scholarly journals P1835 Recognising extracardiac findings in cardiac imaging - a comparison between cardiologists and radiologists

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
K Sapiano ◽  
A Borg

Abstract Background In the past, cardiac imaging modalities did not obtain much information about extracardiac structures. With the introduction of newer modalities such as CT and MRI, diagnostic quality images of structures surrounding the heart are now being obtained. This has led to the need for interpretation of images of extracardiac structures. Nowadays, this is being performed by cardiologists and radiologists; either separately or conjointly. Purpose To evaluate whether there is any difference in the rate of positive extracardiac findings (ECF) between radiologists and cardiologists and to assess whether these ECF are of any clinical importance. Methods All patients having had a cardiac MRI and cardiac CT performed in the year 2017 in a single centre were enrolled (n = 733). Reports of these images were reviewed retrospectively and information was obtained as regards to any differences in number of ECF picked up by cardiologists, radiologists or both working together. These ECF were then stratified according to their clinical importance and these subdivisions compared in the context of reporting physician. Results A total of 733 scans were reviewed, 219 (29.9%) of these had positive ECF whilst 514 (70.1%) had none. Of the total amount, 314 (42.8%) were reported by cardiologists, 318 (43.4%) by radiologists and 101 (13.8%) jointly by both a cardiologist and a radiologist. Cardiologists found positive ECF in 18.2% of scans reviewed, radiologists reported findings in 37.4% of scans and, of those reported jointly, 42.6% were positive, p= <0.001. A pattern emerged where cardiologists found less clinically significant ECF with only 5.3% of findings classified as will definitely change management, in comparison to 19.3% by radiologists and 16.3% when reviewed jointly; and, only 15.8% of findings classified as will probably change management when compared to 23.5% by radiologists and 23.3% when reviewed jointly. However, it is important to note that this pattern was not statistically significant, p = 0.1432. Conclusions A strongly statistically significant difference in the reporting of extracardiac findings has been highlighted in this article with cardiologists picking up less than half of extracardiac findings reported by radiologists. There was a pattern of cardiologists recognising less clinically important extracardiac findings, however this was not found to be statistically significant. These results should be reviewed with caution, taking into consideration the limitations of results obtained from a single centre. However, should this pattern keep repeating itself, one might consider increasing cardiologist training in ECF or having cardiac imaging reported conjointly by a cardiologist and a radiologist. Further studies are also necessary to ascertain the clinical relevance of the difference in ECF between cardiologists, radiologists or both specialists working together.

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Kempny ◽  
K Dimopoulos ◽  
A E Fraisse ◽  
G P Diller ◽  
L C Price ◽  
...  

Abstract Background Pulmonary vascular resistance (PVR) is an essential parameter assessed during cardiac catheterization. It is used to confirm pulmonary vascular disease, to assess response to targeted pulmonary hypertension (PH) therapy and to determine the possibility of surgery, such as closure of intra-cardiac shunt or transplantation. While PVR is believed to mainly reflect the properties of the pulmonary vasculature, it is also related to blood viscosity (BV). Objectives We aimed to assess the relationship between measured (mPVR) and viscosity-corrected PVR (cPVR) and its impact on clinical decision-making. Methods We assessed consecutive PH patients undergoing cardiac catheterization. BV was assessed using the Hutton method. Results We included 465 patients (56.6% female, median age 63y). The difference between mPVR and cPVR was highest in patients with abnormal Hb levels (anemic patients: 5.6 [3.4–8.0] vs 7.8Wood Units (WU) [5.1–11.9], P<0.001; patients with raised Hb: 10.8 [6.9–15.4] vs. 7.6WU [4.6–10.8], P<0.001, respectively). Overall, 33.3% patients had a clinically significant (>2.0WU) difference between mPVR and cPVR, and this was more pronounced in those with anemia (52.9%) or raised Hb (77.6%). In patients in the upper quartile for this difference, mPVR and cPVR differed by 4.0WU [3.4–5.2]. Adjustment of PVR required Conclusions We report, herewith, a clinically significant difference between mPVR and cPVR in a third of contemporary patients assessed for PH. This difference is most pronounced in patients with anemia, in whom mPVR significantly underestimates PVR, whereas in most patients with raised Hb, mPVR overestimates it. Our data suggest that routine adjustment for BV is necessary.


PEDIATRICS ◽  
1993 ◽  
Vol 91 (4) ◽  
pp. 816-819
Author(s):  
Jeanne B. Funk ◽  
John B. Chessare ◽  
Michael T. Weaver ◽  
Anita R. Exley

Given that children with attention deficit hyperactivity disorder (ADHD) are more impulsive than peers, this study explored whether they are correspondingly more creative, and whether creativity declines when impulsivity is decreased through methylphenidate (Ritalin) therapy. A repeated-measures quasi-experimental design was used to compare the performance of 19 boys with previously diagnosed ADHD and 21 comparison boys aged 8 through 11 on two administrations of alternate forms of the Torrance Tests of Creative Thinking-Figural (nonverbal). Boys with ADHD received prescribed methylphenidate only for the first session. Overall, mean Torrance summary scores for comparison boys (mean = 115.1, SD = 16.1) were higher than for boys with ADHD (mean = 107.6, SD = 12.7). However, the difference between means was small (7%) and did not meet the 25% criterion for a clinically significant difference. No changes in performance over time (comparison group) or medication state (ADHD group) were observed. These data suggest that, when measured nonverbally, the creative thinking performance of boys with ADHD is not superior to that of peers who do not have ADHD. Regarding the effects of methylphenidate, prescribed therapy did not influence performance on this measure of creative thinking.


2006 ◽  
Vol 7 (3) ◽  
pp. 22-29
Author(s):  
Farah Masood ◽  
Christos Angelopoulos ◽  
Alan Glaros

Abstract Aim The purpose of this study was to compare two types of conventional radiographic film: Ekta-speed plus and Insight (Eastman Kodak Co, Rochester NY, USA) for accuracy of measurements of approximal bone loss. Methods and Materials Four dried human mandibles with complete dentition were selected. Radiographic images were made with a standardized technique. Mesial and distal bone levels on the mandibular premolar and molar teeth were measured on the two types of radiographs (Ekta-speed plus and Insight) by nine observers. The data obtained by the observers were compared with the primary investigators’ corresponding measurements, which served as “the ground truth” for this study. Results The results of the analysis of variance (ANOVA) demonstrated a significant difference for the Ektaspeed plus film (p = .001), but the difference was not clinically significant. The level of intra-rater reliability was high for the observers (0.969 to 0.990). Conclusion Performance of Ekta-speed plus and Insight films was found to be similar. Citation Masood F, Angelopoulos C, Glaros A. A Comparison Between Two Types of Radiographic Film for Accuracy of Measurements of Approximal Osseous Defects. J Contemp Dent Pract 2006 July;(7)3:022-029.


2021 ◽  
Author(s):  
Marcia Garnica ◽  
Sylvia Dalcolmo ◽  
Bianca Gaio ◽  
Andreia Almeida ◽  
Juliana Rivello ◽  
...  

Abstract Pre-engraftment cytomegalovirus infection (CMVi) is a challenge in patients receiving allogeneic stem cell transplantation (Allo-HCT), as few data have been reported on its clinical importance. This study describes the clinical outcomes of pre-engraftment CMVi and compares them with those of episodes developing after engraftment in HCT patients. We performed a retrospective study of patients who underwent Allo-HCT from 2016 to 2020, including 111 recipients monitored by real-time PCR assay. Clinically significant CMVi (csCMVi) was documented in 81 (73%) patients. There were 29 (26%) cases of pre-engraftment csCMVi. No significant difference was observed regarding virological features, but patients with pre-engraftment csCMVi had a delayed start in treatment (24 vs. 12 days, p < 0.001) compared with those with postengraftment events. Pre-engraftment csCMVi was associated with a delay in engraftment (20 vs. 16 days, p = 0.02) and worse overall survival (54% vs. 73% 1-year OS; p = 0.020) than postengraftment events. In conclusion, pre-engraftment csCMVi occurred in 26% of our patients and was associated with engraftment delay and worse overall survival. Close monitoring of CMV DNAemia is necessary to identify these patients earlier. Prospective studies, including patients with letermovir prophylaxis, are necessary to define the standard in the management and care of this population.


Author(s):  
Theodore Vassilikopoulos ◽  
Athena Kalokairinou ◽  
Georgia Kourlaba ◽  
Eirini Grapsa

The purpose of this study was to investigate the level of renal function knowledge of primary school pupils in Greece. We conducted a cross-sectional study with a convenience sample of 220 pupils, coming from the 5th and 6th grades of general education schools. A questionnaire consisting of 11 questions was developed from scratch. However, based on an analysis of Cronbach’s alpha values obtained when individual questions were deleted, two questions were removed from the analysis, and only nine remained for analysis and participated in the calculation of the knowledge score. Moreover, the gender and daily habits of pupils regarding water consumption and frequency of urination were recorded. Pupils had a high percentage of correct knowledge about the number of kidneys (95.2%), whether a child may have problems with the kidneys (85.5%) and whether a person can survive with one kidney (68.5%). Low levels of knowledge were observed in the function and role of the kidneys (36.4%), as well as the part of the body where the kidneys are located (30.9%). The median (interquartile range (IQR)) total knowledge score was 6 (5–7), with no difference detected between genders (p = 0.135). A statistically significant difference between pupils of 5th and 6th grades was found but the difference did not seem to be clinically significant (p = 0.035). The present research demonstrates that pupils’ knowledge of renal function and the protection of their kidneys needs improvement.


2019 ◽  
Vol 101 (6) ◽  
pp. 411-414 ◽  
Author(s):  
R Peeraully ◽  
M Jancauskaite ◽  
S Dawes ◽  
S Green ◽  
N Fraser

Introduction This single centre study retrospectively analysed the intraoperative findings relative to source of referral for emergency scrotal explorations performed in a tertiary level paediatric surgery department. Methods All patients who underwent emergency scrotal exploration under the care of paediatric surgeons in our unit between April 2008 and April 2016 were identified. Clinical data were obtained from contemporaneous records. Results Over the 8-year study period, 662 boys underwent emergency scrotal exploration: 6 (1%) were internal referrals, 294 (44%) attended our emergency department (ED) directly, 271 (41%) were referred from primary care and 91 (14%) were transferred from other hospitals. Excluding procedures in neonates, testicular torsion was present in 100 cases (15%). Testicular detorsion with bilateral 3-point testicular fixation was performed in 66 (66%) and orchidectomy with contralateral fixation in 34 (34%) where the torted testis was non-viable intraoperatively. The orchidectomy rate in the presence of torsion was 23% in ED referrals (12/52), 43% in primary care referrals (12/28) and 50% for transfers (10/20). The difference in rates between ED referrals and patients transferred from other hospitals was significant (p=0.026). There was no significant difference in median age between any of the groups (p=0.10). Conclusions Boys undergoing emergency scrotal exploration had a higher orchidectomy rate when transferred from other hospitals to our unit. This difference was statistically significant when compared with boys presenting directly to our ED. This supports advice from The Royal College of Surgeons of England for undertaking paediatric scrotal explorations in the presenting hospital when safe to do so rather than delaying the care of these patients by transferring them to a tertiary paediatric surgical unit.


2003 ◽  
Vol 127 (8) ◽  
pp. 1007-1008 ◽  
Author(s):  
Andrew A. Renshaw ◽  
Delray Schultz ◽  
Kerri Cote ◽  
Marian Loffredo ◽  
David E. Ziemba ◽  
...  

Abstract Context.—Gleason grading of prostatic adenocarcinoma in core needle biopsies is important for predicting prognosis and selecting appropriate therapy. Previous studies have shown that Gleason scores assigned by general pathologists have a low correlation with those assigned by urologic pathologists, and that general pathologists tend to undergrade prostate carcinoma. Objective.—To determine if the performance of general pathologists grading prostate needle biopsies has changed over time. Design.—Four hundred sixteen prostate biopsies from men treated at a single community-based institution between 1987 and 2000 were reviewed by one urologic pathologist (A.A.R.). The correlation between the original Gleason score and the reviewer's score was determined over time. Results.—Cases were divided into those performed and originally interpreted in the first half of the study (1987–1996) and those performed and originally interpreted in the second half (1996–2000). Overall concordance for exact Gleason score was 59% (244/416). The exact concordance of the Gleason score assigned by the original pathologist and the reviewer during the first half of the study was 51%, whereas in the second half of the study the concordance was significantly greater (66.3%, P = .002). However, when grouped into score categories of 6 or less, 7, and 8 or greater, there was no significant difference in the exact concordance between the first half of the study (78.3%) and the second half (78.4%). Fifty-five percent of the cases in which there was discordance were graded as 7 by the reference pathologist and 6 or less by the original pathologist. There was no correlation between concordance in Gleason score and the percentage of tissue involved by carcinoma. Conclusion.—The concordance between general pathologists' Gleason grading and that of a reference pathologist in this study is much higher than that in previously reported studies. Although exact concordance has significantly improved over time, concordance by clinically significant groups has remained high throughout the study, is dominated by the difference between Gleason score 7 and 6 or less, and is unrelated to the size of the tumor focus.


2007 ◽  
Vol 4 (3) ◽  
pp. 305-314 ◽  
Author(s):  
Alison L. Marshall

Purpose:The aim of this study was to determine if feedback on step counts from a pedometer encourages participants to increase walking.Methods:Randomly recruited older adults (n = 105) were asked to wear a pedometer for 2 wk. Half the participants were asked to monitor and record daily step counts during week 1 (feedback), then seal the pedometer shut during week 2 (no feedback). Half completed the study in reverse order. Self-reported walking was assessed via telephone interviews.Results:Significantly more steps were recorded per day (approximately 400 steps per day) when participants (n = 103, 63% women; mean BMI 25 ± 4) monitored their daily step count [t (102) = –2.30, P = 0.02)] compared to the no feedback condition. There was no statistically significant difference in self-reported walking (P = 0.31) between feedback conditions.Conclusion:The difference in daily step counts observed between conditions, while statistically significant, may not be considered clinically significant. Further, the non-significant difference in self-reported walking between conditions suggests that feedback on daily step counts from a pedometer does not encourage participants to increase their walking.


Neurology ◽  
2020 ◽  
Vol 95 (20 Supplement 1) ◽  
pp. S1.3-S2
Author(s):  
Michael F. La Fountaine ◽  
Asante Hohn ◽  
Caroline Leahy ◽  
Anthony Testa

ObjectiveTo determine the prevalence of orthostatic hypotension (OHypo) and hypertension (OHTN), respectively after a concussion in collegiate athletes.BackgroundOrthostasis causes a gravity-dependent redistribution of blood volume to the lower extremities. The baroreflex coordinates the cardiovascular autonomic nervous system to mitigate aberrant changes in systolic blood pressure (SBP). In autonomic dysfunction (AD), impaired accommodation may lead to a clinically significant? SBP decreases (OHypo: SBP fall = 20 mm Hg) or paradoxical increases (OHTN: SBP rise = 20 mm Hg) within 3 minutes of assuming the standing (STND) posture. Concussion injuries may induce a transient state of AD. A clinical approach to surveil this state has yet to be defined.Design/MethodsA prospective study was performed in 36 concussed (gender: 23 female, 13 male; age: 20 ± 1 years; height: 1.75 ± 0.12 meters; weight: 73 ± 14 kilograms) and 20 non-concussed athletes (gender: 12 female, 8 male; age: 21 ± 2 years; height: 1.74 ± 0.15 meters; weight: 72 ± 18 kilograms). Continuous beat-to-beat SBP was collected for 10-minutes in a resting supine position (SUP) and then for 3-minutes in the STND position within 48 hours (48H) of concussion. The average SBP was computed from the difference between SUP and the final 15 seconds of STND. SBP were then categorized: Normal (NR: SBP -15 to +15 mm Hg); Borderline OHypo (BordOHypo: SBP −16 to −19 mm Hg) and OHTN (BordOHTN: SBP +16 to +19 mm Hg); OHypo; and, OHTN.ResultsIn concussed athletes, the SBP prevalence rates were 42% NR, 31% OHypo, 11% OHTN, 11% BordOHTN, and 6% BordOHypo compared to 90% NR, 5% OHypo and 5% OHTN in the non-concussed athletes. ?2 test revealed a significant difference in this distribution (p = 0.012).ConclusionsWithin 48H of concussion injury, a combined 42% of injured athletes had an abnormal SBP response to orthostasis and a further 6% had borderline responses that warrant re-evaluation. The incidence rates for each circumstance exceeded the control group.


1981 ◽  
Vol 15 (5) ◽  
pp. 372-376 ◽  
Author(s):  
Randall A. Prince ◽  
Douglas A. Busch ◽  
Charles D. Hepler ◽  
Harley G. Feldick

Sixty-nine informed subjects participated in a split-face, double-blind trial of topical erythromycin base 2% in Vehicle/N® versus Vehicle/N® alone. All subjects had grades II or III acne as described by Pillsbury. Study solutions were assigned to a randomly selected side of the subject's face. Solutions were applied twice daily. Inflammatory lesion counts were performed by the same investigator during the eight weeks of study at biweekly intervals. The difference in inflammatory lesion counts from beginning to end of study for each side of the face was compared utilizing Student's paired t-test There was not a statistically significant difference in mean inflammatory lesions at the end of eight weeks (D̅ = 1.46, t = 1.36, df 68). There was, however, a significant difference at two and six weeks (D̅ = 2.59, t = 3.72, df 68; D̅ = 1.41, t = 2.03, df 68). Observed differences in lesion counts were not considered to be clinically significant.


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