PSIII-7 Relationship of Age and Genetics with the Methylation Profile of Beef Cattle

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 159-159
Author(s):  
Andre M Ribeiro ◽  
Hiruni Wijesena ◽  
Daniel C Ciobanu ◽  
Steve Horvath ◽  
Matthew L Spangler
Keyword(s):  
Binding Sites ◽  
Bovine Genome ◽  
Methylation Status ◽  
Principal Component ◽  
Heritability Estimate ◽  
Bayesian Lasso ◽  
Genome Methylation ◽  
Intergenic Regions ◽  
The Mean ◽  
Relationship Of

Abstract This study aimed to compare models for the prediction of cow age from DNA methylation profiles and estimate the heritability of the proportion of methylated sites (PM) and methylation status at each site (MS). Methylation data from blood samples of cows (n=136) were generated from the HorvathMammalMethylChip40 array that consists of 34,324 CpG sites that mapped to the bovine genome. Methylation status was determined by the distribution of the methylation values, with values above, within and below 2 standard deviations classified as methylated (2), intermediately methylated (1) and unmethylated (0), respectively. Principal component analysis (PCA) was applied to a (co)variance methylation status matrix. The first and second PC accounted for 25.65% and 9% of the total variance, respectively. Five Bayesian models (Bayesian ridge regression, BayesA, BayesB, BayesCπ and Bayesian LASSO) were implemented with the BGLR package in R. Bootstrapping validation (n=400) was used to evaluate the tested models, with 102 and 34 individuals in the training and validation sets, respectively. The correlation between the predicted and true age was high (r = 0.97 to 0.99). A BayesA model performed the best (r = 0.99, MSE = 0.11 and slope = 0.93), while Bayesian LASSO was the least accurate (r = 0.97, MSE = 0.26 and slope = 0.88). Heritability was estimated using GBLUP implemented in the BGLR package. The mean (SD) heritability estimate for PM was 0.46 ± 0.10 and the heritability of MS ranged from 0.18 to 0.73 (mean = 0.33). The 10% of sites with the highest heritability (343 sites; mean = 0.62) were located in exon (91), intron (84), intergenic (152), and promoter (16) regions. The largest number of these top sites (31) were located on chromosome 3 in genetic or intergenic regions close to transcription factor binding sites (i.e., FOXO6, ELAV4 and LMO4).

HUBUNGAN KEPADATAN BIVALVIA DENGAN PARAMETER LINGKUNGAN DI PESISIR TANJUNG PURA KABUPATEN BANGKA TENGAH

2020 ◽  
Vol 13 (2) ◽  
pp. 112-121
Author(s):  
Sudiyar . ◽  
Okto Supratman ◽  
Indra Ambalika Syari
Keyword(s):  
Negative Impact ◽  
Principal Component ◽  
Environmental Parameters ◽  
Data Retrieval ◽  
Distribution Patterns ◽  
Random System ◽  
System Method ◽  
Relationship Of ◽  
The Relationship ◽  
Anadara Granosa

The destructive fishing feared will give a negative impact on the survival of this organism. This study aims to analyze the density of bivalves, distribution patterns, and to analyze the relationship of bivalves with environmental parameters in Tanjung Pura village. This research was conducted in March 2019. The systematic random system method was used for collecting data of bivalves. The collecting Data retrieval divided into five research stasions. The results obtained 6 types of bivalves from 3 families and the total is 115 individuals. The highest bivalve density is 4.56 ind / m², and the lowest bivalves are located at station 2,1.56 ind / m²,  The pattern of bivalve distribution in the Coastal of Tanjung Pura Village is grouping. The results of principal component analysis (PCA) showed that Anadara granosa species was positively correlated with TSS r = 0.890, Dosinia contusa, Anomalocardia squamosa, Mererix meretrix, Placamen isabellina, and Tellinella spengleri were positively correlated with currents r = 0.933.

scholarly journals Towards Understanding Variability in Droughts in Response to Extreme Climate Conditions over the Different Agro-Ecological Zones of Pakistan

2021 ◽  
Vol 13 (12) ◽  
pp. 6910
Author(s):  
Adil Dilawar ◽  
Baozhang Chen ◽  
Arfan Arshad ◽  
Lifeng Guo ◽  
Muhammad Irfan Ehsan ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Principal Component ◽  
Mitigation Strategies ◽  
Precipitation Extremes ◽  
Climate Mitigation ◽  
Mean Annual Temperature ◽  
Climate Extreme ◽  
Ecological Zones ◽  
The Mean ◽  
Agro Ecological Zones

Here, we provided a comprehensive analysis of long-term drought and climate extreme patterns in the agro ecological zones (AEZs) of Pakistan during 1980–2019. Drought trends were investigated using the standardized precipitation evapotranspiration index (SPEI) at various timescales (SPEI-1, SPEI-3, SPEI-6, and SPEI-12). The results showed that droughts (seasonal and annual) were more persistent and severe in the southern, southwestern, southeastern, and central parts of the region. Drought exacerbated with slopes of −0.02, −0.07, −0.08, −0.01, and −0.02 per year. Drought prevailed in all AEZs in the spring season. The majority of AEZs in Pakistan’s southern, middle, and southwestern regions had experienced substantial warming. The mean annual temperature minimum (Tmin) increased faster than the mean annual temperature maximum (Tmax) in all zones. Precipitation decreased in the southern, northern, central, and southwestern parts of the region. Principal component analysis (PCA) revealed a robust increase in temperature extremes with a variance of 76% and a decrease in precipitation extremes with a variance of 91% in the region. Temperature and precipitation extremes indices had a strong Pearson correlation with drought events. Higher temperatures resulted in extreme drought (dry conditions), while higher precipitation levels resulted in wetting conditions (no drought) in different AEZs. In most AEZs, drought occurrences were more responsive to precipitation. The current findings are helpful for climate mitigation strategies and specific zonal efforts are needed to alleviate the environmental and societal impacts of drought.

scholarly journals Voxelwise Principal Component Analysis of Dynamic [S-Methyl-11C]Methionine PET Data in Glioma Patients

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2342
Author(s):  
Corentin Martens ◽  
Olivier Debeir ◽  
Christine Decaestecker ◽  
Thierry Metens ◽  
Laetitia Lebrun ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
Principal Component ◽  
Component Analysis ◽  
Added Value ◽  
Time Activity ◽  
Positron Emission ◽  
Activity Curve ◽  
The Mean ◽  
Mean Time ◽  
Met Pet

Recent works have demonstrated the added value of dynamic amino acid positron emission tomography (PET) for glioma grading and genotyping, biopsy targeting, and recurrence diagnosis. However, most of these studies are based on hand-crafted qualitative or semi-quantitative features extracted from the mean time activity curve within predefined volumes. Voxelwise dynamic PET data analysis could instead provide a better insight into intra-tumor heterogeneity of gliomas. In this work, we investigate the ability of principal component analysis (PCA) to extract relevant quantitative features from a large number of motion-corrected [S-methyl-11C]methionine ([11C]MET) PET frames. We first demonstrate the robustness of our methodology to noise by means of numerical simulations. We then build a PCA model from dynamic [11C]MET acquisitions of 20 glioma patients. In a distinct cohort of 13 glioma patients, we compare the parametric maps derived from our PCA model to these provided by the classical one-compartment pharmacokinetic model (1TCM). We show that our PCA model outperforms the 1TCM to distinguish characteristic dynamic uptake behaviors within the tumor while being less computationally expensive and not requiring arterial sampling. Such methodology could be valuable to assess the tumor aggressiveness locally with applications for treatment planning and response evaluation. This work further supports the added value of dynamic over static [11C]MET PET in gliomas.

Intra-Task Reliability and Specificity of Individual Consistency

1970 ◽  
Vol 30 (2) ◽  
pp. 583-587 ◽  
Author(s):  
Albert V. Carron
Keyword(s):  
Motor Response ◽  
Present Report ◽  
Motor Task ◽  
Response Component ◽  
Linear Movement ◽  
The Mean ◽  
Individual Consistency ◽  
Response Consistency ◽  
Relationship Of ◽  
The Relationship

The present report is based on reanalysis of data of Marisi (1969) in order to examine the relationship of consistency of motor response among the component responses of a single motor task. 120 high school Ss were tested on a special task, the rho. A single trial on this motor task can be logically separated into three component motor responses: reaction time, a short circular movement, and a short linear movement. The results indicated that consistency of motor response was moderately reliable within the response components but tended to be response-component specific. Further, both the reliability and specificity of motor-response consistency were independent of the size of the mean performance scores.

Relationship of Spiritual well-being and emotional intelligence among Iranian' nursing students

2021 ◽  
Vol 15 (6) ◽  
pp. 1634-1640
Author(s):  
Javad Jafari ◽  
Asra Nassehi ◽  
Mohammadali Zareez ◽  
Seydamalek Dadkhah ◽  
Najmeh Saberi ◽  
...  
Keyword(s):  
Emotional Intelligence ◽  
Nursing Students ◽  
Pearson Correlation ◽  
Well Being ◽  
Self Awareness ◽  
Spiritual Well Being ◽  
The Mean ◽  
High Level ◽  
Relationship Of ◽  
Religious Wellbeing

Background: Among all aspects of nursing care, the spiritual one is the issue that has received little attention. Having spiritual wellbeing (SWB) is a necessity to provide appropriate spiritual care. In addition to, the Emotional intelligence (EI) is one of the most important factors in social and professional success and is essential for effective nursing practice. Therefore, aim of study was evaluating the Relationship between SWB and EI among nursing students. Methods: The sample of this descriptive-analytic study consisted of 136 nursing students studying at Bam University of Medical Sciences selected by convenience sampling method. The Bradberry and Greaves 28-item EI scale, Palutzian and Ellison SWB Scale were used to assess the total score of EI and SWB. Collected data were analyzed using descriptive statistics (mean and standard deviation), Pearson correlation coefficient, independent t-test and one-way ANOVA with SPSS v18. Results: The mean score of SWB and EI were 97.1±11.56 and 123.4 + 123.6, respectively. The mean score dimensions of SWB include (religious wellbeing 47.9±6.6, existential wellbeing 49.1±5.7) and dimensions EI: self-awareness, self-management, social awareness, and relationship management were 27.2 3 3.2, 36.2 2 5.4, 25.1 + 3.5 and 35.1 + 4.5, respectively. The majority of students have reported moderate level SWB and high level of emotional intelligence. The factors influencing their level of SWB were academic semester and age (p<0.05). Conclusion: Although the level of students' EI and SWB were at a desirable level in this study, due to the nature of nursing and the interaction between nurses and patients, providing a suitable learning environment for the development of EI is essential. Therefore, it is suggested that nursing policymakers should develop appropriate educational programs for nurses and provide curriculum for students to promote their knowledge and skills. Keywords: spiritual, religious, wellbeing, existential, nursing, emotional intelligence

DNA barcoding and phylogenetic relationship of shrimps (Crustacea: Decapoda) of Bangladesh

2021 ◽  
Vol 7 (1) ◽  
pp. 941-946
Author(s):  
Md Sagir Ahmed ◽  
Sumaiya Salam ◽  
Sayeda Sabrina Sarwar Rumana ◽  
Anindita Barua
Keyword(s):  
Dna Barcoding ◽  
Genetic Divergence ◽  
New Records ◽  
Coi Gene ◽  
Identification System ◽  
Taxonomic Rank ◽  
Macrobrachium Nipponense ◽  
Shrimp Species ◽  
The Mean ◽  
Relationship Of

We adopted DNA barcoding technique using a 658-bp fragment of the mitochondrial cytochrome c oxidase I (COI) gene to identify shrimp species collected from the different areas of Bangladesh. A total of 24 sequences were generated belonging to 14 species including four new records- Macrobrachium nipponense, Macrobrachium kistnense, Exopalaemon carinicauda and Alpheus malleator. Genetic distance measured with Kimura 2 parameter showed that genetic divergence increased with higher taxonomic rank. The mean genetic divergence was evaluated and found to be 0.935%, 22.67% and 30.92% within species, genus and family, respectively. In addition to the barcode-based species identification system, phylogenetic relationships were established where individuals belonging to the same species were grouped under the same clade. Maximum likelihood (ML) was preferred as the statistical method and as expected, the phylogenetic tree complemented and ensured the conventional taxonomy. The present study evidently showed that DNA barcoding can be served as an effective tool to discriminate the shrimp species and this will enhance the understanding on evolution and conservation biology. Bioresearch Commu. 7(1): 941-946, 2021 (January)

Association of Hemoglobin A1C With TDP-43 Pathology in Community-Based Elders

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012025
Author(s):  
Shahram Oveisgharan ◽  
Ana W. Capuano ◽  
Sukriti Nag ◽  
Sonal Agrawal ◽  
Lisa L. Barnes ◽  
...  
Keyword(s):  
Severity Score ◽  
Hemoglobin A1c ◽  
Oldest Old ◽  
Brain Regions ◽  
Inverse Association ◽  
Community Based ◽  
Cytoplasmic Inclusions ◽  
The Mean ◽  
High Level ◽  
Relationship Of

Objective.We tested the hypothesis that an inverse association exists between diabetes mellitus (DM) and hemoglobin A1C (A1C) with Transactive response DNA binding protein 43 (TDP-43) levels in older adults.Methods.We leveraged antemortem and postmortem data of decedents from three community-based clinical-pathological studies. DM status, A1C levels, and medications for DM were documented annually. TDP-43 cytoplasmic inclusions, evaluated in 6 brain regions using immunohistochemistry, were used to obtain a semiquantitative TDP-43 score (0-5) in each region, and scores were averaged across regions to obtain a TDP-43 severity score. We used linear regressions to test the association of DM and A1C with the TDP-43 severity score.Results.On average, participants (n=817) were 90 years old at the time of death, three fourth were women, and one fourth had DM. The mean A1C was 6.0% (SD=0.6). TDP-43 was observed in 54% of participants, and the mean TDP-43 score was 0.7 (range 0-4.5). A higher level of A1C was associated with a lower TDP-43 score (estimate=-0.156, S.E.=0.060, p=0.009) while DM had a borderline inverse association with the TDP-43 score (estimate=-0.163, S.E.=0.087, p=0.060). The association of higher levels of A1C with lower TDP-43 scores persisted after further adjustment by Apolipoprotein ε4, vascular risk factors, stroke, and hypoglycemic medications. Exclusion of the oldest old participants did not change the results.Conclusion.Overall, the results suggest that a high level of A1C is associated with less TDP-43 proteinopathy in older persons while the relationship of DM with TDP-43 needs further study.

Respiratory Periodicity and Electroencephalogram Arousals During Sleep in Older Adults

2007 ◽  
Vol 8 (4) ◽  
pp. 249-260 ◽  
Author(s):  
Barbara Waag Carlson ◽  
Virginia J. Neelon ◽  
John R. Carlson ◽  
Marilyn Hartman ◽  
Sunil Dogra
Keyword(s):  
Older Adults ◽  
Exploratory Study ◽  
High Variability ◽  
Arterial Oxygenation ◽  
Type B ◽  
Breathing Patterns ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship ◽  
Electroencephalogram Eeg

The aim of this exploratory study was to examine the relationship of electroencephalogram (EEG) arousals to breathing patterns and the relationship of both arousals and breathing patterns to arterial oxygenation during sleep in older adults. Five older adults were monitored using standard polysomnography. Records were divided into 5-min segments and breathing patterns identified based on the level of respiratory periodicity and the variability in the frequency of breathing cycles. Standard criteria were used to determine sleep states and occurrence of EEG arousals. High respiratory periodicity was seen in 23% of the segments, whereas 24% had low respiratory periodicity with minimal variability in the frequency of breathing (Type A low respiratory periodicity) and 53% had low respiratory periodicity with high variability in the frequency of breathing (Type B low respiratory periodicity). Nearly all (97%) segments with high respiratory periodicity had EEG arousals, whereas fewer segments (33%) with low respiratory periodicity had arousals, regardless of the stage of sleep. Desaturations occurred more often in segments with high respiratory periodicity, F (2,4) = 57.3, p < .001, but overall, the mean SaO2 of segments with high respiratory periodicity did not differ from levels seen in segments with low respiratory periodicity, F( 2,4) = 0.77, ns. Our findings suggest that high respiratory periodicity is a common feature of EEG arousals and, in older adults, may be important for maintaining oxygen levels during desaturations during sleep.

scholarly journals Relationship of altitude mountain sickness and smoking: a Catalan traveller’s cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017058 ◽  
Author(s):  
Alba Sánchez-Mascuñano ◽  
Cristina Masuet-Aumatell ◽  
Sergio Morchón-Ramos ◽  
Josep M Ramon
Keyword(s):  
Smoking Status ◽  
Medical Advice ◽  
Health Clinic ◽  
Travel Health ◽  
Systemic Corticosteroids ◽  
The Mean ◽  
Mountain Sickness ◽  
Relationship Of ◽  
The Relationship ◽  
Chronic Use

ObjectivesThe aim of this study is to analyse the relationship between smoking andaltitude mountain sicknessin a cohort of travellers to 2500 metres above sea level (masl) or higher.SettingTravel Health Clinic at the Hospital Universitari de Bellvitge, in Barcelona, Spain.ParticipantsA total of 302 adults seeking medical advice at the travel clinic, between July 2012 and August 2014, before travelling to 2500 masl or above, who agreed to participate in the study and to be contacted after the trip were included. Individuals who met the following criteria were excluded: younger than 18 years old, taking carbonic anhydrase inhibitors for chronic use, undergoing treatment with systemic corticosteroids and taking any medication that might prevent or treat altitude mountain sickness (AMS) prior to or during the trip. The majority of participants were women (n=156, 51.7%). The mean age was 37.7 years (SD 12.3). The studied cohort included 74 smokers (24.5%), 158 (52.3%) non-smokers and 70 (23.2%) ex-smokers. No statistical differences were observed between different sociodemographic characteristics, constitutional symptoms or drug use and smoking status.OutcomesThe main outcome was the development of AMS, which was defined according to the Lake Louise AMS criteria.ResultsAMS, according to the Lake Louise score, was significantly lower in smokers; the value was 14.9%, 95% CI (6.8 to 23.0%) in smokers and 29.4%, 95% CI (23.5 to 35.3%) in non-smokers with an adjusted OR of 0.54, 95% CI (0.31 to 0.97) independent of gender, age and maximum altitude reached.ConclusionsThese results suggest that smoking could reduce the risk of AMS in non-acclimated individuals. Further studies should be performed in larger cohorts of travellers to confirm these results. Despite the results, smoking must be strongly discouraged because it greatly increases the risk of cardiorespiratory diseases, cancer and other diseases.

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