scholarly journals 394 Incidence and prevalence of acute myocarditis and pericarditis prior to and during COVID-19 pandemic

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Roberto Licordari ◽  
Chrysanthos Grigoratos ◽  
Giancarlo Todiere ◽  
Andrea Barison ◽  
Antonio Micari ◽  
...  
Keyword(s):  
Heart Disease ◽  
Heart Diseases ◽  
Acute Myocarditis ◽  
Cardiac Injury ◽  
Annual Incidence ◽  
Time Intervals ◽  
Inflammatory Heart Disease ◽  
Heart Disorders ◽  
Areas Of Interest

Abstract Aims Myocarditis and pericarditis have been proposed to account for a proportion of cardiac injury during SARS-CoV-2 infection. During the COVID-19 pandemic, it is reasonable to expect an increasing trend in incidence of this acute inflammatory cardiac diseases. To examine the incidence and prevalence of inflammatory heart disorders prior to and during the COVID-19 pandemic. Methods and results This is a retrospective cohort study examining the incidence and prevalence of acute inflammatory heart diseases (myocarditis, pericarditis) in provinces of Pisa, Lucca and Livorno (total population of 11421285 inhabitants) in two time-intervals: (i) prior to (PRECOVID, from 1 June 2018 to 31 May 2019) and (ii) during the COVID-19 pandemic (COVID, from 1 June 2020 to May 2021). Overall 259 cases of inflammatory heart disease (myocarditis and/or pericarditis) occurred in the areas of interest. The annual incidence was of 11.3 cases per 100 000 inhabitants. Particularly, 138 cases occurred in the PRECOVID, and 121 in the COVID period. The annual incidence of inflammatory heart disease was not significantly different (12.1/100 000 in PRECOVID vs. 10.3/100 000 in COVID; P = 0.22). The annual incidence of acute myocarditis was significantly higher in PRECOVID than in the COVID: respectively, 8.1/100 000/year vs. 5.9/100 000 year (P = 0.047), consisting in a net reduction of 27% of cases. Particularly the incidence of myocarditis was significantly lower in COVID than in PRECOVID in the class of age 18–24 (P = 0.048) (Figure). The annual incidence of pericarditis was not significantly different (4.03/100 000 vs. 4.47/100 000; P = 0.61). Conclusions Despite a possible etiologic role of SARS-CoV-2 and an expectable increased incidence of myocarditis and pericarditis, data suggest a decrease of acute myocarditis and a stable incidence pericarditis and both diseases.

scholarly journals Role of TEE in Improving Diagnostic Accuracy of Congenital Heart Disease

2014 ◽  
Vol 2 (2) ◽  
pp. 68-70
Author(s):  
Sandeep Singh Rana ◽  
Balbir Kumar ◽  
Sethu Madhavan J
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Diagnostic Accuracy ◽  
Multimodal Imaging ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Associated Lesions ◽  
Cardiac Lesions ◽  
Intraoperative Period

ABSTRACT Complex congenital heart diseases (CHD) often present as multiple cardiac lesions. The presence of one anomaly should stimulate the physician to perform a comprehensive assessment and look for other associated anomalies.1 Multimodal imaging may be necessary to diagnose such associated lesions as single imaging may occasionally miss them. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) are complimentary to each other. Routine use of TEE during intraoperative period may help us to refine diagnosis, detect the missing components and guide effective surgical repair. We present one such case where diagnosis and management were optimized by multimodal imaging. How to cite this article Kumar B, Madhavan JS, Puri GD, Rana SS. Role of TEE in Improving Diagnostic Accuracy of Congenital Heart Disease. J Perioper Echocardiogr 2014;2(2):68-70.

A LITERATURE REVIEW ON ANALYSIS OF PALM PATTERNS TO DETECT CONGENITAL HEART DISEASES

2020 ◽  
Vol 32 (02) ◽  
pp. 2050012
Author(s):  
Y. Mahesha ◽  
C. Nagaraju
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases ◽  
Normal People ◽  
Different Types ◽  
Left And Right ◽  
Paper Method

This paper presents the survey on different techniques which can be used to detect congenital heart disease using palm patterns. The congenital heart disease is one of the heart diseases which starts from birth. Research works are carried out towards detecting congenital heart disease before symptom appears using palm patterns so that it avoids critical health problems in future. Researchers have collected palm prints from normal people who are not suffering from any kind of heart disease and from patients who are suffering from different types of congenital heart diseases. These palm prints are collected from different hospitals. The palm prints are taken using ink and paper method. These palm patterns are analyzed to determine the role of palm pattern while detection of the disease. Few researchers have considered only triradius of palm and most of the researchers have considered palm patterns such as whorl, loop, arch and hypothenar pattern. In case of triradius, researchers have calculated position of axial triradius and it is categorized into three types. In case of whorl, loop and arch, they have considered how often they appear in palm of normal people and patients. Few researchers have analyzed both left and right hands of normal people and patients.

The growing landscape of succinylation links metabolism and heart disease

Epigenomics ◽  
2021 ◽  
Author(s):  
Lanting Yang ◽  
Shuo Miao ◽  
Jing Zhang ◽  
Peiyan Wang ◽  
Gaoli Liu ◽  
...  
Keyword(s):  
Heart Disease ◽  
Heart Diseases ◽  
Biochemical Process ◽  
Post Translational Modification ◽  
Functional Changes ◽  
Lysine Succinylation ◽  
Great Progress ◽  
Metabolic Reactions ◽  
Significant Chemical

Post-translational modification of proteins is an important biochemical process that occurs at the protein level. Succinylation is a newly discovered post-translational modification with the hallmark of a significant chemical and structural change. Succinylation has many similarities with other modifications, but succinylation may lead to more functional changes. Although the physiological significance of succinylation has not been well characterized, the lysine succinylation modification shows great potentials during disease processes. The discovery of SIRT5 has made great progress in exploring the role of succinylation in energy metabolism, heart disease and tumorigenesis. In this review, we focus on the discovery of succinylation in organisms and mechanism of succinylation. We are also concerned with the metabolic reactions and heart diseases associated with succinylation.

The Role of MicroRNA and LncRNA–MicroRNA Interactions in Regulating Ischemic Heart Disease

2016 ◽  
Vol 22 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Na Li ◽  
Murugavel Ponnusamy ◽  
Meng-peng Li ◽  
Kun Wang ◽  
Pei-Feng Li
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Heart Diseases ◽  
Noncoding Rnas ◽  
Ischemic Heart ◽  
Messenger Rnas ◽  
Protein Coding ◽  
Coding Regions ◽  
Pathological Cardiac Hypertrophy

Approximately 2% of the human genome consists of protein-coding regions. Therefore, the majority of transcripts are noncoding RNAs, such as microRNA (miRNA) and long noncoding RNAs (lncRNAs). In ischemic heart disease, the majority of miRNAs are repressors or destabilizers of target messenger RNAs. The lncRNAs are a second class of noncoding RNAs that have recently gained attention for their roles in heart disease and in regulating the functions of miRNA. In this review, we summarize the role of miRNA in pathological cardiac hypertrophy and myocardial infarction. In addition, we discuss the functional interactions of miRNA and lncRNA and its impact on these ischemic heart diseases.

scholarly journals The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Ye-Shun Wu ◽  
Bin Zhu ◽  
Ai-Lin Luo ◽  
Ling Yang ◽  
Chun Yang
Keyword(s):  
Cardiovascular Disease ◽  
Heart Disease ◽  
Disease Burden ◽  
Heart Diseases ◽  
Critical Role ◽  
Physiological Role ◽  
Myocardial Damage ◽  
Promising Therapeutic Target ◽  
Potential Therapeutics

Cardiovascular disease remains the leading cause of morbidity and mortality, imposing a major disease burden worldwide. Therefore, there is an urgent need to identify new therapeutic targets. Recently, the concept that the heart acts as a secretory organ has attracted increasing attention. Proteins secreted by the heart are called cardiokines, and they play a critical physiological role in maintaining heart homeostasis or responding to myocardial damage and thereby influence the development of heart diseases. Given the critical role of cardiokines in heart disease, they might represent a promising therapeutic target. This review will focus on several cardiokines and discuss their roles in the pathogenesis of heart diseases and as potential therapeutics.

scholarly journals Potential Role of Nuclear FactorκB in Diabetic Cardiomyopathy

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
O. Lorenzo ◽  
B. Picatoste ◽  
S. Ares-Carrasco ◽  
E. Ramírez ◽  
J. Egido ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Diabetic Cardiomyopathy ◽  
Nuclear Factor Kappa B ◽  
Potential Role ◽  
Heart Diseases ◽  
Cardiac Injury ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis.

scholarly journals Role of obesity and hypertension in the incidence of atrial fibrillation, ischaemic heart disease and heart failure in patients with diabetes

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Lucia La Sala ◽  
Antonio E. Pontiroli
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Primary Care ◽  
Body Mass Index ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Heart Diseases ◽  
Treatment Of Hypertension ◽  
Patients With Diabetes

AbstractIn a cohort study performed using primary care databases in a General Practitioners Network, Groenewegen et al. report a clear association between diabetes and incidence of the major chronic progressive heart diseases, notably heart failure (Groenewegen et al. in Cardiovasc Diabetol 20:123, 2021). However, no mention is made of body mass index and hypertension in the methods or in the results. Obesity is linked to hypertension and hypertension is a major risk factor for all cardiovascular diseases, and prospective studies have shown that obesity and hypertension contribute significantly to atrial fibrillation in persons with diabetes. The data would be improved by assessing the role of obesity and of hypertension in the incidence of heart diseases in these patients. This would also lead to a better and personalized treatment of patients with diabetes, for instance through weight loss and intensification of treatment of hypertension, to modify the incidence of atrial fibrillation, ischaemic heart disease and heart failure.

scholarly journals Seasonal Variations of Heart Failure and Acute Coronary Syndrome in a Referral Center of Heart Diseases in Ahvaz, Southwest of Iran

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Farzaneh Ahmadi ◽  
Parisa Pourkhosravi
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Seasonal Variations ◽  
Heart Diseases ◽  
Cold Season ◽  
Coronary Syndrome ◽  
Number Of Patients

Background: Despite the role of hot weather and activity at high temperatures in physical and environmental stress influencing the occurrence or recurrence of heart disease, the role of seasonal variations in temperature in this disease has not been well studied. Objectives: This study aimed to investigate the relation of seasonal variations in temperature to the number of patients with ischemic heart disease and heart failure (HF). Methods: We extracted data, including file number, diagnosis, age, gender, hospitalization date, and discharge date, from the medical files of patients admitted to a referral center of heart diseases in a tropical region from 2013 to 2015. Results: Diagnosed and studied patients (n = 4,041) were as follows: 625 (patients with HF), 2410 (patients with unstable angina), and 1006 (patients with myocardial infarction). A total of 57% of patients were male, and 43% were female. The average number of patients per day (P/d) in the cold season was higher than in other seasons (5.89 versus 5.53 in the moderate season and 5.18 during the warm season). The mean length of hospitalization for patients with myocardial infarction (MI) and HF in the cold season was longer than in other seasons, and this difference was statistically significant (P = 0.035 and 0.021, respectively). Conclusions: All hospitalizations occurring with these diagnoses in cold seasons are longer, increasing the burden on the health care system. There are considerable seasonal variations in HF hospitalization and mortality. Immunization against pneumococcus and influenza and also more care are recommended in HF patients. There is a need for a season-based approach for better handling of acute coronary syndrome (ACS).

scholarly journals Frequency and pattern of Paediatric Heart Diseases: Five years experience at The Children’s Hospital, Multan

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Muhammad Sohail Arshad ◽  
Hafiz Muhammad Anwar-ul-Haq ◽  
Mudasser Adnan ◽  
Arif Zulqarnain
Keyword(s):  
Heart Disease ◽  
Heart Diseases ◽  
Acute Myocarditis ◽  
Retrospective Chart Review ◽  
Paediatric Population ◽  
Mortality And Morbidity ◽  
Children's Hospital ◽  
Creative Commons ◽  
Heart Lesion ◽  
Children’S Hospital

Background & Objectives: Heart diseases in paediatric population are considered to be significant contributors to mortality and morbidity. Congenital heart disease (CHD) as well as acquired heart disease (AHD) are frequent causes of hospital admission among children. This study was aimed at finding out frequency and pattern of heart diseases in admitted patients at The Children’s Hospital, Multan. Methods: This study is a retrospective chart review of five years at Paediatric Cardiology Department of The Children’s Hospital and The Institute of Child Health, Multan, Pakistan, from January 2015 to December 2019. Children aged one month to 15 years, admitted as a diagnosed case of heart disease on the basis of echocardiography were included. Results: Out of a total of 4115 confirmed cases of heart disease admitted during the study period, 3250 (79.0%) were CHD while 865 (21.0%) were AHD. Overall, 2861 (69.5%) patients were aged less than one year. VSD followed by ASD were the commonest acyanotic heart lesion seen among 927 (28.5%) and 644 (19.8%) cases while TOF was the commonest cyanotic type heart lesion found in 396 (12.2%). Rheumatic heart disease (RHD) was the commonest type of AHD, seen in 330 (38.2%) cases followed by acute myocarditis found in 230 (26.6%) cases. Conclusion: Burden of heart diseases is rising in our region. VSD, ASD and TOF were the most common types of CHDs while RHD and acute myocarditis were the most frequent types of AHDs. doi: https://doi.org/10.12669/pjms.36.6.2312 How to cite this:Arshad MS , Anwar-ul-Haq HM, Adnan M, Zulqarnain A. Frequency and pattern of Paediatric Heart Diseases: Five years experience at The Children’s Hospital, Multan. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2312 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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