scholarly journals Molecular Resiliency and Aging

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 163-163
Author(s):  
Adam Salmon
Keyword(s):  
Healthy Aging ◽  
Regulatory Mechanisms ◽  
Human Populations ◽  
Biological Mechanisms ◽  
Short Term ◽  
Biology Of Aging ◽  
Physiological Markers ◽  
Molecular Regulatory Mechanisms ◽  
Insight Into ◽  
Translational Models

Abstract Resilience is described as the ability to respond to acute forms of stress and recover to normal homeostasis. There is growing evidence that biology of resilience is entwined with the biology of aging. With increasing age, resilience decreases and is a likely contributor to increased morbidity, frailty and susceptibility to death with age. Conversely, increased resilience across numerous physiological markers of function is associated with longevity and healthy aging. The variation in resilience in populations suggests biological and molecular regulatory mechanisms that might provide insight into interventions to improve resilience, healthy aging and longevity. In this session, speakers will provide insight regarding short-term assays of resilience in animal models that prove useful both in delineating these biological mechanisms as well as inform on potential translational models to better understand biological resilience in human populations. The sessions focus is on defining these assays and discussion of the biological relevance each resilience assay in terms of the regulation of aging. The goals of these studies range from identifying potential predictors of individual lifespan within markers of functional resilience to leveraging geroscience to define whether markers of resilience can be modified through interventions to the aging process. Moreover, better understanding of the biology of resilience could assist in defining novel interventions that improve resilience and thereby enhance longevity.

A Bird in the Hand Isn’t Good for Long

2018 ◽  
Vol 65 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Stefan Scherbaum ◽  
Simon Frisch ◽  
Maja Dshemuchadse
Keyword(s):  
Decision Making ◽  
Cognitive Control ◽  
The Other ◽  
Decision Task ◽  
Short Term ◽  
Additional Time ◽  
Control Processes ◽  
Folk Wisdom ◽  
Study Participants ◽  
Insight Into

Abstract. Folk wisdom tells us that additional time to make a decision helps us to refrain from the first impulse to take the bird in the hand. However, the question why the time to decide plays an important role is still unanswered. Here we distinguish two explanations, one based on a bias in value accumulation that has to be overcome with time, the other based on cognitive control processes that need time to set in. In an intertemporal decision task, we use mouse tracking to study participants’ responses to options’ values and delays which were presented sequentially. We find that the information about options’ delays does indeed lead to an immediate bias that is controlled afterwards, matching the prediction of control processes needed to counter initial impulses. Hence, by using a dynamic measure, we provide insight into the processes underlying short-term oriented choices in intertemporal decision making.

scholarly journals Using syndromic measures of mortality to capture the dynamics of COVID-19 in Java, Indonesia, in the context of vaccination rollout

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Bimandra A. Djaafara ◽  
Charles Whittaker ◽  
Oliver J. Watson ◽  
Robert Verity ◽  
Nicholas F. Brazeau ◽  
...  
Keyword(s):  
Rural Areas ◽  
Vaccination Campaign ◽  
Control Measures ◽  
Additional Insight ◽  
Short Term ◽  
If Current ◽  
Vaccine Impact ◽  
Potential Impact ◽  
The Impact ◽  
Insight Into

Abstract Background As in many countries, quantifying COVID-19 spread in Indonesia remains challenging due to testing limitations. In Java, non-pharmaceutical interventions (NPIs) were implemented throughout 2020. However, as a vaccination campaign launches, cases and deaths are rising across the island. Methods We used modelling to explore the extent to which data on burials in Jakarta using strict COVID-19 protocols (C19P) provide additional insight into the transmissibility of the disease, epidemic trajectory, and the impact of NPIs. We assess how implementation of NPIs in early 2021 will shape the epidemic during the period of likely vaccine rollout. Results C19P burial data in Jakarta suggest a death toll approximately 3.3 times higher than reported. Transmission estimates using these data suggest earlier, larger, and more sustained impact of NPIs. Measures to reduce sub-national spread, particularly during Ramadan, substantially mitigated spread to more vulnerable rural areas. Given current trajectory, daily cases and deaths are likely to increase in most regions as the vaccine is rolled out. Transmission may peak in early 2021 in Jakarta if current levels of control are maintained. However, relaxation of control measures is likely to lead to a subsequent resurgence in the absence of an effective vaccination campaign. Conclusions Syndromic measures of mortality provide a more complete picture of COVID-19 severity upon which to base decision-making. The high potential impact of the vaccine in Java is attributable to reductions in transmission to date and dependent on these being maintained. Increases in control in the relatively short-term will likely yield large, synergistic increases in vaccine impact.

Specialist infantry and defence engagement

2020 ◽  
pp. bmjmilitary-2020-001455 ◽  
Author(s):  
Jonathan Blair Thomas Herron ◽  
K M Heil ◽  
D Reid
Keyword(s):  
Armed Forces ◽  
Short Term ◽  
The Future ◽  
Uk Government ◽  
The Uk ◽  
Insight Into

In 2015, the UK government published the National Strategic Defence and Security Review (SDSR) 2015, which laid out their vision for the future roles and structure of the UK Armed Forces. SDSR 2015 envisaged making broader use of the Armed Forces to support missions other than warfighting. One element of this would be to increase the scale and scope of defence engagement (DE) activities that the UK conducts overseas. DE activities traditionally involve the use of personnel and assets to help prevent conflict, build stability and gain influence with partner nations as part of a short-term training teams. This paper aimed to give an overview of the Specialist Infantry Group and its role in UK DE. It will explore the reasons why the SDSR 2015 recommended their formation as well as an insight into future tasks.

scholarly journals Physical Resilience as a Determinant of Healthspan and Lifespan in Mice

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 829-829
Author(s):  
Nathan LeBrasseur
Keyword(s):  
Middle Ages ◽  
Interest Group ◽  
Later Life ◽  
Cytotoxic Drugs ◽  
Geriatric Syndromes ◽  
Age Related ◽  
Fundamental Biology ◽  
Dynamic Measures ◽  
Biology Of Aging ◽  
Insight Into

Abstract Dynamic measures of physical resilience—the ability to resist and recover from a challenge—may be informative of biological age far prior to overt manifestations such as age-related diseases and geriatric syndromes (i.e., frailty). If true, physical resilience at younger or middle ages may be predictive of future healthspan and lifespan, and provide a unique paradigm in which interventions targeting the fundamental biology of aging can be tested. This seminar will discuss research on the development of clinically-relevant measures of physical resilience in mice, including anesthesia, surgery, and cytotoxic drugs. It will further highlight how these measures compare between young, middle-aged, and older mice, and how mid-life resilience relates to later-life healthspan. Finally, it will provide insight into whether interventions targeting the biology of aging can modify physical resilience in mice. Part of a symposium sponsored by Epidemiology of Aging Interest Group.

scholarly journals Using Fourier Transform Infrared Spectroscopy to Study Effects of Magnetic Field Treatment on Wheat (Triticum aestivumL.) Seedlings

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Zhenlin Wei ◽  
Dejie Jiao ◽  
Junxiao Xu
Keyword(s):  
Magnetic Field ◽  
Fourier Transform ◽  
Conformational Changes ◽  
Structural Variation ◽  
Fourier Transform Infrared ◽  
Biological Mechanisms ◽  
Wheat Seedlings ◽  
Wheat Leaves ◽  
Germination And Growth ◽  
Insight Into

Magnetic field treatments have been utilized to promote germination and growth of a variety of species of plants; however the mechanism of concern has not been fully elucidated. In this research, wheat seedlings were treated with 500 mT and 1500 mT static magnetic field (SMF) for 10 and 20 min, respectively. Analyzing Fourier transform infrared spectra collected from leaves of seedlings showed that SMF treatments decreased the contents of lipids and proteins, shifted bands to higher wavenumbers in 3000–2800 cm−1regions, and increased the ratio of CH2/CH3which likely indicates a structural variation of lipids. For bands assigned to different second structures of proteins, slight bands shifting and changing the ratio of different second structures of proteins were observed due to SMF treatments. To summarize, the results revealed that lipids rather than proteins were sensitive to SMF treatments. The results provided insight into the SMF induced conformational changes of lipids and proteins in wheat leaves, which will help elucidate the biological mechanisms of SMF on plant growth and development.

Reduction of Common Synaptic Drive to Ankle Dorsiflexor Motoneurons During Walking in Patients With Spinal Cord Lesion

2005 ◽  
Vol 94 (2) ◽  
pp. 934-942 ◽  
Author(s):  
N. L. Hansen ◽  
B. A. Conway ◽  
D. M. Halliday ◽  
S. Hansen ◽  
H. S. Pyndt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Unit ◽  
Healthy Subjects ◽  
Motor Units ◽  
Central Peak ◽  
Spinal Cord Lesion ◽  
Short Term ◽  
Physiological Markers ◽  
Synaptic Drive ◽  
Cord Lesion

It is possible to obtain information about the synaptic drive to motoneurons during walking by analyzing motor-unit coupling in the time and frequency domains. The purpose of the present study was to compare motor-unit coupling during walking in healthy subjects and patients with incomplete spinal cord lesion to obtain evidence of differences in the motoneuronal drive that result from the lesion. Such information is of importance for development of new strategies for gait restoration. Twenty patients with incomplete spinal cord lesion (SCL) participated in the study. Control experiments were performed in 11 healthy subjects. In all healthy subjects, short-term synchronization was evident in the discharge of tibialis anterior (TA) motor units during the swing phase of treadmill walking. This was identified from the presence of a narrow central peak in cumulant densities constructed from paired EMG recordings and from the presence of significant coherence between these signals in the 10- to 20-Hz band. Such indicators of short-term synchrony were either absent or very small in the patient group. The relationship between the amount of short-term synchrony and the magnitude of the 10- to 20-Hz coherence in the patients is discussed in relation to gait ability. It is suggested that supraspinal drive to the spinal cord is responsible for short-term synchrony and coherence in the 10- to 20-Hz frequency band during walking in healthy subjects. Absence or reduction of these features may serve as physiological markers of impaired supraspinal control of gait in SCL patients. Such markers could have diagnostic and prognostic value in relation to the recovery of locomotion in patients with central motor lesions.

Chrysophycean Microfossils Provide New Insight into the Recent History of a Naturally Acidic Lake (Cone Pond, New Hampshire)

1987 ◽  
Vol 44 (9) ◽  
pp. 1584-1588 ◽  
Author(s):  
Katherine N. Gibson ◽  
John P. Smol ◽  
Jesse Ford
Keyword(s):  
New Hampshire ◽  
Early Spring ◽  
Recent Change ◽  
Fish Populations ◽  
Short Term ◽  
Acidic Lake ◽  
Lake Water Chemistry ◽  
History Of ◽  
Early Snowmelt ◽  
Insight Into

Cone Pond, New Hampshire, is an acidic (pH = 4.5) clearwater lake that is currently fishless. Historical records indicate declining fish populations between 1951 and 1966, but paleolimnological work using diatoms failed to find evidence for further recent acidification of this naturally acid site. We initiated new paleolimnological studies using mallomonadacean chrysophytes to further our understanding of Cone Pond's recent past. Our stratigraphic analyses indicate recent striking changes in the chrysophyte flora of this lake, with Mallomonas hindonii, a species only common in recently acidified lakes, replacing M. crassisquama, a cosmopolitan species that dominated the flora over the preceding 8000 yr; this recent change parallels the declines in fish populations. Because chrysophytes often bloom in early spring and are known, in other lakes, to experience changes in community composition before those expressed by the diatom community, a possibility is that chrysophytes track transient excursions of lake water chemistry associated with early snowmelt conditions. In this scenario, chrysophytes would respond to a constellation of specific short-term chemical changes including, but not restricted to, pH. Such pH associated changes could include changes in concentrations, speciation, or complexation of metals mobilized from the catchment or sediments, all of which are known to affect both chrysophytes and fish.

Sign in / Sign up

Export Citation Format

Share Document