scholarly journals Hormone Replacement Therapy and Hip Fracture Risk: Effect Modification by Tobacco Smoking, Alcohol Intake, Physical Activity, and Body Mass Index

1999 ◽  
Vol 150 (10) ◽  
pp. 1085-1093 ◽  
Author(s):  
S. Hoidrup ◽  
M. Gronba k ◽  
A. T. Pedersen ◽  
J. B. Lauritzen ◽  
A. Gottschau ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Hormone Replacement Therapy ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Tobacco Smoking ◽  
Alcohol Intake ◽  
Hormone Replacement ◽  
Effect Modification ◽  
Risk Effect

Risk Factors for Hip Fracture and a Possible Effect Modification by Hormone Replacement Therapy. The Danish Nurse Cohort Study

2005 ◽  
Vol 20 (10) ◽  
pp. 871-877 ◽  
Author(s):  
Yrsa Andersen Hundrup ◽  
Ola Ekholm ◽  
Susanne Høidrup ◽  
Michael Davidsen ◽  
Erik Bernhard Obel
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Hormone Replacement Therapy ◽  
Hip Fracture ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Effect Modification

Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
Blood Lipids ◽  
The Other ◽  
The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

scholarly journals Modifiable and Non-Modifiable Risk Factors for Atherothrombotic Ischemic Stroke among Subjects in the Malmö Diet and Cancer Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1952
Author(s):  
Anna Johansson ◽  
Isabel Drake ◽  
Gunnar Engström ◽  
Stefan Acosta
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Body Mass Index ◽  
Ischemic Stroke ◽  
Family History ◽  
Diet Quality ◽  
Alcohol Intake ◽  
Modifiable Risk Factors ◽  
History Of ◽  
Diet And Cancer

Risk factors for ischemic stroke is suggested to differ by etiologic subtypes. The purpose of this study was to examine the associations between modifiable and non-modifiable risk factors and atherothrombotic stroke (i.e., excluding cardioembolic stroke), and to examine if the potential benefit of modifiable lifestyle factors differs among subjects with and without predisposing comorbidities. After a median follow-up of 21.2 years, 2339 individuals were diagnosed with atherothrombotic stroke out of 26,547 study participants from the Malmö Diet and Cancer study. Using multivariable Cox regression, we examined non-modifiable (demographics and family history of stroke), semi-modifiable comorbidities (hypertension, dyslipidemia, diabetes mellitus and atherosclerotic disease), and modifiable (smoking, body mass index, diet quality, physical activity, and alcohol intake) risk factors in relation to atherothrombotic stroke. Higher age, male gender, family history of stroke, and low educational level increased the risk of atherothrombotic stroke as did predisposing comorbidities. Non-smoking (hazard ratio (HR) = 0.62, 95% confidence interval (CI) 0.56–0.68), high diet quality (HR = 0.83, 95% CI 0.72–0.97) and high leisure-time physical activity (HR = 0.89, 95% CI 0.80–0.98) decreased the risk of atherothrombotic ischemic stroke independent of established risk factors, with non-significant associations with body mass index and alcohol intake. The effect of the lifestyle factors was independent of predisposing comorbidities at baseline. The adverse effects of several cardiovascular risk factors were confirmed in this study of atherothrombotic stroke. Smoking cessation, improving diet quality and increasing physical activity level is likely to lower risk of atherothrombotic stroke in the general population as well as in patient groups at high risk.

Effect modification of cardiorespiratory fitness, obesity, and physical activity in adults

2021 ◽  
Author(s):  
Maria do Socorro Simoes ◽  
Fernando Wehrmeister ◽  
Marcello Romiti ◽  
Antonio de Toledo Gagliardi ◽  
Rodolfo Arantes ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
Vigorous Physical Activity ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Effect Modification ◽  
Cross Sectional ◽  
Arterial Blood

We investigated if cardiorespiratory fitness modifies the association between obesity and the level of physical activity. In this cross-sectional study, we analyzed data from 746 adults, free of diagnosed cardiorespiratory or locomotor diseases. We analyzed sociodemographic and clinical information, cardiovascular risk factors, cardiorespiratory fitness, anthropometry, and level of physical activity (time spent in moderate-to-vigorous physical activity). Those that spent more time in moderate-to-vigorous physical activity were younger, male, with lower body mass index, without self-reported arterial blood hypertension, diabetes and dyslipidemia, non-smokers, and presented with better cardiorespiratory fitness. The linear regression coefficients showed that cardiorespiratory fitness changes according to the level of physical activity and body mass index (obesity in low cardiorespiratory fitness: β 6.0, p = 0.213, 95%CI -3.5 to 15.6; in intermediate cardiorespiratory fitness: β 6.3, p = 0.114, 95%CI -1.5 to 14.2; in high cardiorespiratory fitness: β -6.3, p = 0.304, 95%CI -18.4 to 5.8). This effect modification trend was present after adjusting the model by covariates. Cardiorespiratory fitness potentially modifies the association between body mass index and the level of physical activity. It should be routinely assessed to identify persons with overweight/ obesity with low/ intermediate cardiorespiratory fitness to prescribe individualized training.

scholarly journals Physical Activity and Osteoporotic Hip Fracture Risk in Men

2000 ◽  
Vol 160 (5) ◽  
Author(s):  
Urho M. Kujala ◽  
Jaakko Kaprio ◽  
Pekka Kannus ◽  
Seppo Sarna ◽  
Markku Koskenvuo
Keyword(s):  
Physical Activity ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Hip Fracture Risk ◽  
Osteoporotic Hip Fracture

Physical activity in middle-aged women and hip fracture risk: the UFO study

2010 ◽  
Vol 22 (2) ◽  
pp. 499-505 ◽  
Author(s):  
U. Englund ◽  
P. Nordström ◽  
J. Nilsson ◽  
G. Bucht ◽  
U. Björnstig ◽  
...  
Keyword(s):  
Physical Activity ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Middle Aged ◽  
Hip Fracture Risk

Combination of hormone replacement therapy and high physical activity is associated with differences in Achilles tendon size in monozygotic female twin pairs

2009 ◽  
Vol 106 (4) ◽  
pp. 1332-1337 ◽  
Author(s):  
T. Finni ◽  
V. Kovanen ◽  
P. H. A. Ronkainen ◽  
E. Pöllänen ◽  
G. R. Bashford ◽  
...  
Keyword(s):  
Physical Activity ◽  
Hormone Replacement Therapy ◽  
Achilles Tendon ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Physically Active ◽  
Tendon Thickness

Estrogen concentration has been suggested to play a role in tendon abnormalities and injury. In physically active postmenopausal women, hormone replacement therapy (HRT) has been suggested to decrease tendon diameter. We hypothesized that HRT use and physical activity are associated with Achilles tendon size and tissue structure. The study applied cotwin analysis of fourteen 54- to 62-yr-old identical female twin pairs with current discordance for HRT use for an average of 7 yr. Achilles tendon thickness and cross-sectional areas were determined by ultrasonography, and tendon structural organization was analyzed from the images using linear discriminant analysis (LDA). Maximal voluntary and twitch torques from plantar flexor muscles were measured. Serum levels of estradiol, estrone, testosterone, and sex hormone binding globulin were analyzed. Total daily metabolic equivalent score (MET-h/day) was calculated from physical activity questionnaires. Results showed that, in five physically active (MET > 4) pairs, the cotwins receiving HRT had greater estradiol level ( P = 0.043) and smaller tendon cross-sectional area than their sisters (63 vs. 71 mm2, P = 0.043). Among all pairs, Achilles tendon thickness and cross-sectional area did not significantly differ between HRT using and nonusing twin sisters. Intrapair correlation for Achilles tendon thickness was high, despite HRT use discordance ( r = 0.84, P < 0.001). LDA distinguished different tendon structure only from two of six examined twin pairs who had a similar level of physical activity. In conclusion, the effect of HRT on Achilles tendon characteristics independent of genetic confounding may be present only in the presence of sufficient physical activity. In physically active twin pairs, the higher level of estrogen seems to be associated with smaller tendon size.

Sign in / Sign up

Export Citation Format

Share Document