Relationship of Lung Adenoma Prevalence and Growth Rate to Acute Urethan Dose and Target Cell Number234

2019 ◽  
Vol 5 (1) ◽  
pp. 1-26 ◽  
Author(s):  
Valeriy V. Mironov ◽  
Liudmila D. Konovalova

The article considers the problem of the relationship of structural changes and economic growth in the global economy and Russia in the framework of different methodological approaches. At the same time, the paper provides the analysis of complementarity of economic policy types, which, on the one hand, are aimed at developing the fundamentals of GDP growth (institutions, human capital and macroeconomic stabilization), and on the other hand, at initiating growth (with stable fundamentals) with the help of structural policy measures. In the study of structural changes in the global economy, new forms of policies of this kind have been revealed, in particular aimed at identifying sectors — drivers of economic growth based on a portfolio approach. In a given paper a preliminary version of the model of the Russian economy is provided, using a multisector version of the Thirlwall’s Law. Besides, the authors highlight a number of target parameters of indicators of competitiveness of the sectors of the Russian economy that allow us to expect its growth rate to accelerate above the exogenously given growth rate of the world economy.


Genetics ◽  
1997 ◽  
Vol 146 (2) ◽  
pp. 629-640
Author(s):  
William R Atchley ◽  
Shizhong Xu ◽  
David E Cowley

A restricted index selection experiment on mice was carried out for 14 generations on rate of early postnatal development (growth rate from birth to 10 days of age) vs. rate of development much later in ontogeny (growth rate from 28 to 56 days of age). Early rate of development (E) approximates hyperplasia (changes in cell number) and later rate (L) reflects hypertropy (changes in cell size). The selection criteria were as follows: E+L0 was selected to increase early body weight gain while holding late body weight gain constant; E–L0 was selected to decrease early body gain while holding late gain constant; E0L+ was selected to increase late gain holding early gain constant; and E0L– was selected to decrease late gain holding early gain constant. After 14 generations of selection, significant divergence among lines has occurred and the changes in the growth trajectories are very close to expectation. The genetic and developmental bases of complex traits are discussed as well as the concept of developmental homoplasy.


1979 ◽  
Vol 34 (3-4) ◽  
pp. 279-283 ◽  
Author(s):  
Jürgen van der Bosch ◽  
Ilse Sommer ◽  
Heinz Maier ◽  
Willy Rahmig

Abstract Lowered extracellular [Ca2+] causes low growth rates and low stationary cell densities in 3T3 cell cultures as compared to physiological [Ca2+]. Under otherwise constant conditions the extra­ cellular [Ca2+] determines a stable stationary cell density, which can be readied by increase of net cell number or decrease of net cell number, depending on cell density at the time of [Ca2+] adjustment. SV40-3T3 cells do not show this [Ca2+] dependency. At 39 °C 3T3 and SV40-3T3 cell populations show an increased growth rate at low cell densities as compared to cell populations at 35 °C. Approaching the stationary density the growth rate of both cell sorts is reduced faster at 39 °C than at 35 °C, leading to lower stationary cell densities at 39 °C than at 35 °C. A temperature change from 39 °C to 35 °C or in the opposite direction can affect the stationary cell density of 3T3 cell populations only if applied before reduction of growth rate by density-dependent growth-inhibiting principles has taken place.


Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011258
Author(s):  
Longting Lin ◽  
Jianhong Yang ◽  
Chushuang Chen ◽  
Huiqiao Tian ◽  
Andrew Bivard ◽  
...  

ObjectiveTo test the hypothesis that acute ischemic patients with poorer collaterals would have faster ischemic core growth, we included 2 cohorts in the study, cohort 1 of 342 patients for derivation and cohort 2 of 414 patients for validation purpose.MethodsAcute ischemic stroke patients with large vessel occlusion were included. Core growth rate was calculated by the following equation: Core growth rate = Acute core volume on CTP/Time from stroke onset to CTP. Collateral status was assessed by the ratio of severe hypoperfusion volume within the hypoperfusion region of CTP. The CTP collateral index was categorized in tertiles; for each tertile, core growth rate was summarized as median and inter-quartile range. Simple linear regressions were then performed to measure the predictive power of CTP collateral index in core growth rate.ResultsFor patients allocated to good collateral on CT perfusion (tertile 1 of collateral index), moderate collateral (tertile 2), and poor collateral (tertile 3), the median core growth rate was 2.93 mL/h (1.10–7.94), 8.65 mL/h (4.53–18.13), and 25.41 mL/h (12.83–45.07) respectively. Increments in the collateral index by 1% resulted in an increase of core growth by 0.57 mL/h (coefficient = 0.57, 95% confidence interval = [0.46, 0.68], p < 0.001). The relationship of core growth and CTP collateral index was validated in cohort 2. An increment in collateral index by 1% resulted in an increase of core growth by 0.59 mL/h (coefficient = 0.59 [0.48–0.71], p < 0.001) in cohort 2.ConclusionCollateral status is a major determinant of ischemic core growth.


1959 ◽  
Vol 53 (3) ◽  
pp. 358-368 ◽  
Author(s):  
Janet P. Tibbits

The relationship between cortical area and fibre area has been examined in the N/N, N/ +, + / +, + /nr and nr/nr genotypes of the New Zealand Romney, using skin biopsies taken at birth, 1, 3 and 16 months of age. The presence of the nr gene was shown to reduce significantly the relative cortical area. Within the genotypes there was an increase in relative cortical area with increasing age and in two-tooth ewes of N/N and N/ + there was an increase in relative cortical area in winter compared to summer.Fibre growth rates in length for primaries and for prenatal and post-natal secondaries were found for lambs between 1 and 3 months and for 16-monthold ewes. In N/N, N/+ and nr/nr primary fibre growth tended to be increased and post-natal secondary fibre growth tended to be decreased relative to + / + values.In both cortical area and fibre growth rate the greatest genotypic effect was shown by the primary fibres.Some estimates of cortical volume have been made by combining the information on cortical area and fibre growth rate and the relationship of these factors to follicle density and mean fibre area has been discussed. Finally, an indication has been given of how the associations of all these four factors might be usefully examined in some British breeds.


1955 ◽  
Vol 6 (2) ◽  
pp. 308 ◽  
Author(s):  
PG Schinckel

Observations are reported on factors affecting the ratio of secondary to primary follicles (SJP) in a flock of Merino sheep.It was found that all follicles were initiated prior to birth but that the number which finally came to maturity (production of fibre) was significantly affected by birth weight and growth from birth to 1 month. Growth at later ages appeared to be unimportant. There was a significant correlation (r = +0.29) between birth weight and log potential S/P at birth. This is interpreted to indicate that while pre-natal growth conditions affect the number of follicles initiated, other factors are also of considerable importance. It is concluded that the larger animals at birth also have a greater total number of primary follicles than smaller animals. It is further concluded that this difference in total primary follicles results primarily from differences in size a t the 90th day of pre-natal life rather than from differences in density a t that time.


Gerontology ◽  
1982 ◽  
Vol 28 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Donald K. Ingram ◽  
Mark A. Reynolds ◽  
Charles L. Goodrick

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