Dermatologic Complications

2017 ◽  
Author(s):  
Kudakwashe Mutyambizi
Keyword(s):  
Quality Of Life ◽  
Immune System ◽  
Opportunistic Infections ◽  
Immune Dysregulation ◽  
Drug Reactions ◽  
Inflammatory Dermatoses ◽  
Metabolic Dysregulation ◽  
Control And Prevention ◽  
Chronic Skin

The hallmark of HIV infection is immune dysregulation and immunosuppression. As the immune system deteriorates, inflammatory dermatoses, metabolic dysregulation, adverse drug reactions, opportunistic infections, and cutaneous malignancies become more common, atypical in presentation, and recalcitrant to therapy. Both acute and chronic skin complaints contribute significantly to reduced quality of life for HIV patients. The Centers for Disease Control and Prevention recommends that individuals between ages 13 and 64 years be tested for HIV at least once in their lifetime, with increased screening of high-risk individuals and testing based on symptoms. The presence of dermatoses uncommon in the general population but concentrated in the HIV population, or dermatoses strikingly recalcitrant to therapy, should warrant suspicion and testing for HIV.

scholarly journals Multidimensional Quality of Life of HIV/AIDS Patients Who Undergo ARV Therapy in Maccini Clinic Makassar

2019 ◽  
Author(s):  
Muh Yusuf Tahir
Keyword(s):  
Quality Of Life ◽  
Immune System ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Incubation Period ◽  
Opportunistic Infections ◽  
Inclusion Criteria ◽  
Aids Patients ◽  
Hiv Aids

Background: AIDS is a collection of symptoms caused by a variety of microorganisms and other ferocity due to the decreased resistance/immunity of the patient.GlobalAIDS epidemicshowsthatthereare34millionpeoplewithHIVworldwide.InSoutheastAsia, there are approximately 4 million people with HIV. HIV infection in humans has a long incubation period (5-10 years), and then the patient can be called as people living with HIVHIVcausesimmunedeficiencysothatthepatientsarevulnerabletoopportunistic infection attack. Antiretroviral (ARV) could be given the patients to stop a virus and restoring the immune system, reduce the occurrence of opportunistic infections, improve the quality of life and decrease disability. Objectives: This study aims to explore the Multidimensional Quality of Life of HIV/AIDS patients in Maccini Clinic Makassar. Methods:Phenomenological study conducted to explore the experiences of informants related to the quality of life of HIV/AIDS patients who have antiretroviral therapy. Ten informants selected based on inclusion criteria using purposive sampling. Data were collected through interviews and analysis with the aid of N Vivo software version 10. Results: The results of this study shows that after having antiretroviral therapy, HIV/AIDS patients have increased in physical, psychological, social, functional, environmental, spiritual, and sexual dimensions. Conclusions: The dimension that gives most inreasing of the quality of life in HIV patients was physical dimension.  

Dukungan sosial dan kualitas hidup orang dengan HIV/AIDS

2017 ◽  
Vol 33 (3) ◽  
pp. 147
Author(s):  
Mardia Mardia ◽  
Riris Andono Ahmad ◽  
Bambang Sigit Riyanto
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Antiretroviral Therapy ◽  
Social Life ◽  
Opportunistic Infections ◽  
People Living With Hiv ◽  
Hiv Diagnosis ◽  
Criteria For Diagnosis ◽  
Hiv Aids

Purpose: This study aimed to determine the quality of life among people living with HIV/AIDS based on the criteria for diagnosis and other factors.Methods: This study was conducted in the VCT clinic hospital of Dr. Moewardi. The population was HIV-positive patients with antiretroviral therapy. Data collection conducted through medical records and interview to patients. Results: Out of a total of 89 respondents, 66.29% were males and 71.91% were aged between 26-45 years. We found significant correlations for diagnosis of HIV/AIDS, opportunistic infections, time since HIV diagnosis, duration of ARV therapy, social support, modes of transport, sex, age, and marital status with the quality of life. Multivariate analysis obtained by each variable showed the strongest association with the quality of life was time since diagnosis, social support and duration of ARV therapy. Conclusion: The quality of life was better for those who have been diagnosed with HIV/AIDS ≥ 32 months, with social support, and who have been undergoing antiretroviral therapy ≥ 29 months. Improved counseling in the early days of ARV therapy is necessary to always maintain the treatment and provide support for their social life.

scholarly journals The patients’ perspective on coordinated action for cancer and AMR

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
K Apostolidis
Keyword(s):  
Quality Of Life ◽  
Immune System ◽  
Cancer Patients ◽  
Cancer Treatments ◽  
Unique Challenge ◽  
Coordinated Action ◽  
The Impact ◽  
Patients Perspective

Abstract The speaker will present the perspective of the cancer patients, and the challenges they encounter across the spectrum of care and what measures they consider relevant in terms of prevention, diagnosis, treatment and, indeed, to raise awareness of the impact of AMR on rendering cancer treatments ineffective. She will elaborate on survivorship, and on the impact of AMR on the quality of life of patients, their carers, and families. Emphasis will be given on the implications of modern therapies, such as immunotherapy, representing a unique challenge in terms of better understanding the effect on overall health of patients, with the effect they have the immune system, further weakening the patient and leaving him/her exposed to infections potentially of higher risk than cancer itself.

scholarly journals Analysis of Influence Factors of Quality of Life of Lung Cancer Patients with Skin Adverse Drug Reactions Under Targeted Therapy

2022 ◽  
Author(s):  
Ruofei Du ◽  
Xin Wang ◽  
Huiyue Zhou ◽  
Lixia Ma ◽  
Leon M. Larcher ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Targeted Therapy ◽  
Adverse Drug Reactions ◽  
Education Level ◽  
Self Management ◽  
Drug Reactions ◽  
The Status ◽  
Nsclc Patients

Abstract Purpose This study was to assess the status of quality of life and explore the possible factors correlated with quality of life among non-small cell lung cancer (NSCLC) patients with skin adverse drug reactions under targeted therapy. Methods We performed a cross-sectional study including 536 NSCLC patients with skin adverse drug reactions by targeted therapy in cancer outpatient clinics of three hospitals in China between May 2020 and May 2021. And we collected data with structured questionnaires and identified the relationships among coping style, self-management and quality of life by Pearson correlation analysis and multiple linear regression algorithm. Results The total score of quality of life was 46±12.84 in 536 NSCLC patients with skin adverse drug reactions undergoing targeted therapy. In multiple linear regression analysis, we identified the significant factors associated with quality of life including age, education level, combination of medicine, Charlson Comorbidity Index (CCI), stages of disease, facing, yield, symptom management, daily activity management, psychological and emotional management, self-efficacy and self-management (P < 0.05). Conclusions NSCLC patients with skin adverse drug reactions undergoing targeted therapy generally had a compromised quality of life. And the critical factors that affected the status of quality of life were age, education level, co-morbidity, the combinatorial application of drugs and stage of disease, self-management and coping styles.

scholarly journals Genital psoriasis: Update on clinical practices and therapeutic options

2021 ◽  
Vol 68 (1) ◽  
pp. 48-51
Author(s):  
Emanuela-Domnica Boieriu ◽  
◽  
Iulia-Elena Negulet ◽  
Ioana-Simona Dinu ◽  
Alexandra-Irina Butacu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Life Quality ◽  
Clinical Findings ◽  
Therapeutic Options ◽  
Topical Steroids ◽  
Clinical Practices ◽  
Clinical Variants ◽  
Genital Psoriasis ◽  
Chronic Skin

Psoriasis is a chronic skin disease with an important inflammatory compound which associates a worldwide prevalence of 0.5% to 8.5%. The involvement of the genital region can be associated with both plaque psoriasis and inverse psoriasis and survey-based studies indicate that up to 45.5% of patients present lesions of genital psoriasis. Genital psoriasis represents a frequent encounter of psoriasis which is often overlooked and which associates a significant impact on their quality of life, measured by Dermatology Life Quality Index (DLQI) scores which are twice as high as those of psoriatic patients without genital involvement. Recognising the specific clinical findings represents an important step in establishing the diagnosis and case management. Classical therapeutic options such as topical steroids or modern treatments such as ixekizumab represent important tools in fighting this affliction and regaining the patient’s quality of life. This review aims to emphasize the up-to-date clinical variants of genital psoriasis, the consequences on the quality of life of patients and to present the newest therapeutic options.

Development of a Comprehensive Quality-of-Life Measure for Facial and Torso Acne

2018 ◽  
Vol 22 (3) ◽  
pp. 304-311 ◽  
Author(s):  
Chelsea McLellan ◽  
Marc P. Frey ◽  
Diane Thiboutot ◽  
Alison Layton ◽  
Mary-Margaret Chren ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Literature Review ◽  
Skin Disorder ◽  
Well Being ◽  
Delphi Survey ◽  
Psychometric Validation ◽  
Cognitive Interviews ◽  
Life Measure ◽  
Chronic Skin

Background Acne is a chronic skin disorder which generally presents in adolescence but continues into adulthood, and negatively affects both physical and psychosocial well-being. Presently, there are no validated acne-specific quality-of-life (QoL) measures that include dimensions for both facial and torso acne. Objective: The objective of this study was to develop a QoL instrument for both facial and torso acne (CompAQ) in accordance with recommended standards. Methods: A literature review and Delphi survey of patients and clinicians were used to develop the conceptual framework for outcomes perceived important to acne patients. An initial version of the measure was developed, CompAQ-v1, and pilot tested with patients via cognitive interviews. Results: The Delphi survey generated 4 domains (physical, psychological, sociological, and treatment) and 54 items. These, along with a literature review and input from clinical experts, informed the development of the CompAQ-v1. Eleven cognitive interviews were conducted, resulting in the second version of the measure, CompAQ-v2. Psychometric validation resulted in the final 20-item CompAQ measure comprising 5 domains. An abbreviated 5-item measure was also developed (CompAQ-SF). Conclusion: CompAQ and CompAQ-SF are instruments intended to evaluate QoL in patients with acne on their face or torso. The former is a 21-item QoL intended for research, while the latter is intended for clinical practice.

scholarly journals Iron deficiency after kidney transplantation

2020 ◽  
Author(s):  
Joanna Sophia J Vinke ◽  
Marith I Francke ◽  
Michele F Eisenga ◽  
Dennis A Hesselink ◽  
Martin H de Borst
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Immune System ◽  
Iron Deficiency ◽  
Patient Outcomes ◽  
Excess Mortality ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
The Impact

Abstract Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.

scholarly journals Digital Immune Gene Expression Profiling Discriminates Allergic Rhinitis Responders from Non-Responders to Probiotic Supplementation

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 889 ◽  
Author(s):  
West ◽  
Watts ◽  
Smith ◽  
Zhang ◽  
Besseling-van der Vaart ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gene Expression ◽  
Allergic Rhinitis ◽  
Immune System ◽  
Immune Gene ◽  
Life Questionnaire ◽  
Probiotic Supplementation ◽  
Immune Genes ◽  
Immune Gene Expression

Probiotic supplementation for eight weeks with a multi-strain probiotic by individuals with allergic rhinitis (AR) reduced overall symptom severity, the frequency of medication use and improved quality of life. The purported mechanism of action is modulation of the immune system. This analysis examined changes in systemic and mucosal immune gene expression in a subgroup of individuals, classified as either responders or non-responders based on improvement of AR symptoms in response to the probiotic supplement. Based on established criteria of a beneficial change in the mini-rhinoconjunctivitis quality of life questionnaire (mRQLQ), individuals with AR were classified as either responders or non-responders. Systemic and mucosal immune gene expression was assessed using nCounter PanCancer Immune Profiling (Nanostring Technologies, Seattle, WA, USA) kit on blood samples and a nasal lysate. There were 414 immune genes in the blood and 312 immune genes in the mucosal samples expressed above the background threshold. Unsupervised hierarchical clustering of immune genes separated responders from non-responders in blood and mucosal samples at baseline and after supplementation, with key T-cell immune genes differentially expressed between the groups. Striking differences in biological processes and pathways were evident in nasal mucosa but not blood in responders compared to non-responders. These findings support the use of network approaches to understand probiotic-induced changes to the immune system.

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