scholarly journals Wound healing center establishment and new technology application in improving the wound healing quality in China

2020 ◽  
Vol 8 ◽  
Author(s):  
Xiaobing Fu
Keyword(s):  
Wound Healing ◽  
Regenerative Medicine ◽  
Tissue Repair ◽  
New Technology ◽  
Skin Wounds ◽  
Technology Application ◽  
Tissue Repair And Regeneration ◽  
Healing Tissue ◽  
Chronic Skin ◽  
Made In

Abstract Wound healing, tissue repair and regenerative medicine are in great demand, and great achievements in these fields have been made. In recent years, many of these successes have benefitted patients, especially in the field of chronic skin wounds. However, perfect tissue repair and regeneration of damaged tissues and organs are still great challenges in the management of trauma and diseases. In this paper, the main achievements in wound healing, tissue repair and regeneration in China are reviewed and the establishment of wound healing centers and new technology application in improving wound healing quality in patients in China is highlighted.

scholarly journals Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 470 ◽  
Author(s):  
Bolat Sultankulov ◽  
Dmitriy Berillo ◽  
Karina Sultankulova ◽  
Tursonjan Tokay ◽  
Arman Saparov
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Tissue Repair ◽  
Chemically Modified ◽  
Tissue Repair And Regeneration ◽  
Current Review ◽  
Free Amine ◽  
Natural Polysaccharide ◽  
Amine Groups ◽  
Made In

Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

scholarly journals Interleukin-17: Potential Target for Chronic Wounds

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Yasmin Hadian ◽  
Michelle D. Bagood ◽  
Sara E. Dahle ◽  
Apra Sood ◽  
R. Rivkah Isseroff
Keyword(s):  
Wound Healing ◽  
Clinical Studies ◽  
Tissue Repair ◽  
Chronic Wounds ◽  
Family Members ◽  
Interleukin 17 ◽  
Skin Wounds ◽  
Interleukin 17A ◽  
Chronic Skin ◽  
Skin Conditions

Chronic wounds exhibit persistent inflammation with markedly delayed healing. The significant burden of chronic wounds, which are often resistant to standard therapy, prompts further research on novel therapies. Since the interleukin-17 family has been implicated as a group of proinflammatory cytokines in immune-mediated diseases in the gut and connective tissue, as well as inflammatory skin conditions, we consider here if it may contribute to the pathogenesis of chronic wounds. In this review, we discuss the interleukin-17 family’s signaling pathways and role in tissue repair. A PubMed review of the English literature on interleukin-17, wound healing, chronic wounds, and inflammatory skin conditions was conducted. Interleukin-17 family signaling is reviewed in the context of tissue repair, and preclinical and clinical studies examining its role in the skin and other organ systems are critically reviewed. The published work supports a pathologic role for interleukin-17 family members in chronic wounds, though this needs to be more conclusively proven. Clinical studies using monoclonal interleukin-17 antibodies to improve healing of chronic skin wounds have not yet been performed, and only a few studies have examined interleukin-17 family expression in chronic skin wounds. Furthermore, different interleukin-17 family members could be playing selective roles in the repair process. These studies suggest a therapeutic role for targeting interleukin-17A to promote wound healing; therefore, interleukin-17A may be a target worthy of pursuing in the near future.

scholarly journals Repair cell first, then regenerate the tissues and organs

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Xiao-Bing Fu
Keyword(s):  
Tissue Repair ◽  
Cell Damage ◽  
Ischemia Reperfusion ◽  
Severe Trauma ◽  
Basic Unit ◽  
Basic Process ◽  
Tissue Repair And Regeneration ◽  
Healing Tissue ◽  
Organ Repair ◽  
And Function

AbstractWound healing, tissue repair and regenerative medicine are in great demand, and great achievements in these fields have been made. The traditional strategy of tissue repair and regeneration has focused on the level of tissues and organs directly; however, the basic process of repair at the cell level is often neglected. Because the cell is the basic unit of organism structure and function; cell damage is caused first by ischemia or ischemia-reperfusion after severe trauma and injury. Then, damage to tissues and organs occurs with massive cell damage, apoptosis and even cell death. Thus, how to achieve the aim of perfect repair and regeneration? The basic process of tissue or organ repair and regeneration should involve repair of cells first, then tissues and organs. In this manuscript, it is my consideration about how to repair the cell first, then regenerate the tissues and organs.

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

scholarly journals Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation

2021 ◽  
Vol 12 ◽  
Author(s):  
Paula Alvarenga Borges ◽  
Ingrid Waclawiak ◽  
Janaína Lima Georgii ◽  
Vanderlei da Silva Fraga-Junior ◽  
Janaína Figueiredo Barros ◽  
...  
Keyword(s):  
Wound Healing ◽  
T Cells ◽  
Receptor Antagonist ◽  
Tissue Repair ◽  
Cellular Response ◽  
Chronic Wounds ◽  
Γδ T Cells ◽  
Receptor Activation ◽  
Skin Wounds ◽  
Diabetic Mice

Chronic wounds are a public health problem worldwide, especially those related to diabetes. Besides being an enormous burden to patients, it challenges wound care professionals and causes a great financial cost to health system. Considering the absence of effective treatments for chronic wounds, our aim was to better understand the pathophysiology of tissue repair in diabetes in order to find alternative strategies to accelerate wound healing. Nucleotides have been described as extracellular signaling molecules in different inflammatory processes, including tissue repair. Adenosine-5’-diphosphate (ADP) plays important roles in vascular and cellular response and is immediately released after tissue injury, mainly from platelets. However, despite the well described effect on platelet aggregation during inflammation and injury, little is known about the role of ADP on the multiple steps of tissue repair, particularly in skin wounds. Therefore, we used the full-thickness excisional wound model to evaluate the effect of local ADP application in wounds of diabetic mice. ADP accelerated cutaneous wound healing, improved new tissue formation, and increased both collagen deposition and transforming growth factor-β (TGF-β) production in the wound. These effects were mediated by P2Y12 receptor activation since they were inhibited by Clopidogrel (Clop) treatment, a P2Y12 receptor antagonist. Furthermore, P2Y1 receptor antagonist also blocked ADP-induced wound closure until day 7, suggesting its involvement early in repair process. Interestingly, ADP treatment increased the expression of P2Y12 and P2Y1 receptors in the wound. In parallel, ADP reduced reactive oxygen species (ROS) formation and tumor necrosis factor-α (TNF-α) levels, while increased IL-13 levels in the skin. Also, ADP increased the counts of neutrophils, eosinophils, mast cells, and gamma delta (γδ) T cells (Vγ4+ and Vγ5+ cells subtypes of γδ+ T cells), although reduced regulatory T (Tregs) cells in the lesion. In accordance, ADP increased fibroblast proliferation and migration, myofibroblast differentiation, and keratinocyte proliferation. In conclusion, we provide strong evidence that ADP acts as a pro-resolution mediator in diabetes-associated skin wounds and is a promising intervention target for this worldwide problem.

scholarly journals Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials

2021 ◽  
Vol 9 ◽  
Author(s):  
Maria Karkanitsa ◽  
Parinaz Fathi ◽  
Tran Ngo ◽  
Kaitlyn Sadtler
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Immune System ◽  
Regenerative Medicine ◽  
Tissue Repair ◽  
Immune Reaction ◽  
Cell Behavior ◽  
Physical Trauma ◽  
Injured Tissue ◽  
Natural Healing

With few exceptions, humans are incapable of fully recovering from severe physical trauma. Due to these limitations, the field of regenerative medicine seeks to find clinically viable ways to repair permanently damaged tissue. There are two main approaches to regenerative medicine: promoting endogenous repair of the wound, or transplanting a material to replace the injured tissue. In recent years, these two methods have fused with the development of biomaterials that act as a scaffold and mobilize the body’s natural healing capabilities. This process involves not only promoting stem cell behavior, but by also inducing activity of the immune system. Through understanding the immune interactions with biomaterials, we can understand how the immune system participates in regeneration and wound healing. In this review, we will focus on biomaterials that promote endogenous tissue repair, with discussion on their interactions with the immune system.

scholarly journals Adaptive immunity and skin wound healing in amphibian adults

2019 ◽  
Vol 14 (1) ◽  
pp. 420-426 ◽  
Author(s):  
Antonella Franchini
Keyword(s):  
Wound Healing ◽  
Tissue Repair ◽  
Tissue Injury ◽  
Skin Wound ◽  
Tissue Response ◽  
Cellular Mechanisms ◽  
Skin Wound Healing ◽  
Whole Process ◽  
Tissue Repair And Regeneration ◽  
Adaptive Immune Cells

AbstractRegeneration and repair with scarring of the skin are two different responses to tissue injury that proceed depending on the animal species. Several studies in multiple organisms have shown that the effectiveness of tissue repair gradually decreases with age in most vertebrates, while the molecular and cellular mechanisms underlying the diverse potentials remain incompletely understood. It is clear, however, that immune system actively participates in the whole process and immune-related activities can mediate both negative and positive roles to influence the quality and diversity of tissue response to damage. Compared with innate immunity, our understanding of the significance of adaptive immune cells in normal repair outcome is limited and deserves further investigation. Here, experimental evidence supporting the contribution of lymphocytes and the involvement of lymphoid organs in skin wound healing are discussed, focusing on the findings emerged in adult amphibians, key animal models for tissue repair and regeneration research.

scholarly journals Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits

2015 ◽  
pp. 1717 ◽  
Author(s):  
Maxim Shevtsov ◽  
Larisa Smagina ◽  
Tatiana Kudriavtceva ◽  
Sergey Petlenko ◽  
Irina Voronkina
Keyword(s):  
Wound Healing ◽  
Skin Wounds ◽  
Chronic Skin
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