scholarly journals Molecular Markers of Dietary Essential Amino Acid-deficiency (P08-059-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Joanna Moro ◽  
Nadezda Khodorova ◽  
Catherine Chaumontet ◽  
Patrick Even ◽  
Anne Blais ◽  
...  
Keyword(s):  
Body Weight ◽  
Molecular Markers ◽  
Lipid Metabolism ◽  
Protein Metabolism ◽  
Essential Amino Acid ◽  
Body Weight Gain ◽  
Mineral Density ◽  
Protein Sources ◽  
Growing Rats

Abstract Objectives The quality of dietary protein sources became a particularly sensitive issue in the current debates on a rebalancing between animal and vegetable food sources. The ability of a protein to meet the nutritional requirements of essential amino acid (EAA) is the basis for assessing the quality of protein. The objective of this study was to characterize the impact of lysine- and threonine-deficient gluten-based diets on the metabolism of growing rats and to identify molecular markers of these diets. Methods Growing rats were fed for 3 weeks with a threonine-supplemented and 70% lysine-deficient gluten diet; a lysine-supplemented and 47% threonine-deficient gluten diet; a gluten diet supplemented in lysine and threonine to meet all the AA requirements, and a control diet with milk protein to meet all the AA requirements. Body weight and food intake were measured daily. At the end of the experiment, tissues and biological fluids were removed. The body composition was analyzed, gene expression measurements involved in protein and lipid metabolism were performed and the urinary metabolome was analyzed by LC-MS. Statistical analysis was done by variance analysis and metabolome analysis by discriminant analysis of independent components. Results These EAA deficiency does not modify the food intake. Lysine deficiency induces a decrease in body weight gain, and lean body mass, associated with an increased in proteolysis and a decreased in proteosynthesis, a decreased in bone mineral density, and no effect on lipid metabolism. Threonine deficiency induces a decrease in body weight gain, and liver and skin weight, without changes in protein metabolism, bone mineral density, and lipid metabolism. After approval of the deficiency model, the metabolomic analysis performed on urine samples revealed the presence of specific discriminating molecules of the diets and types of proteins. Conclusions EAA deficiency has an impact on the growth, and bone and protein metabolism of growing rats. These deficiency states have resulted in different metabolome profiles that could lead to the identification of specific molecular markers of protein sources and related to EAA deficiencies. Funding Sources This study was funded by the UMR Nutrition Physiology and Ingestive Behavior. Supporting Tables, Images and/or Graphs

scholarly journals Molecular markers of dietary essential amino acid-deficiency

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Joanna Moro ◽  
Nadezda Khodorova ◽  
Catherine Chaumontet ◽  
Patrick Even ◽  
Anne Blais ◽  
...  
Keyword(s):  
Body Weight ◽  
Molecular Markers ◽  
Lipid Metabolism ◽  
Protein Metabolism ◽  
Essential Amino Acid ◽  
Body Weight Gain ◽  
Mineral Density ◽  
Protein Sources ◽  
Growing Rats

AbstractIntroduction:The quality of dietary protein sources became a particularly sensitive issue in the current debates on a rebalancing between animal and vegetable food sources.The ability of a protein to meet the nutritional requirements of essential amino acid (EAA) is the basis for assessing the quality of protein.The objective of this study was to characterize the impact of lysine- and threonine-deficient gluten-based diets on the metabolism of growing rats and to identify molecular markers of these diets.Materials and Methods:Growing rats were fed for 3 weeks with a threonine-supplemented and 70% lysine-deficient gluten diet; a lysine-supplemented and 47% threonine-deficient gluten diet; a gluten diet supplemented in lysine and threonine to meet all the AA requirements, and a control diet with milk protein to meet all the AA requirements.Body weight and food intake were measured daily. At the end of the experiment, tissues and biological fluids were removed. The body composition was analyzed, gene expression measurements involved in protein and lipid metabolism were performed and the urinary metabolome was analyzed by LC-MS. Statistical analysis was done by variance analysis and metabolome analysis by discriminant analysis of independent components.Results:This EAA deficiency does not modify the food intake. Lysine deficiency induces a decrease in body weight gain, and lean body mass, associated with an increased in proteolysis and a decreased in proteosynthesis, a decreased in bone mineral density, and no effect on lipid metabolism.Threonine deficiency induces a decrease in body weight gain, and liver and skin weight, without changes in protein metabolism, bone mineral density, and lipid metabolism. After approval of the deficiency model, the metabolomic analysis performed on urine samples revealed the presence of specific discriminating molecules of the diets and types of proteins.Discussion:EAA deficiency has an impact on the growth, and bone and protein metabolism of growing rats. These deficiency states have resulted in different metabolome profiles that could lead to the identification of specific molecular markers of protein sources and related to EAA deficiencies.

scholarly journals Dietary Fish Oil Upregulates Intestinal Lipid Metabolism and Reduces Body Weight Gain in C57BL/6J Mice

2007 ◽  
Vol 137 (12) ◽  
pp. 2629-2634 ◽  
Author(s):  
Takuya Mori ◽  
Hidehiko Kondo ◽  
Tadashi Hase ◽  
Ichiro Tokimitsu ◽  
Takatoshi Murase
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Weight Gain ◽  
Fish Oil ◽  
Body Weight Gain ◽  
Dietary Fish

SF-36 quality of life questionaire evaluation in a large cohort of women with breast cancer treated with hormonotherapy

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19657-19657
Author(s):  
E. L. Morgenfeld ◽  
B. Rolnik ◽  
L. Cassab ◽  
D. Gercovich ◽  
F. Negro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Body Weight ◽  
Body Weight Gain ◽  
Short Form ◽  
Well Being ◽  
Menopausal Symptoms ◽  
Functional Health ◽  
Sf 36

19657 Background: Hormonotherapy (H) is the most widely used treatment against breast cancer (BC). The aim of this study is a prospective evaluation with an enriched the SF-36 questionnaire, of the QOL of BC patients (pt) treated with H at the IOHM. Specific questions regarding menopausal symptoms and body weight were added. Methods: Between Aug 2005 and Nov 2006, all pt that were undergoing H, were requested to fill out a SF-36 self-evaluation form. The SF-36 is a multi-purpose, short-form health survey, with 36 questions about functional health and well-being. The answers were tabulated. The pre-treatment and post-treatment body weight of each pt was registered. Results: Three Hundred and Twenty-six pt were invited to participate, and all of them accepted, and signed a consent form. Characteristics of the population: Diagnosis: DCIS: 36 pt; LCIS: 5 pt; IDC 250 pt; ILC: 35 pt. All cases expressed hormonal receptors. The H was adjuvant in 254 pt (78%) mostly treated with T and palliative in 72 pt (22%) mostly treated with AI. Median age was 62 years, however 63 pt (19%) were pre-menopausal. The median time under treatment was 33 months (range 1–71 m). The pt reported: General evaluation of Quality of life: Very good or excellent: 154 pt (47%) , Good: 134 pt (41%), Poor: 34 pt (11%). Severe limitations for demanding physical activities: 43 pt (13 %). A reduction of time spent on the job: 66 pt (22%). Severe pain during the last four weeks prior to answering the questionnaire: 24 pt (8 %). Weight increase perception: 153 pt (47%). Actual increase of weight: 192 pt (60%) (Median: 4 kg). Menopausal symptoms: Daily Hot Flushes: 132 pt (40%). Vaginal discharge 110 pt (33%) Decrease of libido: 98 pt (30%), Vaginal dryness 76 pt (23%), Nightly sweats: 40 pt (12%). Sixty pt (18%) suffered from and received treatment for menopausal symptoms. Conclusions: 1) The SF-36 is a useful tool to measure the BC patients’ quality of life 2) Although in our cohort most of the patients (88,3%) rated their general QOL as “good to very good”, a third of the pt presented severe menopausal symptoms, and 18% received non hormonal medication for symptoms relief 3) Sixty percent of the pt had a median body weight gain of 4 Kg. No significant financial relationships to disclose.

Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats

2012 ◽  
Vol 519 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Xiaojie Hu ◽  
Yanmei Li ◽  
Chunhua Li ◽  
Yuanqing Fu ◽  
Fang Cai ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Weight Gain ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
High Fat ◽  
Obese Rats

ADMINISTRATION OF ANTERIOR PITUITARY GROWTH HORMONE TO RATS DURING COLD EXPOSURE

1963 ◽  
Vol 41 (1) ◽  
pp. 1449-1453
Author(s):  
John R. Beaton ◽  
T. Orme ◽  
J. Laufer ◽  
A. Turner
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Weight Gain ◽  
Cold Exposure ◽  
Anterior Pituitary ◽  
Body Weight Gain ◽  
Nitrogen Retention ◽  
Growing Rats ◽  
Pituitary Growth Hormone ◽  
Environmental Temperatures

Male, growing rats were injected daily with anterior pituitary growth hormone (3 mg/100 g body weight) and fed ad libitum for 7 days at environmental temperatures of 22 °C and 2–3 °C. Body weight gain, nitrogen retention, and four liver enzyme activities were measured. As observed previously, cold exposure retarded body weight gain and decreased nitrogen retention despite an increased food intake. These effects of cold were not eliminated by administration of growth hormone. The increased activities of liver arginase, alanine-glutamic transminase, and phosphate-activated glutaminase consequent upon cold exposure were not significantly affected by growth hormone although, at 22 °C, growth hormone decreased the activities of liver arginase and alanine-glutamic transaminase. Cold exposure eliminated the lowering effect of growth hormone on liver glutamic acid dehydrogenase activity observed at 22 °C. It is concluded that, under these conditions, growth hormone does not overcome the protein catabolic effects of cold exposure but rather, cold exposure eliminates the protein anabolic effects of the hormone.

Whey peptides exacerbate body weight gain and perturb systemic glucose and tissue lipid metabolism in male high-fat fed mice

2021 ◽  
Author(s):  
Kenneth D'Souza ◽  
Caleb Acquah ◽  
Angella Mercer ◽  
Yadab Paudel ◽  
Thomas Pulinilkunnil ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Whey Proteins ◽  
Tissue Lipid ◽  
High Fat

Consumption of milk-derived whey proteins has been demonstrated to have insulin-sensitizing effects in mice and humans, in part through the generation of bioactive whey peptides. While whey peptides can prevent...

scholarly journals L‐citrulline inhibits body weight gain and hepatic fat accumulation by improving lipid metabolism in a rat nonalcoholic fatty liver disease model

2021 ◽  
Author(s):  
Maya Kudo ◽  
Yoshie Yamagishi ◽  
Shiori Suguro ◽  
Masaaki Nishihara ◽  
Hisae Yoshitomi ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Weight Gain ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Body Weight Gain ◽  
Disease Model ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat

scholarly journals Optimization of lambs feeding in hilly-mountainous region of Serbia

2004 ◽  
Vol 20 (1-2) ◽  
pp. 89-92 ◽  
Author(s):  
Ratimir Cmiljanic ◽  
Miroslav Zujovic ◽  
Zlatica Pavlovski ◽  
Snezana Trenkovski
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Meat Quality ◽  
Diet Composition ◽  
Body Weight Gain ◽  
The Body ◽  
Mountainous Region ◽  
Feed Conversion ◽  
Feeding Systems

The paper gives review on more recent research into the influence of nutrition on production results in fattening lambs. The results regarding the influence of feeding systems and diet composition on body weight gain feed conversion and meat quality in fattening lambs are given. Obtained results show that with suitable feeding system the body weight gain and feed conversion can be increased by 19-21% and 10-17% respectively. Besides, in this way the quality of lamb meat can be improved as well. The research showed that in hilly-mountainous region of Serbia, with 90 day old lambs on proper nutrition system the lambs of body mass of 23,0-25,0 kg with excellent meat quality can be produced.

scholarly journals Effect of supplemental Mn, Zn, Fe and Cu and their interactions on the performance of broiler chickens

2020 ◽  
Vol 3 (3) ◽  
pp. 29-33
Author(s):  
M. Holubiev ◽  
T. Holubieva ◽  
M. Sychov
Keyword(s):  
Body Weight ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Statistical Processing ◽  
Essential Elements ◽  
Control Group ◽  
Manganese Zinc ◽  
Feed Costs ◽  
Mixed Feeds

Based on the results of the analysis of feed materials on the content of micronutrient elements and conducting scientific experiments on broilers chicken, the most effective source of Manganese, Zinc, Iron and Copper in mixed feeds, which contributes to solving the problem of increasing the quality of feeding and intensifying the growth of poultry has been substantiated. The optimum source of essential elements (Mn, Zn, Fe, Cu) for broilers chicken through feeds, the level of their incorporation into mixed fodders have been experimentally determined, and their influence on productivity and feed costs per 1 kg of body weight gain have been investigated. The tasks set in the work have been solved experimentally using analytical (analysis of literature sources), zoo-technical (growth indices, feed intake) and statistical (processing of the results obtained) methods of research. The use of mixed feeds in feeding broilers chicken which contained glycinate of Manganese, Zinc, Iron and Copper making 75 % of the needs, contributes to increasing their body weight by 2.5 % and increasing the growth rate by 2.4 %. Feed costs per 1 kg of broilers chicken growth were 1.5 % lower than the young bird index of the control group.

scholarly journals PEMANFAATAN KULITUBIKAYUFERMENTASIDENGAN METODETAKAKURADALAMPAKANTERHADAP PERTUMBUHANKELINCINEWZEALANDWHITE JANTANLEPASSAPIH

2017 ◽  
Author(s):  
Hasnudi
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
New Zealand ◽  
Body Weight Gain ◽  
Zealand White Rabbit ◽  
New Zealand White Rabbit ◽  
Randomized Design ◽  
Completely Randomized Design ◽  
Cassava Peel

Fermented cassava peel with takakura method can increase the protein content of feed for improving the quality of feed. This study aims to determine the effect of fermented cassava peel fermented with takakura method in feed on the growth of weaning New Zealand white rabbit. The experiment was conducted in the Laboratory of Animal Biology, Faculty of Agriculture, University of Sumatera Utara. The research carried out for 2 months started from September to November 2012. The research design was used in this study was completely randomized design (CRD) with 4 treatments and 5 replications. Treatments consist of P0 (0% fermented cassava peel), P1(10% fermented cassava peel), P2(20% fermented cassava peel) and P3(30% fermented cassava peel).The results showed that administration of a variety of fermented cassava peel levels of takakura method were significantly different (P<0.01) on consumption, body weight gain, and feedcefficiency.Itisconcludedthatfermentedcassavapeelcan’tbeusedasfeedofNewZealandWhiteRabbit

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