scholarly journals Diagnosis and selection of method of combined treatment of local-distributed cancer of the rectum with invasion into organs of the genitals

2018 ◽  
Vol 29 ◽  
pp. v87
Author(s):  
S. Lukmonov ◽  
O. Usmanov ◽  
K. Madatov ◽  
U. Allazarov ◽  
U. Kurbankulov ◽  
...  
2021 ◽  
Vol 14 (7) ◽  
pp. 603
Author(s):  
Vanesa Pérez-Laguna ◽  
Isabel García-Luque ◽  
Sofía Ballesta ◽  
Antonio Rezusta ◽  
Yolanda Gilaberte

The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult.


2020 ◽  
Vol 6 (1) ◽  
pp. 62-67
Author(s):  
Subhasish Dutta ◽  
Apurba Dey

Background: It is a great challenge for scientists to overcome the barrier of Antibiotic resistance by imparting new technologies to form structurally unique and robust antibiotics in an economically scalable way. Rapamycin is a well-known macrolide with numerous applications in the medical field. It is one of the most effective and efficient immunosuppressant antibiotic available in recent history. With the increase of its application, decreasing its production cost stands as one of the most critical challenges. Therefore, the selection of a suitable and potent strain of higher yield has emerged to be of great necessity in the present scenario. Methods: Spores prepared from lyophilised culture when treated with different exposure to UV light, showed a decrease in survival rates in comparison to the untreated sample. Combined treatment of spores with UV mutagenesis and chemical mutagen (NTG) was done. Spores were incubated at 30°C at 120 rpm for 2 hr, and some of them were found viable after the treatment. Agar-disc diffusion method, turbidimetric assay and HPLC analysis were carried out to study the rapamycin concentration by potent strain. Results: Macrolide production was seen to be maximum on the 11th day of fermentation which is 1.76 folds higher as compared to wild type Streptomyces hygroscopicus in shake flask. Structural confirmation and conformation study were supported by the Nuclear Magnetic Resonance (NMR) technique. Conclusion: The maximum amount of antibiotic produced was observed to be 284 mg/L.


2021 ◽  
pp. 25-28
Author(s):  
L. N. Kostyuchenko ◽  
G. G. Varvanina ◽  
G. S. Mikhailyants ◽  
M. A. Danilov

The aim. To determine the definition of nutritional extinction and its characteristics in various phases of carcinogenesis, to show the role of nutritional counseling in the selection of personalized metabolic correction programs.Materials and methods. 107 patients with pancreatic head adenocarcinoma (T3 and T4). In addition to traditional methods, the nutritional status was assessed according to the parameters of the well-known personalized alimentary-volemic diagnosis and the main common metabolic syndromes (inflammatory, hypermetabolism-hypercatabolism, toxic-anemic, anorexia-cachexia).Results. The phases of nutritional extinction are identified, in accordance with which the original schemes of metabolic correction are developed. The effectiveness of the programs used, calculated according to the degree of well-being, was significantly higher in comparison with standard solutions. The feasibility of using this tactic was confirmed (in addition to traditional tests) by measuring the metabolism in lysosomes (according to the analysis of the level of cathepsin L using ELISA in the blood serum of the considered groups of patients).Conclusions. 1) When determining the tactics of nutritional treatment of cancer patients, it is advisable to distinguish the phases of nutritional extinction, on the basis of which to carry out a differentiated metabolic correction. 2) The role of nutritional counseling (along with consulting with a surgeon and an anesthesiologist) allows you to clarify the strategy of treatment of patients with oncological pathology, and in some cases, make adjustments to the choice of the nature of the surgical aid.


2009 ◽  
Vol 8 (4(2)) ◽  
pp. 154-160
Author(s):  
O. A. Poddubnaya ◽  
A. M. Kozhemyakin

In development of new treatment technologies, the reliability of results obtained should be beyond any doubts. The study of conjugacy of the obtained therapeutic effect with peculiarities of the combined treatment of patients with chronic cholecystitis in combination with chronic opistorhcosis and the revealing of predictors of the ultimate result are of great practical significance. The analysis of conjugacy tables and results of logistic regression, which allows one to determine prognostically significant signs (predictors) guaranteeing some or other result, favors the selection of the optimal treatment strategy for this category of patients.


2021 ◽  
pp. 1137-1141
Author(s):  
А. Г. Мамонтова ◽  
Е. Н. Усольцева ◽  
А. Г. Соловьев

Климактерический синдром (КС) является ведущим проявлением патологического климактерия. Наряду с дефицитом половых стероидов, при КС наблюдают изменение синтеза гормона эпифиза мелатонина (МТ), что приводит к формированию синдрома перименопаузального дефицита мелатонина (СПДМ) - симптомокомплекса, клинически характеризующегося доминированием жалоб на нарушение сна, болевые ощущения в теле, а также наличием депрессии, тревоги/страхов и соматических симптомов. КС и СПДМ являются коморбидными состояниями, нарушающими климактерическое здоровье женщин. Представлен алгоритм стратификации женщин в пери-и постменопаузе с КС и СПДМ для подбора дифференцированной терапии, включающий определение показаний к монотерапии препаратами МТ, синтетического гинестеина, а также к сочетанному лечению с менопазульной гормональной терапией. Обосновано применение предложенного подхода для повышения эффективности терапии КС в сочетании с СПДМ, улучшения показателей качества жизни и стимулирования здорового и активного долголетия женщин старшей возрастной группы. Climacteric syndrome (CS) is considered to be a frequent manifestation of pathological menopause. Menopause associated not only with deficiency of sex steroids, decrease of melatonin secretion is observed. Perimenopausal melatonin deficiency syndrome (SPDM) is the complex of symptoms, which is often formed amid decrease of melatonin synthesis and clinically characterized by the prevalence of complaints of sleep disorders (problems), bodily pain, depression, anxiety/fears and somatic symptoms. CS and SPD are co-morbidities, that impair the «women menopausal health». The article presents the stratification algorithm of peri- and post-menopausal women with the co-morbid pathology of CS and SPDM for selection of differentiated therapy. The algorithm involves detection of indications for monotherapy with melatonin or synthetic genistein, and for combined treatment with menopausal hormone therapy. The usage of this concept is reasonable for improvement of treatment efficiency of co-morbid pathology of CS and SPDM, for quality of life improvement and for induction of active ageing of women of senior group.


2006 ◽  
Vol 80 (12) ◽  
pp. 6146-6154 ◽  
Author(s):  
Sophie Le Pogam ◽  
Hyunsoon Kang ◽  
Seth F. Harris ◽  
Vincent Leveque ◽  
Anthony M. Giannetti ◽  
...  

ABSTRACT Multiple nonnucleoside inhibitor binding sites have been identified within the hepatitis C virus (HCV) polymerase, including in the palm and thumb domains. After a single treatment with a thumb site inhibitor (thiophene-2-carboxylic acid NNI-1), resistant HCV replicon variants emerged that contained mutations at residues Leu419, Met423, and Ile482 in the polymerase thumb domain. Binding studies using wild-type (WT) and mutant enzymes and structure-based modeling showed that the mechanism of resistance is through the reduced binding of the inhibitor to the mutant enzymes. Combined treatment with a thumb- and a palm-binding polymerase inhibitor had a dramatic impact on the number of replicon colonies able to replicate in the presence of both inhibitors. A more exact characterization through molecular cloning showed that 97.7% of replicons contained amino acid substitutions that conferred resistance to either of the inhibitors. Of those, 65% contained simultaneously multiple amino acid substitutions that conferred resistance to both inhibitors. Double-mutant replicons Met414Leu and Met423Thr were predominantly selected, which showed reduced replication capacity compared to the WT replicon. These findings demonstrate the selection of replicon variants dually resistant to two NS5B polymerase inhibitors binding to different sites of the enzyme. Additionally, these findings provide initial insights into the in vitro mutational threshold of the HCV NS5B polymerase and the potential impact of viral fitness on the selection of multiple-resistant mutants.


2019 ◽  
Vol 42 ◽  
Author(s):  
Gian Domenico Iannetti ◽  
Giorgio Vallortigara

Abstract Some of the foundations of Heyes’ radical reasoning seem to be based on a fractional selection of available evidence. Using an ethological perspective, we argue against Heyes’ rapid dismissal of innate cognitive instincts. Heyes’ use of fMRI studies of literacy to claim that culture assembles pieces of mental technology seems an example of incorrect reverse inferences and overlap theories pervasive in cognitive neuroscience.


1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.


1978 ◽  
Vol 48 ◽  
pp. 515-521
Author(s):  
W. Nicholson

SummaryA routine has been developed for the processing of the 5820 plates of the survey. The plates are measured on the automatic measuring machine, GALAXY, and the measures are subsequently processed by computer, to edit and then refer them to the SAO catalogue. A start has been made on measuring the plates, but the final selection of stars to be made is still a matter for discussion.


Author(s):  
P.J. Killingworth ◽  
M. Warren

Ultimate resolution in the scanning electron microscope is determined not only by the diameter of the incident electron beam, but by interaction of that beam with the specimen material. Generally, while minimum beam diameter diminishes with increasing voltage, due to the reduced effect of aberration component and magnetic interference, the excited volume within the sample increases with electron energy. Thus, for any given material and imaging signal, there is an optimum volt age to achieve best resolution.In the case of organic materials, which are in general of low density and electric ally non-conducting; and may in addition be susceptible to radiation and heat damage, the selection of correct operating parameters is extremely critical and is achiev ed by interative adjustment.


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