oncological pathology
Recently Published Documents


TOTAL DOCUMENTS

57
(FIVE YEARS 33)

H-INDEX

2
(FIVE YEARS 0)

Vestnik ◽  
2021 ◽  
pp. 285-290
Author(s):  
Б.К. Таракова ◽  
А.С. Култаев ◽  
С.Е. Есентаева ◽  
Ж.К. Жакенова

В 2018 году в Республике Казахстан было зарегистрировано 4648 новых случая рака молочной железы (РМЖ). Результаты: О взаимосвязи уровня витамина Д3 и риска развития РМЖ свидетельствуют результаты достаточного числа исследований. Женщины с высоким содержанием витамина Д в рационе питания имеют меньший риск развития РМЖ. Положительное противоопухолевое действие витамина Д3 связано с двумя основными механизмами: антипролиферативным эффектом, ингибирующим ростом клеток путем подавления сигналов, стимулирующих рост рецепторов, которые имеются в ткани молочной железы, и проапоптотическим эффектом, способствующим естественной гибели клеток молочной железы. Заключение: Накопленные к настоящему времени данные о роли витамина Д3 в организме человека, взаимосвязи его уровня с развитием и течением онкологической патологии позволяют предположить, что коррекция недостаточного уровня витамина Д3 может быть перспективным направлением в профилактике и комплексном лечении онкологических заболеваний. Introduction: In 2018, 4648 new cases of breast cancer (BC) were registered in the Republic of Kazakhstan. Results: The relationship between the level of vitamin D3 and the risk of developing breast cancer is evidenced by the results of a sufficient number of studies. Women with a high vitamin D diet have a lower risk of developing breast cancer. The positive antitumor effect of vitamin D3 is associated with two main mechanisms: the antiproliferative effect, which inhibits cell growth by suppressing signals that stimulate the growth of receptors present in the breast tissue, and the proapoptotic effect, which promotes the natural death of breast cells. Conclusion: The data accumulated to date on the role of vitamin D3 in the human body, the relationship of its level with the development and course of oncological pathology suggests that the correction of insufficient levels of vitamin D3 may be a promising direction in the prevention and complex treatment of cancer.


Author(s):  
Oleg I. Bondarev ◽  
Maria S. Bugaeva ◽  
Nadezhda N. Mikhailova

Introduction. The workers of coal mines are characterized by a high level of not only occupational diseases, but also oncological diseases. Modern knowledge in the field of studying pneumoconiosis contains many contradictions in the assessment of the pathogenetic mechanisms of lung damage, in particular, the morphogenesis of neoplastic changes in the respiratory system at the final stage of the disease with pronounced sclerotic changes. The study is devoted to the occurrence and development of tumor tissue in the miners working in the underground conditions. The task is to identify morphological trigger mechanisms for the development of oncological pathology in miners, relying on pathomorphological, immunohistochemical studies of the changes in the epithelial tissue of the airways, as well as various cellular communities of the bronchi, blood vessels of the lungs and lung tissue parenchyma using the example of epithelial-mesenchymal transformation under dust load. The purpose of this study was to determine the influence of the fibroplastic process on the development of oncological pathology in miners who worked in underground conditions. Materials and methods. Histological, immunohistochemical and morphometric studies of the respiratory system obtained during 50 autopsy works of a group of Kuzbass miners working in underground conditions was carried out. Cancer of various localization and histogenetic affiliation was previously diagnosed in 20 miners. The mucous membrane of the bronchi, respiratory tissue of the lungs, arteries and veins of the pulmonary circulation were studied. Immunohistochemical study was performed using monoclonal antibodies (marker of proliferation Ki-67, oncogene of proapoptotic activity Bcl-2, growth and neoangiogenesis factors, endothelial function factors CD-31 and CD-34, marker of epithelial tissue cytokeratin (cyt), muscle tissue markers - actin, desmin, vimentin, connective tissue markers - collagen, laminil, markers of intercellular interactions EMA, SMA). Results. Transformed fibroblasts, myofibroblasts are a cell population of dedifferentiated epithelial tissue with different expressions of nonspecific markers (desmin, actin, vimentin), capable of tumor transformation. Sclerotic tissue changes in pneumoconiosis are the areas of tumor transdifferentiation. Fibroblasts with an altered phenotype, namely myofibroblasts, are able to give rise to the growth of undifferentiated mesenchymal cell communities (tumor tissue), including atypical epithelial cells, adipocytes, chondrocytes and endotheliocytes. Conclusions. Epithelial-mesenchymal transformation can be a triggering mechanism for the development of tumor transformation from extensive fibrosed zones in miners with dust lung pathology. In this case, the main etiological factor of tumor progression is activated fibroplastic cells.


2021 ◽  
Vol 61 (3) ◽  
pp. 4-8
Author(s):  
M. N. Tillyashaykhov ◽  
S. M. Djanklich ◽  
S. N. Ibragimov ◽  
O. A. Imamov

Relevance: Globocan reports 19.3 million new cases of malignant neoplasms in 2020 globally. Mammary gland cancer has become the most commonly diagnosed oncological pathology, followed by lung, colon and rectum, prostate, and stomach cancers. In Uzbekistan, malignant neoplasms of the breast, stomach, cervix, lungs, and brain dominate the structure of cancer incidence. The study aimed to analyze the cancer incidence trends and structure in the Republic of Uzbekistan in 2020. Results: In 2020, 21976 new cancer cases were registered in Uzbekistan. The ratio of men and women newly diagnosed with cancer was 0.7:1.4. Cancers of the breast, cervix, and ovary were the most common in women; cancers of the stomach, lung, and prostate — in men. Hemoblastoses were more common at a young age, breast cancer – at working age, and stomach cancer – at old age. Conclusions: The statistical information analysis showed that in 2020 the cancers of the mammary gland, stomach, and cervix were leading in the overall cancer structure, with significant differences in different age categories. This determines the need for further improvement of cancer care in Uzbekistan.


2021 ◽  
Vol 61 (3) ◽  
pp. 4-8
Author(s):  
M. N. TILLYASHAYKHOV ◽  
S. M. Djanklich ◽  
S. N. Ibragimov ◽  
O. A. Imamov

Relevance: Globocan reports 19.3 million new cases of malignant neoplasms in 2020 globally. Mammary gland cancer has become the most commonly diagnosed oncological pathology, followed by lung, colon and rectum, prostate, and stomach cancers. In Uzbekistan, malignant neoplasms of the breast, stomach, cervix, lungs, and brain dominate the structure of cancer incidence. The study aimed to analyze the cancer incidence trends and structure in the Republic of Uzbekistan in 2020. Results: In 2020, 21976 new cancer cases were registered in Uzbekistan. The ratio of men and women newly diagnosed with cancer was 0.7:1.4. Cancers of the breast, cervix, and ovary were the most common in women; cancers of the stomach, lung, and prostate - in men. Hemoblastoses were more common at a young age, breast cancer – at working age, and stomach cancer – at old age. Conclusions: The statistical information analysis showed that in 2020 the cancers of the mammary gland, stomach, and cervix were leading in the overall cancer structure, with significant differences in different age categories. This determines the need for further improvement of cancer care in Uzbekistan.


2021 ◽  
Vol 5 (3) ◽  
pp. 286-301
Author(s):  
Dana G. Nurman ◽  
Akzhol K. Karim ◽  
Shokhrukh K. Akhnazarov ◽  
Sultan T. Mukashev ◽  
Olzhas M. Demissenov

Nowadays, it is generally accepted that cancer is a genetic disease. Tumour cells appear due to the accumulation of mutations in critical proto-oncogenes and tumour suppressor genes. Urothelial bladder cancer is a frequent oncological pathology, and therefore it is a significant social problem. The practical relevance of the study is due to the fact that the findings can significantly improve the efficiency of bladder cancer diagnosis. The purpose of the study was to consider all modern methods for diagnosing bladder cancer in one paper. As a research method, the analysis of scientific data obtained from the experimental study of bladder cancer was carried out. According to the data of the investigated sources, a fairly large number of scientists believe that bladder cancer (BC) is one of the most common tumours affecting the urinary tract. It is believed that important prognostic factors include the presence of vascular invasion and tumour complexes in the vessels, which increases the risk of the secondary neoplasm growth even at the pT1 stage. However, when assessing vascular invasion, pathologists often mistake the cracks formed around the tumour complexes for vessels. In this case, the study suggests conducting an immunohistochemical analysis for clear visualisation of blood vessels.


Author(s):  
I.N. Zalyalov ◽  
◽  
E.N. Bulatova ◽  
I.S. Konstantinova ◽  
◽  
...  

Oncological diseases of unproductive animals are becoming increasingly common in veterinary practice, especially in large cities. The basis of tumor growth is the unlimited uncontrolled reproduction of cells by the body, which leads to a complex of structural and functional disorders. Despite the significant achievements of modern veterinary medicine in the field of diagnosis of benign and malignant tumors in animals, the issues of histological and cytological diagnosis of the forms of manifestation of this pathology remain problematic. Long-term statistical data show that there is a tendency to increase the incidence of oncological pathology in domestic carnivores, especially in the malignant form.


2021 ◽  
pp. 25-28
Author(s):  
L. N. Kostyuchenko ◽  
G. G. Varvanina ◽  
G. S. Mikhailyants ◽  
M. A. Danilov

The aim. To determine the definition of nutritional extinction and its characteristics in various phases of carcinogenesis, to show the role of nutritional counseling in the selection of personalized metabolic correction programs.Materials and methods. 107 patients with pancreatic head adenocarcinoma (T3 and T4). In addition to traditional methods, the nutritional status was assessed according to the parameters of the well-known personalized alimentary-volemic diagnosis and the main common metabolic syndromes (inflammatory, hypermetabolism-hypercatabolism, toxic-anemic, anorexia-cachexia).Results. The phases of nutritional extinction are identified, in accordance with which the original schemes of metabolic correction are developed. The effectiveness of the programs used, calculated according to the degree of well-being, was significantly higher in comparison with standard solutions. The feasibility of using this tactic was confirmed (in addition to traditional tests) by measuring the metabolism in lysosomes (according to the analysis of the level of cathepsin L using ELISA in the blood serum of the considered groups of patients).Conclusions. 1) When determining the tactics of nutritional treatment of cancer patients, it is advisable to distinguish the phases of nutritional extinction, on the basis of which to carry out a differentiated metabolic correction. 2) The role of nutritional counseling (along with consulting with a surgeon and an anesthesiologist) allows you to clarify the strategy of treatment of patients with oncological pathology, and in some cases, make adjustments to the choice of the nature of the surgical aid.


2021 ◽  
Vol 11 (2) ◽  
pp. 31-38
Author(s):  
Pavel Khoroshutin ◽  
Galina Reva ◽  
Tatsuo Yamamoto ◽  
Ivan Reva

The study presents an analysis of the available scientific literature and outcomes of clinical trials on biologically active components of the birch Chaga mushroom Inonotus obliquus (I. obliquus). Our experimental and clinical studies were aimed at testing a novel plant-based substance for patients with cancer or tumors of various locations. The paper investigates pathogenetic mechanisms and effectiveness of chaga mushroom extracts depending on the topography of the tumor, the stage of the disease and the age of patients, as well as the questions of pharmacokinetics and pharmacodynamics of the components of I. obliquus. As a result of the analysis of the obtained data, the pathogenetically justified clinical application of extracts of the birch chaga mushroom I. obliquus in patients with oncological pathology was conceptually presented. The study allowed us to reveal possible mechanisms of pathogenetic effects of the birch chaga mushroom (Inonotus obliquus) extracts obtained by different extraction methods. Analysis of the available data enabled us to deepen our understanding of the effectiveness and mechanisms of the effect of the I. obliquus extracts on tumors of various localization. Finally we present recommendations on predicting the possibility of using the I. obliquus to improve outcomes in patients with cancer of various etiology and locations.


Author(s):  
Т.М. Абдирова ◽  
А.К. Ешманова ◽  
С. А. Искакова ◽  
В.В. Чайковская

Проведено поперечное одновыборочное кросссекционное рандомизированное исследование, в котором были опрошены при помощи анкет 1 898 человек старше 60 лет, проживающих в Алматы, для исследования их потребностей в паллиативной и медико-социальной помощи. Изучение потребностей с определением функционального состояния старшего возраста (согласно ВОЗ) с помощью SPSS IBM Statistics version 23.0 и 27.0 выявило, что гериатрические пациенты с неонкологической патологией имеют разные медико-социальные потребности, которые требуют межведомственного взаимодействия. Решение проблемы может быть достигнуто путем создания регистра пожилых пациентов на уровне первичной медикосоциальной помощи и оказания паллиативной помощи на дому с помощью мобильных бригад и мультидисциплинарных команд, которые включают медицинских работников, психологов, социальных работников. The study design was a transversal single-sample cross-section randomized study. In total, 1 898 people over 60 years of age living in Almaty were interviewed on the questionnaire to study their needs for palliative and medical and social care. Study of the need with the definition of functional states of older age (according to WHO) in medical and social care and palliative care in Almaty using SPSS IBM Statistics version 23.0 found that geriatric patients with non-oncological pathology have different characteristics of medical and social needs, which require interagency cooperation. The solution of the problem can be achieved by creating a register of elderly patients at the level of primary care to provide palliative care at home with the help of mobile and multidisciplinary teams, which include health workers, psychologists, social workers.


Sign in / Sign up

Export Citation Format

Share Document