scholarly journals 158 Oral Submucous Fibrosis in A 2-Year-Old Girl Due to Chewing BIDI Stubs

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
D S Sahni ◽  
D Desai ◽  
G Prasad ◽  
S Ramsaha
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Symptomatic Improvement ◽  
Aetiological Factor ◽  
Contributing Factors ◽  
Oral Ulcers ◽  
History Of ◽  
Submucous Fibrosis ◽  
Background History

Abstract A 2-year-old girl, complaining of a gradual increase in the restriction of the mouth opening for 3 months, was referred to the Otolaryngologists based on background history of recurrent oral ulcers. The local examination showed the presence of oral ulcers on the cheek in addition to abnormal oral mucosa which appeared blanched, opaque and fibrotic. This was clinically diagnosed as Oral Submucous Fibrosis, owing to classical presentation and the lack of systemic features. A detailed social and family history revealed that the father of the child used to smoke BIDI, a traditional form of nonfiltered cigarette. The child used to play with the burnt stubs and keep them in her mouth, chewing them for long durations. This was assumed to be the aetiological factor behind the development of the pathology, in absence of any other contributing factors. The patient was treated conservatively, and symptomatic improvement was noted on follow-up. This is the youngest reported patient with OSMF, and this case history brought an unusual aetiological factor to the fore.

scholarly journals Oral submucous fibrosis in children: an alarming condition and challenges in management

2021 ◽  
Vol 14 (3) ◽  
pp. e238718
Author(s):  
Anshul Rai ◽  
Anuj Jain ◽  
Aakash Arora ◽  
Tejas Motiwale
Keyword(s):  
Histopathological Examination ◽  
Indian Subcontinent ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Vital Role ◽  
Treatment Modalities ◽  
Potentially Malignant ◽  
History Of ◽  
Submucous Fibrosis

Oral submucous fibrosis (OSF) is a well-documented potentially malignant condition. It affects most commonly the adult patients of India and Indian subcontinent, only few cases affecting children have been reported in the literature. This paper presents three cases of OSF below the age of 12 years and reviews the aetiology, clinical presentation, treatment modalities in children with improved follow-up results. Clinical features like restricted mouth opening, burning sensation and history of betel nut chewing helps in the diagnosis of the patients, which can be confirmed by histopathological examination. Conservative management and oral physiotherapy in children help in improved mouth opening. Counselling the children, their friends and parents also plays a vital role. The present paper highlights that children on a larger scale are using tobacco products and further studies are required with larger sample size.

scholarly journals Effectiveness of Pentoxifylline Therapy for Management of Oral Submucous Fibrosis

2022 ◽  
Vol 19 (1) ◽  
pp. 51-54
Author(s):  
Dwarika Prasad Bajgai ◽  
Bela Agrawal ◽  
Abadhesh Yadav
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Oral Disease ◽  
Medical College ◽  
Adjacent Structures ◽  
Group A ◽  
Submucous Fibrosis ◽  
Group B

Introduction: Oral submucous fibrosis is a chronic oral disease characterized by progressive buildup of constricting collagen bands in the cheeks and adjacent structures of the mouth due to chewing of areca nut. This can severely restrict mouth opening and tongue movement causing pain and burning sensation in the mouth. Aims: This study evaluates the efficacy of pentoxifylline in the management of oral submucous fibrosis. Methods: A hospital-based study, conducted in the dental outpatient department of Nepalgunj Medical College from October 2019 to September 2020. Forty-nine patients who were diagnosed histopathologically with oral submucous fibrosis were included. The patients were divided into two groups. In group A, patients were given, 200 mg thrice daily for first 30 days, then dose hiked to 400 mg thrice daily for two more months. Group B patients received treatment with multi-vitamin capsules (B-complex one capsule before sleep daily) for three months. All patients were followed up for six months and were assessed for maximum inter-incisor opening, pain on opening of mouth and burning sensation. Results: There was no statistical difference in mouth opening at baseline and first follow up. The mouth opening was significantly more in group A compared to group B from second follow up which persisted till third follow up (p <0.05). Pain and burning sensation significantly reduced in group A compared to group B from 2nd follow up which persisted till 3rd follow up (p <0.05). Few patients had nausea, dyspepsia and vomiting during treatment in group A which resolved within a few days without the need for cessation of the drug. Conclusion: Pentoxifylline can bring about significant clinical improvements in the symptoms of oral submucous fibrosis like mouth opening, pain and burning sensation, thereby improving the quality of life of the affected individuals.

scholarly journals Application of injection Kenacort, intradermal route in oral submucous fibrosis

2020 ◽  
Vol 6 (2) ◽  
pp. 316
Author(s):  
Manjunath K. ◽  
Amardeep Singh ◽  
Manjunatha Rao S. V.
Keyword(s):  
Soft Tissues ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Cost Effective ◽  
Intradermal Injection ◽  
Research Centre ◽  
P Value ◽  
Medical College ◽  
History Of ◽  
Submucous Fibrosis

<p class="abstract"><strong>Background:</strong> Oral submucous fibrosis is a potentially pre-malignant disease, that results in progressive juxta-epithelial fibrosis of oral soft tissues, resulting in increased loss of tissue mobility, marked rigidity and inability to open the mouth. Actual treatment includes iron, multi vitamins, lycopene, pentoxifyline, steroid injections and human placental extracts. Currently available treatment with intradermal injection of Kenacort with hyaluronidase is effective to some extent.</p><p class="abstract"><strong>Methods:</strong> This study was conducted at Basaveshwara Medical College and Hospital, Research Centre, Chitradurga, Karnataka, in the Otorhinolaryngology Department from February 2019 to August 2019 for 6 months duration. A total of 40 patients were included in this study. Mouth opening was recorded from baseline to 6 weeks. Cases were followed up for 6 months thereafter. Patients with positive history of chewing of betel-nuts, pan, gutkha and age from 18-50 years males and females were included in this study. Patients undergoing any surgery, allergic conditions, age more than 50 years were excluded. Mouth opening was assessed by objective type and subjective type.</p><p class="abstract"><strong>Results:</strong> There was significant increase in mouth opening in patients after administration of intra-dermal Kenacort injection and oral lycopene. The results were statistically significant and patients responded better and p value &lt;0.001.</p><p class="abstract"><strong>Conclusions:</strong> Management of moderate oral submucous fibrosis should include counselling of patients along with oral lycopene with intradermal injection of Kenacort with hyaluronidase, is highly efficacious and cost- effective in improving the mouth opening and reducing other symptoms in patients with OSMF, whereas advanced stages should be treated surgically.</p>

scholarly journals Tulasi a magical herb and a boon for management of oral submucous fibrosis: a clinical study

2017 ◽  
Vol 5 (11) ◽  
pp. 4719 ◽  
Author(s):  
G. Madhulatha ◽  
N. Vijayalaxmi ◽  
T. Harshavardhan
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Modern Medicine ◽  
Burning Sensation ◽  
Rank Test ◽  
P Value ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Submucous Fibrosis

Background: Plants are a good source of drugs in traditional and modern medicine. One among these plants is “tulasi” The queen of herbs” which is used in ayurveda for its diverse properties like antioxidant, analgesic, anti-inflammatory, antidiabetic, and others. It belongs to labiate family and is the most sacred and valued in traditional culture of India. AIMS of the study was to evaluate the efficacy of Tulasi in the treatment of OSMF.Methods: The study included 20 individuals, females and males of age group 20-50yrs who visited the outpatient department who were diagnosed clinically as having OSMF, categorized according to pindborg’s classification. Patients were asked to apply 500mg of Tulasi medicine paste (Tulasi powder mixed with glycerine) twice daily for 1month and were recalled for follow up every week for 1month. All the clinical parameters - mouth opening, burning sensation, pain with the lesion and others were evaluated and recorded in specially designed proforma.Results: Friedman test and wilcoxon signed rank test was used for statistical evaluation. Significant improvement with P value <0.05 was noticed in burning sensation, mouth opening and pain associated with the lesion.Conclusions: The study concludes that Tulasi can be used as a main treatment modality in the management of patients with OSMF.

Role of Laser Biostimulation in Treatment of Oral Submucous Fibrosis: A Clinical Trial

2017 ◽  
Vol 1 (7) ◽  
pp. 22-26 ◽  
Author(s):  
Kesari Singh ◽  
Achint Garg ◽  
Mayank Jain ◽  
Mansimranjit Kaur Uppal
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Low Level Laser Therapy ◽  
Entire Study ◽  
Level Laser ◽  
Significant Difference ◽  
Study Population ◽  
Submucous Fibrosis

AIM: To evaluate the efficacy of Low Level Laser Therapy (LLLT) in treatment of Oral Submucous Fibrosis (OSMF).MATERIAL & METHODS: 20 patients with a clinical diagnosis of OSMF were included in the study after informed consents and measurements of mouth opening (mm) and burning sensation (VAS) were made at day 0. Laser biostimulation was performed on right and left cheeks in anterior and posterior bands for 3 cycles of 10 seconds each. They were recalled for follow-up measurements and Laser biostimulation at 3rd, 7th and 15th day. The paired t-test was applied for analysing significant differences, if any, using SPSS version 21.0.RESULTS: In the follow up recordings, generally, there was an increase in mouth opening after LLLT therapy and a significant difference was seen in males(p=.04) as well as the total population(p=0.02). Burning sensation(VAS Scale), on day zero was 5.5±1.20, which was reduced to 3.4±.084 on the 15th day with a significant difference seen in the entire study population(p=0.03).CONCLUSION: Biostimulation by Laser in the treatment of OSMF is a good non-invasive, painless and quick alternative treatment modality for the management of diseases.

scholarly journals Comparative Study of Intralesional Dexamethasone Plus Hyaluronidase & Oral Colchicine in Patients with Oral Submucous Fibrosis

2018 ◽  
Vol 14 (2) ◽  
pp. 60-65
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
R. S. Rathore ◽  
V. K. Bhargava ◽  
A. K. Mahat ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Study Groups ◽  
T Test ◽  
Significant Difference ◽  
Intralesional Injections ◽  
Submucous Fibrosis ◽  
Larger Sample

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

Comparison Of Collagen-Curcumin Blend (Collaper Rtu)With Intralesional Steroid Injections in Oral Submucous Fibrosis a Randomized, Open-Label Interventional Study.

2021 ◽  
Author(s):  
Bharat Kwatra ◽  
Manya Pahwa
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Current Therapy ◽  
Intralesional Injection ◽  
Complete Regression ◽  
Open Label ◽  
Tongue Protrusion ◽  
Interincisal Distance ◽  
Submucous Fibrosis

Abstract Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition characterized by limited mouth opening, burning sensation, stiffness, and blanching of the oral mucosa induced by areca nut eating. With any of the current therapy regimens, complete regression of the illness has not been accomplished in all patients. Curcumin is a yellow pigment found in curry powder that has antioxidant, anti-inflammatory, and pro-apoptotic properties. As a result, interventional research was conducted to determine the efficacy of Collaper RTu a proprietary collagen-curcumin based product in patients with OSMF.Setting and design: Forty patients with clinically and histologically confirmed Oral Submucous Fibrosis participated in a randomized open label interventional research. Method & materials: For the research, forty patients with clinically and histologically verified Oral Submucous Fibrosis were randomly assigned to one of two groups. The first group was given a weekly intralesional injection of 4 mg Dexamethasone and 1500 I.U Hyaluronidase, whereas the second was given two Collagen-Curcumin pills (Collaper Rtu 60mg Collagen with 100 mg Curcumin) every day for three months. On a weekly basis, the improvement of burning sensation, interincisal distance, and tongue protrusion was assessed.Results: From early to late stages, the burning feeling improved in both groups. Collaper Rtu was found to eliminate the burning feeling. In groups 1 and 2, the mean increase in interincisal distance was 3.13 mm and 1.25 mm, respectively. The interincisal distance improved significantly in both groups by the end of the first month. When compared to group 2, group 1's tongue protrusion recovered faster at the conclusion of the first month. Conclusion: Collaper RTu is useful and effective in lowering the burning feeling in people with early OSMF.

scholarly journals Ulnar-sided wrist pain due to radial bifurcation of the extensor digiti minimi tendon: A case report and literature review

2020 ◽  
Vol 28 (2) ◽  
pp. 230949902092231
Author(s):  
Ryo Sasaki ◽  
Koichi Yano ◽  
Yasunori Kaneshiro ◽  
Seungho Hyun ◽  
Hideki Sakanaka
Keyword(s):  
Literature Review ◽  
Distal Portion ◽  
Wrist Pain ◽  
Wrist Flexion ◽  
Tissue Mass ◽  
Frequent Use ◽  
Stenosing Tenosynovitis ◽  
History Of ◽  
Background History

Stenosing tenosynovitis of the extensor digiti minimi (EDM) without trauma is very rare. We report a 21-year-old woman who presented with dorsoulnar wrist pain during palmar wrist flexion and soft tissue mass at the site of pain. Ultrasonography and magnetic resonance imaging showed a round mass radial to the EDM tendon. Conservative treatment for 3 months failed to improve the patient’s pain levels. Intraoperative findings revealed smaller radial slip of the EDM tendon, and bifurcation of these was under the distal portion of the extensor retinaculum (ER). Surgical release of the ER, resection of the smaller slip of the EDM tendon, and tenosynovectomy were performed. Histological examination showed tenosynovitis. At the final follow-up 1 year postoperatively, she was asymptomatic. A literature review suggested that stenosing tenosynovitis of the EDM tendon might be caused by frequent use of the hand with a background history of bifurcation of the EDM tendon.

scholarly journals Immunohistochemical Analysis of Myofibroblasts Using α- SMA in Oral Submucous Fibrosis Turning into Malignancy- A Case Report and Review

2021 ◽  
pp. 192-198
Author(s):  
Swapan Kumar Purkait ◽  
. Abhinandan ◽  
Nimisha Priya ◽  
Sriyanshi Singh ◽  
Sneha Singh
Keyword(s):  
Case Report ◽  
Immunohistochemical Study ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Immunohistochemical Analysis ◽  
Invasive Front ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
Very High ◽  
Premalignant Conditions

Oral submucous fibrosis is a premalignant condition, characterized by fibrosis in oral mucosa causing stiffness of mucosa and leading to reduced mouth opening. The malignant transformation of oral submucous fibrosis is very high among the rest of the premalignant conditions. Chronic chewing of arecanut causes production of myofibroblasts. These myofibroblasts plays an important role in neoangiogenesis as well as disintegration of the basement membrane at the tumor invasive front leading to carcinoma.  Here, we are doing an Immunohistochemical study using alpha SMA for proper microscopic visulizations of myofibroblastic activity in an OSF patient, encompassing the pathogenesis and malignant potentiality of the disease.

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