scholarly journals 1697. The Burden Of Multidrug-Resistant Urinary Tract Infections

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S831-S831
Author(s):  
Fatma Hammami ◽  
Makram Koubaa ◽  
Amal Chakroun ◽  
Khaoula Rekik ◽  
Fatma Smaoui ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Urinary Tract Infections ◽  
Clinical Laboratory ◽  
Antibiotic Consumption ◽  
Multidrug Resistant ◽  
Disease Evolution ◽  
Significant Difference ◽  
The Mean ◽  
Tract Infections

Abstract Background Urinary tract infections (UTIs) are the most common reason for consultation and for antibiotic use. Many factors interfere and increase the risk for antimicrobial resistance. We aimed to study the clinical, laboratory and evolutionary particularities associated with multidrug-resistant (MDR) UTIs. Methods We conducted a retrospective study including all patients hospitalized for UTIs in the infectious diseases department between 2011 and 2018. Results A total of 867 cases of UTIs were included in the study, among which 407 cases (46.9%) were MDR. There were 306 males (35.3%). The mean age was 53±21 years. Overall, MRD UTIs were significantly associated to male gender (39.1% vs 32%; p=0.02). Patients aged ≥65 years were significantly more affected with MRD UTIs (54.5% vs 36.5%; p< 0.001). Previous medical history of diabetes (38.1% vs 24.6%; p< 0.001), antibiotic consumption (30.7% vs 13%; p< 0.001) and surgical intervention of the urinary tract (13% vs 5.4%; p< 0.001) were significantly associated with MDR UTIs. The mean delay to hospitalization was significantly longer among MDR UTIs cases (5[3-10 days] vs 3[2-7 days]; p< 0.001). In total, MDR UTIs were more frequently documented to Klebsiella pneumoniae (19.4% vs 12%; p=0.002). Comparison of the disease evolution showed that MRD UTIs were significantly associated with complications (9.1% vs 5.2%; p=0.02), recurrence (4.4% vs 1.5%; p=0.01) and death (2.2% vs 0.4%; p=0.02). As to laboratory investigations and antibiotic duration, no significant difference was noted. Conclusion Our study showed that MDR UTIs were associated with not only complications, but also with a poor prognosis. The continuous surveillance for antimicrobial resistance and the rational use of antibiotics are crucial in order to improve the prognosis. Disclosures All Authors: No reported disclosures

scholarly journals Randomized Clinical Trial to Evaluate the Effect of Canephron N in Comparison to Ciprofloxacin in the Prevention of Postoperative Lower Urinary Tract Infections after Midurethral Sling Surgery

Health of Man ◽  
2021 ◽  
pp. 43-48
Author(s):  
Ewa Rechberger ◽  
Tomasz Rechberger ◽  
Sara Wawrysiuk ◽  
Pawel Miotla ◽  
Beata Kulik-Rechberger ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Midurethral Sling ◽  
Study Groups ◽  
Antibiotic Consumption ◽  
Female Patients ◽  
Significant Difference ◽  
Sling Surgery ◽  
Gynecological Surgical Procedures ◽  
Tract Infections

Urinary tract infections (UTIs) are one of the most common reasons for antibiotic prescriptions among women worldwide. UTIs are also associated with intra- and postoperative catheterization, which is an essential component of many gynecological surgical procedures, including midurethral sling (MUS) placement. The aim of this study was to compare the incidence of UTI subsequent to a MUS procedure. The study involved 562 female patients who underwent MUS procedures due to stress urinary incontinence (SUI). Patients were assigned in a 1:1 ratio to two study groups: patients receiving 500 mg of ciprofloxacin three times a day for 3 consecutive days after surgery or patients receiving 5 mL of Canephron taken orally three times a day for 3 weeks. After analyzing the collected data, it was found that in the group of patients receiving ciprofloxacin, 29 women (10.98 %) had a UTI, whereas in the group of patients receiving Canephron, 36 women (13.64 %) had a UTI within 6 months after the patient’s MUS procedure. No statistically significant difference between the two groups was noted. Postoperative prophylaxis with a phytodrug can be perceived as an attractive option in the reduction of antibiotic consumption among female patients after a MUS procedure.

scholarly journals A Randomized Clinical Trial to Evaluate the Effect of Canephron N in Comparison to Ciprofloxacin in the Prevention of Postoperative Lower Urinary Tract Infections after Midurethral Sling Surgery

2020 ◽  
Vol 9 (11) ◽  
pp. 3391
Author(s):  
Ewa Rechberger ◽  
Tomasz Rechberger ◽  
Sara Wawrysiuk ◽  
Pawel Miotla ◽  
Beata Kulik- Rechberger ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Midurethral Sling ◽  
Study Groups ◽  
Antibiotic Consumption ◽  
Female Patients ◽  
Significant Difference ◽  
Sling Surgery ◽  
Gynecological Surgical Procedures ◽  
Tract Infections

Urinary tract infections (UTIs) are one of the most common reasons for antibiotic prescriptions among women worldwide. UTIs are also associated with intra- and postoperative catheterization, which is an essential component of many gynecological surgical procedures, including midurethral sling (MUS) placement. The aim of this study was to compare the incidence of UTI subsequent to a MUS procedure. The study involved 562 female patients who underwent MUS procedures due to stress urinary incontinence (SUI). Patients were assigned in a 1:1 ratio to two study groups: patients receiving 500 mg of ciprofloxacin three times a day for 3 consecutive days after surgery or patients receiving 5 mL of Canephron taken orally three times a day for 3 weeks. After analyzing the collected data, it was found that in the group of patients receiving ciprofloxacin, 29 women (10.98%) had a UTI, whereas in the group of patients receiving Canephron, 36 women (13.64%) had a UTI within 6 months after the patient’s MUS procedure. No statistically significant difference between the two groups was noted. Postoperative prophylaxis with a phytodrug can be perceived as an attractive option in the reduction of antibiotic consumption among female patients after a MUS procedure.

scholarly journals Antimicrobial Susceptibility Patterns of Enterococcus species Isolated from urinary tract infections

2017 ◽  
Vol 8 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Jabin Akhter ◽  
Sharmeen Ahmed ◽  
Shaheda Anwar
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Treatment Guidelines ◽  
Clinical Laboratory ◽  
Multidrug Resistant ◽  
Identification System ◽  
Enterococcus Species ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern ◽  
Tract Infections

Enterococci were frequently considered to be commensal organism and were ignored when isolated in clinical laboratory. But recently due to its capability of causing variety of infections, especially in hospitalized patients and difference in antimicrobial sensitivity of each species to varying antibiotics the present study wasundertaken with a view at characterizing the clinical isolates of enterococcus, recovered from the cases of urinary tract infections (UTI). A total of 59 Enterococci were isolated from UTI patient for a period of 1 year. In the present study it was the 3rd leading organism causing UTI. They were speciated by an identification system based on the phenotypic characteristics of enterococcus species and their antimicrobial sensitivity pattern was determined. Most of the isolates were E.faecalis 42(71.18%) followed by E.faecium accounted for 10(16.94%),E.avium 1(2.43%), E.raff 1(2.43%) and 5(8.47%) remained unidentified. E.faecium showed increased resistance to amoxicillin (90%), co-trimoxazole (80%), ciprofloxacin (70%), gentamycin (80%), ceftriaxone (90%), and cefuroxime (80%). Most of the E.faecalis was resistant to amoxicillin (66.66%), cotrimoxazole (71.42%), ciprofloxacin (76.19%), gentamycin (71.42%), ceftriaxone (64.28%) and cefuroxime (80.95%). Multidrug-resistant enterococci are emerging as a leading nosocomial uropathogen. Identification of species along with knowledge of the antimicrobial resistance profile may ultimately contribute to development of strategies for prevention and to formulate treatment guidelines for infections caused by enterococci.Bangladesh J Med Microbiol 2014; 08 (01): 16-20

scholarly journals The Antibacterial Activity of Human Amniotic Membrane against Multidrug-Resistant Bacteria Associated with Urinary Tract Infections: New Insights from Normal and Cancerous Urothelial Models

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 218
Author(s):  
Taja Železnik Ramuta ◽  
Larisa Tratnjek ◽  
Aleksandar Janev ◽  
Katja Seme ◽  
Marjanca Starčič Erjavec ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Amniotic Membrane ◽  
Multidrug Resistant ◽  
Basic Knowledge ◽  
Resistant Bacteria ◽  
Human Amniotic Membrane ◽  
Multidrug Resistant Bacteria ◽  
Tract Infections

Urinary tract infections (UTIs) represent a serious global health issue, especially due to emerging multidrug-resistant UTI-causing bacteria. Recently, we showed that the human amniotic membrane (hAM) could be a candidate for treatments and prevention of UPEC and Staphylococcus aureus infections. However, its role against multidrug-resistant bacteria, namely methicillin-resistant S. aureus (MRSA), extended-spectrum beta-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae, vancomycin-resistant Enterococci (VRE), carbapenem-resistant Acinetobacter baumannii, and Pseudomonas aeruginosa has not yet been thoroughly explored. Here, we demonstrate for the first time that the hAM homogenate had antibacterial activity against 7 out of 11 tested multidrug-resistant strains, the greatest effect was on MRSA. Using novel approaches, its activity against MRSA was further evaluated in a complex microenvironment of normal and cancerous urinary bladder urothelia. Even short-term incubation in hAM homogenate significantly decreased the number of bacteria in MRSA-infected urothelial models, while it did not affect the viability, number, and ultrastructure of urothelial cells. The hAM patches had no antibacterial activity against any of the tested strains, which further exposes the importance of the hAM preparation. Our study substantially contributes to basic knowledge on the antibacterial activity of hAM and reveals its potential to be used as an antibacterial agent against multidrug-resistant bacteria.

Antimicrobial Resistance Among Uropathogens That Cause Childhood Community-acquired Urinary Tract Infections in Central Israel

2017 ◽  
Vol 36 (1) ◽  
pp. 113-115 ◽  
Author(s):  
Renata Yakubov ◽  
Machiel van den Akker ◽  
Kaba Machamad ◽  
Amit Hochberg ◽  
Erez Nadir ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Urinary Tract Infections ◽  
Tract Infections
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