scholarly journals Total antioxidative status and the activity of peroxidase and superoxide dismutase in the haemolymph of Lymnaea stagnalis (L.) naturally infected with digenean trematodes

2013 ◽  
Vol 79 (3) ◽  
pp. 225-229 ◽  
Author(s):  
D. Gornowicz ◽  
K. Dmochowska ◽  
E. Żbikowska ◽  
K. Żółtowska
Keyword(s):  
Superoxide Dismutase ◽  
Lymnaea Stagnalis ◽  
Antioxidative Status ◽  
Total Antioxidative Status

scholarly journals Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity

2019 ◽  
Author(s):  
Grzegorz Józef Nowicki ◽  
Barbara Ślusarska ◽  
Andrzej Prystupa ◽  
Maciej Polak ◽  
Maria Czubaj-Kowal ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adipose Tissue ◽  
Cardiovascular Event ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Overweight And Obesity ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Antioxidative Status ◽  
Total Antioxidative Status

Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress level. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). OxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the studied groups. Significant positive correlation between PerOx and percentage of adipose tissue (FM [%]) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with VAI in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAI of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.

scholarly journals High-level of circulating progranulin and its relationship with plasma glycosaminoglycans, as biochemical indicators of proteolytic and oxidative aggrecan modification, in the course of juvenile idiopathic arthritis

2018 ◽  
Vol 72 ◽  
pp. 906-912
Author(s):  
Katarzyna Winsz-Szczotka ◽  
Kornelia Kuźnik-Trocha ◽  
Katarzyna Komosińska-Vassev ◽  
Wojciech Lemski ◽  
Krystyna Olczyk
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Healthy Children ◽  
Biochemical Indicators ◽  
Antioxidative Status ◽  
Matrix Metalloproteinase 3 ◽  
Reactive Protein ◽  
Before And After ◽  
Total Antioxidative Status ◽  
A Disintegrin And Metalloproteinase ◽  
High Level

Aim: Progranulin (PGRN) plays an important role in cartilage metabolism. The disturbed interaction between PGRN and glycosaminoglycans (GAGs), as biochemical indicators of aggrecan modification, may contribute to articular damage observed in the course of juvenile idiopathic arthritis (JIA). Hence, the aim of this study was to assess quantitatively the level of progranulin in children with JIA as well as to evaluate the correlation between PGRN and GAGs, MMP-3 (matrix metalloproteinase 3), ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) as well as the total oxidative status (TOS) and the total antioxidative status (TAS). We have also evaluated interactions between PGRN and inflammatory and anemia indicators, i.e. C-reactive protein (CRP), and hemoglobin (Hb), respectively. Material/Methods: The PRGN level was measured using the immunoenzymatic method, in blind tested coded plasma samples, obtained from both JIA patients before and after treatment and from healthy children. Results: Increased (p<0.001) plasma progranulin in JIA patients before treatment was observed. Therapy resulted in a decrease in the PRGN level. However, the plasma PRGN level still remained higher (p<0.05) than in the controls. In both groups of patients, we have revealed an insignificant correlation between plasma PGRN and GAGs levels. Moreover, a significant correlation between plasma PGRN level and MMP-3, ADAMTS-4, TOS, TAS, CRP and Hb levels, was stated in untreated JIA patients. Conclusions: The obtained results may indicate that PGRN has antioxidative properties in the course of JIA, but do not confirm the protective roles of this glycoprotein in respect to the destructive effects of proteolytic factors.

scholarly journals Oxidative stress induced by chlorpromazine in patients treated and acutely poisoned with the drug

2016 ◽  
Vol 73 (4) ◽  
pp. 312-317 ◽  
Author(s):  
Bratislav Dejanovic ◽  
Vesna Vukovic-Dejanovic ◽  
Ivana Stevanovic ◽  
Ivana Stojanovic ◽  
Gordana Mandic-Gajic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Serum Concentration ◽  
Control Group ◽  
Sod Activity ◽  
Antioxidative Status ◽  
Oxidative Stress Parameters ◽  
Long Time ◽  
Total Antioxidative Status ◽  
Therapeutic Doses ◽  
Stress Parameters

Background/Aim. Although chlorpromazine (CPZ) is an antipsychotic drug widely used in clinical practice for a long time, its mechanism of action has not been entirely defined. An extremely difficult managing of patients acutely poisoned with CPZ is additional reason for detailed studying its toxicity mechanisms. In this clinical study, we investigated whether the oxidative stress (OS) mediates CPZ toxic effects in the exposed patients. Methods. The patients were organized into 3 groups: the T-group - hospitalized patients receiving therapeutic doses of 75-150 mg CPZ/day; the overdosed group, divided into two subgroups: the group M and the group S - mildly (CPZ serum concentration: 0.21 ? 0.05 mg/L) and severely (CPZ serum concentration: 2.66 ? 0.25 mg/L) poisoned patients, respectively, and the group C (control group of healthy volunteers). Oxidative stress parameters [total antioxidative status (TAS) and malondialdehyde (MDA) in plasma)] and superoxide dismutase (SOD) activity in erythrocytes were measured spectrophotometrically, and CPZ concentrations in serum were monitored chromatographically. One set of measurements was performed in the group C and T, whereas two sets of measurements (after 24 hours and 48 hours) were done in the poisoned patients, groups M and S. Results. A decrease of TAS and increase of SOD activity were obtained in both subgroups of the poisoned patients, compared to the controls and the group receiving therapeutic doses of CPZ. A significant increase of MDA was achieved in severely poisoned patients, compared to all other groups. Conclusion. Changed oxidative stress parameters in patients poisoned with chlorpromazine indicate involvement of oxidative stress in the toxicity mechanism(s) of chlorpromazine.

scholarly journals Effect of different fat supplements on the antioxidant capacity of cow’s milk

2013 ◽  
Vol 56 (1) ◽  
pp. 178-190 ◽  
Author(s):  
K. Puppel ◽  
T. Nałęcz-Tarwacka ◽  
B. Kuczyńska ◽  
M. Gołębiewski ◽  
M. Kordyasz
Keyword(s):  
Fish Oil ◽  
Experimental Period ◽  
Cow’S Milk ◽  
Antioxidative Status ◽  
Cow's Milk ◽  
Supplementation Period ◽  
Holstein Friesian ◽  
Total Antioxidative Status ◽  
Fat Supplements ◽  
Friesian Cows

Abstract. This study examined the effect of different fat supplements on the antioxidants of cow’s milk. Thirty five Polish Holstein Friesian cows at 180±20 day of lactation and averaging 17.71±2.26 kg/d of milk were divided into five equal groups. There were five treatments groups: 300 g/d of fish oil, 500 g/d of Opal linseed, 500 g/d of Szafir linseed, 150 g/d of fish oil + 250 g/d of Opal linseed, 150 g/d of fish oil + 250 g/d Szafir linseed. Milk samples were collected five times during the 21 day of supplementation period: at the 1st, 14th and 21th day of the experimental period, and also at the 14th and 21st day after the supplement withdrawal. Diet supplementation with the Szafir linseed improved the chemical composition and milk yield at the 21st day of experiment. The highest level of malondialdehyde was recorded in fish oil, Opal linseed, fish oil + Opal linseed, and fish oil + Szafir linseed groups, and the lowest in the Szafir linseed group. After the 21st day of supplementation the concentration of α-retinol was significantly increased in all groups by 23 to 183 %. The highest level of α-tocopherol was found in fish oil + Opal linseed group at the 21st day of supplementation. Total antioxidative status increased in all experimental groups; however, the highest peak was recorded in fish oil + Szafir linseed and Szafir linseed group. The experiment confirmed that manipulation in cows’ diet may improve antioxidative capacity of milk.

scholarly journals Enhanced Zinc Intake Protects against Oxidative Stress and Its Consequences in the Brain: A Study in an In Vivo Rat Model of Cadmium Exposure

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 478
Author(s):  
Małgorzata M. Brzóska ◽  
Magdalena Kozłowska ◽  
Joanna Rogalska ◽  
Małgorzata Gałażyn-Sidorczuk ◽  
Alicja Roszczenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Favorable Effect ◽  
Oral Exposure ◽  
Zinc Intake ◽  
Antioxidative Status ◽  
Total Antioxidative Status ◽  
Total Oxidative Status ◽  
The Brain

We examined, in a rat model of moderate environmental human exposure to cadmium (Cd), whether the enhanced intake of zinc (Zn) may protect against Cd-caused destroying the oxidative/antioxidative balance and its consequences in the brain. The intoxication with Cd (5 mg/L, 6 months) weakened the enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (total thiol groups, reduced glutathione) antioxidative barrier decreasing the total antioxidative status and increased the concentrations of pro-oxidants (hydrogen peroxide, myeloperoxidase) in this organ and its total oxidative status. These resulted in the development of oxidative stress and oxidative modifications of lipids and proteins. The co-administration of Zn (30 and 60 mg/L enhancing this element intake by 79% and 151%, respectively) importantly protected against Cd accumulation in the brain tissue and this xenobiotic-induced development of oxidative stress and oxidative damage to lipids and proteins. Moreover, this bioelement also prevented Cd-mediated oxidative stress evaluated in the serum. The favorable effect of Zn was caused by its independent action and interaction with Cd. Concluding, the enhancement of Zn intake under oral exposure to Cd may prevent the oxidative/antioxidative imbalance and oxidative stress in the brain and thus protect against injury of cellular macromolecules in the nervous system.

scholarly journals Magnolol additive improves growth performance of Linwu ducklings by modulating antioxidative status

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0259896
Author(s):  
Qian Lin ◽  
Yang Liu ◽  
Simin Peng ◽  
Chunjie Liu ◽  
Tuo Lv ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Growth Performance ◽  
Body Weight Gain ◽  
Feed Additive ◽  
Control Group ◽  
Related Factor ◽  
Expression Levels ◽  
Antioxidative Status ◽  
Mucosal Morphology ◽  
Biochemical Indices

Magnolol is a bioactive polyphenolic compound commonly found in Magnolia officinalis. The aim of this study is to clarify the contribution of the magnolol additive on the growth performance of Linwu ducklings aging from 7 to 28 d, comparing to the effects of antibiotic additive (colistin sulphate). A total of 325, 7-d-old ducklings were assigned to 5 groups. Each group had 5 cages with 13 ducklings in each cage. The ducklings in different groups were fed with diets supplemented with 0, 100, 200 and 300 mg/kg magnolol additive (MA) (Control, MA100, MA200 and MA300) and 30 mg/kg colistin sulphate (CS30) for 3 weeks, respectively. Parameters regarding to the growth performance, intestinal mucosal morphology, serum biochemical indices, antioxidant and peroxide biomarkers and the expression levels of antioxidant-related genes were evaluated by one way ANOVA analysis. The results showed that 30 mg/kg colistin sulphate, 200 and 300 mg/kg magnolol additive improved the average final weight (P = 0.045), average daily body weight gain (P = 0.038) and feed/gain ratios (P = 0.001) compared to the control group. 200 and 300 mg/kg magnolol additive significantly increased the villus height/crypt depth ratio of ileum, compared to the control and CS30 groups (P = 0.001). Increased serum level of glucose (P = 0.011) and total protein (P = 0.006) were found in MA200 or MA300 group. In addition, comparing to the control and CS30 groups, MA200 or MA300 significantly increased the levels of superoxide dismutase (P = 0.038), glutathione peroxidase (P = 0.048) and reduced glutathione (P = 0.039) in serum. Moreover, the serum and hepatic levels of 8-hydroxy-2’-deoxyguanosine (P = 0.043 and 0.007, respectively) were lower in all MA groups compared to those of the control and CS30 group. The hepatic mRNA expression levels of superoxide dismutase-1, catalase and nuclear factor erythroid-2-related factor 2/erythroid-derived CNC-homology factor were also increased significantly in MA200 and MA300 groups (P < 0.05). Taken together, these data demonstrated that MA was an effective feed additive enhancing the growth performance of Linwu ducklings at 7 to 28 d by improving the antioxidant and intestinal mucosal status. It suggested that MA could be a potential ingredient to replace the colistin sulphate in diets.

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