scholarly journals Adherence to Mediterranean Style Dietary Pattern and Total Cancer Risk in the Framingham Offspring Cohort Study (P05-040-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ioanna Yiannakou ◽  
Martha Singer ◽  
Paul Jacques ◽  
Lynn Moore
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Dietary Pattern ◽  
Protective Effects ◽  
Men And Women ◽  
Beneficial Effects ◽  
Funding Sources ◽  
Total Cancer Risk ◽  
Total Cancer ◽  
Former Smokers

Abstract Objectives This study examines the prospective association between adherence to a Mediterranean style dietary pattern and cancer risk among men and women in the Framingham Offspring (FOS) cohort. Methods The Mediterranean style dietary pattern (MSDP) score was derived from a semi-quantitative food frequency questionnaire taken at examination visit 5 in the prospective FOS cohort. Subjects included 3199 participants (1703 women and 1496 men), aged 30 years old and older, who were free of prevalent cancer. The MSDP score was classified into tertiles and also dichotomized (MSDP score <22 vs. ≥22) used to evaluate the association between the MSDP and cancer risk through the ninth examination cycle. Cox proportional-hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for confounding by age, physical activity, body mass Index, and pack-years of cigarette smoking. Factors found not to confound the effects of the MSDP were excluded from final models. Results During a mean follow-up of approximately 11.5 years, 377 and 273 cancer cases were documented among men and women, respectively. Women in the upper two tertiles of the MSDP score had a 25–30% lower cancer risks than women in the lowest tertile [(HR: 0.70, 95% CI:0.52–0.96 (tertile 2); HR, 0.75; 95% CI:0.56–1.00 (tertile 3)]. Effects in men were weaker [HR: 0.94, 95% CI:0.74–1.21 (tertile 2); HR, 0.90; 95% CI:0.68–1.17(tertile 3)]. The protective effects of higher MSDP adherence were stronger among non-smokers and former smokers than among current smokers. Compared with current smokers with a MSDP score < 22, non-smokers and former smokers with higher MSDP scores had approximately 43% and 39% reductions in total cancer risk, respectively (HR: 0.57; 95% CI: 0.43–0.75 for non-smokers with high MSDP; HR: 0.61; 95% CI: 0.47–0.79 for former smokers with high MSDP scores).SDP scores). Conclusions In this large cohort study, higher adherence to MSDP was associated with reduced risk of total cancer, especially among women. Beneficial effects of the MSDP were also stronger among non-smokers and former smokers. Funding Sources N/A.

scholarly journals Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4064
Author(s):  
Ioanna Yiannakou ◽  
Martha R. Singer ◽  
Paul F. Jacques ◽  
Vanessa Xanthakis ◽  
R. Curtis Ellison ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Dietary Pattern ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Anthropometric Measures ◽  
Eating Pattern ◽  
Cox Models ◽  
Beneficial Effects ◽  
Total Cancer ◽  
Diet Pattern

A Mediterranean-style diet is a healthy eating pattern that may benefit cancer risk, but evidence among Americans is scarce. We examined the prospective association between adherence to such a diet pattern and total cancer risk. A Mediterranean-style dietary pattern (MSDP) score was derived from a semi-quantitative food frequency questionnaire at exam 5 (1991–1995). Subjects included 2966 participants of the Framingham Offspring Study who were free of prevalent cancer. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for demographic, lifestyle, and anthropometric measures. Cox-models were also used to examine effect modification by lifestyle and anthropometric measures. During 18 years of median follow-up, 259 women and 352 men were diagnosed with cancer. Women with moderate or higher adherence to the MSDP had ≥25% lower risks of cancer than women with the lowest MSDP (HR (moderate vs. lowest): 0.71, 95% CI: 0.52–0.97 and HR (highest vs. lowest): 0.74; 95% CI: 0.55–0.99). The association between MSDP score and cancer risk in men was weaker except in non-smokers. Beneficial effects of the MSDP in women were stronger among those who were not overweight. In this study, higher adherence to MSDP was associated with lower cancer risk, especially among women.

X-ray fluorescence spectrometric determination of heavy metals in selected rice samples sold on the Liberian market: a case study conducted in Paynesville City, Greater Monrovia

2020 ◽  
Vol 9 (3) ◽  
pp. 1
Author(s):  
McClain James ◽  
PAYE Plenseh Diana ◽  
N’debewillie Kokolo ◽  
CHEA Sampson K. P. ◽  
Kiazolu J. Boima
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Cancer Risk ◽  
Hazard Index ◽  
Rice Sample ◽  
X Ray ◽  
Total Cancer Risk ◽  
Total Cancer ◽  
Rice Consumption ◽  
The Mean

Background: Environmental pollution with toxic heavy metals can be lead to the possible contamination of rice. Rice is a staple food widely consumed in the urban and rural parts of Liberia daily. Rice is cultivated in approximately 113 countries and a fundamental source for energy and protein. Objective: The study assesses selected heavy metals (As, Pb, Cd, Se, and Cr) concentration in selected imported rice and traditionally grown rice and bulgur wheat in Liberia. Methods: Six grade of imported rice, Bulgar wheat, and traditionally grown rice were purchased from the Duport Road and Red-Light markets in Greater Monrovia and analyze using X-ray Fluorescence Spectrometer. All data were analyzed using XLSTAT, and data was used to calculate the risk factor of each rice sample. Results: The mean concentration of heavy metal found in the rice as follow: As, 1.31ppm; Cd, 9.42ppm; Cr. 12.3ppm; Se, 5.73ppm; and Pb, 1.75ppm. The estimated daily intakes (EDIs) were calculated in combination with the rice consumption data. The mean intakes of As, Cd, Cr, Se, and Pb through rice were estimated to be 1.32, 9.42. 12.4. 5.74, and 1.75 mg/kg BW/day. Chromium has the average estimated daily intake. The combined hazard index for the heavy metals in each sample and the total cancer risk for each sample contributed most significantly to a cancer risk of rice consumption during adult life expectancy.Conclusion: The selected heavy metal concentration from the rice sample was above the FAO/WHO reference Standard but was within the range of the contaminant level except for chromium, which is above the accepted range. However, the hazard index and the total cancer risk indicate a potential non-carcinogenic and carcinogenic risk.  

scholarly journals Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

2014 ◽  
Vol 500-501 ◽  
pp. 243-249 ◽  
Author(s):  
Juan P. Arrebola ◽  
Mariana F. Fernández ◽  
Piedad Martín-Olmedo ◽  
José Manuel Molina-Molina ◽  
María J. Sánchez-Pérez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cancer Risk ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Preliminary Data ◽  
Southern Spain ◽  
Tissue Concentrations ◽  
Total Cancer Risk ◽  
Total Cancer

scholarly journals Evaluation Based on Systematic Review of Epidemiological Evidence Among Japanese Populations: Tobacco Smoking and Total Cancer Risk

2005 ◽  
Vol 35 (7) ◽  
pp. 404-411 ◽  
Author(s):  
Manami Inoue ◽  
Ichiro Tsuji ◽  
Kenji Wakai ◽  
Chisato Nagata ◽  
Tetsuya Mizoue ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Risk ◽  
Tobacco Smoking ◽  
Epidemiological Evidence ◽  
Total Cancer Risk ◽  
Total Cancer

scholarly journals Dietary Purple Potato Supplementation Ameliorates Gut Inflammation and Associated Colitis

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 535-535
Author(s):  
Shima Bibi ◽  
Yansong Xue ◽  
Yang He ◽  
Min Du ◽  
Boon Chew ◽  
...  
Keyword(s):  
Control Diet ◽  
Goblet Cells ◽  
Protective Effects ◽  
Mice Model ◽  
Differentiation Markers ◽  
Beneficial Effects ◽  
Funding Sources ◽  
Epithelial Structure ◽  
Biochemical Analyses ◽  
Deficient Mice

Abstract Objectives The incidence of inflammatory bowel disease (IBD) is rapidly increasing worldwide. Patients with IBD experience increased susceptibility to colorectal cancer and are associated with morbidity and mortality. Diets are known factors associated with IBD. This study examined the beneficial effects of dietary purple potato against spontaneous colitis and improving gut microbiota in interleukin (IL)-10-deficient mice, a commonly used IBD mice model. Methods IL-10-deficient mice at 7-week-old were assigned to a standard rodent diet (CON) or a control diet supplemented with 10% purple potato (dry feed weight) for 11 weeks, when colonic tissues were collected for histological and biochemical analyses. Results Purple potato supplementation had no effect on feed intake and body weight in IL-10-deficient mice during the 11-week feeding trial. Purple potato supplementation improved the colitis symptom and the integrity of the colonic epithelial structure with reduced inflammation and pathological scores. Furthermore, the density of goblet cells and differentiation markers for goblet cells was enhanced due to PP supplementation. Conclusions Data collectively showed that dietary purple potato supplementation had protective effects against colitis onset in IL-10-deficient mice and improved gut epithelial structure, providing a promising dietary approach for the management and prevention of colitis. Funding Sources USDA-NIFA and Northwest Potato Research Consortium.

scholarly journals Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk

2011 ◽  
Vol 12 (8) ◽  
pp. 785-794 ◽  
Author(s):  
Jane Green ◽  
Benjamin J Cairns ◽  
Delphine Casabonne ◽  
F Lucy Wright ◽  
Gillian Reeves ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Cancer Incidence ◽  
Prospective Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Total Cancer Risk ◽  
Total Cancer

scholarly journals Total Carotenoid Intake Reduces the Odds of Frailty over 9 Years in Older Adults: Results from the Framingham Offspring Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 72-72
Author(s):  
Shivani Sahni ◽  
Paul Jacques ◽  
Alyssa Dufour ◽  
Courtney Millar ◽  
Douglas Kiel ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin C ◽  
Dietary Pattern ◽  
Antioxidant Vitamin ◽  
Total Carotenoid ◽  
Total Carotenoids ◽  
Older Americans ◽  
Men And Women ◽  
Funding Sources

Abstract Objectives Frailty occurs in 10–15% of community-living older adults. The benefit of a Mediterranean style diet in reducing frailty is not well established in older Americans. The aim was to determine the association of Mediterranean-Style Dietary Pattern and related antioxidants (vitamin C, E and total carotenoids from diet and supplements) with the odds of frailty over 9y in older adults from the Framingham Offspring study. Methods The Mediterranean-style dietary pattern score (MSDPS) was used to characterize a Mediterranean-style diet in 2541 men and women with completed food frequency questionnaires at baseline (1998–2001). Average intake of each antioxidant (vitamin C, E and total carotenoids, mg/d) at baseline and one prior exam (1995–98) was calculated. Total carotenoids were calculated as the sum of intake of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin. Frailty was assessed using Fried's frailty criteria at baseline and follow-up exam (2005–08). Participants categorized as frail at baseline were excluded (n = 27). Logistic regression was used to calculate odds ratios and 95% confidence intervals (95% CI) adjusting for age, sex, follow-up time, BMI, energy intake, current smoking and multivitamin use. Antioxidants were adjusted for each other in the same model. Results Mean age (±SD) was 60 ± 9y (range 33–86), 55% were female and mean follow-up time was 6.6y (range 3.7–9.1). Mean (±SD) was 45 ± 13 (range: 10.8–84.1) for the MSDPS, 36.5 (±32.3) mg/d for vitamin C, 16.4 (±199) mg/d for vitamin E and 1.8 (±0.8) mg/d for carotenoids. Prevalent frailty at follow-up exam was 5%. Although not significant, a 10 unit increase in MSDPS reduced the odds of frailty by 8.7% (95% CI: 0.78–1.08, P = 0.28) in the combined sample of men and women. Each 10 mg increase in total carotenoid intake reduced the odds of frailty by 29% (95% CI: 0.53–1.01, P = 0.02). Neither Vitamin C (P = 0.79) or E (P = 0.25) were individually associated with frailty. Conclusions A Mediterranean style diet was not significantly associated with frailty in this sample of largely older adults. However, total carotenoids intake reduced the odds of frailty. Future work should consider if a Mediterranean style diet and related antioxidants delay the progression of frailty. Funding Sources Boston Claude D. Pepper Center OAIC and Peter and Barbara Sidel Fund.

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