An overview of sleep dysfunction in Parkinson disease

2017 ◽  
Author(s):  
Elisaveta Sokolov ◽  
K. Ray Chaudhuri
Keyword(s):  
Quality Of Life ◽  
Parkinson Disease ◽  
Sleep Disturbance ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Case Series ◽  
Nocturnal Sleep ◽  
Drug Induced

Disturbances in nocturnal sleep and their consequences during waking in Parkinson disease (PD) were recognized in 1817 by James Parkinson, who described sleep problems in his case series as follows: “His attendants observed, that of late the trembling would sometimes begin in his sleep, and increase until it awakened him: when he always was in a state of agitation and alarm.” Sleep disturbance in PD is complex, with a prevalence of up to 98%, and has been shown to be a key determinant of quality of life. Sleep disturbances in PD are heterogeneous, ranging from insomnia to drug-induced sleep disorders, and now can be assessed by simple validated bedside tools such as the Parkinson’s Disease Sleep Scale (PDSS). Also, sleep, contrary to previous perceptions, can be disordered not just in advanced PD, but also in the pre-motor as well as the untreated states.

scholarly journals The State of Art on Co-Morbid Insomnia and Sleep Apnea (COMISA)

2021 ◽  
Vol 11 (8) ◽  
pp. 1079
Author(s):  
Luigi De Gennaro
Keyword(s):  
Quality Of Life ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Nocturnal Sleep ◽  
Daytime Activity ◽  
Obstructive Sleep ◽  
State Of Art

Insomnia and obstructive sleep apnea (OSA) are two prevalent sleep disorders which share nocturnal sleep disturbances, impairments to daytime activity and quality of life, and high healthcare and social costs [...]

scholarly journals The Relationship Among Sleep Quality, the Stages of Change Readiness and Treatment Eagerness Scale, Abstinence Self-efficacy, and Quality of Life with Alcohol Use Disorder in South Korea

2020 ◽  
Vol 12 (4) ◽  
pp. 69
Author(s):  
EunJu Song
Keyword(s):  
Quality Of Life ◽  
Alcohol Use ◽  
Sleep Quality ◽  
Stages Of Change ◽  
Self Efficacy ◽  
Sleep Disturbances ◽  
Alcohol Use Disorder ◽  
Sleep Problems ◽  
The Relationship

Many patients with alcohol use disorder experienced insomnia or sleep disturbances. However, their sleep problems rarely addressed in the treatment process. It may prove beneficial if treatment programs should intend to help prevent the recurrence of alcohol use disorder by solving patients’ sleep-induced problems and accordingly include appropriate sleep interventions. The present study employed a descriptive design and conducted a cross-sectional survey to assess the relationship among sleep quality, score on the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES), abstinence self-efficacy, and quality of life in inpatients with alcohol use disorders. Data were collected from June to August 2018, from 117 patients admitted to the psychiatric ward for alcohol-use patients in two mental hospitals in South Korea. Sleep quality was significantly correlated with the SOCRATES score (r = .247, p = .007) and quality of life (r = -.346, p = .001). However, it showed no relationship with abstinence self-efficacy (r = -.066, p = .477). These findings suggest that abstinence programs need to employ a comprehensive approach instead of primarily focusing on maintaining abstinence and cessation of alcohol use. However, both sleep disturbances and alcohol abstinence require patience and prolonged treatment. Thus, it is a challenge to design concrete interventions to address the sleep problems experienced by patients with alcohol use disorder.

Sleep disturbance and quality of life in Rheumatoid Arthritis: a prospective mobile health study (Preprint)

2021 ◽  
Author(s):  
John McBeth ◽  
William G Dixon ◽  
Susan Mary Moore ◽  
Bruce Hellman ◽  
Ben James ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Sleep Disturbance ◽  
Mobile Health ◽  
Sleep Disturbances ◽  
Total Sleep Time ◽  
Sleep Onset ◽  
Sleep Time ◽  
Domain Scores

BACKGROUND Sleep disturbance and poor health related quality of life (HRQoL) are common in people with rheumatoid arthritis (RA). Sleep disturbances, such as less total sleep time, more waking periods after sleep onset, and higher levels of non-restorative sleep, may be a driver of HRQoL. However, understanding if these sleep disturbances reduce HRQoL has, to date, been challenging due to the need to collect complex time-varying data in high resolution. Such data collection has now been made possible by the widespread availability and use of mobile health (mHealth) technologies. OBJECTIVE In a mobile health (mHealth) study we tested whether sleep disturbance (both absolute values and variability) caused poor HRQoL. METHODS The Quality of life, sleep and rheumatoid arthritis (QUASAR) study was a prospective mHealth study of adults with RA. Participants completed a baseline questionnaire, and for 30 days wore a triaxial accelerometer to objectively assess sleep, and provided daily reports via a smartphone app of sleep (Consensus Sleep Diary (CSD)), pain, fatigue, mood, and other symptoms. Participants completed the World Health Organization Quality of Life-Brief (WHOQoL-BREF) questionnaire every 10 days. Multi-level modelling tested the relationship between sleep variables and WHOQoL-BREF domains (physical, psychological, environment and social). RESULTS Of 268 recruited participants, 254 were included in this analysis. Across all WHOQoL-BREF domains, participant’s scores were lower than the population average. CSD sleep parameters predicted WHOQoL-BREF domain scores. For example, for each hour increase in the total time asleep physical domain scores increased by 1.11 points (β = 1.11 (0.07, 2.15)) and social domain scores increased by 1.65 points. These associations were not explained by sociodemographic and lifestyle factors, disease activity, medication use, levels of anxiety, sleep quality, or clinical sleep disorders. They were, however, attenuated and no longer significant when pain, fatigue and mood were included in the model. Increased variability in the total time asleep, was associated with poorer physical and psychological domain scores independently of all covariates. There were no patterns of association between actigraphy measured sleep and WHOQoL-BREF. CONCLUSIONS Optimising total sleep time, increasing sleep efficiency, decreasing sleep onset latency, and reducing the variability in total sleep time could improve HRQoL in people with RA.

Gastrointestinal dysfunctions as a risk factor for sleep disorders in children with idiopathic autism spectrum disorder: A retrospective cohort study

Autism ◽  
2017 ◽  
Vol 21 (8) ◽  
pp. 1010-1020 ◽  
Author(s):  
Lena M McCue ◽  
Louise H Flick ◽  
Kimberly A Twyman ◽  
Hong Xian
Keyword(s):  
Quality Of Life ◽  
Autism Spectrum Disorder ◽  
Confidence Interval ◽  
Sleep Disorders ◽  
Sleep Disorder ◽  
Behavioral Problems ◽  
Sleep Problems ◽  
Autism Spectrum ◽  
Spectrum Disorder

Sleep disorders often co-occur with autism spectrum disorder. They further exacerbate autism spectrum disorder symptoms and interfere with children’s and parental quality of life. This study examines whether gastrointestinal dysfunctions increase the odds of having sleep disorders in 610 children with idiopathic autism spectrum disorder, aged 2–18 years, from the Autism Genetic Resource Exchange research program. The adjusted odds ratio for sleep disorder among those with gastrointestinal dysfunctions compared to those without was 1.74 (95% confidence interval: 1.22–2.48). In addition, the odds of having multiple sleep disorder symptoms among children with gastrointestinal dysfunctions, adjusted for age, gender, behavioral problems, bed wetting, current and past supplements, and current and past medications for autism spectrum disorder symptoms were 1.75 (95% confidence interval: 1.10–2.79) compared to children without gastrointestinal dysfunctions. Early detection and treatment of gastrointestinal dysfunctions in autism spectrum disorder may be means to reduce prevalence and severity of sleep problems and improve quality of life and developmental outcomes in this population.

scholarly journals Sleep Disturbance in Gynaecologic Malignancies-an Overview

2020 ◽  
Vol I (2) ◽  
pp. 29-32
Author(s):  
Pavan Deepak
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Sleep Disturbance ◽  
Cancer Patients ◽  
Sleep Disturbances ◽  
Treatment Strategies ◽  
Well Being ◽  
Systematic Research ◽  
Gynaecologic Cancer

Sleep plays a pivotal role in maintaining homeostasis and one of a few foremost determinants of Quality of Life. Quality of life is a well-studied topic in oncology and various measures are taken to improve quality of life in this setting, in order to achieve therapeutic outcome and compliance in general in cancer patients. Sleep disturbances and disruption in circadian rhythm is among a few common presenting complaints of patients with malignancy and affects between 30% to 75% of newly diagnosed or recently treated cancer patients,1 which are reported as double that of the general population, paving the way for decreased compliance and inefficacy of therapy and pose as a detriment to general well-being, and quality of life. It is evident that mood disorders and sleep disturbances are more prevalent in females (1.3 to 1.8 times more than men),2 one may theorize that the prevalence of sleep disturbance in gynaecologic malignancies is greater than that of general population. Sleep disturbances in gynaecologic cancer patients often include difficulty in initiation of sleep, frequent awakening, difficulty in staying asleep, and restless leg syndrome. Systematic research on various sleeps disorders and their therapeutic approach in gynaecologic cancers in general is lacking. This article aims at elucidating and giving overview of sleep pattern changes in gynaecologic malignancies and therapeutic approaches to foster better sleep in this subset of population. This article also emphasizes the need to envisage the treatment strategies targeting cytokines and cortisol in improvement of sleep parameters in gynaecologic malignancies.

scholarly journals Nocturnal Sleep Problems Mediate the Impact on Quality of Life of Early Morning Off in Parkinson's Disease

2021 ◽  
Vol 13 ◽  
Author(s):  
Yu Zhang ◽  
Zi en Zhang ◽  
De Shi ◽  
Yi Zhao ◽  
Lihong Huang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Problems ◽  
Clinical Manifestations ◽  
Early Morning ◽  
Motor Symptoms ◽  
Nocturnal Sleep ◽  
The Impact

Background: Early morning off (EMO) refers to off-states in the morning in people diagnosed with Parkinson's disease (PwPD). This study determined the clinical manifestations of EMO and the association with nocturnal sleep problems and quality of life (QOL) in Chinese PwPD.Methods: In this multicenter, observational, cross-sectional study, data concerning the clinical manifestations of EMO were collected from PwPD in Shanghai by questionnaire. The stepwise logistic regression was performed to analyze the potential risk factors, as well as whether EMO was an independent risk factor for functional dependency in daily life. The mediation analyses were conducted to evaluate whether nocturnal sleep problems might mediate the association between EMO and the QOL.Results: Among the 454 subjects evaluated, EMO occurred in 39.43% of PwPD across all disease stages. The prevalence of EMO increased as the Hoehn and Yahr stage increased and was observed in 35.60% of patients in stages 1–2.5 and 48.85% of patients in stages 3–5. EMO was associated with non-motor symptoms (NMSs). The predominant NMSs associated with EMO were nocturnal sleep problems (98.90%), mood/cognition impairment (93.90%), decreased attention/memory (91.60%), gastrointestinal symptoms (91.60%), and urinary urgency (90.50%). The QOL of PwPD with EMO was significantly reduced (P < 0.001). Moreover, nocturnal sleep problems might partially mediate this relationship (indirect effect: β = 13.458, 95% boot CI: 6.436, 22.042).Conclusion: PwPD have EMO throughout all stages of the disease. Patients with EMO have severe motor symptoms and NMSs. EMO decreases the QOL in PwPD and this relationship is partially mediated by nocturnal sleep problems. In light of these findings, it is suggested that recognition and appropriate treatment of EMO and nocturnal sleep problems could improve the management of PwPD.

Sleep disorders in multiple sclerosis

2017 ◽  
Author(s):  
Luigi Ferini-Strambi ◽  
Sara Marelli
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
General Population ◽  
Sleep Disturbance ◽  
Sleep Disorders ◽  
Depression Symptoms ◽  
Appropriate Treatment ◽  
Immunological Factors ◽  
Clinical Awareness

Though often unrecognized, sleep disorders in MS are seen at higher frequency than the general population, and they may contribute to pain, fatigue and depression—symptoms commonly observed in MS patients. Since several immunological factors in serum have been implicated in the development of sleep disorders, and MS is proven to be characterized by immune abnormalities, the notion that MS and sleep disorders share a similar background seems reasonable. Investigation of sleep disorders in MS is important, especially considering that the treatment of sleep disturbance may contribute to a reduction in debilitating symptoms, such as fatigue. Thus, an increased clinical awareness and appropriate treatment of sleep disorders in the MS population may significantly improve the overall quality of life in these patients.

Association among fatigue, sleep disorders and other clinical parameters in Parkinson’s disease

2020 ◽  
Vol 30 (Supplement_2) ◽  
Author(s):  
A Asano ◽  
N Asano ◽  
D Mota ◽  
I Gondim ◽  
F Aroxa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disorder ◽  
Clinical Parameters ◽  
Motor Symptoms ◽  
Nocturnal Sleep ◽  
Advanced Stages

Abstract Introduction Fatigue and sleep disorders are common in Parkinson disease (PD) patients. Fatigue is not always clinically recognized because of its subjective character manifested by feelings of extreme tiredness. These non-motor symptoms can occur from the early stages of the disease and tend to persist. Objectives To evaluate fatigue in patients with PD and the possible association with sleep disorders and other clinical parameters of the PD; and to evaluate the impact of fatigue on quality of life Methodology A cross-sectional study with 123 patients with PD was implemented. The following instruments were used: Mini Mental State Examination, the Hoehn-Yarh Scale, Beck Depression Inventory, Parkinson’s Disease Quality of Life Questionnaire, Parkinson’s Disease Sleep Scale, Epworth Sleepiness Scale, and Parkinson’s Disease Fatigue Scale. Results Fatigue was found in 48% of patients. Patients with fatigue presented longer duration of illness, depressive symptoms, cognitive impairment, severity of motor symptoms, excessive daytime sleepiness and nocturnal sleep disorder. Fatigue combined with sleep disorder occurred in 21% of the total sample, being more frequent in females (32% vs 15%) and in patients at more advanced stages of the disease (52% in HY3). The multiple logistic regression analysis indicated that the significant independent variables for the presence of fatigue were: cognition (OR = 1.19 P = 0.02), nocturnal sleep disorder (OR = 1.03 P = 0.0001); among PDSS domains, nocturnal motor symptoms (OR = 1.09 P = 0.0005) and sleep refreshment (OR = 1.11 P = 0.02); among PDQ-39 domains, mobility (OR = 0.9323 P < 0.0001) and body discomfort (OR = 0.9767 P = 0.0428). Conclusion Fatigue is common in PD, especially in the more advanced stages, and it seems to be associated with the female gender, nocturnal sleep disorder and cognition, having thus a negative impact on the quality of life.

scholarly journals Efektivitas Baby Massage Dan Baby Gym Terhadap Kualitas Tidur Bayi Usia 3-6 Bulan

2021 ◽  
Vol 8 (1) ◽  
pp. 6
Author(s):  
Rose Nurhudariani ◽  
Yeni Dwi Ratnasari ◽  
Sonhaji Sonhaji ◽  
Siti Nur Umariyah Febriyanti
Keyword(s):  
Sleep Quality ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
P Value ◽  
Test Design ◽  
Quality Of Sleep ◽  
Post Test ◽  
A Minor

Baby massage dan baby gym adalah upaya untuk meningkatkan kualitas tidur pada bayi.  Masalah tidur pada bayi di Indonesia cukup banyak, yaitu sekitar 44,2% bayi mengalami gangguan tidur seperti sering terbangun di malam hari. Namun lebih dari 72% orang tua menganggap gangguan tidur bukan suatu masalah atau hanya masalah kecil, hal tersebut diungkapkan oleh sebuah penelitian pada tahun 2014-2015 yang dilaksanakan di lima kota besar di Indonesia Berdasarkan data awal terdapat 20 bayi yang datang ke posyandu dan ditemukan 17 bayi yang mengalami gangguan tidur. Tujuan penelitian untuk mengetahui efektivitas baby massage dan baby gym terhadap kualitas tidur bayi usia 3-6 bulan di Desa Talang Tegal. Jenis penelitian adalah kuantitatif dengan two group pre and post test  design. Sampel sebanyak 34 bayi yang diberikan perlakuan baby massage dan baby gym dilakukan selama 2 minggu 3x seminggu, untuk baby massage 15 menit sedangkan untuk baby gym 5 menit. Terdapat pengaruh baby massage terhadap kualitas tidur bayi usia 3-6 bulan dengan  p value 0.000. Terdapat pengaruh baby gym terhadap kualitas tidur bayi usia 3-6 bulan dengan  p value 0,001. Tidak terdapat perbedaan efektivitas baby massage dan baby gym terhadap kualitas tidur bayi usia 3 – 6 bulan. Kata kunci : baby gym; baby massage; kualitas tidur bayi  The Effectiveness of Baby Massage And Baby Gym on Sleep Quality of 3-6 Months Baby ABSTRACT  Baby massage and baby gym are efforts to improve the quality of sleep in babies. There are quite a number of sleep problems in infants in Indonesia, which is around 44.2% of infants experiencing sleep disorders such as frequent awakenings at night. However, more than 72% of parents consider sleep disturbances not a problem or just a minor problem, this was revealed by a 2014-2015 study conducted in five major cities in Indonesia. Based on initial data there were 20 babies who came to the Integrated Healthcare Centre and found 17 babies with sleep disorders. The purpose of the study was to determine the effectiveness of baby massage and baby gym on the sleep quality of baby aged 3-6 months in Talang Tegal Village. This type of research was quantitative with two groups pre-post test design. A sample of 34 babies who were given baby massage and baby gym treatment was carried out for 2 weeks 3 time each week, for baby massage 15 minutes while for baby gym 5 minutes. There is an effect of baby massage on the sleep quality of babies aged 3-6 months with a p value of 0.000. There is an effect of baby gym on the sleep quality of babies aged 3-6 months with a p value of 0.001. There is no difference in the effectiveness of baby massage and baby gym on the sleep quality of babies aged 3-6 months. Keywords: baby gym; baby massages; sleep quality of baby

scholarly journals OPRM1 Gene Interaction with Sleep in Chronic Pain Patients Treated with Opioids

2019 ◽  
Vol 1 (22;1) ◽  
pp. 97-107
Author(s):  
Ana M Peiró
Keyword(s):  
Quality Of Life ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Gene Interaction ◽  
Medical Attention ◽  
Anxiety And Depression ◽  
Control Group ◽  
Chronic Noncancer Pain ◽  
Oprm1 Gene

Background: The experience of chronic non-cancer pain (CNCP) is one of the most common reasons individuals seek medical attention. Patients with CNCP frequently experience concomitant sleep-related problems. Objectives: The aim was to evaluate sleep problems in opioid naïve CNCP patients, before and after opioid titration, analyzing the influence of OPRM1 gene variants. Study Design: A prospective, cohort, observational study. Setting: This study was performed at the Pain Unit of the Alicante University General Hospital. Methods: Pain and Medical Outcomes Study Sleep questionnaire (MOS-Sleep) were assessed at baseline and 3 months after opioid titration in 231 opioid naïve CNCP patients. Sleep data was compared with a matched-control group (n = 64). Morphine equivalent daily doses, adverse events, and drugs prescribed for pain were also registered. OPRM1 polymorphism rs1799971 was analyzed by RT-PCR. Ethics Committee approved the study and results were analyzed by R software. Results: After 3 months of opioid titration, patients with CNCP (63 ± 14 years, 64% female, VAS 74 ± 17 mm) significantly decreased pain intensity, anxiety and depression, and increased quality of life. Sleep problems were significantly more frequent in females (P = 0.002). Age, quality of life, anxiety, and depression all influenced sleep disturbances and problems indices, which were significantly different from the control group. Furthermore, the OPRM1 118- GG genotype was also associated with significantly lower sleep adequacy, and more sleep problems. Limitations: Total number of subjects studied was relatively small and most patients were on other non-opioid centrally-acting medications. Conclusions: Opioids decreased CNCP severity, improving patients’ psychological areas, and quality of life. However, patients with OPRM1 118-GG genotype indicated an increase in sleep problems and worsening sleep pattern while taking opioids. Key words: OPRM1, pharmacogenetics, MOS-Sleep, opioids, chronic noncancer pain, sleep related problems, sleep problem index SLP-6 and SLP-9

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