Response to anti-PD1 immunotherapy in patients with metastatic cutaneous sarcoma: case reports and literature review
Keyword(s):
Abstract Dermal sarcomas represent a group or rare malignancies of mesenchymal origin. Although surgical excision with wide margins can be curative, in the advanced/metastatic setting, treatment options are limited and the benefit from anthracycline-based chemotherapy or targeted agents is usually short-lived. Tumor mutational burden and PD-L1 expression scores can be used as predictive biomarker for response to immunotherapy in some metastatic cancers. The role of immune-checkpoint blockade for sarcoma patients remains investigational. Here we present three cases of dermal sarcomas with high TMB and PD-L1 expression and responses to anti-PD1 agents in two of them.
2020 ◽
pp. 42-50
2019 ◽
Vol 14
(6)
◽
pp. 1021-1031
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Keyword(s):
2019 ◽
Vol 16
(1)
◽
pp. 112-115
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Keyword(s):
2019 ◽
Vol 37
(15_suppl)
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pp. 1014-1014
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