Two of a Kind: Conceptual Similarities between Cremation and Inhumation in Early Anglo-Saxon England

Author(s):  
Ruth Nugent

The physical difference in the archaeological traces of the bodies produced by cremation and inhumation have polarized discussions of these two burial practices. Conceptually, the wet, fleshy, decaying inhumed body has long been viewed as the binary opposite of the dry, skeletal, fragmentary cremated body. Inhumed bodies rot in situ, usually below ground, while cremains become portable, capable of being stored above ground. Recent studies aimed at re-integrating our understanding of cremation and inhumation have tended to focus on transitions between the hiatus of one burial mode and the (re-)introduction of another (e.g. Rebay-Salisbury 2012). However, in early Anglo-Saxon England (fifth to seventh centuries AD), cremation and inhumation were concurrently practiced, often in the same cemetery for tens if not hundreds of years. Therefore focusing only on transitions substantially reduces the field of investigation. Such different but contemporaneous burial modes may well have been influenced in part by contrasting and evolving beliefs concerning the body, death and the afterlife. In a recent transhistorical study of cremation and inhumation, Katherine Rebay-Salisbury (2012) identified religion as the primary influential context for funerary practices, with social concerns influencing the choices made within religious practices. However, any divergent cosmologies underpinning this difference still remain frustratingly veiled (Hutton 2010). While early Anglo-Saxon burials reveal a degree of genuine difference in the type and quantity of grave-goods and animals accompanying cremations and inhumations, a range of similarities also exists between them, ripe for further exploration. Cemeteries from Essex and Cambridgeshire provide particularly useful evidence of both cremation and inhumation practices, especially in light of recent publications of organic-rich burial sites of the fifth and sixth centuries AD from this area, notably Mucking I and II (Hirst and Clark 2009) and Springfield Lyons (Tyler and Major 2005). Three overarching concepts of body orchestration are addressed: containment, wrapping, and structuring, the evidence for which is first outlined thematically, then discussed as a whole. These shared concepts may be symptomatic of broader concerns for managing cadavers, which transcended the cremation-inhumation divide that is most clearly expressed through artefact and animal selection.

Author(s):  
Rick Peterson

This chapter examines the diversity of Neolithic cave burial practices after around 3800 BC. In this period there is evidence of a secondary burial rite which is focussed on the cranium. There is also one possible example of mummification or the curation of body parts as part of extended funerary practices. Other secondary burial rites can be recognised in a small number of sites. There are also a very small number of primary burials. The most common burial rite in this period is successive inhumation, which is well documented at a number of sites. There are also sites where multi-stage rites of some kind clearly took place, but without sufficiently well preserved evidence to describe them in more detail and other sites where there are Early Neolithic dates from poorly understood single bones. This diversity of burial practice seems to be linked to the fact that all of these different kinds of rite are also attested at other kinds of Early Neolithic site as well as caves.


Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Cheng Zhou ◽  
Youzhou Yang ◽  
Jiaxin Wang ◽  
Qingyang Wu ◽  
Zhuozhi Gu ◽  
...  

AbstractIn vivo bioprinting has recently emerged as a direct fabrication technique to create artificial tissues and medical devices on target sites within the body, enabling advanced clinical strategies. However, existing in vivo bioprinting methods are often limited to applications near the skin or require open surgery for printing on internal organs. Here, we report a ferromagnetic soft catheter robot (FSCR) system capable of in situ computer-controlled bioprinting in a minimally invasive manner based on magnetic actuation. The FSCR is designed by dispersing ferromagnetic particles in a fiber-reinforced polymer matrix. This design results in stable ink extrusion and allows for printing various materials with different rheological properties and functionalities. A superimposed magnetic field drives the FSCR to achieve digitally controlled printing with high accuracy. We demonstrate printing multiple patterns on planar surfaces, and considering the non-planar surface of natural organs, we then develop an in situ printing strategy for curved surfaces and demonstrate minimally invasive in vivo bioprinting of hydrogels in a rat model. Our catheter robot will permit intelligent and minimally invasive bio-fabrication.


2021 ◽  
pp. 106689692110313
Author(s):  
Alexander M. Strait ◽  
Julia A. Bridge ◽  
Anthony J. Iafrate ◽  
Marilyn M. Li ◽  
Feng Xu ◽  
...  

Myofibroblastoma is a rare, benign stromal tumor with a diverse morphologic spectrum. Mammary-type myofibroblastoma (MTMF) is the extra-mammary counterpart of this neoplasm and its occurrence throughout the body has become increasingly recognized. Similar morphologic variations of MTMF have now been described which mirror those seen in the breast. We describe a case of intra-abdominal MTMF composed of short fascicles of eosinophilic spindle cells admixed with mature adipose tissue. The spindle cells stained diffusely positive for CD34, desmin, smooth muscle actin, and h-caldesmon by immunohistochemistry. Concurrent loss of RB1 (13q14) and 13q34 loci were confirmed by fluorescence in situ hybridization whereas anchored multiplex PCR and whole transcriptome sequencing did not reveal any pathognomonic fusions suggesting an alternative diagnosis. To the best of our knowledge this is the first documented case of leiomyomatous variant of MTMF.


Nanoscale ◽  
2021 ◽  
Author(s):  
Jun Lin ◽  
Binbin Ding ◽  
Pan Zheng ◽  
Dong Li ◽  
Meifang Wang ◽  
...  

Cancer vaccine is to make tumor-specific antigens into vaccines, which then are injected back into the body to activate immune responses for cancer immunotherapy. Despite the high specificity and therapeutic...


Development ◽  
1992 ◽  
Vol 114 (3) ◽  
pp. 711-720 ◽  
Author(s):  
H.V. Isaacs ◽  
D. Tannahill ◽  
J.M. Slack

We have cloned and sequenced a new member of the fibroblast growth factor family from Xenopus laevis embryo cDNA. It is most closely related to both mammalian kFGF (FGF-4) and FGF-6 but as it is not clear whether it is a true homologue of either of these genes we provisionally refer to it as XeFGF (Xenopus embryonic FGF). Two sequences were obtained, differing by 11% in derived amino acid sequence, which probably represent pseudotetraploid variants. Both the sequence and the behaviour of in vitro translated protein indicates that, unlike bFGF (FGF-2), XeFGF is a secreted molecule. Recombinant XeFGF protein has mesoderm-inducing activity with a specific activity similar to bFGF. XeFGF mRNA is expressed maternally and zygotically with a peak during the gastrula stage. Both probe protection and in situ hybridization showed that the zygotic expression is concentrated in the posterior of the body axis and later in the tailbud. Later domains of expression were found near the midbrain/hindbrain boundary and at low levels in the myotomes. Because of its biological properties and expression pattern, XeFGF is a good candidate for an inducing factor with possible roles both in mesoderm induction at the blastula stage and in the formation of the anteroposterior axis at the gastrula stage.


Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1202 ◽  
Author(s):  
Ingo Doench ◽  
Maria Torres-Ramos ◽  
Alexandra Montembault ◽  
Paula Nunes de Oliveira ◽  
Celia Halimi ◽  
...  

The development of non-cellularized injectable suspensions of viscous chitosan (CHI) solutions (1.7–3.3% (w/w)), filled with cellulose nanofibers (CNF) (0.02–0.6% (w/w)) of the type nanofibrillated cellulose, was proposed for viscosupplementation of the intervertebral disc nucleus pulposus tissue. The achievement of CNF/CHI formulations which can gel in situ at the disc injection site constitutes a minimally-invasive approach to restore damaged/degenerated discs. We studied physico-chemical aspects of the sol and gel states of the CNF/CHI formulations, including the rheological behavior in relation to injectability (sol state) and fiber mechanical reinforcement (gel state). CNF-CHI interactions could be evidenced by a double flow behavior due to the relaxation of the CHI polymer chains and those interacting with the CNFs. At high shear rates resembling the injection conditions with needles commonly used in surgical treatments, both the reference CHI viscous solutions and those filled with CNFs exhibited similar rheological behavior. The neutralization of the flowing and weakly acidic CNF/CHI suspensions yielded composite hydrogels in which the nanofibers reinforced the CHI matrix. We performed evaluations in relation to the biomedical application, such as the effect of the intradiscal injection of the CNF/CHI formulation in pig and rabbit spine models on disc biomechanics. We showed that the injectable formulations became hydrogels in situ after intradiscal gelation, due to CHI neutralization occurring in contact with the body fluids. No leakage of the injectate through the injection canal was observed and the gelled formulation restored the disc height and loss of mechanical properties, which is commonly related to disc degeneration.


Author(s):  
O.F. Khairullina ◽  
E.M. Chernykh

The paper is focused on burial grounds of the Mazunino Culture (or Mazunino stage of the Cheganda Cul-ture of the Pyany Bor Cultural-Historical Community by R.D. Goldina) in the Middle Kama Region. They date to the 3rd–5th c. AD and chronologically correlate with the Great Migration Period. The processes of major and minor migrations of that time had an impact on various components of the autochthonous Kama Region cultures. The focus of our research is the burials with throwing weapons, primarily arrowheads found in the Mazunino archers’ burials. The interest in throwing weapon was trigged by the heuristical observation of anthropologist Ivan G. Shi-robokov for the Boyar «Aray» cemetery, where the existence of morphological differences in a group of buried men with arrowheads was statistically proven. To examine this phenomenon, a working hypothesis was put for-ward: intra-group differences of one small necropolis could be reflected in the burial rite and the grave goods of all Mazunino archers’ burials. In total, 148 burials and 146 skeletons with arrowheads from 12 necropolises of the Mazunino Culture have been examined. The comparative analysis of the burial rite features demonstrated a sta-ble correlation between the presence of arrowheads and male burials. The archers’ burials correspond to the burial practices of the majority of the Mazunino population. Rare deviations suggest close relations between local communities and other cultures and ethnicities, primarily with nomadic tribes. Bone arrowheads as a primary weapon of the Mazunino warriors continue the previous traditions of the Ananyino, Pyany Bor (Cheganda) / Kara-Abyz Cultures. A comprehensive analysis of the inter-occurrence of implements in male equipment with arrow-heads allowed distinguishing two conventional groups of burials. The first one is characterized by the presence of only arrowheads in the burial equipment. These grave goods were typical for Mazunino population and consisted of ordinary belts, iron knives, beads, etc. The second group was significantly different, as these were individuals who were skilled in using various weapons, and their kit included various types of weapons for both close and long-range combat. Probably, there was a military gradation among such archers, which needs to be supported by analysis of a larger number of the Mazunino burials. The results of our work need to be verified using the an-thropological materials from other Mazunino burial grounds.


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