duration, contents, experience and effects). Results It was significantly more likely that respondents had a conversation about alcohol in healthcare in 2017 than in 2010 (OR = 1.49; 95% CI = 1.27–1.75; P<0.001). Conversations about alcohol in the healthcare were mostly short (<4 min), both in 2010 and 2017. The alcohol conversations in 2017 included less information about alcohol’s influence on health (P = 0.002) compared with 2010. The experience of the conversation about alcohol was perceived as less dramatic in 2017 than in 2010 (P = 0.038). Conclusions The results suggest that conversations about alcohol were more embedded in routine healthcare practice in Sweden in 2017 than in 2010. This development has occurred since the 2011 publication of the national guidelines. Alcohol conversations targeted also specific groups of drinkers as recommended by the guidelines. However, our study design does not allow for conclusions about the relationship between the guidelines and the changes in healthcare practice.

scholarly journals U-shaped relationship between iodine status and thyroid autoimmunity risk in adults

2019 ◽  
Vol 181 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Bin Wang ◽  
Weiwei He ◽  
Qian Li ◽  
Xi Jia ◽  
Qiuming Yao ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Dose Response ◽  
Meta Analysis ◽  
Thyroid Autoimmunity ◽  
Epidemiological Studies ◽  
Population Based ◽  
Iodine Intake ◽  
Cross Sectional ◽  
Iodine Status ◽  
Iodine Excess

Background Iodine status has long been regarded as an environmental determinant for thyroid dysfunction, but its relationship with thyroid autoimmunity (TAI) is still controversial. Our study aimed to elucidate the relationship between iodine status and TAI through both a population-based study and a dose–response meta-analysis of eligible epidemiological studies. Methods A population-based, cross-sectional study was firstly carried out, which enrolled a total of 2808 Chinese adults. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated through logistic regression analysis. A dose–response meta-analysis of eligible epidemiological studies was also carried out. Results The cross-sectional study showed an U-shaped relationship between iodine intake and TAI in adults. Compared with those with more than adequate iodine status, individuals with iodine deficiency, adequate iodine status and iodine excess all had higher risk of TAI, and the adjusted ORs were 1.50 (95% CI 1.03–2.17, P = 0.032), 1.50 (95% CI 1.09–2.07, P = 0.013) and 1.68 (95% CI 1.11–2.53, P = 0.014), respectively. The dose–response meta-analysis included 22 epidemiological studies with a total of 69,987 participants and further validated the U-shaped relationship between iodine intake and TAI in adults, which proved the significantly increased risk of TAI among individuals with either iodine deficiency or iodine excess. Stratified analysis of studies with low risk of confounding bias also identified similar findings. Conclusion The study suggests an U-shaped relationship between iodine intake and TAI in adults, and both iodine deficiency and iodine excess are risk factors of TAI in adults. The underlying mechanisms need to be elucidated in future studies.

scholarly journals Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 614
Author(s):  
Debra Q. Y. Quek ◽  
Feng He ◽  
Rehena Sultana ◽  
Riswana Banu ◽  
Miao Li Chee ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Meta Analysis ◽  
Urinary Metabolites ◽  
Population Based ◽  
Plasma Metabolites ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Lipoprotein Subclasses ◽  
The Relationship ◽  
Retinal Photographs

Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years: Chinese, 592; Malays, 1052; Indians, 1320) was performed. A panel of 228 serum/plasma metabolites and 54 urinary metabolites were quantified using nuclear magnetic resonance (NMR) spectroscopy. Main outcomes were defined as any DR, moderate/above DR, and vision-threatening DR assessed from retinal photographs. The relationship between metabolites and DR outcomes was assessed using multivariate logistic regression models, and metabolites significant after Bonferroni correction were meta-analyzed. Among serum/plasma metabolites, lower levels of tyrosine and cholesterol esters to total lipids ratio in IDL and higher levels of creatinine were positively associated with all three outcomes of DR (all p < 0.005). Among urinary metabolites, lower levels of citrate, ethanolamine, formate, and hypoxanthine were positively associated with all three DR outcomes (all p < 0.005). Higher levels of serum/plasma 3-hydroxybutyrate and lower levels of urinary 3-hydroxyisobutyrate were associated with VTDR. Comprehensive metabolic profiling in three large Asian cohorts with DR demonstrated alterations in serum/plasma and urinary metabolites mostly related to amino acids, lipoprotein subclasses, kidney function, and glycolysis.

Evaluación Cognitiva Montreal y consumo de alcohol: Un diagnóstico descriptivo del deterioro cognitivo en estudiantes universitarios de Durango, México

2019 ◽  
pp. 28-38
Author(s):  
Karla Liliana Pérez-Sosa ◽  
Edgar Felipe Lares-Bayona
Keyword(s):  
Cognitive Impairment ◽  
Alcohol Consumption ◽  
Cognitive Functions ◽  
Toxic Substance ◽  
Female Gender ◽  
Diagnostic Tools ◽  
Cross Sectional ◽  
Probabilistic Study ◽  
The Central Nervous System ◽  
The Relationship

Alcohol is a toxic substance associated with acute and chronic disorders affecting the Central Nervous System and significantly altering brain function. Objective: To determine the relationship between cognitive impairment and alcohol consumption in university students of the Juárez University of the State of Durango. Methodology: It is a cross-sectional, descriptive, comparative, non-probabilistic study, for convenience. A database was designed on the results obtained in a clinical interview on alcohol consumption and the application of the Montreal Cognitive Assessment (MoCA) test. Contribution: The evaluation of cognitive functions show similar results, the male sex presented a better score in Attention and the female one in Orientation. More involvement was identified in the Deferred Memory functions in both groups. In relation to alcohol consumption, the cognitive functions evaluated show lower levels. The female gender was more evident cognitive impairment in relation to alcohol consumption being statistically significant (p <0.025). Alcohol consumption is a risky behavior that deserves to be recognized by the main actors about neurocognitive effects. Alcohol consumption prevention programs and cognitive diagnostic tools are appropriate strategies to reduce risk behaviors in mental health.

scholarly journals Diurnal Salivary Cortisol in Sarcopenic Postmenopausal Women: The OsteoLaus Cohort

2021 ◽  
Author(s):  
Elena Gonzalez Rodriguez ◽  
Pedro Marques-Vidal ◽  
Bérengère Aubry-Rozier ◽  
Georgios Papadakis ◽  
Martin Preisig ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Salivary Cortisol ◽  
Population Based ◽  
Cross Sectional Study ◽  
Body Composition Assessment ◽  
Cross Sectional ◽  
X Ray ◽  
Free Cortisol ◽  
Cortisol Levels ◽  
The Relationship

AbstractSarcopenia, similar to hypercortisolism, is characterized by loss of muscle mass and strength. Cortisol circadian rhythm changes with aging (blunted late-day nadir values) were suggested to contribute to this decline. We aimed to explore the relationship between diurnal salivary cortisol values and sarcopenia diagnosis and its components in postmenopausal women. This is a cross-sectional study within the OsteoLaus population-based cohort in Lausanne (Switzerland). Participants had a body composition assessment by dual X-ray absorptiometry (DXA), a grip strength (GS) measure, and salivary cortisol measures (at awakening, 30 min thereafter, 11 AM (sc-11AM) and 8 PM (sc-8PM)). Associations between salivary cortisol and sarcopenia diagnosed by six different criteria (based on appendicular lean mass (ALM) assessed by DXA, and muscle strength by GS), and its components, were analyzed. 471 women aged > 50 years (63.0 ± 7.5) were included. Various definitions identified different participants as sarcopenic, who consistently presented higher salivary cortisol at 11 AM and/or 8 PM. There were no associations between salivary cortisol levels and ALM measures, either absolute or after correction to height squared (ALM index) or body mass index. GS was inversely correlated to sc-11AM (r = − 0.153, p < 0.001) and sc-8PM (r = − 0.118, p = 0.002). Each 10 nmol/l increase of sc-11AM, respectively sc-8PM, was associated with a GS decrease of 1.758 (SE 0.472) kg, respectively 2.929 (SE 1.115) kg. In postmenopausal women, sarcopenia is associated with higher salivary cortisol levels at 11 AM and 8 PM. An increase of daily free cortisol levels in the physiological range could participate to sarcopenia development by decreasing muscle function in postmenopausal women.

scholarly journals Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Emanuele F. Osimo ◽  
Luke Baxter ◽  
Jan Stochl ◽  
Benjamin I. Perry ◽  
Stephen A. Metcalf ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Meta Analysis ◽  
Random Effect ◽  
Population Based ◽  
Continuous Variable ◽  
Cross Sectional ◽  
Standard Deviation Increase ◽  
Suspected Infection ◽  
Longitudinal Association ◽  
Incident Cases

AbstractMeta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublished results, including adjustment for age, sex, body mass index, smoking, alcohol use, and socioeconomic status and suspected infection (CRP > 10 mg/L). Based on random effect meta-analysis of 89,792 participants (494 incident cases of psychosis at follow-up), the pooled odds ratio (OR) for psychosis for participants with high (>3 mg/L), as compared to low (≤3 mg/L) CRP levels at baseline was 1.50 (95% confidence interval [CI], 1.09–2.07). Evidence for this association remained after adjusting for potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03–1.66). After excluding participants with suspected infection, the OR for psychosis was 1.36 (95% CI, 1.06–1.74), but the association attenuated after controlling for confounders (aOR = 1.23; 95% CI, 0.95–1.60). Using CRP as a continuous variable, the pooled OR for psychosis per standard deviation increase in log(CRP) was 1.11 (95% CI, 0.93–1.34), and this association further attenuated after controlling for confounders (aOR = 1.07; 95% CI, 0.90–1.27) and excluding participants with suspected infection (aOR = 1.07; 95% CI, 0.92–1.24). There was no association using CRP as a categorical variable (low, medium or high). While we provide some evidence of a longitudinal association between high CRP (>3 mg/L) and psychosis, larger studies are required to enable definitive conclusions.

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