Fib4 index is a more relevant marker for pulse wave velocity but not for carotid intima-media thickness in a men population

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Ojima ◽  
T Kubozono ◽  
S Kawasoe ◽  
T Kawabata ◽  
H Miyahara ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Regression Analysis ◽  
Linear Regression ◽  
Pulse Wave Velocity ◽  
Roc Analysis ◽  
Pulse Wave ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
The Other

Abstract Background Carotid intima-media thickness (IMT) and pulse wave velocity (PWV) are useful markers for predicting cardiovascular disease not only in patients with cardiovascular disease but also in the general population. On the other hand, liver disease due to obesity has become a problem and has been reported to be associated with the progression of atherosclerosis. Recently, an indicator of liver stiffness, the Fibrosis-4 index (Fib4 index), has been used to detect the pre-stage liver diseases. However, there is no report to investigate the association between atherosclerotic parameters such as IMT and PWV, and Fib4 index. The Fib4 index is a simple index calculated from age and three blood sample data, and it will be useful for screening for an early stage of atherosclerosis if we can show the association between Fib4 index and these parameters. Purpose To investigate the association between atherosclerotic parameters such as IMT or PWV and Fib4 index Methods We recruited 3, 128 men participants who underwent health checkup. IMT was evaluated by carotid ultrasonography, and branchial-ankle PWV (baPWV) was measured by an automatic device. We analysed the association of IMT or baPWV with Fib4 index and atherosclerotic risk factors such as age, systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C) and fasting blood sugar (FBS). baPWV ≥1,600 cm/s was defined high baPWV and we performed the receiver operating characteristics (ROC) analysis to demonstrate the significance of Fib4 index for baPWV. Results Mean Fib4 index was 1.39±0.68. In the univariate linear regression analysis, all factors such as age, SBP, LDL-C, FBS, Fib4 index were significantly associated with IMT or baPWV. On the other hand, in the multivariate linear regression analysis, Fib4 index was an independent factor for baPWV but not for IMT (IMT, p=0.498; baPWV, p=0.023). Figure 1 showed the result of ROC analysis to predict the high baPWV by Fib4 index. The area under curve (AUC) was 0.73, with the highest discriminating sensitivity and specificity at 0.71 and 0.65, respectively at Fib4 index = 1.27. Conclusions Fib4 index was significantly related to baPWV and could be the useful screening marker for arterial stiffness in a general men population. Figure 1. ROC curve analysis Funding Acknowledgement Type of funding source: None

scholarly journals Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Delia Taverner ◽  
Dídac Llop ◽  
Roser Rosales ◽  
Raimon Ferré ◽  
Luis Masana ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Disease Risk ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Epigenetic Biomarkers

AbstractTo validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic microRNAs, which we previously identified and that can facilitate earlier diagnosis of cardiovascular disease in rheumatoid arthritis patients. We identified 10 plasma miRs that were downregulated in male rheumatoid arthritis patients and in patients with acute myocardial infarction compared to controls suggesting that these microRNAs could be epigenetic biomarkers for cardiovascular disease in rheumatoid arthritis patients. Six of those microRNAs were validated in independent plasma samples from 214 rheumatoid arthritis patients and levels of expression were associated with surrogate markers of cardiovascular disease (carotid intima-media thickness, plaque formation, pulse wave velocity and distensibility) and with prior cardiovascular disease. Multivariate analyses adjusted for traditional confounders and treatments showed that decreased expression of microRNA-425-5p in men and decreased expression of microRNA-451 in women were significantly associated with increased (β = 0.072; p = 0.017) and decreased carotid intima-media thickness (β = −0.05; p = 0.013), respectively. MicroRNA-425-5p and microRNA-451 also increased the accuracy to discriminate patients with pathological carotid intima-media thickness by 1.8% (p = 0.036) in men and 3.5% (p = 0.027) in women, respectively. In addition, microRNA-425-5p increased the accuracy to discriminate male patients with prior cardiovascular disease by 3% (p = 0.008). Additionally, decreased expression of microRNA-451 was significantly associated with decreased pulse wave velocity (β = −0.72; p = 0.035) in overall rheumatoid arthritis population. Distensibility showed no significant association with expression levels of the microRNAs studied. We provide evidence of a possible role of microRNA-425-5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.

scholarly journals Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community‐Based Cohort Studies

2021 ◽  
Author(s):  
Quentin Lisan ◽  
Thomas van Sloten ◽  
Pierre Boutouyrie ◽  
Stéphane Laurent ◽  
Nicolas Danchin ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Elastic Modulus ◽  
High Risk ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vascular Aging ◽  
Community Based

Background The mechanisms underlying the association between obstructive sleep apnea (OSA) and cardiovascular disease may include accelerated vascular aging. The aim was to compare the magnitude of vascular aging in patients with high versus low risk of OSA. Methods and Results In 2 community‐based studies, the PPS3 (Paris Prospective Study 3) and the Maastricht Study, high risk of OSA was determined with the Berlin questionnaire (a screening questionnaire for OSA). We assessed carotid artery properties (carotid intima‐media thickness, Young’s elastic modulus, carotid‐femoral pulse wave velocity, carotid pulse wave velocity, carotid diameter using high precision ultrasound echography), and carotid‐femoral pulse wave velocity (in the Maastricht Study only). Regression coefficients were estimated on pooled data using multivariate linear regression. A total of 8615 participants without prior cardiovascular disease were included (6840 from PPS3, 62% men, mean age 59.5±6.2 years, and 1775 from the Maastricht Study, 51% men, 58.9±8.1 years). Overall, high risk of OSA prevalence was 16.8% (n=1150) in PPS3 and 23.8% (n=423) in the Maastricht Study. A high risk of OSA was associated with greater carotid intima‐media thickness (β=0.21; 0.17–0.26), Young’s elastic modulus (β=0.21; 0.17–0.25), carotid‐femoral pulse wave velocity (β=0.24; 0.14–0.34), carotid pulse wave velocity (β=0.31; 0.26–0.35), and carotid diameter (β=0.43; 0.38–0.48), after adjustment for age, sex, total cholesterol, smoking, education level, diabetes mellitus, heart rate, and study site. Consistent associations were observed after additional adjustments for mean blood pressure, body mass index, or antihypertensive medications. Conclusions These data lend support for accelerated vascular aging in individuals with high risk of OSA. This may, at least in part, underlie the association between OSA and cardiovascular disease.

scholarly journals A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Ping-Hsun Wu ◽  
Yi-Ting Lin ◽  
Pei-Yu Wu ◽  
Jiun-Chi Huang ◽  
Szu-Chia Chen ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cognitive Function ◽  
Linear Regression ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Linear Regression Analysis ◽  
Ankle Brachial Index ◽  
Increased Risk ◽  
Moca Score

Patients with end-stage renal disease (ESRD) have an increased risk of both impaired cognitive function and peripheral artery disease (PAD) than the general population. The association between PAD and dementia is recognized, but there are limited studies in patients with ESRD. The aim of this study was to evaluate the relationship between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) and cognitive impairment in patients receiving hemodialysis (HD). We enrolled 136 prevalent HD patients (mean age 59.3±10.5 years, 55.9% male). Cognitive performance was measured using the Montreal Cognitive Assessment (MoCA) and Cognitive Abilities Screening Instrument (CASI) by trained psychiatrists. Associations between the cognitive function and ABI and baPWV were assessed using multiple linear regression analysis. Compared with HD patients with ABI≥0.9, patients with ABI<0.9 had lower MoCA score (p=0.027) and lower CASI score but did not achieve significant level (p=0.056). In the multivariate stepwise linear regression analysis, ABI (per 0.1) was independently positively associated with the MoCA score (β coefficient=0.62, p=0.011) and the CASI score (β coefficient=1.43, p=0.026). There is a negative association between baPWV (per 100 cm/s) and CASI (β coefficient=−0.70, p=0.009). In conclusion, a low ABI or high baPWV was associated with a lower cognitive function in HD patients.

scholarly journals Serum Osteopontin Level Correlates with Carotid-Femoral Pulse Wave Velocity in Geriatric Persons

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chung-Jen Lee ◽  
Ji-Hung Wang ◽  
Yu-Chih Chen ◽  
Mei-Ling Chen ◽  
Chiu-Fen Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Linear Regression ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Enzyme Linked Immunosorbent Assay

Osteopontin (OPN) is involved in the regulation of vascular calcification processes. The aim of this study was to evaluate the relationship between fasting serum OPN concentration and carotid-femoral pulse wave velocity (cfPWV) in geriatric persons. Fasting blood samples were obtained from 93 geriatric persons. cfPWV were performed by SphygmoCor system. Serum OPN levels were measured using a commercially available enzyme-linked immunosorbent assay. Geriatric adults who had diabetes (P=0.007) or dyslipidemia (P=0.029) had higher cfPWV levels than those without diabetes or dyslipidemia. The univariable linear regression analysis showed that age (P=0.002), waist circumference (P=0.048), body mass index (P=0.004), systolic blood pressure (P=0.001), diastolic blood pressure (P=0.036), pulse pressure (P=0.017), creatinine (P=0.002), and log-OPN level (P=0.001) were positively correlated with cfPWV levels, while the high-density lipoprotein cholesterol (HDL-cholesterol) level (P=0.007) and glomerular filtration rate (P=0.001) were negatively correlated with cfPWV levels among the geriatric adults. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPN (β=0.233,R2=0.123, regression coefficient: 1.868,P=0.011) was still an independent predictor of cfPWV levels in geriatric persons.

scholarly journals Cardio-ankle Vascular Index Is More Closely Associated Than Brachial-ankle Pulse Wave Velocity With Variables Predicting Future Cardiovascular Disease in Patients With Diabetes

2021 ◽  
Author(s):  
Taro Saigusa ◽  
Kentaro Watanabe ◽  
Yurika Hada ◽  
Kota Ishii ◽  
Wataru Kameda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Patients With Diabetes

Abstract Background: This study aimed to compare the usefulness of arterial stiffness parameters, cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV), for evaluating future cardiovascular disease (CVD) in subjects with diabetes.Methods: The study subjects were 277 patients with type 1 or type 2 diabetes. All subjects were evaluated for vascular stiffness using CAVI (n = 154) or baPWV (n = 123). Carotid intima-media thickness (IMT) and the Suita score were also measured because these are established risk factors for future CVD. Associations of both CAVI and baPWV with these established parameters were evaluated in all subjects, and then in 172 subjects with adjustment for covariates by using propensity score matching.Results: In all subjects, CAVI and baPWV correlated significantly with both IMT (r = 0.470, P < 0.001, and r = 0.256, P = 0.004, respectively) and the Suita score (r = 0.558, P < 0.001, and r = 0.360, P < 0.001, respectively). The correlation between CAVI and IMT was more significant than that between baPWV and IMT (Z = 2.03, P = 0.042).　Similarly, the correlation between CAVI and the Suita score was more significant than that between baPWV and the Suita score (Z = 2.07, P = 0.039). After adjustment by matching, significant correlations between CAVI and IMT (r = 0.459, P < 0.001) and between CAVI and the Suita score (r = 0.526, P < 0.001) were preserved, though only the association between baPWV and the Suita score was significant (r = 0.270, P = 0.011) while that between baPWV and IMT showed no significance. Again, CAVI showed a significantly stronger association with the Suita score than baPWV (Z = 1.99, P = 0.046).Conclusions: CAVI is more closely associated than baPWV with variables predicting future CVD in patients with diabetes.

scholarly journals The Effect of Pre Order Online Sales to Company Profits on PT. Aventama Hervent Solusindo Bandung

2020 ◽  
Vol 1 (3) ◽  
pp. 88-92
Author(s):  
Tiris Sudrartono
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Electronic Devices ◽  
Production Costs ◽  
The Other ◽  
The Internet ◽  
Simple Linear Regression ◽  
Online Sales ◽  
Internet Network

This research aims to find out how online pre order sales and profit earning on PT Aventama, also how big is the effect of pre order online sales towards the profit on PT Aventama, and to get to know about what are the efforts that could be able to do for increase the company profits through online pre order sales. Theory that supports in this research was revealed by Oki Pamungkas, 2018 who said that online sales is  conducting sales activities from looking for potential buyers to offering products or goods by utilizing the internet network that is supported by a set of electronic devices as a link to the internet network, while Toto Prihadi 2012 said that profit is a measure of company's performance obtained from the results of reduction results of sales minus production costs. From conducted research, it can be obtained of the results of online pre order sales and company profits on PT Aventama, it's obtained results of 77.2% for online pre order sales and 35.7% for the profits and are categorized well. Then the correlation test is used for find out about the effect of online pre order sales with the results obtained at 84%, this value can be interpreted that the effect of online pre order sales to profits is very strong, while the other 16% is effected by other factors that it’s not examined by the author. Based on a simple linear regression analysis obtained Y '= 3.307 + 0.420X it means every online pre order sale is improved, it will be followed by an improve in company profit of 0.420 at a constant 3.037. With this research, it's expected that there will be a change in the company's profit through increasing online pre-order sales by creating advertisements, providing more complete ready stock products, and adding new suppliers so that the ordering process of products is faster to consumers

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