scholarly journals Risk factors in young patients with myocardial infarction: what is different from the general population?

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
H Wienbergen ◽  
K Guenther ◽  
D Boakye ◽  
J Schmucker ◽  
S Mkalaluh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Metabolic Syndrome ◽  
Family History ◽  
General Population ◽  
Case Control Study ◽  
Case Control ◽  
Active Smoking ◽  
Younger Age ◽  
Control Study

Abstract Introduction Patients that suffer from myocardial infarction (MI) at a younger age are of special medical and socioeconomic interest. Data on risk factors for MI in this patient group are however scarce. Methods In this case–control study, clinical characteristics of consecutive patients admitted to hospital with MI at age of ≤45 years were compared to a randomly selected cohort from the general population in the same geographic region in Germany. After 3:1 matching on age and gender and multivariable analyses, independent risk factors for the occurrence of MI at a younger age were analyzed. Results 522 patients with MI ≤45 years were compared to 1191 matched controls from the general population. The proportion of active smokers was more than 3-fold higher in younger MI-patients compared to the general population (82.4% vs. 24.1%, p<0.01), while the proportion of persons consuming alcohol at least 2 times a week was higher in the general population (19.9% vs. 36.6%, p<0.01). Younger patients with MI were more often obese (median body mass index 28.4 vs. 25.5 kg/m2, p<0.01), had a higher proportion of hypertension (25.1% vs. 0.5%, p<0.01) or diabetes mellitus (11.7% vs. 1.7%, p<0.01) and had more often a family history of the father (22.4% vs. 7.1%, p<0.01) or the mother (7.5% vs. 1.3%, p<0.01) for premature coronary artery disease. In multivariable analysis, hypertension or diabetes, active smoking, family history and body mass index ≥30 kg/m2 were strong predictors for the occurrence of MI at a younger age, while alcohol consumption was a protective factor (Figure). Conclusions This case-control study demonstrates a very strong association of active smoking, metabolic syndrome and family history with the occurrence of MI at a younger age. The contrary is found regarding alcohol consumption. These data suggest that the risk of young-onset MI goes beyond family history and underline the importance of primary prevention efforts to reduce smoking and metabolic syndrome in children, adolescents and young adults in order to reduce the burden of cardiovascular diseases. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Bremen Heart FoundationLeibniz Institute for Prevention Research and Epidemiology

The Malaysian Acute Vascular Events Risk (MAVERIK) study: a resource to study genetic and other determinants of first-ever myocardial infarction in Malaysia (Preprint)

2021 ◽  
Author(s):  
Rajiv Chowdhury ◽  
Mohd Fairulnizal Bin Md Noh ◽  
Sophia Rasheeqa Ismail ◽  
Kim Robin van Daalen ◽  
Puteri Sofia Nadira Megat Kamaruddin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Family History ◽  
Case Control Study ◽  
Case Control ◽  
Smoking History ◽  
Vascular Events ◽  
Public Health Action ◽  
History Of ◽  
Control Study

UNSTRUCTURED Introduction: Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to enable investigation of genomic, lipid-related and other determinants of acute MI in Malaysia. To our knowledge, it represents the largest case-control study of MI and related traits in Malaysia. In this paper, we report the study’s design and initial results. Methods: By June 2019, MAVERIK had enrolled about 2500 patients with first-ever MI and 2500 controls without cardiovascular disease (CVD), frequency-matched by age, sex and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic and behavioural information has been obtained using a 200-item questionnaire. Results: Tobacco consumption, history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and family history of coronary disease were more prevalent in cases than controls. Crude and adjusted (age, sex) logistic regression models for traditional risk factors indicated that current smoking, previous smoking, history of high blood pressure, history of diabetes mellitus, family history of CHD and obesity (BMI>30) were associated with MI in age- and sex-adjusted models. Conclusion: The MAVERIK study can serve as a useful platform to investigate genetic and other risk factors for MI in an under-studied South-East Asian population. It should help to hasten discovery of disease-causing pathways and to inform regionally appropriate strategies that optimise public health action.

scholarly journals 346. Factors Associated with Hypertension in Young Adults with Perinatally-Acquired HIV Infection: a Case–Control Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S184-S184
Author(s):  
Patrick O’Neil ◽  
Patrick Ryscavage ◽  
Kristen A Stafford
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Family History ◽  
Case Control Study ◽  
Case Control ◽  
Systemic Hypertension ◽  
Early Management ◽  
Factors Associated ◽  
History Of ◽  
Control Study

Abstract Background The incidence of systemic hypertension (HTN) among perinatally-HIV-infected (PHIV) patients appears to increase as they enter adulthood. Among non-perinatally HIV-infected adults both traditional and HIV-associated risk factors have been found to contribute to HTN. Whether these same factors contribute to HTN in PHIV is unknown. The purpose of this study was to determine the socio-demographic, clinical, virologic, and immunologic factors associated with HTN among a cohort of PHIV adolescents and young adults, aged ≥18 years. Methods We conducted a case–control study among a population of 160 PHIV adults with and without HTN who were receiving care at the University of Maryland and aged 18–35 years as of December 31, 2017. Covariates assessed included traditional risk factors such as age, family history of HTN, and smoking, as well as HIV- and antiretroviral-associated covariates. Results We identified 49 HTN cases (30.6%) and 111 (69.4%) controls. There were no significant differences in the odds of most traditional (age, gender, race, family history of HTN, tobacco, alcohol, and/or other drug use) or HIV-associated (CD4 nadir <100 cells/mm3, individual ART exposure, ART interruption) risk factors among PHIV adults with HTN compared with those with no diagnosis of HTN. Cases had lower odds of a history of treatment with lopinavir/ritonavir (LPV/r). Cases had 3.7 (95% CI 1.11, 12.56) times the odds of a prior diagnosis of chronic kidney disease (CKD) compared with controls after controlling for CD4 nadir and ARV treatment history. Conclusion The results of this study suggest that most traditional and HIV-related risk factors do not appear to increase the odds of having HTN in this PHIV cohort. However, HTN among PHIV may be driven in part by CKD, and a focus on the prevention and early management of CKD in this group may be necessary to prevent the development of HTN. Additionally, there may be as yet unidentified risk factors for HTN among PHIV which require further exploration. Given the large and growing population of PHIV entering adulthood worldwide, it is imperative to explore risk factors for and effects of HTN in large, diverse PHIV populations. Disclosures All authors: No reported disclosures.

scholarly journals The Risk Factors of Premature Myocardial Infarction: A Case Control Study in Iran

2016 ◽  
Vol 8 (11) ◽  
pp. 69 ◽  
Author(s):  
Mehdi Ehtesham ◽  
Ali Akbar Haghdoost ◽  
Seyed Vahid Ahmadi Tabatabaei ◽  
Hooman Bakhshandeh
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Family History ◽  
Case Control Study ◽  
Vascular Diseases ◽  
Current Smoking ◽  
History Of ◽  
Premature Myocardial Infarction ◽  
Cardio Vascular ◽  
Control Study

<p><strong>BACKGROUND:</strong> Although, our knowledge about the factors of cardio vascular diseases (CVD) is relatively acceptable, we have few publications about the risk factors of premature CVD particularly from developing countries such as Iran.</p><p><strong>OBJECTIVES:</strong> The present study is aimed to assess the risk of the modifiable risk factors of coronary heart disease (CHD) in the first cardiac attack of patients classified by age to check which risk factors might have a more significant impact to increase the risk of premature myocardial infarction (MI).</p><p><strong>METHODS:</strong> In a case control study, 122 and 266 cases and controls were recruited from one of the main referral centres in Tehran. Cases were those who were hospitalized because of their first myocardial infarction before the ages of 50 and 55 years in males and females respectively, and compared their risk factor profiles with those experienced first MI in higher age. Main independent variables in this study were: the demographic variables, distress, lipid profile, diabetes, smoking, family history of cardio vascular diseases, and physical activity.</p><p><strong>RESULTS: </strong>The results showed that distress (OR= 3.95), minorities (compare to Fars race) (OR= 3.30), higher education (OR= 1.30), family history of hyperlipidaemia (OR=1.89) significantly increased the risk of premature MI. We also found that family history of hypertension (OR=1.35), current smoking versus no smoking (OR=1.60), fast-food consumption (OR=1.48), non-alcoholic beverages (OR= 1.12) had also association with the risk of premature MI but only in crude model. We also found that regular physical activity (OR=0.42), ex-smoker versus current smoking (OR=0.27) and regular consumption of milk (OR=0.73) was protective against premature MI.</p><p><strong>CONCLUSION:</strong> Our findings demonstrate that the effect of most of risk factors were mostly related to their life-style (distress, smoking, physical inactivity and dietary pattern); while family history of diseases was also important.</p>

scholarly journals Metabolic Syndrome Components and Risk Factors for Pancreatic Adenocarcinoma: A Case-Control Study in China

Digestion ◽  
2012 ◽  
Vol 86 (4) ◽  
pp. 294-301 ◽  
Author(s):  
Qiao Wu ◽  
Ge Chen ◽  
Wen-ming Wu ◽  
Li Zhou ◽  
Lei You ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Pancreatic Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Metabolic Syndrome Components ◽  
Control Study
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