scholarly journals Key aspects of statin intolerance leading to treatment discontinuation: a patient perspective

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A L Catapano ◽  
O Wiklund ◽  
D M Bushnell ◽  
M L Martin ◽  
E Sidelnikov ◽  
...  
Keyword(s):  
Side Effects ◽  
Standard Of Care ◽  
Statin Treatment ◽  
Treatment Discontinuation ◽  
Cross Sectional Survey ◽  
Statin Intolerance ◽  
Private Company ◽  
Cross Sectional ◽  
Funding Sources ◽  
Key Aspects

Abstract Background and aims Statins are the standard of care for patients with dyslipidemia, but some patients develop intolerance to treatment. The experience of statin intolerant (SI) patients is poorly understood. The objective of this study was to identify key aspects of SI that may be associated with treatment discontinuation. Methods Using a previously created questionnaire, we conducted a pilot cross-sectional survey to identify items important for describing patient-centric aspects of SI. The study recruited adult (18+) patients with a history of statin-associated side effects from 9 clinics in 6 countries (France, Italy, Norway, Spain, Sweden, and the United Kingdom), who had received statin treatment within the previous two years. Results We surveyed 104 patients (mean age 61.5 SD=11.2 years, 63.5% men, 50% currently on statins). Patients most frequently reported muscle-related symptoms: pain (90.9%), cramps (63.7%), and stiffness (58.2%). Using a 0–10 point scale, significant differences were found between those continuing versus discontinuing their statins for being bothered by side effects (7.5 vs 9.2, p=0.001), for an inability to tolerate side effects (6.7 vs 9.0, p<0.001), and those having too much side effects interference with their daily life (5.7 vs 8.6, p<0.001; see figure). For patients whose doctors worked on adjusting statin regimen, 67% stayed on treatment; for those whose doctors did not, only 10% continued treatment. Conclusions Results of this pilot survey suggest patients who experience greater side effects severity and interference with daily activity, along with lower efforts by clinicians to work with adjusting their statin regimen, are at greater risk for discontinuing treatment. A wider survey and larger study population is needed to confirm the results of this pilot study. FUNDunding Acknowledgement Type of funding sources: Private company. Main funding source(s): This study was sponsored by Amgen Inc.

Side effects following COVID-19 vaccination: A cross-sectional survey with age-related outcomes in Saudi Arabia

2021 ◽  
Vol 11 (3) ◽  
pp. 119-125
Author(s):  
Ahlam Alghamdi ◽  
Alnada Ibrahim ◽  
Mohammed Alraey ◽  
Afrah Alkazemi ◽  
Isra Alghamdi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Side Effects ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Age Related

scholarly journals What is associated with increased side effects and lower perceived efficacy following switching to a generic medicine? A New Zealand cross-sectional patient survey

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e023667 ◽  
Author(s):  
Kate MacKrill ◽  
Keith J Petrie
Keyword(s):  
New Zealand ◽  
Side Effects ◽  
Generic Version ◽  
Drug Efficacy ◽  
Patient Survey ◽  
Generic Medicine ◽  
Cross Sectional Survey ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Perceived Efficacy

ObjectiveFollowing a switch from either a generic or branded antidepressant (venlafaxine) to a new generic, we investigated the factors associated with a preference for branded medicines, side effects reported following switching and efficacy ratings of the new generic drug.DesignA cross-sectional survey of patients switched to a new generic.SettingPatients accessing venlafaxine information online from the New Zealand government pharmaceuticals funding website.Participants310 patients, comprising 205 originally on branded venlafaxine and 105 previously taking a generic version.Main outcome measuresAn online questionnaire assessing demographic factors, perceived sensitivity to medicines, trust in pharmaceutical agencies, sources of switch information, preference for branded medicine, new medicine perceptions, side effects and efficacy ratings.ResultsPreference for branded medicine was significantly stronger in older patients (OR=1.04, 95% CI 1.01 to 1.05), those taking branded venlafaxine (OR=2.02, 95% CI 1.13 to 3.64) and patients with a higher perceived sensitivity to medicine (OR=1.23, 95% CI 1.06 to 1.19). Different factors predicted side effects in those switching from the branded and those switching from the generic venlafaxine. Trust in pharmaceutical agencies and the number of side effects were significant predictors of efficacy ratings of the new generic in both patients switching from a branded and those switching from a generic version of venlafaxine.ConclusionsIn patients switching from a branded medicine and those already taking a generic, different demographic and psychological factors are associated with preference for branded medicine, side effect reporting and perceived efficacy of the new drug. When switching to new generic, there appears to be a close bidirectional relationship between the experience of side effects and perceived drug efficacy. Trust in pharmaceutical agencies impacts directly on perceived efficacy and increasing such trust could reduce the nocebo response following a generic switch.

Medicinal plants’ use among patients with dyslipidemia: an Iranian cross-sectional survey

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Mohammad Hashem Hashempur ◽  
Seyed Hamdollah Mosavat ◽  
Mojtaba Heydari ◽  
Mesbah Shams
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Demographic Data ◽  
Zingiber Officinale ◽  
Cross Sectional Study ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Herbal Preparations ◽  
Positive Effects ◽  
High Prevalence

Abstract Background Despite growing demand for medicinal plants, there is little data about their use by patients with dyslipidemia. We aimed to determine the prevalence, pattern, and associated factors for the use of medicinal plants among patients with dyslipidemia. Methods A 17-item semi-structured questionnaire was filled out by 195 patients with dyslipidemia in a cross-sectional study carried out in two academic endocrinology clinics in Shiraz, Iran. The questionnaire comprised of three main domains of demographic data (6 questions), clinical data (2 of them), and data related to the use of medicinal plants (totally 9 questions). Results A total of 77.4% of patients took medicinal plants. The most common medicinal herbs used by dyslipidemic patients were Zataria multiflora, Cinnamomum zeylanicum, and Zingiber officinale. Duration of dyslipidemia was significantly longer in herbal users than non-herbal users (p=0.04). Patients believing that concomitant use of conventional drugs and herbal preparations had synergic positive effects in addition to those persuaded that herbal preparations possessed less side effects, were significantly more likely to use medicinal plants (p=0.008 and 0.005, respectively). Additionally, most of the medicinal herb users (87.4%) changed neither the pattern nor the dosage of their medications all during herbal preparations use. Conclusions This study demonstrated a high prevalence of medicinal plants’ use among patients with dyslipidemia, which was associated with the duration of dyslipidemia, patients’ viewpoints about herbal preparations’ synergic positive effects, and their fewer side effects.

scholarly journals Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia

2021 ◽  
Vol 14 (9) ◽  
pp. 873
Author(s):  
Abanoub Riad ◽  
Barbora Hocková ◽  
Lucia Kantorová ◽  
Rastislav Slávik ◽  
Lucia Spurná ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Healthcare Workers ◽  
Large Scale ◽  
Large Population ◽  
Medical Attention ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Phase Iv

mRNA-based COVID-19 vaccines such as BNT162b2 have recently been a target of anti-vaccination campaigns due to their novelty in the healthcare industry; nevertheless, these vaccines have exhibited excellent results in terms of efficacy and safety. As a consequence, they acquired the first approvals from drug regulators and were deployed at a large scale among priority groups, including healthcare workers. This phase IV study was designed as a nationwide cross-sectional survey to evaluate the post-vaccination side effects among healthcare workers in Slovakia. The study used a validated self-administered questionnaire that inquired about participants’ demographic information, medical anamneses, COVID-19-related anamnesis, and local, systemic, oral, and skin-related side effects following receiving the BNT162b2 vaccine. A total of 522 participants were included in this study, of whom 77% were females, 55.7% were aged between 31 and 54 years, and 41.6% were from Banska Bystrica. Most of the participants (91.6%) reported at least one side effect. Injection site pain (85.2%) was the most common local side effect, while fatigue (54.2%), headache (34.3%), muscle pain (28.4%), and chills (26.4%) were the most common systemic side effects. The reported side effects were of a mild nature (99.6%) that did not require medical attention and a short duration, as most of them (90.4%) were resolved within three days. Females and young adults were more likely to report post-vaccination side effects; such a finding is also consistent with what was previously reported by other phase IV studies worldwide. The role of chronic illnesses and medical treatments in post-vaccination side effect incidence and intensity requires further robust investigation among large population groups.

scholarly journals Healthcare personnel knowledge, motivations, concerns and intentions regarding COVID-19 vaccines: a cross-sectional survey

2021 ◽  
Author(s):  
Vivek Jain ◽  
Sarah B. Doernberg ◽  
Marisa Holubar ◽  
Beatrice Huang ◽  
Carina Marquez ◽  
...  
Keyword(s):  
Side Effects ◽  
San Francisco ◽  
Vaccine Uptake ◽  
Healthcare Personnel ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Adult Age ◽  
Raising Awareness ◽  
Few Data ◽  
The University

AbstractBackgroundHealthcare personnel (HCP) are prioritized for earliest SARS-CoV-2 vaccine administration, yet relatively few data exist on HCP’s knowledge, motivations, concerns, and intentions regarding COVID-19 vaccines.MethodsWe conducted a cross-sectional survey Nov.16-Dec.8, 2020 among HCP enrolled in a cohort study at three Northern California medical centers serving diverse roles including COVID-19 patient care. Eligible HCP were adult (age≥18) on-site employees of the University of California, San Francisco, San Francisco General Hospital, and Stanford Healthcare. A one-time electronically-administered survey was sent to cohort HCP on November 16, 2020 and responses analyzed.ResultsOverall, among 2,448 HCP invited, 2,135 completed the COVID-19 vaccine survey (87.2% response rate). HCPs had mean age 41 years, were 73% female, and had diverse jobs including COVID-19 patient contact. Enthusiasm for vaccination was overall strong, and more HCP (1,453, 69%) said they would definitely/likely receive vaccine if formally FDA-approved versus if approved via emergency use authorization only (785, 35%). While 541 (25%) respondents wanted to be among the earliest to receive vaccine, more desired vaccination after the first round (777, 36%) or >2 months after vaccinations began (389, 18%). Top factors increasing motivation for vaccination included perceiving risk from COVID-19 to self (1,382, 65%) or to family/friends (1355, 63%). Top concerns were vaccine side effects, cited by 596 (28%), and concerns about political involvement in FDA’s approval process (249, 12%).ConclusionsHCP were enthusiastic about COVID-19 vaccination for individual protection and protecting others, but harbored concerns about vaccine side effects. Our data may inform emerging vaccine education campaigns.Key PointsAmong 2,135 healthcare personnel surveyed, we found enthusiasm for COVID-19 vaccination both for individual benefit and protecting others. However, healthcare personnel rated their knowledge of COVID-19 vaccines as only moderate and harbored concerns about vaccine side effects. Education raising awareness of vaccine efficacy and side effects may help maximize vaccine uptake.

scholarly journals Nursing students' attitudes, knowledge, and willingness to receive the COVID-19 vaccine: A cross-sectional study

2021 ◽  
Author(s):  
Ning Jiang ◽  
Baojian Wei ◽  
Hua Lin ◽  
Youjuan Wang ◽  
Shouxia Chai ◽  
...  
Keyword(s):  
Nursing Students ◽  
Side Effects ◽  
Influencing Factors ◽  
Family Members ◽  
Cross Sectional Survey ◽  
School Students ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
Academic Background ◽  
To Receive

Aim: To investigate nursing students' konwledge, attitudes and willingness to receive the COVID-19 vaccine, and the influencing factors. Background: Vaccination is one of the effective measures to prevent COVID-19, but the vaccination acceptance varies across countries and populations. As reserve nurses, nursing students have both the professionalism of medical personnel and the special characteristics of school students, their attitudes, knowledge, and willingness to receive the COVID-19 vaccine may greatly affect the vaccine acceptance of the population now and in the future. But little research has been done on vaccine acceptance among nursing students. Design: A cross-sectional survey of nursing students was conducted via online questionnaires in March 2021. Methods: Descriptive statistics, independent sample t tests/one-way ANOVA (normal distribution), Mann-Whitney U tests/Kruskal-Wallis H tests (skewness distribution) and multivariate linear regression were performed. Results: The score rate of attitude, knowledge and vaccination willingness were 70.07%, 80.70% and 84.38% respectively. Attitude was significantly influenced by family economic conditions and whether a family member had been vaccinated. The main factors influencing knowledge were gender, grade and academic background. In terms of willingness, gender, academic background, visits to risk areas, whether family members were vaccinated, and whether they had side effects were significant influencing factors. Conclusions: The vaccine acceptance of nursing students was fair. Greater focus needed to be placed on the males, those of younger age, with a science background, and having low grades, as well as on students whose family members had not received the COVID-19 vaccine or had side effects from the vaccine. Targeted intervention strategies were recommended to improve vaccination rates.

scholarly journals Concerning Impact of Decreasing Infant Cereal Consumption on Essential Nutrient Intakes of Breastfed Babies: Feeding Infants and Toddlers Study (FITS) 2016 (P11-064-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Kristen Finn ◽  
Brian Kineman ◽  
Ryan Carvalho
Keyword(s):  
Infant Formula ◽  
Nutrient Intakes ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Dietary Recall ◽  
Breastfed Infants ◽  
Funding Sources ◽  
Calcium Phosphorus ◽  
Dietary Nutrient ◽  
Essential Nutrient

Abstract Objectives Infant cereal consumption among 6–11.9 month old infants has declined from 72% in 2002 to 52% in 2016. This is especially concerning for breastfed infants since infant cereal is a top source of iron and other key nutrients. The purpose of this study is to determine how infant cereal consumption impacts nutrient intakes of breastfed infants. Methods FITS 2016 is a cross sectional survey of caregivers across the U.S. assessing food and nutrient intakes. A 24 hour dietary recall was administered to caregivers of children aged 0–47.9 months (n = 3235). For this analysis, only infants aged 6–11.9 months who were either breastfed (no infant formula provided, n = 296) or mixed fed (breastmilk and infant formula provided, n = 102) were included. If any amount of infant cereal was consumed, the infant was considered a cereal user. Dietary supplements were excluded to determine usual nutrient intakes from diet only. Infants were categorized as a breastfed cereal user, breastfed non-user, mixed fed cereal user, or mixed fed non-user. The percentage of infants with dietary nutrient intakes below the adequate intake (AI) or estimated average requirement (EAR) were analyzed for significant differences between cereal users and non-users among breastfed and mixed fed infants using paired T-tests. Results Among breastfed infants, a significantly higher percentage of cereal users had intakes above the EAR or AI level for iron, vitamin C, thiamine, riboflavin, niacin, vitamin B6, folate, vitamin B12, calcium, phosphorus, magnesium, vitamin A, zinc, potassium, and choline compared to non-users (See Figure 1). Among mixed fed infants, a significantly higher percentage of cereal users had intakes above the EAR or AI level for iron, magnesium, and choline (See Figure 2). Most infants had inadequate intakes of vitamin D. Conclusions Breastfed and mixed fed infants who consume infant cereal are more likely to have adequate intakes of iron, choline, and magnesium than their non-infant cereal consuming counterparts. Among breastfed infants, infant cereal consumers are also more likely to consume adequate amounts of 12 other nutrients compared to non-users. Infant cereal is a source of many key nutrients and is an important complementary food, especially for breastfed infants. Funding Sources Nestlé Research Center, Switzerland. Supporting Tables, Images and/or Graphs

Local Side Effects Caused by Hair Dye Use in Females: Cross-sectional Survey

2012 ◽  
Vol 16 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Khalid M. Alghamdi ◽  
Noura A. Moussa
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Public Awareness ◽  
Hair Dyes ◽  
Cross Sectional Survey ◽  
Hair Dye ◽  
Cross Sectional ◽  
Relevant Variables ◽  
Skin Redness ◽  
Local Side

Background: Despite its association with a number of side effects, hair dye use is common worldwide. Objective: To explore the local side effects of hair dye use and to relate these effects to features of hair dyeing. Methods: A questionnaire about hair dye use was distributed to a random sample of 650 female patients at various outpatient clinics in 2008. Results: A total of 567 females returned the questionnaire (87.2% response rate). Of these respondents, 82.6% (464 of 562) had used hair dye products in the past. The mean age at first use was 22.23 ± 7.05 years, and the median time between two consecutive dyes was 6 months. Of these respondents, 76.8% (354 of 461) used permanent dyes. Participants reported that they suffered skin redness caused by hair dyes (15.1%, 65 of 431), had scaling (14.4%, 60 of 417), or had itchiness (31.3%, 134 of 428). In addition, 74% (262 of 354) of the participants reported that they had issues with the texture or condition of hair following hair dye use; 77.7% (314 of 404) reported split ends, whereas 69.6% (273 of 392) reported hair dryness, 69.4% (256 of 369) lusterless hair, 77.2% (308 of 399) excessive hair loss, and 53.6% (210 of 392) excessive hair graying. Furthermore, 55.1% (196 of 356) of the participants reported a slowing of hair growth. The total number of hair dyeing events was associated with increased hair loss (p = .04) and excessive graying (p < .001) after controlling for all relevant variables. Conclusion: Hair dye is associated with local side effects to the skin and hair. Increased public awareness of these risks could help inform consumer choices and reduce excessive use.

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