scholarly journals Early growth and carotid intima-media thickness at midlife: Northern Finland 1966 Birth Cohort study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
N Korpela ◽  
K Kaikkonen ◽  
J Auvinen ◽  
M.P Tulppo ◽  
J Junttila ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cardiovascular Diseases ◽  
Gestational Age ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Early Growth ◽  
Height Velocity ◽  
Funding Source ◽  
Peak Weight ◽  
Cardiometabolic Factors

Abstract Background Carotid intima-media thickness (CIMT) reflects atherogenesis and is a strong predictor of cardiovascular diseases. Although cardiovascular diseases have been shown to originate in foetal life and childhood, the information on the contribution of early growth to CIMT in adulthood remains limited. Purpose To assess the influence of early growth patterns on CIMT in midlife. Methods A subpopulation of the Northern Finland Birth Cohort 1966 took part in follow-up, including CIMT evaluation by ultrasound (n=1155) at the age of 46 years. Maternal pre-pregnancy body mass index (BMI) was self-reported and birth weight and gestational age were measured after delivery. BMI growth curves were modelled based on frequent anthropometric measurements in infancy and childhood. Peak weight and height velocity in infancy (0–2 years of age, n=637) as well as age and BMI at adiposity peak (AP, mean age 9 months, n=461) and at adiposity rebound (AR, mean age 5.8 years, n=562) were established. Results are reported as unstandardized beta (β) with 95% confidence intervals for one standard deviation increase in early growth variable. Associations were adjusted for sex, birth weight, maternal pre-pregnancy BMI as well as adult weight, height, systolic blood pressure, low-density lipoprotein cholesterol, physical activity, diabetes, heart diseases and antihypertensive medication. Results Infant peak weight velocity (β=0.018 (0.011, 0.025), p<0.001) was associated with a higher CIMT in midlife, independently of adjustments for sex, early life factors and adult cardiometabolic factors (β=0.011 (0.003, 0.019), p=0.010). Infant peak height velocity was also associated with adult CIMT, but only in females (β=0.012 (0.004, 0.021), p=0.004) and the association was attenuated after adjustments (β=0.010 (0.0, 0.021), p=0.055). Birth weight and gestational age were not associated with adult CIMT. BMI at AP (β=0.011 (0.003, 0.019), p=0.007) and BMI at AR (β=0.010 (0.003, 0.018), p=0.005) were directly associated with CIMT in midlife in univariate analysis, but not independently of adult cardiometabolic factors. Timing of AP and AR were not related to adult CIMT. Finally, maternal pre-pregnancy BMI (β=0.005 (0.0, 0.011), p=0.066) also tended to be associated with a higher CIMT in midlife. Conclusions Rapid growth in infancy was the most important early growth-related factor associating with CIMT in midlife, and this relationship was not fully mediated by adult anthropometrics, cardiometabolic risk factors and morbidity. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Yrjö Jahnsson Foundation, Aarne Koskelo Foundation

Apolipoprotein(a), Fibrinopeptide A and Carotid Atherosclerosis in Middle-Aged Men

1994 ◽  
Vol 72 (04) ◽  
pp. 563-566 ◽  
Author(s):  
Tuomo Rankinen ◽  
Sari Väisänen ◽  
Michele Mercuri ◽  
Rainer Rauramaa
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Fibrinopeptide A ◽  
Carotid Imt ◽  
Apolipoprotein A ◽  
The Difference

SummaryThe association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% Cl 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% Cl 1.73; 2.09)] apo(a) quartile. The difference remained (p=0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.

scholarly journals PERCENTILE DISTRIBUTION OF CAROTID INTIMA-MEDIA THICKNESS IN THE GENERAL WORKING-AGE POPULATION

2019 ◽  
Vol 34 (1) ◽  
pp. 145-151
Author(s):  
Kaveshnikov Kaveshnikov ◽  
V. N. Serebryakova ◽  
I. A. Trubacheva
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Informed Consent Form ◽  
Gender And Age ◽  
Working Age ◽  
The Mean ◽  
Working Age Population

Objective.To study the gender- and age-specific percentile distribution of carotid intima-media thickness (cIMT) in the unorganized urban working-age population.Material and Methods. Presented data were obtained in the ESSE-RF study in the city of Tomsk (1,412 participants, 25–64 years old without cardiovascular diseases, 59% women). All the surveyed signed voluntary informed consent form to participate in the study. We studied distributions of the mean and maximum cIMT obtained by the automatic and manual measurements, respectively. An error probability of less than 5% was considered statistically significant.Results. Both indicators of cIMT consistently increased with age in both gender groups. Maximum cIMT (max-cIMT) increased stronger than the mean cIMT (mean-cIMT). Compared with data obtained in other studies, the mean-cIMT estimates were distributed closer to the upper pole of the spectrum presented and increased stronger in 35–55-year-old men compared with those in the populations of Central and Southwestern Europe; the mean-cIMT estimates showed the most pronounced gender effect. Similar trends were identified in relation to the max-cIMT distribution.Conclusion. Obtained data allowed for specific assessment of the individual cIMT values by gender and age within the framework of risk stratification among people of working age without cardiovascular diseases. Further studies aimed at clarifying the prognostic role of high cIMT values in general population, taking into account the influence of traditional and new cardiovascular risk factors, can broaden the understanding of the significance of vascular state assessment as one of the key points, linking risk factors to clinical events, for primary prevention of cardiovascular diseases in population.

scholarly journals The Role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases

2020 ◽  
pp. 118-127
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
High Density Lipoprotein ◽  
Inverse Relationship ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
High Density ◽  
Peripheral Tissues ◽  
Hdl Function

High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationship, clinical evidence has only challenged the usefulness of higher levels of HDL-C in predicting the risk of cardiovascular diseases (CVD) and have proven that the structure of HDL is altered and loosed function. Therefore, extensive research is needed to identify new agents and biomarkers to improve HDL function and reduce the risk of cardiovascular disease. Given that the most important function of HDL is to transfer excess cholesterol from peripheral tissues and macrophage cells through a receptor called ABCA1 and direct it to the liver, plays an important role in protecting the formation of atherosclerotic plaque. This molecule can provide a strong protective effect against oxidative damage caused by free radicals with intermittent inhibition of the production of pro-inflammatory oxidized lipids in the intima layer of arteries. There is an inverse relationship between the ability to efflux cholesterol and the prevalence of CVD. The ability to remove cholesterol from macrophages by HDL, it is a crucial criterion for determining HDL performance, and it has a strong inverse relationship with carotid intima-media thickness and coronary artery stenosis in angiography independent of HDL level. Key Words: High Density Lipoprotein; Cardiovascular Disease; Atherosclerosis; Lipoprotein

scholarly journals Lipid Profile and Carotid Intima-Media Thickness in a Prospective Cohort of Very Preterm Subjects at Age 19 Years: Effects of Early Growth and Current Body Composition

2006 ◽  
Vol 59 (4 Part 1) ◽  
pp. 604-609 ◽  
Author(s):  
Martijn J J Finken ◽  
Akin Inderson ◽  
Nadine Van Montfoort ◽  
Mandy G Keijzer-Veen ◽  
Anton W M van Weert ◽  
...  
Keyword(s):  
Body Composition ◽  
Lipid Profile ◽  
Prospective Cohort ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Early Growth ◽  
Very Preterm ◽  
Media Thickness

scholarly journals Growth Hormone Treatment in Short Children Born Prematurely—Data from KIGS

2011 ◽  
Vol 96 (6) ◽  
pp. 1687-1694 ◽  
Author(s):  
Margaret C. S. Boguszewski ◽  
Hanna Karlsson ◽  
Hartmut A. Wollmann ◽  
Patrick Wilton ◽  
Jovanna Dahlgren
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Growth Response ◽  
Growth Failure ◽  
Hormone Treatment ◽  
Height Velocity ◽  
First Year ◽  
Gh Treatment ◽  
Provocative Test ◽  
Short Children

Context: Children born prematurely with growth failure might benefit from GH treatment. Objectives: The aim was to evaluate the first year growth response to GH treatment in short children born prematurely and to identify predictors of the growth response. Design/Patients: A total of 3215 prepubertal children born prematurely who were on GH treatment were selected from KIGS (The Pfizer International Growth Database), a large observational database. They were classified according to gestational age as preterm (PT; 33 to no more than 37 wk) and very preterm (VPT; <33 wk), and according to birth weight as appropriate for gestational age [AGA; between −2 and +2 sd score (SDS)] and small for gestational age (SGA; −2 SDS or below). Results: Four groups were identified: PT AGA (n = 1928), VPT AGA (n = 629), PT SGA (n = 519), and VPT SGA (n = 139). GH treatment was started at a median age of 7.5, 7.2, 6.7, and 6.0 yr, respectively. After the first year of GH treatment, all four groups presented a significant increase in weight gain and height velocity, with a median increase in height SDS higher than 0.6. Using multiple stepwise regression analysis, 27% of the variation in height velocity could be explained by the GH dose, GH peak during provocative test, weight and age at GH start, adjusted parental height, and birth weight SDS. The first year growth response of the children born PT and SGA could be estimated by the SGA model published previously. Conclusion: Short children born prematurely respond well to the first year of GH treatment. Long-term follow-up is needed.

scholarly journals PERCENTILE DISTRIBUTION OF CAROTID INTIMA-MEDIA THICKNESS IN THE GENERAL WORKING-AGE POPULATION

2019 ◽  
Vol 34 (1) ◽  
pp. 145-151
Author(s):  
Kaveshnikov Kaveshnikov ◽  
V. N. Serebryakova ◽  
I. A. Trubacheva
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Informed Consent Form ◽  
Gender And Age ◽  
Working Age ◽  
The Mean ◽  
Working Age Population

Objective.To study the gender- and age-specific percentile distribution of carotid intima-media thickness (cIMT) in the unorganized urban working-age population.Material and Methods. Presented data were obtained in the ESSE-RF study in the city of Tomsk (1,412 participants, 25–64 years old without cardiovascular diseases, 59% women). All the surveyed signed voluntary informed consent form to participate in the study. We studied distributions of the mean and maximum cIMT obtained by the automatic and manual measurements, respectively. An error probability of less than 5% was considered statistically significant.Results. Both indicators of cIMT consistently increased with age in both gender groups. Maximum cIMT (max-cIMT) increased stronger than the mean cIMT (mean-cIMT). Compared with data obtained in other studies, the mean-cIMT estimates were distributed closer to the upper pole of the spectrum presented and increased stronger in 35–55-year-old men compared with those in the populations of Central and Southwestern Europe; the mean-cIMT estimates showed the most pronounced gender effect. Similar trends were identified in relation to the max-cIMT distribution.Conclusion. Obtained data allowed for specific assessment of the individual cIMT values by gender and age within the framework of risk stratification among people of working age without cardiovascular diseases. Further studies aimed at clarifying the prognostic role of high cIMT values in general population, taking into account the influence of traditional and new cardiovascular risk factors, can broaden the understanding of the significance of vascular state assessment as one of the key points, linking risk factors to clinical events, for primary prevention of cardiovascular diseases in population.

scholarly journals Predictors of early growth failure in preterm, very low birth weight infants during hospitalization

2019 ◽  
Vol 59 (1) ◽  
pp. 44-50
Author(s):  
Noviyani Leksomono ◽  
Retno Sutomo ◽  
Ekawaty Lutfia Haksari
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Respiratory Distress ◽  
Gestational Age ◽  
Medical Records ◽  
Very Low Birth Weight ◽  
Growth Parameters ◽  
Growth Failure ◽  
Early Growth ◽  
Vlbw Infants

Background Preterm, very low birth weight (VLBW) infants experience intrauterine nutritional deficits and perinatal comorbidities that may impair early growth parameters. Early growth failure has detrimental effects on later growth and neurodevelopment in childhood. Objective To analyze predictors of early growth failure in preterm, VLBW infants and differences in early growth parameters between small-for-gestational age (SGA) and appropriate-for-gestational age (AGA) infants. Methods This retrospective cohort study was conducted at Dr. Sardjito Hospital, Yogyakarta from 2011 to 2016. Subjects were preterm infants, with birth weights of 1,000-1,499 g. Twins, those who died during hospitalization, were discharged against medical advice, or had incomplete medical records were excluded. Adequate intrauterine growth was determined by the Lubchenco table criteria. Growth parameters and perinatal comorbidities were collected from medical records. Growth failure was defined as discharge weight less than 10th percentile of the Fenton growth curve. Bivariate and multivariate analysis were used to analyze potential predictive factors of early growth failure. Results Of 646 preterm, VLBW infants during the study period, 398 were excluded. Respiratory distress and SGA were predictors of early growth failure (AOR 6.94; 95%CI 2.93 to 16.42 and AOR 34.44; 95%CI 7.79 to 152.4, respectively). Mean weight velocities in SGA and AGA infants were not significantly different [16.5 (SD 5.9) and 17.5 (SD 5.3) g/kg/day, respectively; (P=0.25)]. Median time to regain, time to reach full feeding, and time to reach 120 kcal/kg/day were also not significantly different between SGA and AGA infants. Conclusions SGA and respiratory distress are predictors of early growth failure in preterm, VLBW infants during hospitalization. The SGA infants grow slower than AGA infants.

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