scholarly journals Olfactory Adaptation is Dependent on Route of Delivery

2018 ◽  
Vol 43 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Alex M Pierce ◽  
Christopher T Simons
Keyword(s):  
Olfactory Adaptation ◽  
Route Of Delivery

scholarly journals Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Youdong Pan ◽  
Luzheng Liu ◽  
Tian Tian ◽  
Jingxia Zhao ◽  
Chang Ook Park ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Vectors ◽  
Effector T Cells ◽  
T Cell Immunity ◽  
Smallpox Vaccine ◽  
Respiratory Pathogens ◽  
Cell Immunity ◽  
Respiratory Challenge ◽  
Respiratory Droplets ◽  
Route Of Delivery

AbstractModified Vaccinia Ankara (MVA) was recently approved as a smallpox vaccine. Variola is transmitted by respiratory droplets and MVA immunization by skin scarification (s.s.) protected mice far more effectively against lethal respiratory challenge with vaccinia virus (VACV) than any other route of delivery, and at lower doses. Comparisons of s.s. with intradermal, subcutaneous, or intramuscular routes showed that MVAOVA s.s.-generated T cells were both more abundant and transcriptionally unique. MVAOVA s.s. produced greater numbers of lung Ova-specific CD8+ TRM and was superior in protecting mice against lethal VACVOVA respiratory challenge. Nearly as many lung TRM were generated with MVAOVA s.s. immunization compared to intra-tracheal immunization with MVAOVA and both routes vaccination protected mice against lethal pulmonary challenge with VACVOVA. Strikingly, MVAOVA s.s.-generated effector T cells exhibited overlapping gene transcriptional profiles to those generated via intra-tracheal immunization. Overall, our data suggest that heterologous MVA vectors immunized via s.s. are uniquely well-suited as vaccine vectors for respiratory pathogens, which may be relevant to COVID-19. In addition, MVA delivered via s.s. could represent a more effective dose-sparing smallpox vaccine.

scholarly journals 317 Type 2 diabetes and neonatal hypoglycemia: role of route of delivery and insulin infusion

2021 ◽  
Vol 224 (2) ◽  
pp. S208-S209
Author(s):  
Michal Fishel Bartal ◽  
Mesk Alrais ◽  
Joycelyn A. Cornthwaite ◽  
Han-Yang Chen ◽  
Suneet P. Chauhan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Infusion ◽  
Neonatal Hypoglycemia ◽  
Route Of Delivery

scholarly journals Odor response adaptation in Drosophila—a continuous individualization process

2021 ◽  
Vol 383 (1) ◽  
pp. 143-148
Author(s):  
Shadi Jafari ◽  
Mattias Alenius
Keyword(s):  
Sensory Neurons ◽  
Olfactory System ◽  
Multiple Time Scales ◽  
Multiple Time ◽  
Olfactory Perception ◽  
Adaptation Mechanisms ◽  
Metabolic States ◽  
The Central Nervous System ◽  
Olfactory Adaptation ◽  
Central Adaptation

AbstractOlfactory perception is very individualized in humans and also in Drosophila. The process that individualize olfaction is adaptation that across multiple time scales and mechanisms shape perception and olfactory-guided behaviors. Olfactory adaptation occurs both in the central nervous system and in the periphery. Central adaptation occurs at the level of the circuits that process olfactory inputs from the periphery where it can integrate inputs from other senses, metabolic states, and stress. We will here focus on the periphery and how the fast, slow, and persistent (lifelong) adaptation mechanisms in the olfactory sensory neurons individualize the Drosophila olfactory system.

scholarly journals Complications and Route of Delivery in a Large Cohort Study of HIV-1–Infected Women—IMPAACT P1025

2016 ◽  
Vol 73 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Elizabeth G. Livingston ◽  
Yanling Huo ◽  
Kunjal Patel ◽  
Ruth E. Tuomala ◽  
Gwendolyn B. Scott ◽  
...  
Keyword(s):  
Cohort Study ◽  
Large Cohort ◽  
Large Cohort Study ◽  
Route Of Delivery ◽  
Hiv 1

Cisterna Magna Administration: A Robust Alternative Non-Systemic Route of Delivery for New Drug Entities in Non-Human Primates

2021 ◽  
Vol 350 ◽  
pp. S226
Author(s):  
A. Dütting ◽  
T. Voß ◽  
F. Runge ◽  
J. Luft ◽  
B. Pajaziti ◽  
...  
Keyword(s):  
Cisterna Magna ◽  
New Drug ◽  
Route Of Delivery

Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model

2018 ◽  
Vol 5 (2) ◽  
pp. 281-291 ◽  
Author(s):  
Daniel L. Clemens ◽  
Bai-Yu Lee ◽  
Sheba Plamthottam ◽  
Michael V. Tullius ◽  
Ruining Wang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Intramuscular Route ◽  
Nanoparticle Formulation ◽  
Route Of Delivery

scholarly journals Effect of an Accompanying Midwife on Maternal Resilience and Preferred Route of Delivery in Pregnant Women

2019 ◽  
Vol 3 (4) ◽  
pp. 7-12
Author(s):  
Anahita Khodabakhshi-koolaee ◽  
Fariba Rooshani Koosha ◽  
Leili Mosalanejad ◽  
◽  
◽  
...  
Keyword(s):  
Pregnant Women ◽  
Route Of Delivery

scholarly journals A Systematic Review on Drug Delivery Systems Based on Their Mechanism of Drug Release and Their Applications

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Amit Prakash ◽  
Amit Prakash
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Cost Effective ◽  
Delivery Systems ◽  
Oral Drug ◽  
Effective Delivery ◽  
Route Of Delivery

Oral drug delivery is the most commonly used and preferred route of delivery of pharmaceuticals which has been successfully treating wide number of diseases. The advantages of this method of delivery are patient friendly, cost effective, established delivery system, noninvasiveness and convenient, and In the pharmaceutical field it is the most favored drug delivery system. Oral drug delivery systems along with other effective delivery system types that are effective and promising are discussed in this paper based on the mechanism of drug release.

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