TP1.2.2CT Colonography (CTC) Should be the ‘Gold Standard’ in Suspected Colonic Malignancy: Results of a Retrospective Cohort Study

Abstract Aim Colonoscopy is the ‘gold’ standard with CT Colonography (CTC) being an alternative to investigate symptoms of colorectal cancer (CRC). Colonoscopy is invasive and can be embarrassing and distressing for patients. This retrospective cohort study aimed to investigate the validity of CTC in patients with suspected CRC. Methods We retrospectively reviewed 815 electronic patient records for those undergoing CTC in a large teaching hospital, between 2013 and 2015. Demographic data in addition to specific data on indication for CTC, endoscopic evaluation and further radiological imaging was collected until 2018. Results Mean age of the cohort was 67 (21 - 93 years). 326 (40%) patients underwent lower GI endoscopy in the three months preceding CTC, whilst 90 (11%) patients underwent endoscopy in the year following CTC. 37 patients had a CT Colonography Reporting Data System score (C-RADS) of C4 suggesting a colonic malignancy. Of these 21 (57%) were confirmed CRC, others demonstrated benign pathology (32%) or were unit or lost to follow up (11%). 56 (7%) had C-RADS of E4 suggesting significant extracolonic findings, 6 (11%) of which were renal cell carcinomas. Only 2 patients went on to develop a colorectal malignancy within our follow up period. Conclusions This large retrospective cohort study demonstrates that CTC is a reliable and valid tool. The authors propose that CTC should be the first line investigation with endoscopy reserved for use as an adjunct for diagnosis.Despite the limitations of a retrospective review, we were able to generate large patient numbers in order to establish our outcomes.

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Faculty Opinions recommendation of Evaluation of the economic burden of kidney stone disease in the UK: a retrospective cohort study with a mean follow-up of 19 years.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737186277.793570254 ◽

2020 ◽

Author(s):

Walter Strohmaier

Keyword(s):

Cohort Study ◽

Economic Burden ◽

Retrospective Cohort Study ◽

Kidney Stone ◽

Retrospective Cohort ◽

Stone Disease ◽

Kidney Stone Disease ◽

The Uk

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An Analysis of Dental Implants Survival and Success

Revista de Chimie ◽

10.37358/rc.18.9.6554 ◽

2018 ◽

Vol 69 (9) ◽

pp. 2465-2466

Author(s):

Iustin Olariu ◽

Roxana Radu ◽

Teodora Olariu ◽

Andrada Christine Serafim ◽

Ramona Amina Popovici ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Medical History ◽

Retrospective Cohort Study ◽

Odds Ratio ◽

Retrospective Cohort ◽

Demographic Data ◽

Kaplan Meier ◽

Number Of Patients ◽

Health Related

Osseointegration of a dental implant may encounter a variety of problems caused by various factors, as prior health-related problems, patients� habits and the technique of the implant inserting. Retrospective cohort study of 70 patients who received implants between January 2011- April 2016 in one dental unit, with Kaplan-Meier method to calculate the probability of implants�s survival at 60 months. The analysis included demographic data, age, gender, medical history, behavior risk factors, type and location of the implant. For this cohort the implants�survival for the first 6 months was 92.86% compared to the number of patients and 97.56% compared to the number of total implants performed, with a cumulative failure rate of 2.43% after 60 months. Failures were focused exclusively on posterior mandible implants, on the percentage of 6.17%, odds ratio (OR) for these failures being 16.76 (P = 0.05) compared with other localisations of implants, exclusively in men with median age of 42 years.

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Status and Determinants of Treatment Outcomes Among New Tuberculosis Patients in South Korea: A Retrospective Cohort Study

Asia Pacific Journal of Public Health ◽

10.1177/10105395211000529 ◽

2021 ◽

pp. 101053952110005

Author(s):

Hyunjin Son ◽

Jeongha Mok ◽

Miyoung Lee ◽

Wonseo Park ◽

Seungjin Kim ◽

...

Keyword(s):

Cohort Study ◽

South Korea ◽

Success Rate ◽

Treatment Outcomes ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Health Care Facilities ◽

Tuberculosis Patients ◽

Lost To Follow Up

This is a retrospective cohort study using notification data in South Korea. We evaluated the nationwide status, regional differences, and the determinants of treatment outcomes among tuberculosis patients. Treatment success rate improved from 77.0% in 2012 to 86.0% in 2015. The lost to follow-up rate was higher among older people, males, and foreign nationals. Health care facilities designated for the Public-Private Mix (PPM) project showed higher success rate and lower rate of lost to follow-up. Moreover, municipalities with low regional deprivation index had higher PPM project coverage. Since there is a large regional difference in the coverage of the PPM project, an additional community-based support program should be implemented, especially for tuberculosis patients residing in region with low PPM project coverage.

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Pioglitazone use and Parkinson’s disease: a retrospective cohort study in Taiwan

BMJ Open ◽

10.1136/bmjopen-2018-023302 ◽

2018 ◽

Vol 8 (8) ◽

pp. e023302 ◽

Cited By ~ 10

Author(s):

Hsiu-Feng Wu ◽

Li-Ting Kao ◽

Jui-Hu Shih ◽

Hui-Han Kao ◽

Yu-Ching Chou ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Asian Population ◽

Secondary Outcome ◽

Study Cohort ◽

Patients With Diabetes

ObjectivesMany researchers have expected pioglitazone to serve as an effective neuroprotective agent against Parkinson’s disease (PD). Therefore, we conducted this cohort study to investigate the association between pioglitazone use and PD by using a large Asian population-based dataset in Taiwan.DesignRetrospective cohort study.SettingTaiwan.Participants7906 patients with diabetes who had received pioglitazone were defined as the study cohort, and 7906 matched patients with diabetes who had not received pioglitazone were defined as the comparison cohort.Primary and secondary outcome measuresWe tracked each patient individually over a 5-year follow-up period to identify those diagnosed as having PD during this period. We performed Cox proportional hazard regression analyses to evaluate the HRs for PD between the study and comparison cohorts.ResultsThe findings indicated that among the sampled patients, PD occurred in 257 (1.63%): 119 (1.51%) pioglitazone users and 138 (1.75%) non-users. The adjusted HR for PD within the follow-up period was 0.90 (95% CI: 0.68 to 1.18) in the patients who had received pioglitazone compared with the matched patients who had not received pioglitazone. Moreover, this study revealed that pioglitazone use was not associated with PD incidence in men (HR: 1.06, 95% CI: 0.71 to 1.59) or women (HR: 0.84, 95% CI: 0.61 to 1.15).ConclusionsThis study did not find the relationship between pioglitazone use and PD incidence, regardless of sex, among an Asian population of patients with diabetes.

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