scholarly journals Dietary Iron Intake Does Not Predict Anemia, Iron Deficiency or Iron Deficiency Anemia Among 12-month Old Rwandan Children (P10-124-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Eric Matsiko ◽  
Alida Melse-Boonstra ◽  
Lisine Tuyisenge ◽  
Edith J M Feskens
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Post Partum ◽  
Sandwich Elisa ◽  
Hemoglobin Concentration ◽  
Rural Setting ◽  
Deficiency Anemia ◽  
Dietary Iron ◽  
Iron Intake ◽  
Cox Proportional Hazard Regression

Abstract Objectives In Rwanda, anemia affects 38% of all under five and 61% of those aged 9–11 months old; however, the contribution of diet to anemia remains less known. This study aimed to assess if dietary iron intake predicts the risk of anemia and iron deficiency among Rwandan children of 12 months old. Methods A longitudinal study of 192 children was conducted in 2016–2018 in a rural setting in Rwanda. We measured hemoglobin concentration, and collected blood samples from the infant-mother pairs at birth, 4 and 12 months post-partum. Plasma or serum ferritin, soluble transferrin receptors (sTfR), C-reactive protein (CRP), and α-Acid Glycoprotein (AGP) concentrations were measured using sandwich ELISA technique. Body iron stores were calculated from the sTfR/Ferritin ratio. Hemoglobin and ferritin values were adjusted for altitude and infection, respectively. Dietary iron intake data were collected using a full 24-hour recall, and the intake of iron from micronutrient powders was captured by questionnaire. Predictors of anemia, iron deficiency, and iron deficiency anemia at 12 months of age were modelled using Cox proportional hazard regression with robust variance. Results Anemia, iron deficiency (ID), and iron deficiency anemia (IDA) occurred in 73%, 56%, and 44% of the infants at 4 months, and 48%, 88% and 45% of the children at 12 months, respectively. For their mothers, anemia, ID, and IDA occurred in 12%, 59%, and 9% at 4 months, and 12%, 49%, and 8% at 12 months. Child's dietary iron intake did not significantly predict anemia [PR = 1.00 (0.96–1.04)], ID [PR = 0.99 (0.98–1.01)], or IDA [PR = 0.99 (0.95–1.03)] at 12 months. However, this study revealed that the child's hemoglobin concentration at birth was inversely associated with anemia at 12 months [PR = 0.92 (0.86–0.99)], whereas inflammation [PR = 1.23 (1.03–1.46)] and IDA at 4 months [PR = 1.44 (1.04–1.99)] increased the risk of anemia at 12 months. Presence of inflammation additionally predicted risk of IDA at 12 months [PR = 1.27 (1.05–1.54)]. Conclusions While dietary iron intake is not a significant predictor of anemia, 94% of anemia cases coincide with ID at 12 months of age. In addition, inflammation is the most important predictor of anemia and IDA at this age. Therefore, prevention of inflammation is crucial to make dietary measures effective. Funding Sources Embassy of the Kingdom of the Netherlands in Rwanda; UNICEF Rwanda; Nuffic.

IRON-FORTIFIED FORMULAS

PEDIATRICS ◽  
1971 ◽  
Vol 47 (4) ◽  
pp. 786-786
Author(s):  
L. J. Filer ◽  
Lewis A. Barness ◽  
Richard B. Goldbloom ◽  
Malcolm A. Holliday ◽  
Robert W. Miller ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Dietary Iron ◽  
Iron Intake ◽  
Feeding Problems ◽  
Whole Milk ◽  
Dietary Component ◽  
Recent Statement ◽  
Marketing Information

In its recent statement on iron,1 the Committee on Nutrition emphasized the value of iron-fortified, proprietary milk formulas for the prevention of iron-deficiency anemia of infancy. Despite this recommendation, the most recent marketing information available to the Committee shows that more than 70% of the proprietary formulas currently prescribed by physicians do not contain added iron. The reasons for continuing routine use of formulas not fortified with iron are not entirely clear. One reason may be that some physicians still believe iron additives increase the incidence of feeding problems or gastrointestinal disturbances. There is no documented evidence that this is a significant problem. The Committee strongly recommends when proprietary formulas are prescribed that iron-supplemented formulas be used routinely as the standard–that is, that this be the rule rather than the exception. There seems to be little justification for continued general use of proprietary formulas not fortified with iron. The Committee is fully aware that only a small percentage of American infants are fed proprietary formulas after 6 months of age. Fluid whole milk (available in bottle or carton ) or evaporated milk, both of which contain only trace amounts of iron, are substituted at the time of greatest iron need and highest prevalence of iron-deficiency anemia. The infant's diet is usually deficient in iron, unless other foods are carefully selected to insure adequate iron intake. Since the major dietary component during infancy is milk, two courses of action should be taken: (1) Pediatricians and other health professionals should engage in a program of public education to convince American mothers to provide their infants with a source of dietary iron.

scholarly journals Iron intake and its association with iron-deficiency anemia in agricultural workers' families from the Zona da Mata of Pernambuco, Brazil

2014 ◽  
Vol 27 (2) ◽  
pp. 217-227 ◽  
Author(s):  
Débora Silva Cavalcanti ◽  
Priscila Nunes De Vasconcelos ◽  
Vanessa Messias Muniz ◽  
Natália Fernandes Dos Santos ◽  
Mônica Maria Osório
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Bioavailability ◽  
Agricultural Workers ◽  
Deficiency Anemia ◽  
Dietary Iron ◽  
Iron Intake ◽  
Study Population ◽  
Iron Heme ◽  
Prevalence Of Anemia

OBJECTIVE: To verify the association between dietary iron intake and the occurrence of iron-deficiency anemia in agricultural workers' families from the municipality of Gameleira in the state of Pernambuco, Brazil. METHODS: The study population consisted of 46 harvesters' families, consisting of 225 individuals. The food intake of each individual was recorded on three different days by directly weighing the foods consumed. Hemoglobin was determined by fingerstick (HemoCue). This research used the probability of adequacy method to assess iron intake and the paired t test for comparing groups. The Spearman Mann-Whitney test estimated associations between the dietary variables and anemia. RESULTS: The prevalence of anemia was high in all ages groups and highest (67.6%) in children aged <5 years with a mean hemoglobin of 10.37 g/dL (±1.30 g/dL). Children aged <5 years had low percentage of iron intake adequacy (53.1%). Most of them consumed diets with low iron bioavailability (47.5%). Associations between the occurrence of anemia and dietary variables were significant for total iron (heme and nonheme), its bioavailabilities, and general meat intake. CONCLUSION: Inadequate dietary iron intake and inadequate intake of factors that facilitate iron absorption can be considered decisive for the occurrence of iron-deficiency anemia. Food insecurity occurs between family members, with some members being favored over others with regard to the intake of good dietary iron sources.

scholarly journals Anemia in pregnancy: cliniсо-pathogenetic approaches to the management of pregnancy

2017 ◽  
Vol 66 (5) ◽  
pp. 56-63
Author(s):  
Anna S. Atajanyan
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Postpartum Period ◽  
Review Article ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Iron Intake ◽  
Anemia In Pregnancy ◽  
In Pregnancy

The review article defines iron deficiency anemia, the mechanisms determining iron deficiency in pregnancy, the complications of pregnancy, childbirth and the postpartum period, the methods of correction and prevention of iron deficiency, including a modern alternative to oral iron intake-its intravenous forms, which contribute to a rapid increase of iron levels. And also do not have toxicity and are easily tolerated.

scholarly journals Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

2018 ◽  
Vol 15 (10) ◽  
pp. 2156 ◽  
Author(s):  
Joanna Gajewska ◽  
Jadwiga Ambroszkiewicz ◽  
Witold Klemarczyk ◽  
Ewa Głąb-Jabłońska ◽  
Halina Weker ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Status ◽  
Hematological Parameters ◽  
Daily Intake ◽  
Normal Weight ◽  
Deficiency Anemia ◽  
Dietary Iron ◽  
Iron Intake ◽  
Obese Children ◽  
Iron Concentrations

Iron metabolism may be disrupted in obesity, therefore, the present study assessed the iron status, especially ferroportin and hepcidin concentrations, as well as associations between the ferroportin-hepcidin axis and other iron markers in prepubertal obese children. The following were determined: serum ferroportin, hepcidin, ferritin, soluble transferrin receptor (sTfR), iron concentrations and values of hematological parameters as well as the daily dietary intake in 40 obese and 40 normal-weight children. The ferroportin/hepcidin and ferritin/hepcidin ratios were almost two-fold lower in obese children (p = 0.001; p = 0.026, respectively). Similar iron concentrations (13.2 vs. 15.2 µmol/L, p = 0.324), the sTfR/ferritin index (0.033 vs. 0.041, p = 0.384) and values of hematological parameters were found in obese and control groups, respectively. Iron daily intake in the obese children examined was consistent with recommendations. In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024). In the multivariate regression model an association between the ferroportin/hepcidin ratio and the sTfR/ferritin index in obese children (β = 0.399, p = 0.017) was found. These associations did not exist in the controls. The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia. The role of other micronutrients, besides dietary iron, may also be considered in the iron status of these children.

scholarly journals Towel curettage for a new definition of postpartum period after cesarean section

2018 ◽  
Vol 7 (7) ◽  
pp. 2537
Author(s):  
Suzan Elsharkawy
Keyword(s):  
Iron Deficiency ◽  
Caesarean Section ◽  
Blood Loss ◽  
Iron Deficiency Anemia ◽  
Postpartum Period ◽  
Post Partum ◽  
Controlled Trial ◽  
Maternity Hospital ◽  
Deficiency Anemia ◽  
Group B

Background: The objective of the present study was to compare effect of towel curettage as a new technique, to no curettage in caesarean section on postpartum period duration and hemoglobin level.Methods: Prospective, randomized controlled trial included 403 eligible participants that were attending Elshatby maternity hospital in the duration of this study (2016) and scheduled for primary caesarean section. The patients were randomized into two groups A and B. Group A had towel curettage after manual separation of the placenta, where the decidua and the placental bed were thoroughly curetted by a surgical towel. Group B had manual separation of placenta only.Results: Towel curettage actually shortens the puerperal bleeding days by almost a week and the volume of blood loss by around half a gram/dl, a situation that could be of great concern in the developing countries where iron deficiency anemia can be considered endemic.Conclusions: Suzan towel curettage is a new, simple, cheap methods that deceases duration of puerperium and the amount of useless blood loss post-partum, which may save a good percentage of women from suffering the negative influences of iron deficiency anemia.

The association between iron deficiency anemia and febrile seizure

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Parviz Karimi ◽  
Koroush Sayehmiri ◽  
Milad Azami ◽  
Zeinab Tardeh
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Mean Corpuscular Hemoglobin ◽  
Protective Effects ◽  
Corpuscular Hemoglobin

Abstract Objective Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. Patients and methods This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. Results A total of 34.6% in the FS group, 66.7% in the afebrile seizure group and 41.2% in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 [95% confidence interval (CI) = 0.34–1.68; p = 0.493] and that for FS compared to seizure was 0.265 (95% CI = 0.085–0.823; p = 0.022). Conclusions This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended.

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