scholarly journals Ketogenic Diet as an Adjunctive Therapy on the Treatment of Oral Tumor (P05-020-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jacquelyne Motta ◽  
Fabiola Donadao ◽  
Carolina Giuberti
Keyword(s):  
Ketogenic Diet ◽  
Adjunctive Therapy ◽  
Ketone Bodies ◽  
Conventional Medicine ◽  
Mesenchymal Cell ◽  
Surgical Excision ◽  
Dietary Therapy ◽  
Survival Times ◽  
Funding Sources ◽  
Oral Tumor

Abstract Objectives This case is here to demonstrate the effectiveness of the Ketogenic Diet (KD) as adjunctive therapy in the treatment of oral fibrosarcoma tumor. Methods Brad, a five-year-old male mix-breed-dog was submitted on a ketogenic diet after mandibulectomy of the oral tumor. KD a high-fat/low-carbohydrate/adequate-protein diet has recently been proposed as adjuvant therapy in cancer treatment. KDs target the Warburg effect, a biochemical phenomenon in which cancer cells predominantly utilize glycolysis instead of oxidative phosphorylation to produce ATP; therefore, some cancers cannot metabolize ketone bodies, due to mitochondrial dysfunction and down-regulation of enzymes necessary for ketone utilization. Furthermore, by reducing blood glucose, insulin and insulin-like growth factor, the drivers of cancer cell proliferation, are also reduced in the bloodstream. Results This cancer, whose origin is a mesenchymal cell and consists of a malignant tumor of fibroblasts has a reported survival times after surgical excision ranging from 7.0 to 12.2 months. After eighteen months of dietary therapy, the tumor-associated inflammation was completely reduced, and no more lesions were found during clinical exams. The dog in this study showed significant improvement and came back to his normal life and activities right at the beginning of the therapy. Today, he has a healthy happy and very active life. Conclusions There are alternatives other than conventional medicine. The therapy plans must include diet either as an adjuvant or whenever possible as the main treatment. Nutrition plays an important role in the future of Medicine. Nontoxic metabolic therapy is effective, and those interested in cancer prevention should know about this. Although the study was managed in a dog, the ketogenic diet is effective in preventing and reducing cancer risks in humans. Integrative Medicine conducted with criteria and responsibility leads to health and vitality for patients. Funding Sources N/A. Supporting Tables, Images and/or Graphs

scholarly journals Crosstalk between the Ketogenic Diet and Epilepsy: From the Perspective of Gut Microbiota

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Yuying Fan ◽  
Hua Wang ◽  
Xueyan Liu ◽  
Junmei Zhang ◽  
Gang Liu
Keyword(s):  
Gut Microbiota ◽  
Ketogenic Diet ◽  
Gut Microbiome ◽  
Ketone Bodies ◽  
Positive Impact ◽  
Neurological Diseases ◽  
Dietary Therapy ◽  
Neuroprotective Effects ◽  
Wide Range ◽  
Underlying Mechanisms

Given the association between a range of neurological disorders and changes in the gut microbiota, interest in the gut microbiota has recently increased. In particular, the significant involvement of the autoimmune processes in the development of epilepsy, one of the most serious and widespread neurological diseases, has led to a suggested link with the gut microbiome. Because the constitution of the gut microbiome can be influenced by diet, dietary therapy has been shown to have a positive impact on a wide range of conditions via alteration of the gut microbiota. An example of one such diet is the ketogenic diet (KD), which promotes a diet that contains high levels of fat, adequate levels of protein, and low levels of carbohydrate. Due to the near-total elimination of carbohydrates from the individual’s food in this ultra-high-fat diet, ketone bodies become an important source of energy. Although the ketogenic diet has proven successful in the treatment of refractory epilepsy and other illnesses, the underlying mechanisms of its neuroprotective effects have yet to be fully elucidated. Nevertheless, recent studies strongly indicate a role for the gut microbiota in the effective treatment of epilepsy with the ketogenic diet. The latest advances regarding the links between the ketogenic diet, gut microbiota, and epilepsy are reviewed in this article, with a particular focus on the role of the gut microbiota in the treatment outcome.

Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy

2021 ◽  
Author(s):  
Liyuan Qian ◽  
Yunzheng Li ◽  
Yajuan Cao ◽  
Gang Meng ◽  
Jin Peng ◽  
...  
Keyword(s):  
Ketone Bodies ◽  
Dietary Therapy ◽  
Metabolic Genes ◽  
Pan Cancer

scholarly journals Patient with Recurrent Glioblastoma Responding Favorably to Ketogenic Diet Combined with Intranasal Delivery of Perillyl Alcohol: A Case Report and Literature Review

2017 ◽  
Vol 36 (03) ◽  
pp. 194-199 ◽  
Author(s):  
Juliana Santos ◽  
Wanise Cruz ◽  
Axel Schönthal ◽  
Marcela Salazar ◽  
Cristina Fontes ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Ketone Bodies ◽  
Methylation Status ◽  
Perillyl Alcohol ◽  
Recurrent Glioblastoma ◽  
Intranasal Delivery ◽  
Reduced Body ◽  
Reduced Frequency ◽  
Methylguanine Methyltransferase ◽  
Magnetic Resonance Imaging Mri

Introduction Monoterpene perillyl alcohol (POH) is cytotoxic to temozolomide-resistant glioma cells, regardless of its O6-methylguanine-methyltransferase (MGMT) promoter methylation status. Moreover, adherence to a ketogenic diet (KD) produced successful outcomes in preclinical and clinical studies in the glioma setting. Case Presentation A 54-year-old Caucasian man had a confirmed diagnosis of refractory glioblastoma multiforme (GBM). The immunohistochemical evaluation was negative for methylation, and failed to detect mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes. In January 2016, the patient was enrolled in a clinical trial combining daily intranasal delivery of POH in combination with a KD. The KD was administered concomitantly with inhalation of POH (55 mg, 4 times a day) in an uninterrupted administration schedule for 3 months. Results The combination treatment was well-tolerated. The nutritional status and anthropometric measurements of the patient were measured. Adherence to the KD was confirmed by measuring the levels of ketone bodies in the urine. Throughout the treatment, a reduced frequency of seizures was observed. After three months of adherence to the treatment, the patient presented with weight loss, reduced body fat, increased water retention, and a slight increase in bone and muscle mass. A follow-up magnetic resonance imaging (MRI) scan after 3 months of treatment revealed marked reduction of the enhancing lesion. Conclusion Intranasal delivery of POH combined with concomitant adherence to a KD appeared to have a beneficial therapeutic effect in a patient with recurrent GBM. Further studies are needed to evaluate the efficacy of this therapeutic strategy in a larger cohort of treatment-refractory GBM patients.

scholarly journals Ketone Bodies as a Possible Adjuvant to Ketogenic Diet in PDHc Deficiency but Not in GLUT1 Deficiency

2017 ◽  
pp. 53-59 ◽  
Author(s):  
F. Habarou ◽  
N. Bahi-Buisson ◽  
E. Lebigot ◽  
C. Pontoizeau ◽  
M. T. Abi-Warde ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Ketone Bodies ◽  
Glut1 Deficiency

scholarly journals Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy

iScience ◽  
2020 ◽  
Vol 23 (9) ◽  
pp. 101453
Author(s):  
Jantzen Sperry ◽  
Michael C. Condro ◽  
Lea Guo ◽  
Daniel Braas ◽  
Nathan Vanderveer-Harris ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Ketogenic Diet ◽  
Ketone Bodies ◽  
Diet Therapy

scholarly journals Satiating Effect of a Ketogenic Diet and Its Impact on Muscle Improvement and Oxidation State in Multiple Sclerosis Patients

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1156 ◽  
Author(s):  
María Benlloch ◽  
María Mar López-Rodríguez ◽  
María Cuerda-Ballester ◽  
Eraci Drehmer ◽  
Sandra Carrera ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Body Composition ◽  
Ketogenic Diet ◽  
Oxidation State ◽  
Lean Mass ◽  
Ketone Bodies ◽  
Paraoxonase 1 ◽  
Before And After ◽  
Multiple Sclerosis Patients ◽  
Beta Hydroxybutyrate

Background: It was previously established that Multiple sclerosis (MS) generates energy alterations at the mitochondrial level related to the loss of muscle mass. Ketone bodies, mainly beta-hydroxybutyrate (BHB), re-establish this energy alteration causing satiety, changes in body composition and a decrease in hormone-dependant hunger, such as ghrelin. The aim of this study was to establish possible improvements in body composition and the level of oxidation in patients with MS, by means of the satiating effect of a ketogenic diet. Methods: A pilot study was carried out with 27 MS patients who were given a Mediterranean isocaloric and ketogenic diet for 4 months. Anthropometric measurements, as well as satiety and hunger perception (VAS scale), were taken. In addition, BHB and paraoxonase 1 (PON1), as an oxidation marker, were measured by spectrophotometric automated assays, and ghrelin was determined by an enzyme immunoassay in the serum. All measurements were taken before and after the intervention. Results: A significant increase in satiety perception at lunch and dinner and of BHB in the blood was obtained. Hunger perception decreased significantly at lunch and dinner with similar levels of ghrelin. In addition, an important increase in lean mass and PON1 was observed. To our knowledge, this is the first study addressing improvements in body composition, oxidation state and metabolism in MS patients, based on the satiating effect of a Mediterranean isocaloric diet. Conclusion: A ketogenic diet increases lean mass and decreases inflammation and oxidation possibly as a consequence of an increase in satiety and decrease in hunger in MS patients.

Pediatric to Adult Transitions of Ketogenic Dietary Therapy for Epilepsy

2020 ◽  
Vol 35 (13) ◽  
pp. 896-900
Author(s):  
Kristin Seaborg ◽  
Xing Wang ◽  
Clara Olson ◽  
Elizabeth A. Felton
Keyword(s):  
Young Adult ◽  
Ketogenic Diet ◽  
Life Stage ◽  
Insurance Coverage ◽  
Intractable Epilepsy ◽  
Adult Patients ◽  
Adolescent And Young Adult ◽  
Dietary Therapy ◽  
Transition To Adult Care ◽  
Adult Care

Ketogenic therapy is now an accepted treatment for pediatric and adult patients with medically refractory epilepsy.1-3 However, young adults treated with a ketogenic diet face unique challenges when transitioning to adult neurology providers.4 The variable acceptance of dietary therapy, paucity of nutritionists and adult neurology providers educated in dietary therapy, and lack of insurance coverage for dietary education may interfere with transition to adult care. In addition, patients in this life stage may just begin to independently seek medical care, cook meals, and manage medications, making strict dietary limitations difficult.4 In this worldwide study, we surveyed 191 pediatric and adult neurology providers who prescribe ketogenic dietary therapy for epilepsy. Our response rate was 39% with a total of 74 valid surveys received. Our goal was to identify perceived barriers that inhibit effective transition and successful continuation of dietary therapy during transition to adult care. We found that dietary therapy is a more accepted treatment of intractable epilepsy in children (84%) than adults (17%) in all geographic areas. Although half of pediatric neurology providers (50%) transition their young adult patients on dietary therapy to adult providers, only 23% have a documented transition plan or a formal transition protocol. Most (87%) pediatric providers who prescribe the ketogenic diet feel the lack of sufficient adult providers who prescribe dietary therapy as a barrier to transitioning adolescent and young adult patients.

KETOGENIC DIET | Dietary Management of Epilepsy: Role of Glucose and Ketone Bodies

2009 ◽  
pp. 687-693 ◽  
Author(s):  
T.N. Seyfried ◽  
J.G. Mantis ◽  
M.T. Todorova ◽  
A.E. Greene
Keyword(s):  
Ketogenic Diet ◽  
Ketone Bodies ◽  
Dietary Management

Ketogenic Diet in Status Epilepticus

2016 ◽  
Author(s):  
Rima Nabbout
Keyword(s):  
Intensive Care ◽  
Status Epilepticus ◽  
Intensive Care Units ◽  
Ketogenic Diet ◽  
Significant Risk ◽  
Refractory Status Epilepticus ◽  
Dietary Therapy ◽  
Risk Of Death ◽  
Refractory Status ◽  
Neurological Morbidity

Refractory status epilepticus (RSE) is associated with a significant risk of death or neurological morbidity. The ketogenic diet (KD) is a dietary therapy that succeeds in controlling seizures in otherwise RSE in children and adult patients. Inflammatory etiologies might be a particular target, but KD has reported efficacy in other etiologies. KD is well tolerated, and the effect is seen within days. Randomized and controlled studies are lacking in this area, and studies are needed to prove the efficacy of KD in RSE and to identify specific indications. This would help to increase its use and to implement it in intensive care units to resolve severe epileptic conditions quickly.

Dietary Therapy in Adults

2016 ◽  
Author(s):  
Emily L. Johnson ◽  
Mackenzie C. Cervenka
Keyword(s):  
Ketogenic Diet ◽  
Refractory Status Epilepticus ◽  
Dietary Therapy ◽  
Intentional Weight Loss ◽  
Modified Atkins Diet ◽  
New Antiepileptic Drugs ◽  
Ketogenic Diets ◽  
Secondary Benefits ◽  
Gastrointestinal Side Effects ◽  
Dietary Treatments

First described over a century ago, dietary treatments for adults with epilepsy were rarely used until the last two decades. Studies show that ketogenic diets are feasible and effective in adults as well as children, and there is growing use in adults with medically refractory epilepsy. Children on ketogenic diets are also transitioning to adulthood and require ongoing neurology care. The classic ketogenic diet and the modified Atkins diet are most commonly used in adults. Results are encouraging, with response rates potentially rivaling those of new antiepileptic drugs. Dietary therapies offer adults with epilepsy an alternative that may reduce antiepileptic drug burden. While lipid elevations and gastrointestinal side effects are common, many patients find intentional weight loss and improved cognition as additional secondary benefits. The ketogenic diet is also a promising therapy for refractory status epilepticus in adults. This chapter examines the use of dietary therapies in adult epilepsy.

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