scholarly journals INNV-23. GLIOBLASTOMA AND FACEBOOK: AN ANALYSIS OF PERCEIVED ETIOLOGIES AND TREATMENTS.

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi135-vi135
Author(s):  
Naveen Kumar Reddy ◽  
Nicholas Blondin
Keyword(s):  
Radiation Exposure ◽  
Ketogenic Diet ◽  
Standard Of Care ◽  
Chemical Exposure ◽  
Medical Advice ◽  
Faith Healing ◽  
Online Media ◽  
Group Members ◽  
Similar Content ◽  
Online Sources

Abstract Facebook has become one of the most widely used platforms by patients and caregivers for information on GBM. As such, physicians treating GBM are challenged with reconciling their medical advice with online media sources. In many cases, the information from these online sources can run counter to the advice given by physicians. OBJECTIVE This study sought to understand the type of information being shared on a popular GBM Facebook community titled, “GLIOBLASTOMA SURVIVORS TO THRIVERS!” with regards to 1. The perceived causes of GBM and 2. The therapies that led to GBM remission. METHODS All the posts in a 30-day period (5/01/2019-6/01/2019) were screened for information on GBM etiologies and GBM therapies. Within each group, posts were sorted into distinct sub-categories with posts of similar content. The sub-categories were ranked to determine which etiologies and therapies were most commonly seen by group members. RESULTS A total of 83 posts were on the topic of “GBM Etiologies” and 80 on the topic of “GBM Therapies.” Within the “GBM Etiologies”, the reasons for developing GBM were due to 1. Unknown (31.3%) 2. Previous Radiation Exposure (24.1%) 3. Chemical Exposure (17%) 4. Genetic (12%) 5. Infectious Disease (6%) 6. Losartan/Valsartan (4.8 %). and 7. Head Trauma (2.4%) and Emotional Trauma (2.4%). Within the GBM Therapy category, the therapies that led to remission were 1. Standard of Care (36.3%) 2. CBD/THC (16.3%) 3. Ketogenic Diet (12.5%) 4. Avastin (7.5%) and Optune (7.5%) 5. IV Vitamin C (6.25%) and COC Protocol (6.25%) 6. Meditation/Yoga/Acupuncture (5.0%) and 7. Faith Healing (2.5%). CONCLUSION In the Facebook group titled, ““GLIOBLASTOMA SURVIVORS TO THRIVERS!,” the top three most commonly posted reasons for developing GBM were “Unknown” “Previous Radiation Exposure” and “Chemical Exposure.” The top three therapies that led to remission were “Standard of Care” “CBD/THC” and “Ketogenic Diet.”

scholarly journals Descending Mediastinitis in a Child: Diagnostic Challenges and a Different Treatment Approach

2021 ◽  
Vol 11 (3) ◽  
pp. 505-508
Author(s):  
Joana Lira ◽  
Joana Santos ◽  
Mariana Capela ◽  
Joana Rodrigues ◽  
Otília Cunha ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Radiation Exposure ◽  
Ultrasound Imaging ◽  
Treatment Approach ◽  
Standard Of Care ◽  
Patient Response ◽  
Care Treatment ◽  
Intravenous Antibiotics ◽  
Standard Of Care Treatment ◽  
Descending Mediastinitis

In children, spontaneous mediastinitis is a rare, severe and commonly misdiagnosed disease. Although standard of care treatment frequently involves surgery, we report a case of mediastinitis in a five-year-old child, successfully treated with 4 weeks of intravenous antibiotics. Ultrasound imaging was used to monitor patient response to conservative treatment while reducing radiation exposure.

Ketogenic Diet in Established Epilepsy Indications

2016 ◽  
Author(s):  
Ann M. Bergin
Keyword(s):  
Ketogenic Diet ◽  
Current Knowledge ◽  
Standard Of Care ◽  
Diet Therapy ◽  
Controlled Study ◽  
Control Group ◽  
Randomized Controlled ◽  
Diet Treatment ◽  
Continued Use

The ketogenic diet is a metabolic therapy that provides an alternative strategy for seizure control in medication-resistant epilepsy. Many decades of continued use of diet therapy, amassing consistent observational evidence, was recently supported by a randomized, controlled study indicating benefit of diet treatment in children with refractory epilepsy as compared with a control group who continued with standard of care and delayed diet treatment for three months. Well-established uses include children with refractory, nonsurgical epilepsies and epileptic encephalopathies including infantile spasms and West syndrome, Lennox Gastaut syndrome, and Dravet and Doose syndromes. Current knowledge on the efficacy and role of diet therapy in these conditions are discussed.

scholarly journals ACTR-15. PHASE 1 TRIAL OF A KETOGENIC DIET IN PATIENTS RECEIVING STANDARD-OF-CARE TREATMENT FOR RECENTLY DIAGNOSED GLIOBLASTOMA

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi15-vi15
Author(s):  
Gillian Gresham ◽  
Lauren Amaral ◽  
Laura Lockshon ◽  
Dana Levin ◽  
Jeremy Rudnick ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Medical Center ◽  
Phase 1 ◽  
Standard Of Care ◽  
Preliminary Evidence ◽  
Feasibility Trial ◽  
Open Label ◽  
Immune Biomarkers ◽  
Standard Of Care Treatment ◽  
High Doses

Abstract BACKGROUND There is abundant interest in the potential therapeutic and supportive role of a ketogenic diet (KD) in patients with glioblastoma (GBM). The KD is a high fat/low carbohydrate metabolic therapy that modulates several of the bioenergetic and biosynthetic pathways that are dysregulated in GBM. To date, studies of the KD in cancer patients have been limited in scope. This study will provide preliminary evidence on the safety and feasibility of a 16-week ketogenic diet in patients with GBM. METHODS This is an open-label single-arm feasibility trial being conducted at Cedars-Sinai Medical Center. We will recruit 20 recently diagnosed GBM patients who are receiving standard-of-care (SOC) treatment. Patients may enroll within 3 months of diagnosis, thus allowing patients who have already begun SOC chemoradiation the opportunity to participate. Excluded are patients with a KPS < 70, BMI < 22, or on high doses of steroids. Consenting patients will maintain a 16-week ketogenic diet (KD) supervised and monitored by study dietitians (RD). The primary outcome of safety will be assessed by monitoring weight, BMI, and adverse events. Secondary outcomes are: 1) Adherence to the KD, as assessed by BID blood glucose and ketone levels; 2) Time to progression and overall survival from date of KD initiation 3) Mean change in overall QOL, as measured using the QLQ30 and QLQ-BN20 questionnaires; and 4) Mean change in cognitive scores at 16 weeks from baseline. Exploratory outcomes include metabolic, inflammatory, and immune biomarkers; gut microbiota analysis; large oncosome analysis; and daily activity assessed with a wearable activity monitor. This novel trial incorporates multiple digital devices and mobile applications into the study design. Accrual is ongoing with 10 patients currently enrolled (NCT03451799).

PENGARUH MOTIF PENGGUNAAN MEDIA TERHADAP KEPUASAN ANGGOTA WHATSAPP GROUP NEW WAVE INTERNATIONAL MINISTRY

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Tang Natasha Chrisanti Saputra ◽  
Siti Meisyaroh
Keyword(s):  
Group Communication ◽  
Personal Relationships ◽  
Online Media ◽  
Sampling Techniques ◽  
New Wave ◽  
Considerable Influence ◽  
Global Era ◽  
Group Members ◽  
International Ministry ◽  
Method Approach

Humans as social beings communicate for various purposes, in this global era, online media is the choice for audiences when compared to other media. One of the most important communication media in Indonesia is WhatsApp with the WhatsApp group feature for group communication. The theory used is the Theory of Uses and Gratifications which examines the effect of media use. The method approach used in this study is quantitative by explanatory survey and using saturated sampling or census sampling techniques by distributing questionnaires to 113 respondents who are members of the WhatsApp group New Wave International Ministry. The influence of the motives of personal relationships has a considerable influence on the satisfaction of WhatsApp group members New Wave International Ministry, while the motives of surveillance, motives of personal identity and motives of diversity have sufficient influence on the satisfaction of WhatsApp members in the New Wave International Ministry. Keywords: Motive, Satisfaction, WhatsApp group

QOLP-04. THE KETOGENIC DIET PLUS STANDARD CARE FOR RECENTLY DIAGNOSED GLIOBLASTOMA: A PHASE 1 SAFETY AND FEASIBILITY TRIAL

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi183-vi183
Author(s):  
Jethro Hu ◽  
L J Amaral ◽  
Gillian Gresham ◽  
Thomas Nelson ◽  
Amelia Welborn ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Phase 1 ◽  
Progression Free Survival ◽  
Standard Of Care ◽  
Primary Objective ◽  
Feasibility Trial ◽  
Phase 2 Trial ◽  
Related Quality ◽  
Health Related ◽  
Grade 3

Abstract INTRODUCTION There is abundant interest in the potential therapeutic and supportive role of a ketogenic diet (KD) for glioblastoma patients. We conducted a single-arm phase 1 trial to assess the safety and feasibility of KD plus standard-of-care (SOC) in glioblastoma patients (NCT03451799). METHODS Adults within 3 months of diagnosis participated in a 16-week intervention of a classic 3:1 KD (grams fat : grams carbohydrate + protein) with dietitian support. Blood glucose and ketone levels were assessed twice daily (Keto-Mojo), with remote monitoring of daily weight and activity (Fitbit). The primary objective was to assess safety (weight stability, CTCAE) and feasibility (maintaining ketosis &gt; 0.3mM for &gt; 50% of study period). Secondary objectives included assessments of progression-free survival (PFS), overall survival (OS), health-related quality of life (HRQOL), and cognition (MoCA). RESULTS From 04/2018-02/2021, 14 patients were evaluable: female:male, 8:6, median age 55 years, KPS 80, BMI 24.5. MGMT promoter methylation: 6 present, 7 absent, 1 indeterminate. Adherence to KD was high, with all patients maintaining ketosis ( &gt; 0.3mM) &gt; 50% and 11 patients maintaining ketosis &gt; 85% of study days. Adverse events (&gt; Grade 2) potentially attributable to KD: appetite loss (Grade 2: 2); fatigue (Grade 2: 5); flu-like symptoms (Grade 2: 1); constipation (Grade 2: 5, Grade 3: 1). No patients were removed from study for safety reasons. HRQOL was stable, with improvements in role function (not statistically significant). MoCA score improved in 10/14 patients. Median PFS and OS from KD initiation were 11.7 and 29.1 months, respectively. CONCLUSION Our findings suggest that a supervised KD plus SOC is safe and feasible in glioblastoma patients. KD was well-tolerated with encouraging trends in HRQOL and cognition. PFS and OS in this small trial compare favorably to historical control. A multicenter phase 2 trial powered to assess efficacy is planned.

Multimodality Imaging Guidance in Interventional Pain Management

2016 ◽  
Keyword(s):  
Computed Tomography ◽  
Pain Management ◽  
Soft Tissue ◽  
Radiation Exposure ◽  
Multimodality Imaging ◽  
Standard Of Care ◽  
Ultrasound Guided ◽  
Ct Guided ◽  
Imaging Guidance ◽  
Interventional Pain Management

Multimodality Imaging Guidance for Interventional Pain Management is a comprehensive resource covering fluoroscopy-guided procedures, ultrasound interventions, and computed tomography (CT)-guided procedures used in interventional pain management. Fluoroscopy-guided procedures have been the standard of care for many years and are widely available and affordable. Due to the lack of radiation exposure and the ability to see various soft tissue structures, ultrasound-guided interventions are more precise and safer. The benefits, disadvantages, and basic techniques of CT-guided procedures, primarily performed by radiologists, are also included in the volume. By covering all imaging modalities, Multimodality Imaging Guidance for Interventional Pain Management allows for an efficient comparison of the capabilities of each modality.

scholarly journals Regulation of the hedgehog pathway by the ketogenic diet with radiation exposure

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Deepa Sharma ◽  
Bianca Xu ◽  
Avery Zhang ◽  
Hong Chen
Keyword(s):  
Radiation Exposure ◽  
Ketogenic Diet ◽  
Hedgehog Pathway

Online Media as Research Topic and Research Tool

2018 ◽  
Author(s):  
Elizabeth Monier
Keyword(s):  
Social Media ◽  
Middle East ◽  
Research Methodology ◽  
Academic Research ◽  
Research Topic ◽  
Political Life ◽  
Online Media ◽  
Conducting Research ◽  
The Many ◽  
Online Sources

The chapter focuses on researching social media and using online media to conduct research. In recent years, social media has become part of the way we receive and interact with information and understanding its impact on social and political life has become increasingly important in academic research. This presents new sets of challenges in terms of the research methodology and necessitates the cultivation of a very clear awareness of the limitations and shortcomings of conducting research using social media and online sources. In this chapter, Elizabeth Monier examines the advantages of using online media to do fieldwork on the Middle East while highlighting the many pitfalls that researchers can meet online.

Singapore teens' perceived ownership of online sources and credibility

First Monday ◽  
2010 ◽  
Author(s):  
Andrew Michael Duffy ◽  
Tan Liying ◽  
Larissa Ong
Keyword(s):  
Young People ◽  
Information Sources ◽  
Online News ◽  
Online Media ◽  
Secondary Importance ◽  
Mainstream Media ◽  
Current Affairs ◽  
Perceived Ownership ◽  
Online Sources ◽  
Source Of Information

This study investigates teenage attitudes towards unofficial versus mainstream media as a source of information. It starts from three unproven premises. First, that young people place more trust in unofficial online news than in mainstream media, because they feel a greater ownership of the cyberworld. Second, due to a perception of authoritarian control over Singapore's mainstream media, truth and accuracy in unofficial sources are of secondary importance to a feeling of ownership. Third, teenagers' need for accuracy is secondary to their need for ownership and differentiation; and, unofficial information sources are a badge of identity worn by the young. The study found that perceived ownership of a medium is secondary to its utilitarian function. Content is more important than platform. Off-line media were preferred for current affairs and sports, where reliability and convenience were important. This went in tandem with greater interest in current affairs among academic high fliers, and a greater interest in entertainment among others. Online media were preferred for entertainment and leisure information, where accuracy and reliability were secondary to attitude.

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