P5299Epicardial obesity as a significant predictor of leptino and insulin resistance

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Ott ◽  
G A Chumakova
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Linear Regression Analysis ◽  
Clinical Manifestations ◽  
Visceral Obesity ◽  
Soluble Receptors ◽  
Correlation Relationship ◽  
Group 2 ◽  
The Right

Abstract Leptino (LR) and insulin resistance (IR) are significant predictors of atherosclerosis, thrombosis, type 2 diabetes. The effect of epicardial obesity (EO) (as a type of visceral obesity) on the formation of LR and IR is studied. Objective To study the effect of EO on the formation of LR and IR among men with arterial hypertension (AH). Materials and methods The study included 130 men 49.5±4.3 years old, with AH of 1–3 degrees and the absence of clinical manifestations of coronary heart disease and atherosclerosis of other localizations, type 2 diabetes with a BMI of 20–35 kg /m2 and abdominal obesity according to WC ≥94 cm. Patients were divided into two groups depending on the thickness of epicardial adipose tissue (EAT), measured behind the free wall of the right ventricle by echocardiography. Group 1 consisted of 60 patients with epicardial obesity (EAT ≥7 mm), group 2 included 70 patients without epicardial obesity (EAT <7 mm). All subjects assessed indicators of LR and IR: measured levels of serum leptin (SL), soluble receptors for leptin (SLR), free leptin index (FLI), calculated as the ratio SL/SLR (as the only currently existing marker LR); IR was estimated by calculating the HOMA-IR index. IR was diagnosed with the generally accepted HOMA-IR index >2.7. Results When comparing LR indices in the studied groups, higher average values of SL, FLI were observed in the group with EO (EAT ≥7 mm) than in the group without EO (EAT <7 mm): (SL = 32.16 ng/ml (26.7; 37.62) versus SL = 14.92 ng/ml (11.62; 18.22), p=0.01, respectively); (FLI = 1.67 (0.47; 2.87) versus FLI = 0.37 (0.28; 0.46), p=0.01, respectively). Also in the EO group, higher indices of the HOMA-IR index were observed compared with the group without EO: (2.16 (1.62; 2.66) versus 1.35 (1.06; 1.64), p=0,01, respectively). When conducting the correlation analysis between FLI (as a marker of LR) and various obesity indicators (BMI, WC, EO) in the studied groups, a significant positive correlation relationship between FLI and EO was found in both the first and second groups (r=0.67, p=0.01; r=0.62, p=0.01, respectively). The IR index HOMA-IR also significantly positively correlated with EO in the group with a EAT ≥7 mm (r=0.68, p=0.01). BMI and WC did not correlate with FLI, IR in both groups 1 and 2 (p>0.05). In the EO group, 11 patients had IR with a HOMA-IR index >2.7. Using the linear regression analysis, the regression equation was obtained and the value of EO was calculated, from which the IR with HOMA-IR >2.7 started to be determined. This figure was 9.5 mm. Conclusions EO (EAT ≥7 mm) is a significant predictor of LR and IR, unlike the generally accepted criteria for obesity (BMI, WC). A EAT ≥9.5 mm can be a significant predictor of the development of type 2 diabetes, so these patients need additional examinations.

scholarly journals Increased Plasma DPP4 Activity Is Predictive of Prediabetes and Type 2 Diabetes Onset in Chinese Over a Four-Year Period: Result From the China National Diabetes and Metabolic Disorders Study

2014 ◽  
Vol 99 (11) ◽  
pp. E2330-E2334 ◽  
Author(s):  
Tianpeng Zheng ◽  
Yun Gao ◽  
Attit Baskota ◽  
Tao Chen ◽  
Xingwu Ran ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Confidence Interval ◽  
Proportional Hazards ◽  
Chinese Women ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cox Proportional Hazards ◽  
Dipeptidyl Peptidase 4

Context: The significance of associations between prediabetes, type 2 diabetes, and dipeptidyl peptidase-4 (DPP4) activity in a Chinese population is not clear. Objective: The objective of the study was to determine whether DPP4 activity and active glucagon-like peptide-1 (GLP-1) were predictive of the onset of prediabetes and type 2 diabetes. Design, Setting, and Patients: This was a 4-year follow-up study conducted in Sichuan, China. A total of 474 Chinese women and men aged 18–70 years were studied. Main Outcome Measures: All subjects were divided into 3 groups (normal glucose tolerance, prediabetes, and type 2 diabetes) on the basis of their glucose metabolism status after 4 years. The DPP4 activity, active GLP-1, and glucagon were measured at baseline and 4 years later. Results: The baseline DPP4 activity was significantly higher in subjects who had progressed to prediabetes or type 2 diabetes compared with subjects who remained normoglycemic (P &lt; .01). In a multiple linear regression analysis, baseline DPP4 activity and active GLP-1 were independent predictors of an increase in insulin resistance over a 4-year period (P &lt; .05). Cox proportional hazards models revealed that DPP4 activity independently predicted the risk of developing prediabetes [relative risk 2.77 (95% confidence interval 1.38–5.55), P &lt; .01] and type 2 diabetes [5.10 (95% confidence interval 1.48–17.61), P &lt; .05] after adjustment for confounding risk factors. Conclusions: DPP4 activity is an important predictor of the onset of insulin resistance, prediabetes, and type 2 diabetes in apparently healthy Chinese individuals. This finding may have important implications for understanding the etiology of diabetes.

scholarly journals The polycystic ovary syndrome per se is not associated with increased chronic inflammation

2004 ◽  
pp. 525-532 ◽  
Author(s):  
M Mohlig ◽  
J Spranger ◽  
M Osterhoff ◽  
M Ristow ◽  
AF Pfeiffer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fat Mass ◽  
Linear Regression Analysis ◽  
Diabetes Risk ◽  
Total Testosterone ◽  
Multivariate Linear Regression Analysis ◽  
Metabolic Alterations ◽  
Markers Of Inflammation

OBJECTIVE: The syndrome of polycystic ovaries (PCOS) is a known risk factor for type 2 diabetes. It is not known, however, whether the increase in diabetes risk is related to endocrine abnormalities associated with PCOS such as hyperandrogenemia, or whether it is a consequence of the anthropometric or metabolic alterations frequently observed in PCOS women. DESIGN: Since markers of inflammation are supposed to predict type 2 diabetes, interleukin-6 (IL-6) and C-reactive protein (CRP) in combination with parameters of obesity, insulin resistance and hyperandrogenism were determined in 57 PCOS women and in 20 age-matched healthy controls. In addition, the C-174G IL-6 promoter polymorphism was analyzed as a determinant in influencing IL-6, obesity, and androgen levels in women. RESULTS: Neither CRP nor IL-6 were significantly elevated in lean or obese PCOS women compared with age-matched lean or obese controls. In PCOS patients, variables of body composition (body mass index (BMI), waist to hip ratio, dual-energy X-ray-absorptiometry fat mass) and of insulin resistance were correlated with IL-6 or CRP, while parameters of hyperandogenism were not. Multivariate linear regression analysis revealed that obesity is the dominant force, thus explaining 18% and 24% of the IL-6 or CRP levels, respectively, in PCOS women. No association of IL-6 or BMI to a certain genotype at C-174G could be demonstrated in 50 PCOS patients. The heterozygous GC genotype, however, was associated with lower androstendione levels. Metformin treatment of 9 obese, insulin-resistant PCOS patients over a period of 6 months caused a significant decrease in body weight, body fat mass and total testosterone, but showed no significant decline in IL-6 or CRP concentrations. CONCLUSIONS: In PCOS women, plasma levels of IL-6 and CRP were not increased when compared with age- and BMI-matched controls. BMI was, however, the parameter most strongly related to IL-6 and CRP in PCOS; thus PCOS-related endocrine abnormalities do not appear to activate inflammatory parameters thereby enhancing the risk of diabetes. In PCOS, the type 2 diabetes risk may, therefore, be confined to those with obesity and/or metabolic alterations rather than affecting all women suffering from the syndrome.

scholarly journals РОЛЬ МАРКЕРА КОСТНОГО РЕМОДЕЛИРОВАНИЯ ОСТЕОКАЛЬЦИНА В РЕГУЛЯЦИИ ЭНЕРГЕТИЧЕСКОГО ГОМЕОСТАЗА ПРИ САХАРНОМ ДИАБЕТЕ 2 ТИПА

World Science ◽  
2020 ◽  
Vol 2 (5(57)) ◽  
pp. 20-29
Author(s):  
Ковальчук А. В. ◽  
Зиныч О. В. ◽  
Корпачев В. В. ◽  
Кушнарева Н. Н. ◽  
Прибила О. В.
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Energy Homeostasis ◽  
Visceral Obesity ◽  
Mineral Density ◽  
General Group ◽  
Men And Women ◽  
Visceral Adipose

Osteocalcin (OK) is actively involved in the humoral regulation of energy homeostasis. However, the relationship between the level of OK as a modulator of metabolic processes and constitutional and metabolic features in patients with type 2 diabetes mellitus (DM) of a different gender remains not thoroughly studied.The study included 127 patients with type 2 diabetes ≥ 50 years of age. Of these, 70 were postmenopausal women and 57 men.It was found that in the general group of women, the concentration of OK in the blood serum was significantly higher than in men. The observed difference is due to significantly higher levels of OK in women of the older age group (≥ 60 years) in comparison with men. At the same time, a decrease in bone mineral density (BMD) in the femoral neck was observed in subgroups of men and women aged ≥ 60 years and older, while in the younger subgroups of patients, the BMD of lumbar and femoral zones were close to each other.The relationships between OK levels and adipose tissue parameters, evaluated by calculating the morphological and functional index of visceral obesity (IVO), were investigated. An increase in the OK level in the groups of men and women was accompanied by a decrease in the IVO values. The highest degree of insulin resistance was determined in groups of patients with minimal levels of OK and high IVO, and the lowest values were recorded in patients with high levels of OK and low IVO.The decrease of the blood OK level in patients with type 2 diabetes occurs in parallel with an increase in the degree of insulin resistance and dysfunction of visceral adipose tissue. In this case, IVO is a more accurate parameter reflecting the constitutional and metabolic phenotypic changes, compared with the index of the waist circumference. The decrease in BMD in patients with type 2 diabetes is the result of predominantly involutive processes that are noticeable at the age of ≥ 60 years and occur against the background of a decrease in the content of OK with age.

scholarly journals Optimal Waist Circumference Cutoff Value Based on Insulin Resistance and Visceral Obesity in Koreans with Type 2 Diabetes

2015 ◽  
Vol 39 (3) ◽  
pp. 253 ◽  
Author(s):  
Jung Soo Lim ◽  
Young Ju Choi ◽  
Soo-Kyung Kim ◽  
Byoung Wook Huh ◽  
Eun Jig Lee ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Waist Circumference ◽  
Visceral Obesity ◽  
Cutoff Value

scholarly journals Incidence of type 2 diabetes in familial combined hyperlipidemia

2020 ◽  
Vol 8 (1) ◽  
pp. e001107 ◽  
Author(s):  
Martijn C G J Brouwers ◽  
Jacqueline de Graaf ◽  
Nynke Simons ◽  
Steven Meex ◽  
Sophie ten Doeschate ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Liver ◽  
Visceral Obesity ◽  
High Risk Population ◽  
Model Assessment ◽  
Familial Combined Hyperlipidemia ◽  
Original Cohort

ObjectiveFamilial combined hyperlipidemia (FCHL) is common among survivors of a premature myocardial infarction. FCHL patients are characterized by visceral obesity, fatty liver, and insulin resistance. The aim of the present study was to determine the incidence and determinants of type 2 diabetes (T2D) in a longitudinal cohort of FCHL pedigrees.Research design and methodsFCHL patients, their unaffected relatives and spouses included in our baseline cohort in 1998–2005 (n=596) were re-invited to determine the incidence of self-reported T2D (that was confirmed by medical records), used as the primary outcome measure. The Fatty Liver Index (FLI) and Homeostasis Model Assessment Insulin Resistance (HOMA2-IR) were used as markers of fatty liver and insulin resistance, respectively. A subset of the original cohort underwent ultrasound of the liver, and subcutaneous and visceral fat in 2002–2005 (n=275; ‘ultrasound subcohort’).ResultsFollow-up data (median: 15 years) was acquired for 76%. The incidence rate of T2D was significantly higher in FCHL patients compared with spouses (19.2 per 1000 person-years vs 2.8 per 1000 person-years; HR : 6.3, 95% CI: 2.4 to 16.8), whereas no differences were observed between unaffected relatives and spouses (HR: 0.9, 95% CI: 0.3 to 2.6). Cox’s proportional hazard regression analyses showed that baseline HOMA2-IR and FLI≥60, but not waist circumference, BMI, or the FCHL affected state, were independently associated with incident T2D. Similar results were obtained in the ultrasound subcohort (median follow-up: 11 years), in which baseline HOMA2-IR and fatty liver (assessed by ultrasound) were independently associated with incident T2D.ConclusionThis study further corroborates the suggestion that the liver plays a central role in the pathogenesis of cardiometabolic complications in FCHL. It supports periodical screening for T2D in this high-risk population.

scholarly journals Ketone Bodies Are Mildly Elevated in Subjects with Type 2 Diabetes Mellitus and Are Inversely Associated with Insulin Resistance as Measured by the Lipoprotein Insulin Resistance Index

2020 ◽  
Vol 9 (2) ◽  
pp. 321 ◽  
Author(s):  
Erwin Garcia ◽  
Irina Shalaurova ◽  
Steven P. Matyus ◽  
David N. Oskardmay ◽  
James D. Otvos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mass Spectrometry ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ketone Bodies ◽  
Linear Regression Analysis ◽  
Resistance Index ◽  
Insulin Resistance Index

Background: Quantifying mildly elevated ketone bodies is clinically and pathophysiologically relevant, especially in the context of disease states as well as for monitoring of various diets and exercise regimens. As an alternative assay for measuring ketone bodies in the clinical laboratory, a nuclear magnetic resonance (NMR) spectroscopy-based test was developed for quantification of β-hydroxybutyrate (β-HB), acetoacetate (AcAc) and acetone. Methods: The ketone body assay was evaluated for precision, linearity and stability and method comparisons were performed. In addition, plasma ketone bodies were measured in the Insulin Resistance Atherosclerosis Study (IRAS, n = 1198; 373 type 2 diabetes mellitus (T2DM) subjects). Results: β-HB and AcAc quantified using NMR and mass spectrometry and acetone quantified using NMR and gas chromatography/mass spectrometry were highly correlated (R2 = 0.996, 0.994, and 0.994 for β-HB, AcAc, acetone, respectively). Coefficients of variation (%CVs) for intra- and inter-assay precision ranged from 1.3% to 9.3%, 3.1% to 7.7%, and 3.8% to 9.1%, for β-HB, AcAc and acetone, respectively. In the IRAS, ketone bodies were elevated in subjects with T2DM versus non-diabetic individuals (p = 0.011 to ≤0.001). Age- and sex-adjusted multivariable linear regression analysis revealed that total ketone bodies and β-HB were associated directly with free fatty acids (FFAs) and T2DM and inversely with triglycerides and insulin resistance as measured by the Lipoprotein Insulin Resistance Index. Conclusions: Concentrations of the three main ketone bodies can be determined by NMR with good clinical performance, are elevated in T2DM and are inversely associated with triglycerides and insulin resistance.

scholarly journals Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Peng Duan ◽  
Min Yang ◽  
Meilin Wei ◽  
Jia Liu ◽  
Ping Tu
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Postmenopausal Women ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Glucose Regulation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Potential Biomarker ◽  
Chinese Postmenopausal Women

The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (n=93), impaired glucose regulation (IGR) (n=90), and normal glucose regulation group (NGR) (n=88), according to different glucose regulation categories. Serum OPG levels were measured by enzyme-linked immunosorbent assay. The serum OPG concentration in NGR group, 151.00 ± 45.72 pg/mL, was significantly lower than that in IGR group (169.28 ± 64.91 pg/mL) (p=0.031) and T2DM group (183.20 ± 56.53 pg/mL) (p<0.01), respectively. In multiple linear regression analysis, HOMA-IR, age, 2hPG, AST, ALP, and eGFR were found to be independent predictors of OPG. Increased serum OPG levels (OR = 1.009,p=0.006) may be a risk factor for insulin resistance. The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.

scholarly journals Effect of visceral obesity on main artery elasticity and vascular age in patients with hypertension, obesity, and type 2 diabetes

2021 ◽  
Vol 26 (4) ◽  
pp. 4466
Author(s):  
M. E. Statsenko ◽  
M. V. Derevyanchenko
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Events ◽  
Visceral Obesity ◽  
Main Artery ◽  
Group 4 ◽  
Vascular Age ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. To assess the effect of visceral obesity on main artery elasticity and vascular age in patients with hypertension (HTN), obesity, and type 2 diabetes (T2D).Material and methods. A total of 320 patients with stage II-III HTN aged 4570 years were divided into 4 groups: isolated HTN (group 1), HTN and obesity (group 2), HTN, obesity and T2D (group 3), HTN and T2D without obesity (group 4). We assessed the clinical status, parameters of visceral obesity, main artery elasticity, and vascular age. We used nonparametric statistics, Spearman correlation analysis.Results. At least 50% of all patients had visceral obesity, despite no BMI-estimated obesity in groups 1 and 4: 57,5 vs 100,0 vs 100,0 vs 50,0% in groups 1, 2, 3 and 4, respectively (p<0,0001).In the groups where hypertension was combined with obesity and T2D, the proportion of patients with leptin content above 32,7 ng/ml significantly increased to 80% (in total for groups 2 and 3) compared with 25,0% among HTN people without obesity (in total for groups 1 and 4). There was a significant increase in proportion of patients with a adiponectin decrease <14,6 ng/ml among patients with a combination of HTN and T2D ± obesity (45% in total for groups 3 and 4) in comparison with those with HTN and without T2D ± obesity (22,5% in total for groups 1 and 2).The visceral adiposity index (VAI) was significantly higher among patients with HTN, obesity and T2D compared with those with isolated HTN and HTN in combination with T2D only (2,96 [2,36; 3,98] vs 1,87 [1,40; 2,67] vs 2,22 [1,61; 3,26], respectively). A higher proportion of subjects with adipose tissue dysfunction was noted in groups 2 and 3 compared to groups 1 and 4 (75 vs 81,1 vs 41,5 vs 53,4%, respectively, p1-2<0,001, p1-3<0,001, p2-4=0,023, p3-4=0,002).The proportion of patients with a pulse wave velocity >10 m/s was consistently more common among patients of group 3 compared with patients in groups 1 and 2 (77,0 vs 57,9 and 55,3%, respectively, p1-3=0,004, p2-3=0,006).Vascular age was significantly lower in group 1 compared with groups 3 and 4 (64,0 [57,8; 71,0] vs 69,0 [62,0; 73,0] and 69,5 [66,0; 74,3] years, respectively), as well as in group 2 compared with group 4 (64,0 [56,5; 70,5] vs 69,5 [66,0; 74,3] years). The 5-year risk of cardiovascular events was significantly higher among patients with hypertension, obesity and T2D and those with HTN and T2D without obesity, compared with patients with isolated HTN, and with those with HTN and obesity (5,9 [3,9; 7,9] and 6,5 [4,7; 8,7] vs 4,4 [2,7; 6,8] and 3,6 [2,4; 5,8], respectively). Correlation analysis revealed the relationship between the visceral obesity parameters, main artery elasticity, vascular age and the 5-year risk of cardiovascular events, demonstrating the special aspects of HTN course in each of the studied groups.Conclusion. The paper showed peculiarities of the effect of visceral obesity on main artery elasticity and vascular age in patients with HTN in combination with obesity and T2D.

scholarly journals Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yuanyuan Luo ◽  
Hua Qu ◽  
Hang Wang ◽  
Huili Wei ◽  
Jing Wu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Multiple Linear Regression Analysis ◽  
Chinese Patients ◽  
Model Assessment ◽  
Related Factors

The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin levels in the T2DM group were significantly higher than the NGT group (P<0.01). Patients with both OB and T2DM had the highest periostin levels. Correlation analysis showed that plasma periostin levels were positively correlated with weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-α, and IL-6 (P<0.05or 0.001) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.001). Multiple linear regression analysis showed that TG, TNF-α, and HOMA-IR were independent related factors in influencing the levels of plasma periostin (P<0.001). These results suggested that Chinese patients with obesity and T2DM had significantly higher plasma periostin levels. Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance.

scholarly journals Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Alex S. Yamashita ◽  
Thiago Belchior ◽  
Fábio S. Lira ◽  
Nicolette C. Bishop ◽  
Barbara Wessner ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Chronic Disease ◽  
Visceral Fat ◽  
Visceral Obesity ◽  
Low Grade ◽  
Cell Dysfunction ◽  
Low Grade Inflammation

Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β-cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation.

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