Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mahira Hamdy El Sayed ◽  
Marwa Yassin Soltan ◽  
Ahmed Sadek ◽  
Mohamed Abo Shabana Hussein Mohamed
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Early Onset ◽  
University Hospital ◽  
Androgenetic Alopecia ◽  
Control Group ◽  
Terminal Hair ◽  
Reactive Oxygen Species Scavenger ◽  
Male Pattern

Abstract Background Androgenetic alopecia (AGA), the most common form of hair loss in men, involves the progressive loss of visible pigmented terminal hair on the scalp in response to circulating androgens. AGA is an autosomal disorder which begins in puberty in genetically predisposed individuals. Aim of the Work To study the effectiveness and safety of the reactive oxygen species scavenger Nacetyl-cysteine (NAC) as a single therapy and in combination with the topically applied minoxidil for treatment of the early-onset androgenetic alopecia in men. Patients and Methods The present study included 100 patients with male pattern hair loss whose age ranged from 18 to 30 years old, recruited from dermatology clinics in Ain Shams University Hospital and Kafr El Sheik University Hospital. Results Overall, all treatments could improve significantly some of the trichoscopic parameters as compared to the control group who did not receive any treatment. The number of terminal hair count increased and the vellus hair count decreased in response to either of treatments; minoxidil, NAC, or both as compared to control. These changes were noticed at both the vertex and frontotemporal sites. The treatment was generally tolerable and the side effects encountered did not necessitate stoppage of the treatment course. Conclusion On the basis of the findings of current study we can conclude that, the role of trichoscopy in increasing the accuracy for diagnosing hair disorders as well as to detect response or failure to treatment, N-acetylcysteine (NAC) improved significantly most of the trichoscopic features of AGA and it was was generally tolerable and the side effects encountered did not necessitate stoppage of the treatment course.

scholarly journals Comparative Study on the Efficacy of Intralesional Minoxidil Injection Alone and in Combination versus the Standard Intralesional Corticosteroid Injection in the Treatment of Alopecia Areata

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Abdallah ◽  
M Y Soltan ◽  
R S Mohammed
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Corticosteroid Injection ◽  
University Hospital ◽  
Control Group ◽  
Study Objective ◽  
Treatment Groups ◽  
Intralesional Corticosteroid ◽  
Clinical Trail

Abstract Background Alopecia areata (AA) is a common, inflammatory, non-scarring type of hair loss. Although hair loss can affect all hair bearing sites, patchy alopecia affecting the scalp is the most common type. Hair loss may progress to alopecia totalis (AT) which is complete balding at the scalp, or to alopecia universalis (AU), describing loss of all hairs on the scalp and body. Consequently, this can cause a devastating emotions effects on patients and may be expose them to psychological comorbidities such as depression, anxiety and social phobia. Objectives To assess the efficacy and safety of intradermal delivery of minoxidil 5% alone and in combination with intralesional triamcinolone acetonide for treatment of alopecia areata. Patients and Methods This study is prospective randomized intra-patients comparative control clinical trail that include 20 Egyptian patients suffering from multiple patches of AA during December 2017 till November 2018 which approved by The Dermatology Research Ethical Committee, Faculty of Medicine, Ain Shams University. Each patient had at least 5 scalp patches of approximately similar size (minimally 3 cm2) with a severity of alopecia tool (SALT) score up to S2 (less than 50% of scalp involvement) either in stable or progressive course. Patients were recruited from outpatient clinic of Dermatology, Ain Shams University Hospital and Al-houd Al-marsoud Hospital and informed written consent was obtained from all of them after explanations the study objective before enrollment in it. Results Considering the side effects of the treatment, all patients in all groups develop different types of side effects only the intolerable pain of injection was common between them and it was statistically not significant in comparison between the treatment groups. All the treatment groups showed significant reduction in dermoscopic finding of AA after treatment except in control group. Conclusion Standard intralesional corticosteroids are the mainstay first line treatment of patchy alopecia that involving less than 50% of the scalp and for cosmetics areas such as beard and eyebrows.

scholarly journals A preliminary observation: Male pattern hair loss among hospitalized COVID‐19 patients in Spain – A potential clue to the role of androgens in COVID‐19 severity

2020 ◽  
Vol 19 (7) ◽  
pp. 1545-1547 ◽  
Author(s):  
Andy Goren ◽  
Sergio Vaño‐Galván ◽  
Carlos Gustavo Wambier ◽  
John McCoy ◽  
Alba Gomez‐Zubiaur ◽  
...  
Keyword(s):  
Hair Loss ◽  
Preliminary Observation ◽  
Male Pattern

Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride

2014 ◽  
Vol 9 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Christine Anne Ganzer ◽  
Alan Roy Jacobs ◽  
Farin Iqbal
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Hair Loss ◽  
Reductase Inhibitor ◽  
Psychological Symptoms ◽  
Physical Symptoms ◽  
Internet Survey ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Male Pattern

Finasteride is a synthetic 5-α reductase inhibitor, which prevents the conversion of testosterone to dihydrotestosterone and has been used for more than 20 years in the treatment of male pattern hair loss. Randomized, controlled trials have associated finasteride with both reversible and persistent adverse effects. In this pilot study, we sought to characterize sexual and nonsexual adverse effects that men reported experiencing at least 3 months after stopping the medication. Based on previous research on persistent side effects of finasteride, we constructed an Internet survey targeting six domains: physical symptoms, sexual libido, ejaculatory disorders, disorders of the penis and testes, cognitive symptoms, and psychological symptoms and was e-mailed to patients who reported experiencing symptoms of side effects of finasteride. Responses from 131 generally healthy men (mean age, 24 years) who had taken finasteride for male pattern hair loss was included in the analysis. The most notable finding was that adverse effects persisted in each of the domains, indicating the possible presence of a “post-finasteride syndrome.”

scholarly journals EARLY PROBIOTICS IN PREVENTING VENTILATOR-ASSOCIATED PNEUMONIA AFTER MULTIPLE TRAUMA

2020 ◽  
pp. 83-85
Author(s):  
TAMER HABIB ◽  
AMIRA B KASSEM ◽  
ISLAM AHMED
Keyword(s):  
Multiple Trauma ◽  
University Hospital ◽  
Control Group ◽  
Trauma Patients ◽  
Ventilator Associated Pneumonia ◽  
Mechanically Ventilated ◽  
Significant Difference ◽  
Multiple Trauma Patients ◽  
And Control

Objective: Using probiotics in preventing ventilator-associated pneumonia (VAP) remain controversial due to different intensive care unit (ICU) populations included in such studies. The aim of this study is to evaluate the role of probiotics in prophylaxis of VAP after multiple trauma. Methods: Sixty-five adult multiple trauma patients on mechanical ventilator (expected ≥48 h) after admission to the Critical Care Medicine Department, Alexandria Main University Hospital from June to November 2018. Patients were randomly assigned using computer sheet into two groups; probiotics group (32 patients received one Lacteol Forte® sachet through orogastric/nasogastric tube 3 times daily during their ICU stay) and control group (33 patients received similar regimen of placebo sachets). All patients were followed up and subjected to all possible strategies of the diagnosis of microbiologically confirmed VAP. Results: Sixty-five patients were enrolled with a mean of age (39.48±7.692) years, 80% of them were male. Regarding the incidence of VAP, it was 18.46% of all patients without statistically significant difference between probiotics group (15.63%) and control group (21.21%) (p=0.751). Conclusion: Routine use of early probiotics in mechanically ventilated multiple trauma patients was not associated with lower incidence of VAP, duration of MV, or ICU mortality.

Scalp cooler efficacy to reduce anthracycline-induced alopecia and its QOL impact in breast cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e13539-e13539 ◽  
Author(s):  
R. O. El-saka ◽  
G. El-Husseiny ◽  
Y. Rostom ◽  
A. Salama
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Hair Loss ◽  
Emotional Functioning ◽  
Performance Status ◽  
The Body ◽  
Control Group ◽  
Scalp Cooling ◽  
Moderate Disturbance

e13539 Background: Hair loss is a common, unavoidable, and stressful side effect of chemotherapy. This work was performed to evaluate the role of scalp cooling in reducing anthracycline-induced hair loss and its impact on Quality of life (QOL). Methods: The study was conducted from July 2007 to August 2008. It included 120 females with breast cancer, treated in adjuvant setting. Patients were chosen according to certain criteria (age ≤ 70 years, WHO performance status 0–1, no cardiac disease, no serious psychiatric conditions, no previous chemotherapy). Patients were divided randomly into 2 groups according to whether scalp cooler was used or not during chemotherapy. Chemotherapy consisted of doxorubicin (50 mg/m2), 5-FU (500 mg/m2) and cyclophosphamide (500 mg/m2) for 6 cycles. Paxman Scalp Cooler was used. The cap was applied 20 minutes before, during and 2 hours after infusion. Hair loss was assessed using WHO criteria at each cycle and after 6 cycles of chemotherapy. QOL was assessed using EORTC QLQ-C30 and BR23. Results: After 4 cycle, 61.7 % of patients in scalp cooling group had grade 4 hair loss compared to 81.7 % of patients in control group. After 6 cycles, 85% of patients in scalp cooling group experienced grade 4 hair loss compared to 100% of patients in the control group. Only 9 patients (15%) in the scalp cooling group developed grade 1–2 hair loss. No significant relation was found between the degree of hair loss and the liver function tests. Most patients (73.3%) were comfortable during cooling. QOL scores were comparable between the two groups except for emotional functioning and body image. In the hair loss group, 71.2% of patients showed severe disturbance of emotional functioning and 54.1% of patients had moderate disturbance in body image. In hair preservation group (9 patients), 77.8% developed moderate disturbance of emotional functioning and all patients had mild disturbance in the body image. Conclusions: The role of scalp cooling is limited at the total dose of 300 mg/m2 doxorubicin. It may be more effective with fewer cycles or less aggressive drug combination. Hair loss affects various aspects of QOL, especially emotional functioning and body image. More time is needed to assess the long term effect of hair loss on QOL and the incidence of scalp metastasis in the two study groups. No significant financial relationships to disclose.

scholarly journals Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Maria Cristina Pintus ◽  
Milena Lussu ◽  
Angelica Dessì ◽  
Roberta Pintus ◽  
Antonio Noto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neonatal Intensive Care ◽  
Biological Fluids ◽  
Medical Knowledge ◽  
University Hospital ◽  
Control Group ◽  
Multivariate Statistical ◽  
H Nmr ◽  
And Oxidative Stress

Despite the advancements in medical knowledge and technology, the etiopathogenesis of bronchopulmonary dysplasia (BPD) is not yet fully understood although oxidative stress seems to play a role, leading to a very demanding management of these patients by the neonatologist. In this context, metabolomics can be useful in understanding, diagnosing, and treating this illness since it is one of the newest omics science that analyzes the metabolome of an individual through the investigation of biological fluids such as urine and blood. In this study, 18 patients admitted to the Neonatal Intensive Care Unit of the Cagliari University Hospital were enrolled. Among them, 11 patients represented the control group and 7 patients subsequently developed BPD. A sample of urine was collected from each patient at 7 days of life and analyzed through 1H-NMR coupled with multivariate statistical analysis. The discriminant metabolites between the 2 groups noted were alanine, betaine, trimethylamine-N-oxide, lactate, and glycine. Utilizing metabolomics, it was possible to detect the urinary metabolomics fingerprint of neonates in the first week of life who subsequently developed BPD. Future studies are needed to confirm these promising results suggesting a possible role of microbiota and oxidative stress, and to apply this technology in clinical practice.

scholarly journals A ROLE OF JALUAKAAVCHARANAAND NIMBA HARIDRACHOORNA LEPA IN TREATMENT OF INDRALUPTA - A CASE STUDY

2021 ◽  
Vol 9 (6) ◽  
pp. 1299-1302
Author(s):  
Sejalgamit Sejalgamit
Keyword(s):  
Side Effects ◽  
Female Patient ◽  
Hair Loss ◽  
Medical Science ◽  
Modern Science ◽  
Human Being ◽  
Contemporary Science

Hair is crowning glory and mark of identity of human being. Indralupata in modern science correlate with alopecia aereata. It is characterized by localised areas of non-scarring hair loss which can be co-related with indralupta. Due to side effects and limitation of contemporary science, some harmless and effective medicines are expected from alternative medical science. indralupta disease is described under heading of kshudraroga by sushruta, vagbhata etc.in modern science its main treatment is corticosteroids which is having harmful side effects and not advisable for long term use.so it is necessary to find better remedies .it can be easily fulfilled by Ayurveda. Here, a case of female patient suffering from indralupta was successfully treated with jaluaka and haridra and nimbalepa. Keywords: kshudraroga, indralupta, jaluaka, haridra and nimbalepa

Platelet‑rich plasma as a method of treatment of androgenetic alopecia in men — a case report

2020 ◽  
Vol 3 (1) ◽  
pp. 27-33
Author(s):  
Patrycja Przybylska ◽  
Teresa Matthews‑Brzozowska
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Nutritional Supplementation ◽  
Androgenetic Alopecia ◽  
Common Condition ◽  
Minimal Invasiveness ◽  
Photographic Documentation ◽  
Hair Transplant

Androgenetic alopecia is a common condition, accounting for about 95% of all male hair loss. Standard therapeutic solutions recommend the use of minoxidil, finasteride, spironolactone, nutritional supplementation, phototherapy and hair transplant surgery. An increasingly popular alternative method that has been used in the case report is platelet rich plasma (PRP) mesotherapy characterized by autologous character, minimal invasiveness and no serious side effects. A series of 3 treatments was performed at 3-week intervals. The effects of using medical photographic documentation after completing a series of treatments.

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