scholarly journals Depression Screening and Rates of Mood Disorder Diagnosis and Suicide in Younger and Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 369-369
Author(s):  
Julie Lutz ◽  
Kenneth Conner ◽  
Michael Hasselberg ◽  
Kathleen Fear ◽  
Kim Van Orden
Keyword(s):  
Older Adults ◽  
Mood Disorder ◽  
Large Scale ◽  
Medical Center ◽  
Severe Depression ◽  
Care Physician ◽  
Depression Screening ◽  
Established Risk Factor ◽  
Patient Reported ◽  
The University

Abstract Rates of suicide are elevated among older adults in the U.S. and around the world, with the highest rates in older men (CDC, 2019; WHO, 2014). More than half of older adults who die by suicide were in contact with a primary care physician within the month prior to death, and almost one-third within the prior week (Luoma et al., 2002; Stene-Larsen & Reneflot, 2019), demonstrating the importance of better identification and treatment of mental health issues among older adults across healthcare systems. Depression, a well-established risk factor for suicide, goes under-diagnosed and under-treated, especially among older adults (Bryant, 2010). The University of Rochester Medical Center has led integration of patient-reported outcomes assessment via large-scale implementation of PROMIS measures across multiple departments. We compared results of PROMIS depression screening from 1/1/2015 to 8/31/2019 with mood disorder diagnoses within the year prior and year following screening. Twenty-six percent (39491/154669) of adults under age 65 and 23% (11694/51702) of those age 65 and older screened positive for mild, moderate, or severe depression. Whereas 29.0% of younger adults who screened positive received mood disorder diagnoses, 22.1% of older adults received a diagnosis (χ2(1)=214.69, p<.001). Suicide outcomes using National Death Index data will also be reported. Results confirm depression is underdiagnosed (and, by extension, likely undertreated) at all ages, but show a distinct disparity for older adults, which may put them at greater risk for negative outcomes such as suicide.

scholarly journals Interview with Mr. Jeffrey Alderman, CEO, ACBSP

2017 ◽  
Vol 8 (2) ◽  
pp. 51
Author(s):  
Alderman Dr.
Keyword(s):  
Kansas City ◽  
Large Scale ◽  
Medical Center ◽  
Vice President ◽  
Management Program ◽  
Faculty Members ◽  
General Motors ◽  
University Of Kansas ◽  
Team Student ◽  
The University

SDMIMD is proud in receving the accreditation from the Accreditation Council for Business Schools and Programm (ACBSP), US, for our flagship management program PGDM. Mr. Jeffrey Alderman, President/ CEO, ACBSP, recently, has visited India. Prior to joining ACBSP, Mr. Alderman served as Vice President of the Kansas City, Kansas Chamber of Commerce overseeing business development for the Chamber by working with small to large scale businesses on consulting, branding, and marketing initiatives. A sampling of member companies includes General Motors, Kansas Speedway, Sporting Kansas City, and The University of Kansas Medical Center. SDMIMD had the honor to have Mr. Alderman in the campus, where he addressed the students and interacted with the faculty members. The Dimension Team (Student Magazine) from SDMIMD has an opportunity to interview Mr. Alderman on various aspects. The discussion has been summarized below.

scholarly journals Supporting COVID-19 Vaccine Rollout before Charter Class Arrives: The University of California, Irvine Experience

Pharmacy ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 164
Author(s):  
Alexandre Chan ◽  
Melanie D. Joe ◽  
Jan D. Hirsch
Keyword(s):  
Interprofessional Education ◽  
Large Scale ◽  
Medical Center ◽  
The United States ◽  
University Of California ◽  
Pharmaceutical Sciences ◽  
Patient Centered ◽  
Raising Awareness ◽  
Centered Care ◽  
The University

Despite numerous challenges in relation to being a recently established school, the University of California, Irvine (UCI) School of Pharmacy and Pharmaceutical Sciences (SPPS), similar to many schools of pharmacy in the United States, was highly committed to supporting the rollout of COVID-19 vaccines. UCI SPPS and our affiliated UCI Medical Center (UCIMC) Pharmacy Department partnered to spearhead the pharmacy element of a large-scale COVID-19 vaccination clinic on campus for both employees and the community. Three key initiatives were established in order to overcome the obstacles we faced in the large-scale roll out of COVID-19 vaccines: (1) forging new collaborations within the pharmacy team, (2) leveraging interprofessional education and practice, and (3) raising awareness of the pharmacists’ role. Our response to the COVID-19 vaccines at UCI was a tangible, visible model that demonstrated that, while we continue to embrace our role in team-based, patient-centered care, it is also important for us to step up and lead the profession. Additionally, this vaccine rollout experience is a teachable moment for our communities and our health professional partners as we continue to march forward as one voice to serve the American public.

scholarly journals The Design and Rationale of a Phase 2b, Randomized, Double-Blinded, and Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Lomecel-B in Older Adults with Frailty

2022 ◽  
pp. 1-10
Author(s):  
K. Yousefi ◽  
K.N. Ramdas ◽  
J.G. Ruiz ◽  
J. Walston ◽  
H. Arai ◽  
...  
Keyword(s):  
Older Adults ◽  
Medical Center ◽  
Controlled Trial ◽  
Dose Range ◽  
Data Safety Monitoring Board ◽  
Cognitive Status ◽  
Necrosis Factor Alpha ◽  
Frailty Status ◽  
Patient Reported ◽  
Double Blinded

Background: Frailty in older adults is a rapidly growing unmet medical need. It is an aging-related syndrome characterized by physical decline leading to higher risk of adverse health outcomes. OBJECTIVES: To evaluate the efficacy of Lomecel-B, an allogeneic medicinal signaling cell (MSC) formulation, in older adults with frailty. DESIGN: This multicenter, randomized, parallel-arm, double-blinded, and placebo-controlled phase 2b trial is designed to evaluate dose-range effects of Lomecel-B for frailty on physical functioning, patient-reported outcomes (PROs), frailty status, and biomarkers. SETTING: Eight enrolling clinical research centers, including the Miami Veterans Affairs Medical Center. PARTICIPANTS: Target enrollment is 150 subjects aged 70-85 years of any race, ethnicity, or gender. Enrollment criteria include a Clinical Frailty Score of 5 (“mild”) or 6 (“moderate”), a 6MWT of 200-400 m, and serum tumor necrosis factor-alpha (TNF-α) ≥2.5 pg/mL. INTERVENTION: A single intravenous infusion of Lomecel-B (25, 50, 100, or 200 million cells) or placebo (N=30/arm). Patients are followed for 365 days for safety, and the efficacy assessments performed at 90, 180, and 270 days. MEASUREMENTS: The primary endpoint is change in 6MWT in the Lomecel-B-treated arms versus placebo at 180 days post-infusion. Secondary and exploratory endpoints include change in: 6MWT and other physical function measures at all time points; PROs; frailty status; cognitive status; and an inflammatory biomarkers panel. A pre-specified sub-study examines vascular/endothelial biomarkers. Safety is evaluated throughout the trial. RESULTS: The trial is conducted under a Food and Drug Administration Investigational New Drug (IND), with Institutional Review Board approval, and monitoring by an NIH-appointed independent Data Safety Monitoring Board. CONCLUSION: This clinical trial investigates the use of a regenerative medicine strategy for frailty in older adults. The results will further the understanding of the potential for Lomecel-B in the geriatric condition of frailty.

scholarly journals Implementing patient-reported outcome surveys as part of routine care: lessons from an academic radiation oncology department

2017 ◽  
Vol 24 (5) ◽  
pp. 964-968 ◽  
Author(s):  
Lisa S Rotenstein ◽  
Ankit Agarwal ◽  
Kelly O’Neil ◽  
Andrea Kelly ◽  
Maureen Keaty ◽  
...  
Keyword(s):  
Radiation Oncology ◽  
Large Scale ◽  
Medical Center ◽  
Academic Medical Center ◽  
Data Access ◽  
Routine Care ◽  
Patient Reported Outcome ◽  
Routine Practice ◽  
Successful Implementation ◽  
Patient Reported

Abstract Patient reported outcomes (PROs) are reports of health conditions that come directly from patients. Use of PROs has been associated with improved patient outcomes, enhanced quality of life, and reduced end-of-life spending. Yet there are still outstanding questions regarding the process of implementing PRO collection in routine practice. In this article, we describe the experience of selecting and implementing PROs in a multisite, multidisease academic medical center–based radiation oncology practice and demonstrate that such large-scale rollout is feasible. We establish that PROs can be implemented with minimal to no workflow delays, are generally seen as valuable by clinicians, and can enhance patient-doctor communication. We additionally detail the challenges involved in selecting clinically relevant PRO questionnaires and the centrality of physician buy-in, easy data access, and clear workflows to successful implementation.

scholarly journals Tracing diagnosis trajectories over millions of inpatients reveal an unexpected association between schizophrenia and rhabdomyolysis

2018 ◽  
Author(s):  
Hyojung Paik ◽  
Matthew J. Kan ◽  
Nadav Rappoport ◽  
Dexter Hadley ◽  
Marina Sirota ◽  
...  
Keyword(s):  
San Francisco ◽  
Large Scale ◽  
Medical Center ◽  
Hospital Readmissions ◽  
Case Review ◽  
Health Records ◽  
Disease Registries ◽  
Disease Associations ◽  
Muscle Breakdown ◽  
The University

AbstractWhile it has been technically feasible to create longitudinal representations of individual health at a nationwide scale, the use of these techniques to identify novel disease associations for the risk stratification of patients has had limited success. Here, we created a large-scale US longitudinal disease network of traced readmission patterns (i.e., disease trajectories), merging data from over 10.4 million inpatients from 350 California hospitals through the Healthcare Cost and Utilization Project between 1980 and 2010. We were able to create longitudinal representations of disease progression mapping over 300 common diseases, including the well-known complication of heart failure after acute myocardial infarction. Surprisingly, out of these generated disease trajectories, we discovered an unknown association between schizophrenia, a chronic mental disorder, and rhabdomyolysis, a rare disease of muscle breakdown. It was found that 92 of 3674 patients (2.5%) with schizophrenia were readmitted for rhabdomyolysis (relative risk, 2.21 [1.80–2.71, confidence interval = 0.95] P-value 9.54E-15), which has a general population incidence of 1 in 10,000. We validated this association using independent electronic health records from over 830,000 patients treated over seven years at the University of California, San Francisco (UCSF) medical center. A case review of 29 patients at UCSF who were treated for schizophrenia and who went on to develop rhabdomyolysis demonstrated that the majority of cases (62%) are idiopathic, which suggests a biological connection between these two diseases. Together, these findings demonstrate the power of using public disease registries in combination with electronic medical records to discover novel disease associations.One Sentence SummaryBased on the longitudinal health records from millions of California inpatient discharges, we created a temporal network that enabled us to understand statewide patterns of hospital readmissions, which led to the novel finding that hospitalization for schizophrenia is significantly associated with rehospitalization for rhabdomyolysis.

scholarly journals Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Hyojung Paik ◽  
Matthew J. Kan ◽  
Nadav Rappoport ◽  
Dexter Hadley ◽  
Marina Sirota ◽  
...  
Keyword(s):  
San Francisco ◽  
Medical Records ◽  
Large Scale ◽  
Medical Center ◽  
Disease Incidence ◽  
Muscle Disease ◽  
Case Review ◽  
Large Scale Analysis ◽  
Disease Associations ◽  
The University

Abstract The identification of novel disease associations using big-data for patient care has had limited success. In this study, we created a longitudinal disease network of traced readmissions (disease trajectories), merging data from over 10.4 million inpatients through the Healthcare Cost and Utilization Project, which allowed the representation of disease progression mapping over 300 diseases. From these disease trajectories, we discovered an interesting association between schizophrenia and rhabdomyolysis, a rare muscle disease (incidence < 1E-04) (relative risk, 2.21 [1.80–2.71, confidence interval = 0.95], P-value 9.54E-15). We validated this association by using independent electronic medical records from over 830,000 patients at the University of California, San Francisco (UCSF) medical center. A case review of 29 rhabdomyolysis incidents in schizophrenia patients at UCSF demonstrated that 62% are idiopathic, without the use of any drug known to lead to this adverse event, suggesting a warning to physicians to watch for this unexpected risk of schizophrenia. Large-scale analysis of disease trajectories can help physicians understand potential sequential events in their patients.

scholarly journals Life satisfaction and depressive symptoms of mentally active older adults in Poland: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Katarzyna Van Damme-Ostapowicz ◽  
Mateusz Cybulski ◽  
Monika Galczyk ◽  
Elżbieta Krajewska-Kulak ◽  
Marek Sobolewski ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Life Satisfaction ◽  
Depressive Symptoms ◽  
Mental Disorders ◽  
Large Scale ◽  
Depression Scale ◽  
Satisfaction With Life Scale ◽  
The University

Abstract Background For older adults, life satisfaction and depressive symptoms are related to quality of life. In this group of society, life satisfaction is particularly associated with the emotional area. The notion of life satisfaction is related to many factors, such as personality traits, moods and various life events, and poses challenges in various aspects of everyday life. Given that mental health is one of the determinants of the quality of life of older adults, it is reasonable to conduct research among this growing group of the population. The aim of this study was to assess life satisfaction and depressive symptoms in mentally active older adults in Poland. Methods The study covered 125 attendees at the University of Healthy Senior (UHS) and 125 auditing students at the University of Psychogeriatric Prophylaxis (UPP), organised by the Faculty of Health Sciences at the Medical University of Bialystok, of whom 78.3% were female and 21.7% male. The study was conducted using four standardised scales: the Satisfaction with Life Scale (SWLS), Beck Depression Inventory, Geriatric Depression Scale (GDS), and Hospital Anxiety and Depression Scale (HADS). Results Seniors who participated in the study were satisfied with their lives; the average SWLS score was 23 points. Men rated their level of satisfaction higher than women: the median score on the SWLS was 26 points for men and 23 points for women. Life satisfaction and mental disorders did not differ on the basis of sex, age, or education (the type of place of education attended). As the level of depression increased, life satisfaction decreased. Statistically significant correlations of average strength were found between the point values of the four measures of depression under consideration and were evenly distributed from 0.57 to 0.69. Conclusions The high level of life satisfaction and a low level of mental disorders should be maintained in this population, and additional educational activities should be organised among seniors on a large scale. There were no differences in the distribution of psychometric measure scores among the three compared age groups of respondents in this study. Each of the questionnaires used measured of different aspects of depressive conditions, and it is worth using them in parallel rather than interchangeably.

scholarly journals Homeopathic dilutions of TNF-alfa in psoriasis and rheumatoid arthritis

2021 ◽  
Vol 11 (40) ◽  
pp. 204-205
Author(s):  
Adrian Alecu ◽  
Dumitru Gafitanu ◽  
Mariana Alecu ◽  
Diana Popa ◽  
Ioana Cridon
Keyword(s):  
Rheumatoid Arthritis ◽  
Adverse Reactions ◽  
Medical Center ◽  
Treatment Protocol ◽  
Previous Treatment ◽  
Liquid Form ◽  
Knowing That ◽  
Biological Studies ◽  
Patient Reported ◽  
The University

Aim: Clinical and biological studies in the past years underlined the proinflammatory action of the citokine Tumoral Necrosis Factor in the pathophysiolology of psoriasis, psoriatic arthritis, rheumatoid arthritis. Knowing that the high dilution of substances can have an inverted effect, our hypotesis was that dillution made of TNF-alfa can decrease the clinical manifestation of such diseases. Materials and method: We included as a pilot group 10 patients presented in Lotus Life Integrative Medicine Center or Profamilia Medical Center Iasi with psoriasis and rheumatoid arthritis previously diagnosed by specialists, under speciality treatment with insufficient results and patients who deliberately expressed their preference for alternative treatment. We decided to exclude the patients which during the study could present aggravation of symptoms. The treatment protocol consisted in the administration under the tongue of the dilution of TNF-alfa 9CH in liquid form, 12 drops twice a day for at least 3 months. This was prepared diluting from Guna TNF-alfa 4CH in distiled water, completing with 30% of alcohol in the last solution. Patients under other medications continued to take their previous treatment unchanged. We called the patients for follow-up after 3 months. We took the written consent from the patients and the approval of the Ethical Committee of the University of Medicine and Pharmacy "Gr. T. Popa" of Iasi. Results: To analize the results we followed the subjective evolution of the patients, the total surface and thickness of eruptions in psoriasis patients and the pain intensity and stiffness in arthritis patients. Under this conditions, all the patients showed amelioration, with 2 out of 6 psoriasis patients showing complete clearance of eruptions. No patient reported adverse reactions during the treatment Conclusions: Even though the group of patients was small and not appropriate for statistical data the presence of a clinical response in all the patients and the absence of adverse reactions sustains the opportunity to extend the research on this subject.

SOCIAL PROJECT AS A PLATFORM FOR THE IMPLEMENTATION OF PROFESSIONAL SKILLS OF FUTURE INFORMATICS TEACHERS

2019 ◽  
pp. 16-22
Author(s):  
E. V. Klimenko ◽  
N. S. Buslova
Keyword(s):  
Large Scale ◽  
Modern Society ◽  
Professional Competencies ◽  
Future Teachers ◽  
Professional Skills ◽  
Knowledge And Skills ◽  
Theoretical Reasoning ◽  
Social Project ◽  
The University

The article is devoted to the consideration of ways to solve one of the actual problems in theory and methodology of training and upbringing — the problem of developing professional skills of future informatics teacher. As a way to adapt students to the profession, the possibility of their involvement in social designing was chosen. Participation in social projects contributes to the approbation and introduction of new forms and methods in teaching informatics. Expanding the experience of future teachers in carrying out large-scale events contributes to the formation of a socially adapted personality competitive in modern society. The potential of a social project in consolidating the knowledge and skills obtained during the theoretical training at the university is indicated. In the article, theoretical reasoning is accompanied by examples of real social projects and activities aimed at the formation of professional competencies of future informatics teachers.

Sign in / Sign up

Export Citation Format

Share Document