scholarly journals 515Association between hysterectomy and risk of thyroid cancer

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Sabbir Rahman ◽  
Nirmala Pandeya ◽  
Rachel Neale ◽  
Donald McLeod ◽  
Susan Jordan
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Healthcare Services ◽  
Surgical Removal ◽  
Bleeding Disorders ◽  
Frequent Use ◽  
Increased Risk ◽  
Thyroid Function Testing ◽  
Thyroid Cancer Risk ◽  
Function Testing

Abstract Background Hysterectomy (surgical removal of the uterus) has been consistently associated with increased thyroid cancer risk. While there may be a biologic explanation, increased ascertainment (over-diagnosis) because of greater healthcare use by women having this procedure might also contribute to the observed increased risk. We explored this association considering indications for hysterectomy, age at hysterectomy, and the potential for the association to be mediated by increased contact with health professionals or increased thyroid function testing. Methods We recruited 730 women diagnosed with thyroid cancer and 785 age-matched population controls. We estimated odds ratios (OR) using logistic regression to assess the associations and used causal mediation analysis to investigate potential mediation. Results Prior hysterectomy was associated with an increased thyroid cancer risk (OR = 1.55, 95% CI: 1.14-2.12). When stratified by indication for hysterectomy, the increased risk was apparent only among those who had undergone hysterectomy for bleeding disorders (OR = 1.79, 95% CI: 1.26-2.56). Additionally, the association varied by age at hysterectomy (<55 years, OR = 1.68, 95% CI: 1.22-2.31 versus ≥ 55 years, OR = 0.87, 95% CI: 0.42-1.81). Around 30% of the association was mediated by more frequent use of healthcare services. Conclusions Hysterectomy for bleeding disorders was associated with an increased risk of thyroid cancer among women and a moderate proportion of this appeared due to frequent medical contact. Key messages The way in which women use health services probably explains at least some of the association between hysterectomy and risk of thyroid cancer.

scholarly journals Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
QingAn Yu ◽  
XiaoYing Lv ◽  
KunPeng Liu ◽  
DaKun Ma ◽  
YaoHua Wu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Clomiphene Citrate ◽  
Positive Association ◽  
Female Infertility ◽  
Cochrane Library ◽  
Significant Positive Association ◽  
Fertility Drugs ◽  
Increased Risk ◽  
Thyroid Cancer Risk

Associations have been demonstrated between fertility drugs and a variety of hormone-sensitive carcinomas. The purpose of this study was to determine the relationship between fertility drugs used in the treatment of female infertility and the risk of thyroid cancer. To investigate the clinical significance of fertility drugs used for the treatment of female infertility and the risk associated with thyroid cancer, we performed a literature search using PubMed, MEDLINE, the Cochrane Library, the Web of Science, and EBSCOHOST for comparative studies published any time prior to July 21, 2017. The studies included women who were treated for infertility with fertility drugs, such as clomiphene citrate, gonadotropins, or other unspecified fertility agents, which reported the incidence of thyroid cancer as the main outcome. Eight studies were included in the meta-analyses. Among women with infertility, there was a significant positive association between thyroid cancer risk and the use of fertility drugs (relative risk [RR] = 1.35; 95% confidence interval [CI] 1.12–1.64; P=0.002). Additionally, among women with infertility, the use of clomiphene citrate was associated with an increased risk of thyroid cancer compared to women who did not use fertility drugs (RR = 1.45; 95% CI 1.12–1.88; P=0.005). After pooling results, we found that the parity status of infertile women using fertility drugs was not associated with thyroid cancer risk (RR = 0.99; 95% CI 0.61–1.58, P=0.95). In summary, clomiphene citrate (the most commonly used fertility drug) and other fertility drugs are associated with an increased risk of thyroid cancer.

scholarly journals Considerations for total thyroidectomy in an adolescent with PTEN mutation

2018 ◽  
Vol 9 (9) ◽  
pp. 299-301 ◽  
Author(s):  
Mustafa Tosur ◽  
Mary L. Brandt ◽  
Ioanna D. Athanassaki ◽  
Surya P. Rednam
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Total Thyroidectomy ◽  
Pten Gene ◽  
Prophylactic Measure ◽  
Clinical Scenarios ◽  
Increased Risk ◽  
Thyroid Cancer Risk ◽  
History Of ◽  
Well Differentiated

Individuals with PTEN Hamartoma Tumor Syndrome (PHTS) are at greatly increased risk for developing well-differentiated thyroid cancer. Specific circumstances in which total thyroidectomies should be considered have not been defined. A 14-year-old macrocephalic female with history of developmental delay and lipoma over her left flank presented with neck swelling and was found have multinodular goiter and auto-immune thyroiditis. Asymptomatic tracheal narrowing was also detected on her initial diagnostic imaging. Later on, she developed positional dyspnea during sleep. Genetic testing revealed a heterozygous pathogenic variant in the PTEN gene (c.463T>A). A total thyroidectomy was performed. In addition to addressing the symptomology in our case, a total thyroidectomy also fortuitously eliminated the thyroid cancer risk. This case spurred us on further to identify specific clinical scenarios where total thyroidectomy may be considered as a true prophylactic measure to manage thyroid cancer risk in PHTS patients.

Increased thyroid cancer risk in acromegaly

2013 ◽  
Author(s):  
Selcuk Dagdelen ◽  
Nese Cinar ◽  
Tomris Erbas
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Cancer Risk

scholarly journals The association between XRCC3 rs1799794 polymorphism and cancer risk: a meta-analysis of 34 case–control studies

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Weiqing Liu ◽  
Shumin Ma ◽  
Lei Liang ◽  
Zhiyong Kou ◽  
Hongbin Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Large Scale ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Cancer Type ◽  
Increased Risk ◽  
Risk Of Cancer

Abstract Background Studies on the XRCC3 rs1799794 polymorphism show that this polymorphism is involved in a variety of cancers, but its specific relationships or effects are not consistent. The purpose of this meta-analysis was to investigate the association between rs1799794 polymorphism and susceptibility to cancer. Methods PubMed, Embase, the Cochrane Library, Web of Science, and Scopus were searched for eligible studies through June 11, 2019. All analyses were performed with Stata 14.0. Subgroup analyses were performed by cancer type, ethnicity, source of control, and detection method. A total of 37 studies with 23,537 cases and 30,649 controls were included in this meta-analysis. Results XRCC3 rs1799794 increased cancer risk in the dominant model and heterozygous model (GG + AG vs. AA: odds ratio [OR] = 1.04, 95% confidence interval [CI] = 1.00–1.08, P = 0.051; AG vs. AA: OR = 1.05, 95% CI = 1.00–1.01, P = 0.015). The existence of rs1799794 increased the risk of breast cancer and thyroid cancer, but reduced the risk of ovarian cancer. In addition, rs1799794 increased the risk of cancer in the Caucasian population. Conclusion This meta-analysis confirms that XRCC3 rs1799794 is related to cancer risk, especially increased risk for breast cancer and thyroid cancer and reduced risk for ovarian cancer. However, well-designed large-scale studies are required to further evaluate the results.

Contribution of industrial density and socioeconomic status to the spatial distribution of thyroid cancer risk in Hangzhou, China

2018 ◽  
Vol 613-614 ◽  
pp. 679-686 ◽  
Author(s):  
Xufeng Fei ◽  
Zhaohan Lou ◽  
George Christakos ◽  
Qingmin Liu ◽  
Yanjun Ren ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Spatial Distribution ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Cancer Risk

scholarly journals A Study of Artificial Sweeteners and Thyroid Cancer Risk

2020 ◽  
Vol 12 (8) ◽  
pp. 492-498
Author(s):  
Navdeep Singh ◽  
Sandeep Singh Lubana ◽  
Saurabh Arora ◽  
Issac Sachmechi
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Artificial Sweeteners ◽  
Thyroid Cancer Risk

scholarly journals An overall and dose-response meta-analysis for thyrotropin and thyroid cancer risk by histological type

Oncotarget ◽  
2016 ◽  
Vol 7 (30) ◽  
pp. 47750-47759 ◽  
Author(s):  
Na Hu ◽  
Zhan-Ming Li ◽  
Jin-Feng Liu ◽  
Zhen-Zhen Zhang ◽  
Li-Shun Wang
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Histological Type ◽  
Thyroid Cancer Risk

scholarly journals The effect of raw vegetable and fruit intake on thyroid cancer risk among women: a case–control study in South Korea

2012 ◽  
Vol 109 (1) ◽  
pp. 118-128 ◽  
Author(s):  
Su Kyoung Jung ◽  
Kirang Kim ◽  
Kyung Tae ◽  
Gu Kong ◽  
Mi Kyung Kim
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Early Stage ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Dietary Factors ◽  
Inverse Association ◽  
Thyroid Cancer Risk ◽  
Control Study

Thyroid cancer is the most common cancer among Korean women. However, there are few data on dietary factors related to thyroid cancer risk. The objective of the present study was to evaluate the association between raw vegetables and fruits intake and thyroid cancer in a case–control study. We included 111 histologically confirmed malignant thyroid cancer cases and 115 benign cases. Controls who did not have nodules in thyroid ultrasonography were matched to cases by age ( ± 2 years). Food and nutrient intakes were estimated using a quantitative FFQ with 121 items. Conditional logistic regression analysis was used to obtain OR and corresponding 95 % CI. The intake of total vegetables was not associated with malignant thyroid cancer, but inversely associated with benign cases. High raw vegetable intake was inversely associated with thyroid cancer risk both in malignant and benign cases (P for trend = 0·01 in both malignant and benign cases). Among fruits, persimmon intake had an inverse association with thyroid cancer risk in both malignant and benign cases (P for trend = 0·06 in malignant cases; P for trend = 0·01 in benign cases) and tangerine intake had an inverse association in malignant cases (P for trend = 0·03). The frequency of consumption of raw vegetables and persimmon also had a consistent inverse association in both malignant and benign cases. These results suggest that high consumption of raw vegetables, persimmons and tangerines may decrease thyroid cancer risk and help prevent early-stage thyroid cancer.

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