[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Family-based treatments for children with mental health, physical health, and developmental disorders often convey secondary benefits to caregivers and siblings who participate in those treatments. Yet, there are no systematic evaluations of these secondary benefits, which suggests that current estimates of the effectiveness of family treatments do not accurately represent the full scope of benefits to participants. In the present study, a three-level meta-analysis was used to (a) characterize the nature and quality of research on the secondary benefits of family-based treatments for childhood disorders, (b) synthesize the findings and estimate an overall effect size of family-based treatments on secondary benefits across 7 domains of childhood disorders, and (c) evaluate the influence of moderators (e.g., characteristics of participants, treatments, and methods) on secondary benefits. Results from 133 studies revealed multiple strengths in the research literature, including frequent use of standardized treatments, random assignment of participants to treatment conditions, and comparison of family-based treatments to usual services. The meta-analysis examined 422 effect sizes and showed that family-based treatments produced small but statistically significant secondary benefits (d = 0.25) relative to individually focused comparison conditions. In addition, moderator analyses revealed that the extent of secondary benefits was influenced by characteristics of the measures, with a smaller effect for measures when information was provided by male caregivers. The findings of this study have implications for administrators, policymakers, and treatment providers who make decisions about interventions that are delivered to families of children with a wide range of disorders.